Cannabis Analysis
Integrated Solutions for Potency and Safety with the
expression Compact Mass Spectrometer and Solation ICP-MS
Potent Solutions For Your Budding Lab
Advion.com/Cannabis • [email protected]
Analysis for Cannabinoids and
Contamination Measurements
Outfit your lab with Advion’s line of custom cannabis solutions,
including the expression® Compact Mass Spectrometer (CMS),
the SOLATION ICP-MS, and a customizable (U)HPLC solution
Your Complete Lab Solution:
Advion provides integrated laboratory solutions for comprehensive cannabis
testing, including potency testing and cannabinoid levels as well as pesticide
measurement and quantitation of heavy metals.
expression CMS - Waste no time introducing your sample
in to the mass spec with the expression CMS, offering the
industry’s widest range of sample introduction techniques
in an easy-to-use, compact system.
SOLATION ICP-MS - Advion’s ICP-MS provides fast, simple
measurement of levels of toxic metals in a wide array of
samples, including heavy metals in cannabis. Measure
Arsenic, Cadmium, Lead and Mercury and more in plant
material, extracts, oils and edibles.
Customizable HPLC & UHPLC - Advion’s range of high
performance, liquid chromatography systems can be used
standalone with UV and UV/Vis detector options, or with
the expression CMS to provide seamlessly integrated
LC/CMS under the full control of Advion’s simple, intuitive
software suite.
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Cannabis Sampling Solutions
Streamline your sample prep with these easy techniques
from the expression® CMS
Plate Express: Push-Button Analysis of TLC Plates
With the Plate Express TLC plate reader, you can now
use TLC plates to analyze cannabis samples in a fast,
efficient way. With the Advion Plate Express you can:
• Analyze directly from TLC plates
• Identify spots in <1 minute
• Simplify the process of obtaining spectra -
ideal for multi-user labs
• No scraping TLC spots
ASAP Direct Sample Probe - Results in < 30 Seconds
The ASAP probe requires no sample preparation, no
chromatography, and provides sensitive analysis of the
widest range of compounds in less than 30 seconds.
Ergonomically designed for work flow efficiency, the ASAP
probe has a push-button grip and release to quickly pick up
a glass capillary for fast assays. The capillary and sample
holder provides even greater ease of use and maintains
organization, even when running back-to-back samples -
simply swipe and insert.
The Advion ASAP probe offers:
• Fast and affordable sample analysis
• No sample preparation
• No chromatography
• Solvent-free - green technique
• Analyzes a wide range of compounds
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Cannabinoid Testing for
Quality Control Using ASAP/CMS
High-Throughput Cannabinoid Testing Method for Cannabis Quality Control
Using ASAP/CMS
ASAP/CMS provides a simple, sensitive and selective sample introduction
approach to measure the presence of two isobaric compounds, CBDA and
THCA, contained in a complex sample such as hemp or cannabis plants or
their corresponding extraction products.
The expression CMS with ASAP probe provides:
• A method to determine the relative composition of CBDA and THCA in
hemp and marijuana plants using the ion current abundance
differences in their respective precursor/fragment ion transitions (m/z
341 to m/z 261).
• A simple, sensitive and selective sample technique.
• A simple, high-throughput screening approach to potentially
differentiate hemp and marijuana or possibly other cannabis strains.
Figure: High-throughput screening (blind) for 34 different cannabis plants. These results show
the use of ASAP/CMS to determine the relative composition of CBDA and THCA in the plants.
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Optimize Your Harvest with
Advion LC/CMS
LC/CMS provides fast, accurate, high throughput quantitative analysis
LC/CMS with selected ion monitoring (SIM) provides quantification of
cannabinoids to help determine the optimal harvest timing. It is also used for
measurement of pesticide levels.
• Use LC/CMS for CBDA, THCA, CBD, THC and CBN to determine
when to harvest for optimal yield.
Weekly Harvest Testing Data
Week 1 Week 2 Week 3
• Quantify
pesticides
using the
LC/CMS
testing
method.
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Detecting CBN, CBD and THC
Using Plate Express TLC/CMS
Rapid Detection of Cannabinoids with the Plate Express
TLC Plate Reader:
The Plate Express TLC plate reader can provide push-button
analysis of a TLC plate, extract the compounds present and
transport them to the expression CMS for rapid analysis.
The CMS offers a fast scan speed, on-line polarity
switching and in-source CID, generating valuable
information in the analysis of natural products.
A typical TLC/CMS analysis of THC is shown in A, B. Despite
a different molecular structure, both THC and CBD have not
only the same isotopic mass, but also fragment identically in
positive ion mode ESI/CMS, which makes it difficult to distinguish
between them. However, in negative ion mode, in-source CID results
in the same m/z fragments, but at significantly different relative
intensities which allows a distinction between them, shown in D.
Figure: TLC/CMS analysis of cannabinoids. TLC/CMS analysis of the Rf region of THC
(Rf=0.47) shows a strong MS TIC signal (B) with a prominent negative ion signal at m/z
313.2 (data not shown) and the characteristic in-source CID fragments of THC (C).
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Detecting THC/Cannabinoids by
ASAP/CMS
Direct Sample Analysis for Rapid Screening of Cannabinoids:
ASAP/CMS is a rapid mass spectral analysis approach that can
screen a variety of samples and surfaces for the
presence of cannabinoids
• Dried plant material can readily be screened for the
presence of cannabinoids such as Cannabinol,
THC/CBD or the acids THCA/CBDA
• Alternating acquisition of positive
and negative ion mass spectra
improves detection when sampling
from complex samples such as skin
contaminated with small quantities of plant
material
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Experience the Full Advion Suite
The expression family of compact mass spectrometers was developed with
maximum versatility in mind. They allow users to switch rapidly between
the many different sample introduction techniques required throughout
an analyst’s workflow; from simple direct probe analysis to ultra-high
performance liquid chromatography and prep-scale purification. Now with
the SOLATION ICP-MS, Advion provides a full elemental analysis for a
robust family of cannabis analysis solutions.
Contact:
North America • Advion, Inc. Advion Central Europe
61 Brown Road, Suite 100, Ithaca, NY +49 175 596 3572
14850 [email protected]
+1 877 5 ADVION • [email protected]
Advion China
Advion Europe • Advion, Ltd. +86 800 8101294 • [email protected]
Harlow Enterprise Hub, Kao Hockham
Building Visit www.advion.com for a complete
Edinburgh Way, Harlow list of global distributors.
CM20 2NQ United Kingdom
+44 (0)1279 311432
[email protected]
