223-60230AD

Oct. 2018

LabSolutions LC/GC

Release Notes
Version 5.96
Read the instruction manual thoroughly before you use the product.
Keep this instruction manual for future reference.
<< Notices >>
1) If the user or usage location changes, be sure this Instruction Manual is always kept together
with the product.
2) To ensure safe operation, contact your Shimadzu representative for installation, adjustment, or
re-installation after moving the instrument to a different site.
3) The content of this manual is subject, without notice, to modifications for the sake of
improvement.
4) Every effort has been made to ensure that the content of this manual was correct at the time of
creation. However, in the event that any mistakes or omissions are discovered, it may not be
possible to correct them immediately.
5) The contents of the hard disk in a PC can be lost due to an accident. To protect your important
data from accidents, be sure to back up your data.
6) Microsoft, Windows, Windows 10 and Windows 7 are registered trademarks of Microsoft
Corporation in the USA and other countries.
The copyright of this manual is owned by Shimadzu Corporation. Reproduction and duplication of
whole or part of the content without permission of the company are strictly prohibited.

© 2011-2018 Shimadzu Corporation. All rights reserved.

 CONTENTS
1. Overview ........................................................................................................................... 7
2. Installation Notes ............................................................................................................. 7
2.1. Operating Environment ................................................................................................................ 7
2.1.1. Windows Version ...................................................................................................................... 7
2.1.2. Database Management System ............................................................................................... 7
2.2. Computer System Issues ............................................................................................................. 7
2.2.1. Memory Requirements ............................................................................................................. 7
2.2.2. Windows Virtual Memory Settings ............................................................................................ 7
2.2.3. Windows User Account ............................................................................................................. 7
2.2.4. Notice for Display Properties Settings ...................................................................................... 7
2.2.5. Notice for Free Disk Space ....................................................................................................... 8
2.2.6. Keeping Computer System Stable............................................................................................ 8
2.2.7. Number of Systems being controlled with a PC........................................................................ 8
2.2.8. Notice for Windows User Switching .......................................................................................... 8
2.2.9. Notice for Windows Aero in Windows 7 .................................................................................... 8
2.2.10. Notice for Taskbar ..................................................................................................................... 8
2.2.11. Notice for Executing the Analysis Program ............................................................................... 9
2.2.12. Precautions regarding hard disk defragmentation .................................................................... 9
2.2.13. Restriction in using LabSolutions Direct ................................................................................... 9
2.3. PDA/MWD Installation Issues ...................................................................................................... 9
2.3.1. Wavelength Calibration............................................................................................................. 9
3. LabSolutions Software Notes ....................................................................................... 10
3.1. General ........................................................................................................................................ 10
3.1.1. LabSolutions File Compatibilities ............................................................................................ 10
3.1.2. Area and Height Values Determined with LabSolutions.......................................................... 10
3.1.3. Compatibility with CLASS-LC10/GC10 and CLASS-VP Area and Height Values ................... 10
3.1.4. Compatibility of User Administrations Information ................................................................... 11
3.1.5. Notice for System Log of LCsolution and GCsolution less than version 5 ............................... 11
3.1.6. Notice for System Administration, Log and User Profile Database .......................................... 11
3.1.7. Notice when multiple programs are performed concurrently.................................................... 11
3.1.8. Notice for File Naming ............................................................................................................. 11
3.1.9. Notice for Saving Method ....................................................................................................... 12
3.1.10. Restriction in multiple files selection ....................................................................................... 12
3.1.11. Restriction in handling multiple data files ................................................................................ 12
3.1.12. Assistant Bar Customization ................................................................................................... 12
3.1.13. Maximum Number of Detectors Supported by an HPLC System[LC] ....................................... 12
3.1.14. Notice of Displaying Channel name........................................................................................ 13
3.1.15. Notice for System Check Result Output[LC] ............................................................................. 13
3.1.16. Notice for absorbance range of PDA Contour plots[LC]............................................................ 13
3.1.17. Notice for the Graph Comment of the Magnification Intensity................................................. 13
3.1.18. Notice for opened child windows at starting the program ....................................................... 13
3.1.19. Notice for the Complexity of User’s Password ........................................................................ 14
3.1.20. Notice for Screen Lock on the Multi-User Login Mode ........................................................... 14
3.1.21. Notice when Analysis program is hung up by an unexpected error ........................................ 14
3.1.22. Notice when printing a log from the Shimadzu User Authentication Tool ................................ 15
3.1.23. Notice for Screen Lock on the [Login by Windows account] mode ......................................... 15
3.1.24. Notice for peak integration by setting minimum area/height ................................................... 15
3.1.25. Notice for compatibility with LCsolution GPC Software[LC] ...................................................... 15

