(Organic Chemistry) BIOMOLECULES

EXERCISE-I
Q.1 Iso-electric point of alanine is (pH = 6). At which pH, maximum concentration of zwitter ion of
alanine will be present?
(A) pH > 6 (B) pH < 6 (C) pH = 6 (D) pH = 7
Q.2 At iso-electric point :
(A) Concentration of cation is equal to concentration of anion
(B) Net charge is zero
(C) Maximum conc. of di-pole ion (Zwitter ion) will be present
(D) All of the above
Q.3 Which of following amino acid has lowest iso-electric point ?
(A) Glycine (B) Alanine (C) Aspartic acid (D) Lysine

→ ( A ) ⎯⎯⎯⎯→
( ) 3
( B) ; Product (B) of given reaction is :
HgSO4 1 NH + HCN
Q.4 H — C  C — H ⎯⎯⎯
H2SO4 ( 2) H O+
3

(A) Glycine (B) Alanine (C) Valine (D) Leucine

Q.5 Which amino acid does not contain chiral centre?
(A) Valine (B) Leucine (C) Glycine (D) Iso-leucine
Q.6 Which of the following is Sanger reagent ?
(A) 2,4-Di-nitro flurobenzene (B) Phenyl isocyanane
(C) 2,4-Di-nitro chlororbenzene (D) 12,4-Di-nitro-iodobenzene
Q.7 A D-carbohydrate is :
(A) Always dextrorotatory
(B) Always laevorotatrory
(C) Always the mirror of the corresponding L-carbohydrate
(D) None of these

Q.8 The given osazone can be obtained by :

(A) D-glucose (B) D-mannose (C) D-Idose (D) Both (A) & (B)
Q.9 Which of the following pair gives same phenyl osazone?
(A) D-Glucose and D-Allose (B) D-Glucose and D-Altrose
(C) D-Glucose and D-Mannose (D) D-Glucose and D-Talose

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Q.10 Which of the following represents the anomer of the compound shown?

(A) (B)

(C) (D) None of these

Q.11 For the complex conversion of D-glucose into the corresponding osazone, the minimum number
of equivalents of phenyl hydrzine required is :
(A) Two (B) Three (C) Four (D) Five
Q.12 Which of the following structure is L-arabinose?

(A) (B)

(C) (D)

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Q.13 Which one of the statements concerning the equilibrium shown is true?

(A) The two structures are enantiomers of each other. They have equal but oppostie optical
rotations and recemize slowly at room temperature
(B) The two structures are enantiomers of each other. They racemize too rapidly at room
temperature for their optical rotations to be measured
(C) The two structures are diastereomers of each other. Their interconversion is called
mutarotation
(D) The two structures are diastereomers of each other. Their interconversion does not require
breaking and making bonds, only a change in conformation
Q.14 Major product of following reaction is :

(A)

(B)

(C)

(D)

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Q.15 What is the structure of L-glucose ?

(A) (B)

(C) (D) None of these

Q.16 What is the structure of L-glyceraldehyde?

(A) (B)

(C) (D) Both (A) and (B)

Q.17 the given is enol form of :

(A) D-glucose (B) D-mannose (C) D-fructose (D) All of these

Q.18 D-glucose & D-fructose can be differentiated by :
(A) Fehling solution (B) Tollen's reagent (C) Benedict test (D) Br2 /H2 O
Q.19 D-Glucose exist in x different forms. The value of x (stereoisomer) is :
(A) 2 (B) 3 (C) 4 (D) 5

Q.20
Product (A) of above reaction is :
(A) D-glucose (B) D-fructose (C) D-talose (D) D-idose
Q.21 Which of the following statement is not correct for maltose.
(A) It is a disaccharide (B) It undergoes mutarotation
(C) It is a reducing sugar (D) It does not have hemiacetal group.
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Q.22 A compound which does not react with Brady's reagent but decolourise Br2 /H2 O solution is :

(A) (B) (C) (D)

Q.23 Maltose is made up of to two sugars-
(A) Glucose (B) Fructose (C) Glucose & galactose (D) Glucose & fructose
Q.24 D-Ribose when treated with dilute HNO3 forms.

(A) (B)

(C) (D)

Q.25 Consider the given process

and identify the incorrect statement.

(A) Configuration at C − 2 is lost on enolization
(B) I and III are epimers
(C) Proton transfer from water to C − 1 converts ene diol to an aldose.
(D) D-glucose can isomerise to D-fructose through enol intermediate.
Q.26 When methyl D-glucopyranoside is treated with HIO4 its number of mole consumed per mole of
the sugare is -
(A) 2 (B) 3 (C) 4 (D) 5
Q.27 α - amino acid when heated with NaOH/CaO forms -
(A) α, β - unsaturated acid (B) α, β - unsaturated amine
(C) Carboxylic acid (D) Amine

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Q.28 The configuration of the C − 2 epimer of D-glucose is-
(A) 2R, 3 S, 4R, 5 S (B) 2 S, 3 S, 4R, 5R (C) 2 S, 3R, 4 S, 5R (D) 2R, 3 S, 4R, 5R
Q.29 Mutarotation involve-
(A) Racemisation (B) Diastereomerisation
(C) Optical resolution (D) Conformational inversion
Q.30 Consider the reaction sequence -
+
PhNHNH2 H3O
Glucose ⎯⎯⎯⎯
excess
→ P ⎯⎯
⎯
→ Q ⎯⎯⎯
Zn
AcOH
→R
The product R is -
(A) Arbinose (B) Sorbitol (C) Fructose (D) Mannose

Q.31 The pH of the solution containing following zwitter ion species is

(A) 4 (B) 5 (C) 7 (D) 9

Q.32 Peptide linkage is –

(A) (B) (C) (D)

