Syllabus Sem4
Syllabus Sem4
UNIT-I 10 Hours
Stereo isomerism
Optical isomerism –
Optical activity, enantiomerism, diastereoisomerism, meso compounds
Elements of symmetry, chiral and achiral molecules
DL system of nomenclature of optical isomers, sequence rules, RS system of
nomenclature of optical isomers
Reactions of chiral molecules
Racemic modification and resolution of racemic mixture.
Asymmetric synthesis: partial and absolute
UNIT-II 10 Hours
Geometrical isomerism
Nomenclature of geometrical isomers (Cis Trans, EZ, Syn Anti systems)
Methods of determination of configuration of geometrical isomers.
Conformational isomerism in Ethane, n-Butane and Cyclohexane.
Stereo isomerism in biphenyl compounds (Atropisomerism) and conditions for optical
activity.
Stereospecific and stereoselective reactions
UNIT-III 10 Hours
Heterocyclic compounds:
Nomenclature and classification
Synthesis, reactions and medicinal uses of following compounds/derivatives
Pyrrole, Furan, and Thiophene
UNIT-IV 8 Hours
UNIT-V 07 Hours
UNIT-II 10 Hours
UNIT-III 10 Hours
Micromeretics: Particle size and distribution, mean particle size, number and weight
distribution, particle number, methods for determining particle size by different
methods, counting and separation method, particle shape, specific surface, methods for
determining surface area, permeability, adsorption, derived properties of powders,
porosity, packing arrangement, densities, bulkiness & flow properties.
UNIT-V 10 Hours
Drug stability: Reaction kinetics: zero, pseudo-zero, first & second order, units of basic
rate constants, determination of reaction order. Physical and chemical factors influencing
the chemical degradation of pharmaceutical product: temperature, solvent, ionic strength,
dielectric constant, specific & general acid base catalysis, Simple numerical problems.
Stabilization of medicinal agents against common reactions like hydrolysis & oxidation.
Accelerated stability testing in expiration dating of pharmaceutical dosage forms.
Photolytic degradation and its prevention
PT 496. PHYSICAL PHARMACEUTICS- II (Practical)
3 Hrs/week
General Pharmacology
a. Pharmacodynamics- Principles and mechanisms of drug action. Receptor theories
and classification of receptors, regulation of receptors. drug receptors interactions
signal transduction mechanisms, G-protein–coupled receptors, ion channel receptor,
transmembrane enzyme linked receptors, transmembrane JAK-STAT binding
receptor and receptors that regulate transcription factors, dose response
relationship, therapeutic index, combined effects of drugs and factors modifying
drug action.
b. Adverse drug reactions.
c. Drug interactions (pharmacokinetic and pharmacodynamic)
d. Drug discovery and clinical evaluation of new drugs -Drug discovery phase,
preclinical evaluation phase, clinical trial phase, phases of clinical trials and
pharmacovigilance.
UNIT-III 10 Hours
2. Pharmacology of drugs acting on peripheral nervous system
a. Organization and function of ANS.
b. Neurohumoral transmission, co-transmission and classification of neurotransmitters.
c. Parasympathomimetics, Parasympatholytics, Sympathomimetics,sympatholytics.
d. Neuromuscular blocking agents and skeletal muscle relaxants (peripheral).
e. Local anesthetic agents.
f. Drugs used in myasthenia gravis and glaucoma
UNIT-IV 08 Hours
3. Pharmacology of drugs acting on central nervous system
a. Neurohumoral transmission in the C.N.S. special emphasis on importance of
various neurotransmitters like with GABA, Glutamate, Glycine, serotonin,
dopamine.
b. General anesthetics and pre-anesthetics.
c. Sedatives, hypnotics and centrally acting muscle relaxants.
d. Anti-epileptics
e. Alcohols and disulfiram
UNIT-V 07 Hours
3. Pharmacology of drugs acting on central nervous system
a. Psychopharmacological agents: Antipsychotics, antidepressants, anti-anxietyagents,
anti-manics and hallucinogens.
b. Drugs used in Parkinsons disease and Alzheimer’s disease.
c. CNS stimulants and nootropics.
d. Opioid analgesics and antagonists
e. Drug addiction, drug abuse, tolerance and dependence.
PT 498. PHARMACOLOGY-I (Practical)
4Hrs/Week
1. Introduction to experimental pharmacology.
2. Commonly used instruments in experimental pharmacology.
3. Study of common laboratory animals.
4. Maintenance of laboratory animals as per CPCSEA guidelines.
5. Common laboratory techniques. Blood withdrawal, serum and plasma separation,
anesthetics and euthanasia used for animal studies.
