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Paracetamol

The document provides information about the drug Paracetamol (also known as acetaminophen or Tylenol). Key details include its classification as a non-opioid analgesic and antipyretic, dosing ranges from 10-15 mg/kg every 4 hours up to a maximum of 1 g three or four times daily, and mechanisms of action involving blocking pain impulses and inhibiting prostaglandins. Contraindications include hypertension and use with other drugs like barbiturates that can reduce its therapeutic effects or enhance hepatotoxicity. Potential adverse reactions involve hematologic, hepatic and skin issues.

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Blesyl Sison Mabano
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1K views2 pages

Paracetamol

The document provides information about the drug Paracetamol (also known as acetaminophen or Tylenol). Key details include its classification as a non-opioid analgesic and antipyretic, dosing ranges from 10-15 mg/kg every 4 hours up to a maximum of 1 g three or four times daily, and mechanisms of action involving blocking pain impulses and inhibiting prostaglandins. Contraindications include hypertension and use with other drugs like barbiturates that can reduce its therapeutic effects or enhance hepatotoxicity. Potential adverse reactions involve hematologic, hepatic and skin issues.

Uploaded by

Blesyl Sison Mabano
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOC, PDF, TXT or read online on Scribd
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Drug Data Generic Name: Paracetamol Trade Name: Abenol, acephen, aceta elixir, acetaminophen , anacin, tempra, tylenol

Pts Dose: 50 mg IVTT T.I.D. Minimum Dose: 10-15 mg/kg/ dose q4 hrs, prn P.O. Maximum Dose: 650 mgP.O. q46hrs or 1 g TID or QID or prn Content: Acetamenophe n 500 mg diphenylhydra mine citrate 38mg Availability: Caplets,capsul e, oral syrup,oral suspension Route of Administration: P.O., IVTT

Classifica tion Non-opioid analgesics and antipyretic s

Mechanism of Action A>rapid and complete D>25% proteinbound. Level isnt connected strongly with analgesic effect but is with toxicity M>90-95% metabolized in liver E>in urine Onset: Unknown Peak: 1-3 hrs Duration: 1-3 hrs Half-life: 1-4 hrs Chemical Effect: may produce analgesic effect by blocking pain impulses, by inhibiting prostaglandin or pain receptor sebsitizer. May relieve fever by acting in hypothalamic heat-regulating center. Therapeutic Effect: Relieves pain and reduces fever

Indication General Indication: >mild pain or fever >osteoarth ritis Patients Indication: >patient is febrile and also has arthritis

Contra indication Concentration: Contraindicated in patients hypertensive to drug Precaution: Use cautiously in patients with history of chronic alcohol abuse because hepatotoxicity may occur after the therapeutic dose Drug-drug: Barbiturates, carbamazepine, hydantoins,isoni azid, rifampin with high dose use of these drugs, may reduce therapeutic effects and enhanced hapatotoxic effects. Avoid use together. Drug-food: Caffeine may enhance analgesic effects.

Adverse Reaction Hematologi c Hemolytic anemia, neutropeni a, leucopenia, pancytopen ia, thrombocyt openia Hepatic Liver damage (with toxic doses), jaundice Metabolic Hypoglyce mia Skin Rash, urticaria

Nursing Responsibilities Before: >orient self to patient >note significant lab results >note pts drug allergy >Explain therapeutic effects of the drug Calculate dose effectively and accurately During: >use liquid form to children >administer as directed >warn pt to avoid alcoholic intake After: >hypersensitivity reaction caution >management of side effects >evaluate drug effectiveness of the drug

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