Q.33 Same osazone derivative is obtained in case of D-glucose, D-Mannose and D-Fructose due to
(A) The same configuration at C − 5
(B) The same constitution.
(C) The same constitution at C − 1 and C − 2
(D) The same constitution and acid configuration at C-3, C-4, C-5 and C-6 but different
constitution and configuration at C − 1 and C − 2 which becomes identical by osazone
formation.
Q.34 D( − ) − Erythrose ⎯⎯⎯
NaBH4
→( P )

D( − ) − Threose ⎯⎯⎯
NaBH4
→(R )
Which of the following statement is correct about P and R ?
(A) Both are optically active
(B) Both are optically inactive
(C) P is optically inactive and R is optically active
(D) Neither P nor R has asymmetric carbon.
Q.35 The monomer of nucleic acids are held together by
(A) Phosphodiester linkage (B) Amide linkage
(C) Glycosidic linkage (D) Ester linkage
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Q.36 Select the incorrect statement about Nylon 2-nylon-6.
(A) It is a copolymer.
(B) It is biodegradable.
(C) It is an alternating polyamide.
(D) It is made up of and H2 N(CH2 )5 COOH.

Q.37 The monomer that can undergo radical, cationic and anionic polymerisation with equal case-
(A) (B) Ph − CH = CH2

(C) CH2 = CH2 (D) CH2 = CH − CN

Q.38 Consider the reaction-

Mixture of A and B can be best separated by -

(A) Steam distillation (B) Vacuum distillation
(C) Fractional distillation (D) Crystallisation
Q.39 Which of the following statements are incorrect :
(A) Copolymer of 1,3-butandiene & acrylonitrile is Buna-S
(B) HDPE is obtained by Ziegler-Natta polymerization
(C) Polymer dacron can be polyester fabric
(D) Phenol & formaldehyde resin is called novolac
Q.40 A segment (X) of cellulose obtained on partial hydrolysis has molecular mass 1476gm . On
complete acidic hydrolysis, mass of the product obtained is 1620gm. Find out the number of
glycosidic linkage(s) present in segment (X) :
(A) 8 (B) 6 (C) 4 (D) 10
Q.41 When solidum extract is treated with FeCl3 solution a blood red coloured is obtained due to the
presence of -

(A) (B)

(C) (D)

Q.42 The monomer that undergo radical polymerisation most easily is

(A) CH2 = CH2 (B) C6 H5 CH = CH2 (C) (D) CH3 − CH = CH2

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EXERCISE # II
Q.1 Carbohydrates may be:
(A) Sugars (B) Starch
(C) Polyhydroxy aldehyde/ketones (D) Compounds that can be hydrolysed to sugar
Q.2 Select the correct statement :
(A) Glycosides do not undergo mutarotation
(B) All OH groups of a cyclic monosaccharides are converted to ethers by treatment with base
and an alkyl halide
(C) α-D glucose reacts with Ag 2 O and excess CH3 I to form tetramethyl ether
(D) D-glucose upon treatment with warm HNO3 forms D-glucaric acid
Q.3 "Aspartame" is roughly 100 times as sweet as cane sugar. On complete hydrolysis of aspartame,
products obtained is/are :

(A) (B) (C) CH3 OH (D)

Q.4 Starch molecules are polymer with repeating glucose units. Select the correct statement(s).
(A) Glucose units are joined through α-glycosidic linkage
(B) The branches of amylopectin are linked to the chain with α − 1, 6′ -glycosidic linkages
(C) The linear linkages of amylopectin are formed by α − 1,6-glycosidic bond
(D) Amylose has an unbranched skeleton of glucose molecules with α − 1,4 '-glycosidic linkages
Q.5 Select the correct option.
(A) Isoelectric point is the pH at which an amino acid exists primarily in its neutral form.
(B) Isoelectric point is the average of pK a values of α − COOH amino α − NH3+ groups [ valid only
for neutral amino acid]
(C) Glycine is characterised by two pK a values
(D) For neutral amino acid the concentration of zwitter ion is maximum at its isoelectric point
Q.6 Amino acids are synthesised from
(A) α-Halo acids by reaction with NH3
(B) Aldehydes by reaction with NH3 and cyanide ion followed by hydrolysis
(C) Pyruvic acid is treated with NH3 followed by addition of H2 (Ni)
(D) Alcohols by reaction with NH3 and CN− ion followed by hydroysis.
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Q.7 Which of the following carbohydrates developes blue colour on treatment with iodine solution?
(A) Glucose (B) Amylose (C) Starch (D) Fructose
Q.8 Select the correct statement
(A) High density polythene is a linear polymer.
(B) Low density polythene is a branched chain polymer.
(C) Chain growth polymers are also known as addition polymer.
(D) Step growth polymer is also known condensation polymer.
Q.9 Select the correct statement.
(A) Elastomers have the weakest intermolecular forces
(B) Buna-N is example of synthetic copolymer
(C) Some fibres have crystalline nature
(D) Thermoplastic polymers have stronger intermolecular forces than fibres
Q.10 Which of the following options are correct :

(A)

+ AgNO3
(B) Na extract of sample containing chlorobenzene ⎯⎯⎯ → white ppt. of AgCl
(C) Na extract of sample containing chlorobenzene ⎯⎯⎯
+ AgNO3
→ No ppt. of AgCl

(D)

Q.11

Before isolating (P) unreacted Ph − CHO is removed first. Select the correct statement.
(A) P is cinnamaldehyde (B) P is crotonic acid
(C) Removal is done by simple distillation (D) P is cinnamic acid.
Q.12 If on a strand of DNA the base sequence is ATTGACGCAT then the sequence transcription on RNA
would be -
(A)UAACUGCGUA (B) AUUCUGCGUA (C) UAACTGCGUA (D) TAACTGCGTA
Q.13 Select the correct statement among following
(A) Number of chiral atom in α-D-glucose is less than D-glucose
(B) D-glucose and D-fructose give same product with HIO4
(C) D-glucose and D-fructose give same product with H2 NOH
(D) D-glucose and D-fructose form same product with H2 N − NH − Ph