6. Study of different routes of drugs administration in mice/rats.
7. Study of effect of hepatic microsomal enzyme inducers on the phenobarbitone sleeping
time in mice.
8. Effect of drugs on ciliary motility of frog oesophagus
9. Effect of drugs on rabbit eye.
10. Effects of skeletal muscle relaxants using rota-rod apparatus.
11. Effect of drugs on locomotor activity using actophotometer.
12. Anticonvulsant effect of drugs by MES and PTZ method.
13. Study of stereotype and anti-catatonic activity of drugs on rats/mice.
14. Study of anxiolytic activity of drugs using rats/mice.
15. Study of local anesthetics by different methods
Note: All laboratory techniques and animal experiments are demonstrated by simulated
experiments by software’s and videos
Recommended Books (Latest Editions)
1. Rang H. P., Dale M. M., Ritter J. M., Flower R. J., Rangand Dale’s
Pharmacology,.Churchil Livingstone Elsevier
2. Katzung B. G., Masters S. B., Trevor A. J., Basic and clinical pharmacology, Tata Mc
Graw-Hill
3. Goodman and Gilman’s, The Pharmacological Basis of Therapeutics
4. Marry Anne K. K., Lloyd Yee Y., Brian K. A., Robbin L.C., Joseph G. B., Wayne A.
K., Bradley R.W., Applied Therapeutics, The Clinical use of Drugs, The Point Lippincott
Williams & Wilkins
5. Mycek M.J, Gelnet S.B and Perper M.M. Lippincott’s Illustrated Reviews-
Pharmacology
6. K.D.Tripathi. Essentials of Medical Pharmacology, JAYPEE Brothers Medical
Publishers (P) Ltd, New Delhi.
7. Modern Pharmacology with clinical Applications, by Charles R.Craig& Robert,
8. Ghosh MN. Fundamentals of Experimental Pharmacology. Hilton & Company,
Kolkata.
9. Kulkarni SK. Handbook of experimental pharmacology. Vallabh Prakashan,
PT 412.PHARMACOGNOSY AND PHYTOCHEMISTRY I (Theory)
45 Hours
Scope: The subject involves the fundamentals of Pharmacognosy like scope, classification of
crude drugs, their identification and evaluation, phytochemicals present in them and their
medicinal properties.
Course Content:
UNIT-I 10 Hours
Introduction to Pharmacognosy:
(a) Definition, history, scope and development of Pharmacognosy
(b) Sources of Drugs – Plants, Animals, Marine &Tissue culture
(c) Organized drugs, unorganized drugs (dried latex, dried juices, dried extracts, gums and
mucilages, oleoresins and oleo- gum -resins).
Classification of drugs:
Alphabetical, morphological, taxonomical, chemical, pharmacological, chemo and sero
taxonomical classification of drugs
UNIT-II 10 Hours
Cultivation, Collection, Processing and storage of drugs of natural origin:
Cultivation and Collection of drugs of natural origin
Factors influencing cultivation of medicinal plants.
Plant hormones and their applications.
Polyploidy, mutation and hybridization with reference to medicinal plants
UNIT-III 07 Hours
Plant tissue culture:
Historical development of plant tissue culture, types of cultures, Nutritional requirements,
growth and their maintenance.
Applications of plant tissue culture in pharmacognosy.
Edible vaccines
UNIT IV 10 Hours
Pharmacognosy in various systems of medicine:
Role of Pharmacognosy in allopathy and traditional systems of medicine namely, Ayurveda,
Unani, Siddha, Homeopathy and Chinese systems of medicine.
UNIT V 08 Hours
Study of biological source, chemical nature and uses of drugs of natural origin containing
following drugs
Plant Products:
Fibers - Cotton, Jute, Hemp
Hallucinogens, Teratogens, Natural allergens
Primary metabolites:
General introduction, detailed study with respect to chemistry, sources, preparation,
evaluation, preservation, storage, therapeutic used and commercial utility as Pharmaceutical
Aids and/or Medicines for the following Primary metabolites:
Carbohydrates: Acacia, Agar, Tragacanth, Honey
Proteins and Enzymes : Gelatin, casein, proteolytic enzymes (Papain, bromelain,
serratiopeptidase, urokinase, streptokinase, pepsin).
Lipids(Waxes, fats, fixed oils) : Castor oil, Chaulmoogra oil, Wool Fat, Bees Wax
Marine Drugs:
Novel medicinal agents from marine sources
PT 492. PHARMACOGNOSY AND PHYTOCHEMISTRY I (Practical)
4 Hours/Week
1. Analysis of crude drugs by chemical tests: (i)Tragacanth (ii) Acacia (iii)Agar (iv)
Gelatin (v) starch (vi) Honey (vii) Castor oil
2. Determination of stomatal number and index
3. Determination of vein islet number, vein islet termination and paliside ratio.
4. Determination of size of starch grains, calcium oxalate crystals by eye piece
micrometer
5. Determination of Fiber length and width
6. Determination of number of starch grains by Lycopodium spore method
7. Determination of Ash value
8. Determination of Extractive values of crudedrugs
9. Determination of moisture content of crudedrugs
10. Determination of swelling index andfoaming
UNIT- I 10 Hours
UNIT- II 10 Hours
Drugs acting on Autonomic Nervous System Adrenergic
Neurotransmitters:
Biosynthesis and catabolism of catecholamine.
Adrenergic receptors (Alpha & Beta) and their distribution.
Adrenergic Antagonists:
Alpha adrenergic blockers: Tolazoline*, Phentolamine, Phenoxybenzamine,
Prazosin, Dihydroergotamine, Methysergide.
Beta adrenergic blockers: SAR of beta blockers, Propranolol*, Atenolol, Esmolol,
Metoprolol, Labetolol, Carvedilol.
UNIT-III 10 Hours
Cholinergic neurotransmitters:
UNIT- IV 08 Hours
B. Antipsychotics
Phenothiazines: SAR of Phenothiazeines - Chlorpromazine hydrochloride*,
Triflupromazine, Thioridazine hydrochloride, Trifluoperazine hydrochloride.
Ring Analogues of Phenothiazines: Chlorprothixene, Thiothixene, Loxapine
succinate, Clozapine.
Fluro buterophenones: Haloperidol, Droperidol, Risperidone.
Beta amino ketones: Molindone hydrochloride.
Benzamides: Sulpieride.
UNIT – V 07 Hours
Drugs acting on Central Nervous System
General anesthetics:
Inhalation anesthetics: Halothane*, Methoxyflurane, Enflurane, Isoflurane, Desflurane.
Ultra short acting barbitutrates: Methohexital sodium*, Thiamylal sodium, Thiopental
sodium.
Dissociative anesthetics: Ketamine hydrochloride.*
Narcotic and non-narcotic analgesics
Morphine and related drugs: SAR of Morphine analogues, Morphine sulphate, Codeine,
Meperidine hydrochloride, Loperamide hydrochloride, Fentanyl citrate*, Methadone
hydrochloride*, Pentazocine, Levorphanol tartarate.
Narcotic antagonists: Nalorphine hydrochloride, Naloxone hydrochloride.
Anti-inflammatory agents: Sodium salicylate, Aspirin, Mefenamic acid*, Meclofenamate,
Indomethacin, Sulindac, Tolmetin, Zomepriac, Diclofenac, Ketorolac, Ibuprofen*, Naproxen,
Piroxicam, Phenacetin, Acetaminophen, Antipyrine, Phenylbutazone.
MAULANA ABUL KALAM AZAD UNIVERSITY OF TECHNOLOGY
(Formerly West Bengal University of Technology)
B.PHARM Syllabus
(Effective from 2021-2022 Admission Session)
4 Hours/Week
I Preparation of drugs/ intermediates
1 1,3-pyrazole
2 1,3-oxazole
3 Benzimidazole
4 Benztriazole
6 Benzocaine
7 Phenytoin
8 Phenothiazine
9 Barbiturate
MAULANA ABUL KALAM AZAD UNIVERSITY OF TECHNOLOGY
(Formerly West Bengal University of Technology)
B.PHARM Syllabus
(Effective from 2021-2022 Admission Session)
II Assay of drugs
1 Chlorpromazine
2 Phenobarbitone
3 Atropine
4 Ibuprofen
5 Aspirin
6 Furosemide
7 Chlorpromazine
8 Phenobarbitone
9 Atropine
10 Ibuprofen
11 Aspirin
12 Furosemide
Course content:
UNIT–I 07Hours
UNIT–II 07Hours
Effective Written Communication: Introduction, When and When Not to Use Written
Communication - Complexity of the Topic, Amount of Discussion’ Required, Shades of
Meaning, FormalCommunication
Writing Effectively: Subject Lines, Put the Main Point First, Know Your Audience,
Organization of theMessage
UNIT–IV 05Hours
UNIT–V 04Hours
2 Hours / week
The following learning modules are to be conducted using Wordsworth English
®
Meeting People
Asking Questions
Making Friends
Advanced Learning
of Speech
Effective Communication
Writing Skills
Effective Writing
E-Mail etiquette
Presentation Skills
MAULANA ABUL KALAM AZAD UNIVERSITY OF TECHNOLOGY
(Formerly West Bengal University of Technology)
B.PHARM Syllabus
(Effective from 2021-2022 Admission Session)