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Q.14 The N-base which differenciate DNA with RNA is :
(A) Cytosine (B) Uracil (C) Adenine (D) Guanine
Q.15 Correct statement
(A) Nylon-66 is example of addition polymer
(B) Alanin having pH9 at isoelectric point
(C) Fructose when reacts with fehling solution reddish brown ppt. formed
(D) All of these
Q.16 Match the column :
Column I Column II
(A) Sucrose (P) Two acetals
(B) Maltose (Q) No hemiacetal
(C) Lactose (R) β − 1,4 '-glycosidic bond
(D) Cellulose (S) One of the hydrolysis product is glucose
Q.17 Match the column
Column I Column II
(Component of mixture) (Reagent)
(A) Crystalline Na2 CO3 + (P) Fehling solution
Sodium citrate +CuSO4 (aq. sol.)
(B) CuSO4 + Rochelle Salt +NaOH (Aq. sol.) (Q) Nesseler's Reagent
(C) 10%α - naphthol in alcohol (R) Bennedict's solution
(D) HgCl + KI + KOH (aq. sol.) (S) Molisch's Reagent

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EXERCISE # III
Assertion Reason
Q.1 Statement 1 : Furanose ring, like pyranose rings are not planar.
Statement 2 : The most stable conformation of furanose is envelope form.
(A) Statement- 1 is true, statement- 2 is true and statement- 2 is correct explanation for
statement- 1 .
(B) Statement- 1 is true, statement- 2 is true and statement- 2 is NOT the correct explanation for
statement- 1 .
(C) Statement-1 is true, statement- 2 is false.
(D) Statement- 1 is false, statement- 2 is true.
Q.2 Statement 1 : Bromine water changes glucose to gluconic acid.
Statement 2 : Bromine water acts as oxidising agent.
(A) Statement- 1 is true, statement- 2 is true and statement- 2 is correct explanation for
statement- 1 .
(B) Statement- 1 is true, statement- 2 is true and statement- 2 is NOT the correct explanation for
statement-1.
(C) Statement- 1 is true, statement- 2 is false.
(D) Statement- 1 is false, statement- 2 is true.
Q.3 Statement 1 : All monosaccharide ketoses are reducing sugars.
Statement 2 : Monosaccharide ketose give positive Tollen's and Fehling's test.
(A) Statement- 1 is true, statement- 2 is true and statement- 2 is correct explanation for
statement- 1 .
(B) Statement- 1 is true, statement- 2 is true and statement- 2 is NOT the correct explanation for
statement- 1 .
(C) Statement-1 is true, statement- 2 is false.
(D) Statement- 1 is false, statement- 2 is true.
Comprehension (Q.4 to Q.6)
Consider the following reversible process for a reaction of D-glucose.

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Q.4 The structure of intermediate [X] is

(A) (B)

(C) (D)

Q.5 Select the correct option.

(A) (B)

(C) (D)

Q.6 Select the correct statement.

(A) Y is more stable than Z due to H-bond
(B) Y is less stable than Z due to anomeric effect.
(C) Y is more stable than Z due to anomeric effect
(D) Y is less stable than Z due to H-bond.
Comprehension (Q.7 to Q.9)

The monomer (G = Me or Cl) when treated with Zieglar - Natta catalyst undergo
polymerisation in the manner given below –

Q.7 The Zieglar-Natta catalyst is

(A) TiCl4 (B) R 3 Al (C) R 3 Al/TiCl4 (D) R 3 B/TiCl4

Q.8 The polymer obtained when monomeric unit used is

(A) Neoprene (B) Stilbene (C) Styrene (D) Chloropicrin
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Q.9 Which of the following statement is not true considering the process given above.
(A) The general class of polymer formed is known as homopolymer
(B) The polymer obtained is stereoregular
(C) Buna- N can be prepared using above process
(D) Synthetic rubber can be formed by above process using 1,3- butadiene.
Match the Column
Q.10 Match the compounds given below existing in equilbrium mixture with their percentage given
in the right hand side.
Column I Column II

(A) (P) 36%

(B) (Q) 63.8%

(C) (R) 99.9%

(D) (S) 0.2%

Q.11 Match the column:

Column I Column II
(Carbohydrate) (Properties)
(A) Starch (P) Mutarotation
(B) Sucrose (Q) Non reducing sugar
(C) Lactose (R) β-glycosidic bond
(D) Maltose (S) α-glycosidic bond
(T) Reducing sugar
(U) Hemiacetal

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Q.12 Match the column:
Column I Column II

(A) (P) α-glycoside bonds

(B) (Q) Reducing sugar

(C) (R) Forms enediol intermediate

(D) (S) β-glycoside bond

Q.13 Match the column

Column I Column II
(Functional group) (Test used or complex formed during confirmatory test)
(A) Aldehydic (P) [(C6 H5 O)6 Fe]−3 (violet)

(B) Phenolic (Q)

(C) Alcohol (R)

(D) α-D- Glucopyranose (S) (ROH)2 Ce(NO3 )4 (Red)

(T) Molisch's Test
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Q.14 Match the column:
Column I Column II
(A) Addition polymer (P) Buna-S
(B) Condensation polymer (Q) Buna-N
(C) Homopolymer (R) Polythene
(D) Copolymers (S) Nylon 6,6
Q.15 Match the column
Presence of the element in Complex formed in one Colour of the complex
Na – extract of the test
(A) N (P) Na4 [Fe(CN)5 NOS] (W) Prussian Blue
(B) S (Q) Fe(CNS)3 (X) Black
(C) N and S together (R) PbS (Y) Violet
(S) Fe4 [Fe(CN)6 ] (Z) Blood Red
Subjective Type:
Q.16 The pKa values for the three acidic group P, Q, R are 4.3,9.7 and 2.2 respectively

Calculate the isoelectric point of the amino acid?

Q.17 How will you separate?
(a) Ethane & Ethyne (b) 1-Butyne & 2-Butyne (c) Phenol & Propanol
(d) 2-Propanol & Propanone (e) CH3 COOH&HCOOCH3 (f) PhOH&PhCOOH
(g) C2 H4 &C2 H2 (h) EtNH2 &Me2 NH (i) EtOH&Et − O − Et
Q.18 How will you differentiate?
(a) Propane & Propene (b) 1,1-Dichloroethane & 1,2-Dichloroethane
(c) Chloroethane & Chloroethene (d) Pure & Oxidized CHCl3
(e) p-chlorotoluene & benzylchloride (f) n-propylchloride & isopropylchloride
(g) Methanol & ethanol (h) Isobutanol & tert-butanol
(i) 2-Pentanol & 3-pentanol (j) O-cresol & benzylalcohol
(k) Ethanol & Propanol (l) Propanone & Ethanol
(m) HCHO&PhCHO (n) Glucose & Fructose
(o) HCOOH&CH3 COOH (p) HCOOH&HCHO

(q) MeNH2 &Me2 NH (R)

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Q.19 (a) What is the structure of nylon-6, made by alkaline polymerisation of caprolactum.

(b) Suggest mechanism for the process. Is polymerisation of the chain reaction or step reaction
type.
Q.20 Compound (A) C5 H10 O5 give a tetra-acetate with Ac2 O & oxidation of A with Br2 /H2 O gives an
acid C5 H10 O6 . Reduction of A with HI&RedP. Give 2-methyl butane. What is structure of ' A '
Q.21 (i) Sulphanilic acid although has acidic as well as basic group. It is soluble in alkali but insoluble
in mineral acid. Explain.
(ii) Explain why sulphonic acid is not soluble in organic solvents.
Q.22 Account for the fact that 2-amino ethanoic acid (glucine) exist as a dipolar ion as does p-
aminobenzene sulphonic acid but p-amino benzoic acid does not.
Q.23 For given compound

(a) Which glycosidic linkage is present (b) Name of the compound

(c) Products obtained on hydrolysis (d) Is it reducing sugar
(e) Number of moles of HIO4 consumed (f) Is mutarotation possible
(g) Number of moles of CH3 COCl consumed per mole of compound.
Q.24 For given compound

(i) Number of possible isomers

(ii) Number of possible D-configuration isomers
(iii) Number of possible L-configuration isomers

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Q.25 Number of possible isomers of α-D-gluco pyronose configuration.

Q.26 Calculate isoelectric point of following amino acid

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EXERCISE # IV (JEE-MAIN)
Q.1 Which of the following pairs give positive Tollen's test? [JEE-Main-2004]
(1) Glucose, sucrose (2) Glucose, fructose
(3) Hexanal, Acetophenone (4) Fructose, sucrose
Q.2 Two forms of D-glucopyranose, are called. [JEE-Main-2005]
(1) Enantiomers (2) Anomers (3) Epimers (4) Diastereomers
Q.3 When benzene sulfonic acid and p-nitrophenol are treated with NaHCO3 , the gases released
respectively are [JEE-Main-2006]
(1) SO2 , NO2 (2) SO2 , NO (3) SO2 , CO2 (4) CO2 , CO2
Q.4 Statement-1 : Glucose gives a reddish-brown precipitate with Fehling's solution. because
[JEE-Main-2007]
Statement-2 : Reaction of glucose with Fehling's solution gives CuO and gluconic acid.
(1) Statement-1 is True, Statement-2 is True; Statement-2 is a correct explanation for Statement-1.
(2) Statement-1 is True, Statement-2 is True; Statement-2 is NOT a correct explanation for
Statement-1.
(3) Statement-1 is True, Statement-2 is False.
(4) Statement-1 is False, Statement-2 is True.
Q.5 Which one of the following bases is not present in DNA ? [JEE-Main-2014]
(1) Cytosine (2) Thymine (3) Quinoline (4) Adenine
Q.6 Which one is classified as a condensation polymer? [JEE-Main- 2014]
(1) Teflon (2) Acrylonitrile (3) Dacron (4) Neoprene
Q.7 Which of the vitamins given below is water soluble? [JEE-Main- 2015]
(1) Vitamin E (2) Vitamin K (3) Vitamin C (4) Vitamin D
Q.8 Which of the following compounds is not an antacid? [JEE-Main- 2015]
(1) Phenelzine (2) Ranitidine
(3) Aluminium hydroxide (4) Cimetidine

Q.9 is used as: [JEE-Main-2015]

(1) Insecticide (2) Antacid (3) Antihistamine (4) Analgesic

Q.10 Thiol group is present in : [JEE-Main-2016]
(1) Methionine (2) Cytosine (3) Cystine (4) Cysteine
Q.11 The distillation technique most suited for separating glycerol from spent-lye in the soap industry
is [JEE-Main-2016]
(1) Distillation under reduced pressure (2) Simple distillation
(3) Fractional distillation (4) Steam distillation

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Q.12 Which of the following statements about low density polythene is FALSE? [JEE-Main-2016]
(1) It is used in the manufacture of buckets, dust-bins etc
(2) Its synthesis requires high pressure
(3) It is a poor conductor of electricity
(4) Its synthesis requires dioxygen or a peroxide initiator as a catalyst.
Q.13 Which of the following is an anionic detergent? [JEE-Main-2016]
(1) Glyceryl oleate (2) Sodium stearate
(3) Sodium lauryl sulphate (4) Cetyltrimethyl ammonium bromide
Q.14 The formation of which of the following polymers involves hydrolysis reaction?
[JEE-Main-2017]
(1) Nylon 6 (2) Bakelite (3) Nylon 6,6 (4) Terylenes
Q.15 Which of the following compounds will behave as a reducing sugar in an aqueous KOH solution?
[JEE-Main-2017]

(A) (B)

(C) (D)

Q.16 Glucose on prolonged heating with HI gives : [JEE-Main-2018]

(1) 6-iodohexanal (2) n-Hexane (3) 1-Hexene (4) Hexanoic acid
Q.17 The increasing order of pKa of the following amino acids in aqueous solution is : Gly Asp Lys Arg
[JEE-MAIN2019]
(1) Asp < Gly < Arg < Lys (2) Arg < Lys < Gly < Asp
(3) Gly < Asp < Arg < Lys (4) Asp < Gly < Lys < Arg
Q.18 The correct sequence of amino acids present in the tripeptide given below is :
[JEE MAIN-2019]

(1) Val - Ser – Thr (2) Leu - Ser – Thr (3) Thr - Ser- Leu (4) Thr - Ser – Val

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Q.19 The correct structure of product ' P ' in the following reaction is : [JEE MAIN-2019]

(A)

(B)

(C)

(D)

20. Among the following compound which one is found in RNA ? [JEE MAIN-2019]

(A) (B) (C) (D)

21. The correct match between Item I and Item II is :-

[JEE MAIN-2019]
Item I Item II
(A) Ester test (P) Tyr
(B) Carbylamine test (Q) Asp
(C) Phthalein dye test (R) Ser
(S) Lys
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(Organic Chemistry) BIOMOLECULES
(1) (A)→(R); (B)→(S); (C)→(Q) (2) (A)→(R); (B)→(Q); (C)→(P)
(3) (A)→(Q); (B)→(S); (C)→(R) (4) (A)→(Q); (B)→(S); (C)→(P)
22. Among the following compounds most basic amino acid is : [JEE MAIN-2019]
(1) Lysine (2) Asparagine (3) Serine (4) Histidine
23. The correct structure of histidine in a strongly acidic solution (pH = 2) is [JEE MAIN-2019]

(1) (2)

(3) (4)

24. Amylopection is composed of : [JEE MAIN-2019]

(1) α-D-glucose, C1 − C2 and C1 − C6 linkages
(2) β-D-glucose, C1 − C4 and C1 − C6 linkages
(3) β-D-glucose, C1 − C4 and C2 − C6 linkages
(4) α-D-glucose, C1 − C4 and C2 − C6 linkages
25. Number of stereo centers present in linear and cyclic structures of glucose are respectively :
[JEE MAIN-2019]
(1) 4 & 4 (2) 4 & 5 (3) 5 & 5 (4) 5 & 4
26. Glucose and Galactose are having identical configuration in all the positions except position.
(1) C − 5 (2) C − 3 (3) C − 2 (4) C − 4
27. Which of the following statements is not true about RNA? [JEE MAIN-2019]
(1) It has always double stranded α-helix structure
(2) It usually does not replicate
(3) It is present in the nucleus of the cell
(4) It controls the synthesis of protein
28. Which of the given statements is INCORRECT about glycogen? [JEE MAIN-2019]
(1) Only α-linkages are present in the molecule.
(2) It is present in animal cells.
(3) It is present in some yeast and fungi.
(4) It is a straight chain polymer similar to amylose.

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(Organic Chemistry) BIOMOLECULES
29. Maltose on treatment with dilute HCl gives : [JEE MAIN-2019]
(1) D-Glucose (2) D-Fructose
(3) D-Glucose and D-Fructose (4) D-Galactose
30. The major product in the following reaction is : [JEE MAIN-2019]

(1) (2) (3) (4)

31. Fructose and glucose can be distinguished by : [JEE MAIN-2019]

(1) Fehling's test (2) Benedict's test (3) Seliwanoff's test (4) Barfoed's test
32. Which of the following statements is not true about sucrose ? [JEE MAIN-2019]
(1) It is also named as invert sugar
(2) On hydrolysis, it produces glucose and fructose
(3) The glycosidic linkage is present between C1 of α-glucose and C1 of β-fructose
(4) It is a non reducing sugar
33. The peptide that gives positive ceric ammonium nitrate and carbylamine tests is :
[JEE MAIN-2019]
(1) Asp-Gln (2) Ser-Lys (3) Lys-Asp (4) Gln-Asp
34. The correct sequence of amino acids presents in the [JEE MAIN-2019]

(1) Val - Ser - Thr (2) Thr - Ser - Val (3) Leu - Ser - Val (4) Thr - Ser – Leu
35. The inereasing order of pKa of the following amino acids in aqueous solution is:
[JEE MAIN-2019]
Gly Asp Lys Arg
(1) Asp < Gly < Arg < Lys (2) Gly < Asp < Arg < Lys
(3) Asp < Gly < Lys < Arg (4) Arg < Lys < Gly < Asp
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(Organic Chemistry) BIOMOLECULES
36. The correct structure of product ' P ' in the following reaglion is: [JEE MAIN-2019]

Asn − ser + ( CH3CO )2 O ⎯⎯→

NEt 3
P
( excess )

(1) (2)

(3) (4)

37. The correct match between Item I and Item II is: [JEE MAIN-2019]
Item I Item II
(I) Ester test (P) Tyr
(II) Carbylamine test (Q) AsP
(III) Phthalein dye test (R) Ser
(S) Lys
(1) (I) → (Q, R); (II) → (S); (III) → (P) (2) (I) → (R); (II) → (Q); (III) → (P)
(3) (I) → (R); (II) → (S); (III) → (Q) (4) (I) → (Q); (IV) → (S); (III) → (R)
38. fonsider the following rections: [JEE MAIN-2020]
dry HCI x eq. of
(i) Glucose +ROH → Acetal (CH acetyl derivative
3 CO)2 O
Ni/H2 y eq. of
(ii) Glucose → A (CH acetyl derivative
3 CO)2 O
z eq. of
(iii) Glucose (CH acetyl derivative
3 CO)2 O

' x ', ' y ' and ' z ' in these reactions are respectively.
(A) 4,5&5 (B) 4,6&5 (C) 5,4&5 (D) 5,6&5
39. The correct observation in the following reactions is [JEE MAIN-2020]

(A) Gives no colour (B) Formation of red colour

(C) Formation of violet colour (D) Formation of blue colour

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(Organic Chemistry) BIOMOLECULES
40. Which one of the following statements is not true? [JEE MAIN-2020]
(A) Lactose contains α-glycosidic linkage between C1 of galactose and C4 of glucose
(B) Lactose is a reducing sugar and it gives Fehling's test
(C) On acid hydrolysis, lactose gives one molecule of D(+) -glucose and one molecule of
D(+) galactose
(D) Lactose (C11 H22 O11 ) is a disaccharide and it contains 8 hydroxyl groups
41. A, B and C are three biomolecules. The results of the tests performed on them are given below:
A, B and C are respectively: [JEE MAIN-2020]
Molisch's's Test Barfored Test Biuret Test
A Positive Negative Negative
B Positive Positive Negative
C Negative Negative Positive
(A) A = Lactose, B = Glucose, C = Alanine (B) A = Glucose, B = Fructose, C = Albumin
(C) A = Lactose, B = Glucose, C = Albumin (D) A = Lactose, B = Fructose, C = Alanine
42. A peptide synthesized by the regetions of one molecule each of Glycine, Leucine, Aspartic
acid and Histidine will have _____ peptide linkages. [JEE MAIN-2021]
43. Hydrolysis of sucrose gives : [JEE MAIN-2021]
(1) α-D-(-)-Glucose and β-D- (-)-Fructose
(2) α-D-(+)-Glucose and α − D − (−)-Fructose
(3) α-D-(-)-Glucose and α-D-(+)-Fructose
(4) α-D-(+)-Glucose and β − D − (−)-Fructose
44. The warter soluble protein is [JEE MAIN-2021]
(1) Fibrin (2) Albumin (3) Myosin (4) Collagen
45. Which one of the lollowing is correct structure for cytosine? [JEE MAIN-2021]

(1) (2) (3) (4)

46. Match List I with List II. [JEE MAIN-2022]

List-I List -II
Enzyme Conversion of
P. Invertase I. Starch into maltose
Q. Zymase II. Maltose into glucose
R. Diastase III. Glucose into ethanol
S. Maltase IV. Cane sugar into glucose
Choose the most appropriate answer from the options given below :
(1) P-III, Q-IV. R-II. S-I (2) P-III. Q-II. R-I. S-IV
(3) P-IV, Q-IIL R-I. S-II (4) P-IV, Q-II. R-III. S-I
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(Organic Chemistry) BIOMOLECULES
47. Given below are two statements. [JEE MAIN-2022]
Statements I: Maltose has two α-D-glucose units linked at C1 and C4 and is a reducing sugar.
Statement II: Maltose has two monesaccharides: α-D-glucose and β-D-glucose linked at C1 and
C6 and it is a non-reducing sugar.
In the light of the above statements, choose the correct answer from the options given
below.
(A) Both Statement I and Statement II are true
(B) Both Statement I and Statement II are false
(C) Statement I is true but Statement II is false
(D) Statement I is false but Statement II is true
48. Stability of α-Helix structure ofproteins depends upon [JEE MAIN-2022]
(A) dipolar interaction (B) H-bonding interaction
(C) van der Waals forces (D) π-stacking interaction
49. C6H12O6 ⎯⎯⎯
Zymase
→ A ⎯⎯→
NaOl

B + CHI3

The number of carbon atoms present in the product B is [JEE MAIN-2022]

50. Uracil is base present in RNA with the following structure. % of N in uracil is

Given:
Molar mass N = 14 g mol−1 ; O = 16 g mol−1 ; C = 12 g mol−1 ; H = 1 g mol−1; [JEE MAIN-2023]

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(Organic Chemistry) BIOMOLECULES
EXERCISE # V (A) (JEE-ADVANCE) (OBJECTIVE)
Q.1 Statement-1 : p-Hydroxybenzoic acid has a lower boiling point than o-hydroxybenzoic acid.
Because [JEE 2007]
Statement-2 : o-Hydroxybenzoic acid has intramolecular hydrogen bonding.
(A) Statement-1 is True, Statement-2 is True; Statement-2 is a correct explanation for Statement-1.
(B) Statement-1 is True, Statement-2 is True; Statement-2 is NOT a correct explanation for Statement-1.
(C) Statement-1 is True, Statement-2 is False.
(D) Statement-1 is False, Statement-2 is True.
Q.2 Match the chemical substances in Column I with type of polymers / type of bonds in Column II.
Indicate your answer by darkening the appropriate bubbles of the 4 × 4 matrix given in the
ORS. [JEE 2007]
Column I Column II
(A) Cellulose (P) Natural polymer
(B) Nylon-6, 6 (Q) Synthetic polymer
(C) Protein (R) amide linkage
(D) Sucrose (S) Glycoside linkage
Q.3 Match the compounds/ion in column I with their properties/ reaction in Column II. Indicate
your answer by darkening the appropriate bubbles of the 4 × 4 matrix given in the ORS.
[JEE 2007]
Column I Column II
(A) C6 H5 CHO (P) gives precipitate with 2,4-
dinitrophenylhydrazine
(B) CH3 C ≡ CH (Q) gives precipitate with AgNO3
(C) CN − (R) is a nucleophile
(D) I −
(S) is involved in cyanohydrin formation
Q.4 Cellulose upon acetylation with excess acetic anhydride / H2SO4 (catalytic) gives cellulose
triacetate whose structure is [JEE 2008]

(A) (B)

(C) (D)

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(Organic Chemistry) BIOMOLECULES
Q.5 Match the compounds in Column I with their characteristic test(s)/reaction(s) given in Column
II. Indicate your answer by darkening the appropriate bubbles of the 4 × 4 matrix given in the
ORS. [JEE 2008]
Column-I Column II
⊕ ⊖
(A) H2 N − NH3 Cl (P) Sodium fusion extract of the compound
gives Prussian blue colour with FeSO4

(B) (Q) Gives positive FeCl3 test

(C) (R) Gives white precipitate with AgNO3

(D) (S) Reacts with aldehydes to form the

corresponding Hydrazone derivative

Q.6 The correct statement(s) about the following sugars X and Y is(are) [JEE 2009]

(A) X is a reducing sugar and Y is a non-reducing sugar

(B) X is a non-reducing sugar and Y is a reducing sugar
(C) The glucosidic linkages in X and Y are α and β, respectively.
(D) The glucosidic linkages in X and Y are β and α, respectively
Q.7 Among cellulose, poly (vinyl chloride), nylon and natural rubber, the polymer in which the
intermolecular force of attraction is weakest is [JEE 2009]
(A) Nylon (B) Poly (vinyl chloride)
(C) Cellulose (D) Natural Rubber
Q.8 The following carbohydrate is [JEE 2011]

(A) a ketohexose (B) an aldohexose (C) an α-furanose (D) an α-pyranose

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(Organic Chemistry) BIOMOLECULES
Q.9 The major product of the following reaction is

(A) a hemiacetal (B) an acetal (C) an ether (D) an ester

Q.10 Amongst the compounds given, the one that would form a brilliant coloured dye on treatment
with NaNO2 in dil. HCl followed by addition to an alkaline solution of β-naphthol is–[JEE 2011]

(A) (B) (C) (D)

Q.11 The correct functional group X and the reagent/reaction conditions Y in the following scheme
are [JEE 2011]

(A) X = COOCH3 , Y = H2 /Ni/ heat (B) X = CONH2 , Y = H2 /Ni/ heat

(C) X = CONH2 , Y = Br2 /NaOH (D) X = CN, Y = H2 /Ni/ heat
Q.12 The structure of D-(+)-glucose is [IIT 2011]

The structure of L(−)-glucose is

(A) (B) (C) (D)

Q.13 For 'invert sugar', the correct statement(s) is (are) : [JEE 2016]
(Given : specific rotations of (+)-sucrose, (+)-maltose, L-(-)-glucose and L-(+)-fructose in
aqueous solution are +66∘ , +140∘ , −52∘ and +92∘ , respectively)
(A) 'invert sugar' is prepared by acid catalyzed hydrolysis of maltose
(B) 'invert sugar' is an equimolar mixture of D − (+) glucose and D − (−)-fructose
(C) specific rotation of 'invert surgar' is −20∘
(D) on reaction with Br2 water, 'invert sugar' forms saccharic acid as one of the products

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(Organic Chemistry) BIOMOLECULES
Comprehension : Q.No. 14 to 15
Treatment of compound O with KMnO4 /H + gave P, which on heating with ammonia
gave Q . The compound Q on treatment with Br2 /NaOH produced R . On strong
heating, Q gave S, which on further treatmenet with ethyl 2-bromopropanoate in the
presence of KOH following by acidification, gave a compound T.
Q.14 The compound R is: [JEE 2016]

(A) (B) (C) (D)

Q.15 The compound 𝐓 is: [JEE 2016]

(A) Glycine (B) Alanine (C) Valine (D) Serine
Q.16 The Fischer presentation of D-glucose is given below. [JEE 2018]

The correct structure(s) of β-L-glucopyranose is (are)

(A) (B) (C) (D)

17. Which of the following statement(s) is(are) true? [JEE 2019]

(A) The two six-membered cyclic hemiacetal forms of D − (+)-glucose are called anomers
(B) Monosaccharides cannot be hydrolysed to give polyhydroxy aldehydes and ketones
(C) Oxidation of glucose with bromine water gives glutamic acid
(D) Hydrolysis of sucrose gives dextrorotatory glucose and laevorotatory fructose
18. Given: [JEE-2021]

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(Organic Chemistry) BIOMOLECULES
The compound(s), which on reaction with HNO3 will give the product having a degree of
rotation, [α]D = –52.7º is(are);

(A) (B) (C) (D)

19. Treatment of D-glucose with aqueous NaOH resuts in a mixture of monosaccharides, which are
[JEE- 2022]

(A)

(B)

(C)

(D)

20. In the given reaction scheme, 𝐏 is a phenyl alkyl ether, 𝐐 is an aromatic compound; 𝐑 and 𝐒 are
the major products. [JEE-2023]
( i) NaOH
(ii)CO2 ( i )(CH CO) O
P ⎯⎯
→Q ⎯⎯⎯→R ⎯⎯⎯⎯→
Hl 3

( iii ) H3O+
( ii )H O+
2
S
3

The correct statement about 𝐒 is

(A) It primarily inhibits noradrenaline degrading enzymes.
(B) It inhibits the synthesis of prostaglandin.
(C) It is a narcotic drug.
(D) It is ortho-acetyl benzoic acid.
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(Organic Chemistry) BIOMOLECULES
EXERCISE # V (B) (JEE-ADVANCE) (SUBJECTIVE)
Q.1 Give the structures of the products in each of the following reactions. [JEE 2000]

+
(i) Sucrose ⎯⎯
H
→A + B (ii)

Q.2 Aspartame, an artifical sweetener, is a peptide and has the following structure: [JEE 2001]

(i) Identify the four functional groups.

(ii) Write the zwitterionic structure.
(iii) Write the structures of the amino acids obtained from the hydrolysis of aspartame.
(iv) Which of the two amino acids is more hydrophobic?
Q.3 Following two amino acids lysine and glutamine form dipeptide linkage. What are two possible
dipeptides? [JEE 2003]

Q.4 The structure of D-Glucose is as follows- [JEE 2004]

(a) Draw the structure of L-Glucose
(b) Give the reaction of L - Glucose with Tollens reagent.

Q.5 Monomer A of a polymer on ozonolysis yields two moles of HCHO and one mole of CH3 COCHO.
[JEE 2005]
(a) Deduce the structure of A.
(b) Write the structure of "all cis" - form of polymer of compound A.
Q.6 A decapeptide (Mol. Wt. 796) on complete hydrolysis gives glycine (Mol. Wt. 75), alanine and
phenylalanine. Glycine contributes 47.0% to the total weight of the hydrolysed products. The
number of glycine units present in the decapeptide is [JEE 2011]

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(Organic Chemistry) BIOMOLECULES
Q.7 The substitutes R1 and R 2 for nine peptides are listed in the table given below. How many of
these peptides are positively charged at pH = 7.0 ? [JEE 2012]

Peptide 𝐑1 𝐑2
I H H
II H CH3
III CH2 COOH H
IV CH2 CONH (CH2 )4 NH2
V CH2 CONH2 CH2 CONH2
VI (CH2 )4 NH2 (CH2 )4 NH2
VII CH2 COOH CH2 CONH2
VIII CH2 OH (CH2 )4 NH2
IX (CH2 )4 NH2 CH3
Q.8 When the following aldohexose exists in its d-configuration, the total number of stereoisomers
in its pyranose form is – [JEE 2012]

Q.9 A tetrapeptide has −COOH group on alanine. This produces glycine (Gly), valine (Val), phenyl
alanine (Phe) and alanine (Ala), on complete hydrolysis. For this tetrapeptide, the number of
possible sequences (Primary structures) with −NH2 group attached to a chiral center is
[JEE 2013]
Q.10. The total number of lone-pairs of electrons in melamine is: [JEE 2013]
Q.11 The total number of distinct naturally occurring amino acids obtained by complete acidic
hydrolysis of the peptide shown below is [JEE 2014]

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(Organic Chemistry) BIOMOLECULES
Q.12 A disaccharide 𝐗 cannot be oxidised by bromine water. The acid hydrolysis of 𝐗 leads to a
laevorotatory solution. The disaccharide 𝐗 is [JEE ADV. 2023]

(A)

(B)

(C)

(D)

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(Organic Chemistry) BIOMOLECULES
ANSWER KEY
EXERCISE-I
1. C 2. D 3. C 4. B 5. C 6. A 7. C
8. D 9. C 10. B 11. B 12. C 13. C 14. A
15. A 16. D 17. D 18. D 19. B 20. B 21. D
22. B 23. A 24. A 25. C 26. A 27. D 28. B
29. B 30. C 31. C 32. C 33. D 34. C 35. A
36. D 37. B 38. C 39. A 40. A 41. B 42. B
EXERCISE-II
1. ABCD 2. ABD 3. ABC 4. ABD 5. ABD 6. ABC 7. BC
8. ABCD 9. ABC 10. BD 11. D 12. A 13. D 14. B
15. C
16. (A)→ PQS; (B)→S; (C)→RS; (D)→QRS;
17. (A)→R; (B)→P; (C)→; (D)→Q;
EXERCISE-III
1. A 2. A 3. A 4. A 5. D 6. B 7. C
8. A 9. C
10. (A)→S; (B)→Q; (C)→P; (D)→R;
11. (A)→QS; (B)→QRS; (C)→PRTU; (D)→PSTU;
12. (A)→PQR; (B)→P; (C)→PS ; (D)→PQR;
13. (A)→QR; (B)→P; (C)→S; (D)→T;
14. (A)→PQR; (B)→S; (C)→R; (D)→PQS;
15. (A)→S-W; (B)→P-Y; R-X (C)→Q-Z
16. 3.25
EXERCISE-IV (JEE-MAIN)
1. 2 2. 2 3. 4 4. 3 5. 3 6. 3 7. 3
8. 1 9. 4 10. 4 11. 1 12. 1 13. 3 14. 1
15. 1 16. 2 17. 4 18. 1 19. 1 20. 3 21. 4
22. 4 23. 4 24. 4 25. 2 26. 4 27. 1 28. 4
29. 1 30. Bonus 31. 3 32. 3 33. 2 34. C 35. A
36. B 37. A 38. D 39. B 40. A 41. C 42. 3
43. D 44. B 45. C 46. C 47. C 48. B 49. 1
50. 25
EXERCISE # V(A) (JEE-ADVANCE) OBJECTIVE
1. D
2. (A)→PS; (B)→QR; (C)→PR; (D)→S;
3. (A)→PS; (B)→Q; (C)→QRS; (D)→QR;
4. A
5. (A)→RS; (B)→PQ; (C)→PQR; (D)→PS
6. BC
7. D 8. B 9. B 10. C 11. ABCD 12. A 13. BC
14. A 15. B 16. D 17. AD 18. C,D 19. C 20. B

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