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 3.1.26. Notice for Converting 3D Data to ASCII Format [LC] ................................................................ 15
3.1.27. Notice for the Floating-Point Arithmetical Results ................................................................... 15
3.1.28. Notice for Changes to Numerical Exponential Notation .......................................................... 16
3.2. Instrument Configuration........................................................................................................... 16
3.2.1. Notice for Changing Instrument Configuration ........................................................................ 16
3.2.2. Notice for Changing Configuration.......................................................................................... 16
3.2.3. Notice for LC-2010 Unit ID[LC] ................................................................................................. 16
3.2.4. Notice for the external detector for the LC-2030/LC-2040 (PDA detector model) ................... 17
3.2.5. Notice when configured instrument does not exist ................................................................. 17
3.2.6. Supporting Fast LC Control Mode[LC] ...................................................................................... 17
3.3. Instrument Operation ................................................................................................................. 17
3.3.1. Notice for Turning Power Off the Instrument........................................................................... 17
3.3.2. Notice for the ROM version up ............................................................................................... 17
3.3.3. Notice for LC-2010/LC-2030/LC-2040 On Time Injection[LC] ................................................... 17
3.3.4. Notice for Performing Baseline Check after Auto Purge in LC instrument[LC] .......................... 18
3.3.5. Notice for System Check to LC instrument[LC]......................................................................... 18
3.3.6. Notice for the download of the Instruments Parameters[LC]..................................................... 18
3.3.7. Notice for Reading the Method File when the Auto Purge is running[LC] ................................. 18
3.3.8. 3.3.8 Notice for changing the Instrument Monitor in the "Fast LC" mode[LC] ........................... 18
3.3.9. Notice for System Check to GC instrument[GC] ....................................................................... 18
3.3.10. Notice for Baseline Check to CBM-201m ............................................................................... 18
3.3.11. Notice for Connecting GC and LabSolutions by CBM-201m [GC] ............................................ 18
3.3.12. Notice for the Pressure Limits for Pumps [LC] .......................................................................... 18
3.3.13. Notice for the time of the operation logs for instrument's GXP mode [LC] ................................ 19
3.3.14. Cautions for Executing [Carrier Gas Leak Check] or [Standard Diagnosis] from the GC-2030
Instrument [GC] .................................................................................................................................... 19
3.3.15. Notice for using GC-2010 Pro [GC] ........................................................................................... 19
3.4. Data Acquisition ......................................................................................................................... 19
3.4.1. Notice for Multiple Channel Data Plot ..................................................................................... 19
3.4.2. Notice for the synchronization of the data acquisition between LC-2030/LC-2040 and
PDA/MWD [LC] ..................................................................................................................................... 19
3.4.3. Notice for changing parameters on Instrument Monitor .......................................................... 19
3.4.4. Acquisition Time for Status Log .............................................................................................. 19
3.4.5. Retention Time Information of LC Instrument Operational Log[LC] .......................................... 20
3.4.6. Notice for Acquiring Data from Other Vendor Instrument ........................................................ 20
3.4.7. Notice for Sharing Method File ............................................................................................... 20
3.4.8. Notice for Performing Background Subtraction....................................................................... 20
3.4.9. Notice for Starting LC Analysis with No Injection Mode[LC] ...................................................... 20
3.4.10. Notice for Extending Data Acquisition ..................................................................................... 20
3.4.11. Notice for the Method File when the Analysis is stopped. ....................................................... 20
3.4.12. Notice for Starting Analysis in Analysis Editor......................................................................... 21
3.4.13. Notice for using Dilution Factor............................................................................................... 21
3.4.14. Restriction after changing Sampling Rate............................................................................... 21
3.4.15. Display Settings after PDA data acquisition[LC] ....................................................................... 21
3.4.16. Detectors Intensity Unit Issues[LC] ........................................................................................... 21
3.4.17. Notice of data file in Snapshot ................................................................................................ 21
3.4.18. Restriction in data recovering function[LC] ............................................................................... 21
3.4.19. Notice of Contour plotting in PDA tab[LC] ................................................................................. 21
3.4.20. Restriction in data recovering function of PDA 2D mode and MWD[LC] ................................... 21
3.5. Batch Analysis ............................................................................................................................ 22
3.5.1. Notice for Terminating LabSolutions after Stopping Batch ...................................................... 22
3.5.2. The transition to another window during Realtime Batch analysis .......................................... 22
3.5.3. Time consumption to register batch tables ............................................................................. 22

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 3.5.4. Estimated time for Realtime Batch analysis............................................................................ 22
3.5.5. Notice to run Realtime Batch with using method file opened by others .................................. 22
3.5.6. Restrictions on the type of character for data filename ........................................................... 22
3.5.7. Notice for Sharing Batch Table ............................................................................................... 22
3.5.8. Notice for Registering Batch Table to the Queue .................................................................... 23
3.5.9. Notice for Restarting Batch Queue ......................................................................................... 23
3.5.10. Limitation of Registering Batch Table to the Queue ................................................................ 23
3.5.11. Notice for Printing from Realtime Batch analysis .................................................................... 23
3.5.12. Restriction on space in Report Format filename ..................................................................... 23
3.5.13. Restriction on re-registration of the batch file when it's running .............................................. 23
3.5.14. Notice for registration of batch, which includes the same data filenames ............................... 23
3.5.15. Notice for Start/End Settings of Batch Table ........................................................................... 24
3.6. Data Analysis .............................................................................................................................. 24
3.6.1. Notice for Calculating Theoretical Plates and Resolution ....................................................... 24
3.6.2. Notice for Registering Column Performance into Agent Database ......................................... 24
3.6.3. Notice for Manual Integration Command ................................................................................ 24
3.6.4. Notice for Manual Calibration ................................................................................................. 24
3.6.5. Notice for QA/QC Calibration Results when Ref STD ID is specified ..................................... 24
3.6.6. Notice for QA/QC terms .......................................................................................................... 24
3.6.7. Notice for Data Comparison (chromatogram division, multiplication) ..................................... 24
3.6.8. ASCII output of the calculation results from the Data Comparison ......................................... 25
3.6.9. Notice for checking raw data .................................................................................................. 25
3.6.10. Notice for Method Created by LCsolution Version 1.2 or before[LC] ........................................ 25
3.6.11. Notice for Max. Slices ............................................................................................................. 26
3.6.12. Notice for Custom Parameter ................................................................................................. 26
3.6.13. Notice of Statistic Calculation (Average, %RSD, Standard Deviation, etc.) ............................ 26
3.7. PDA Data Analysis[LC] ................................................................................................................. 26
3.7.1. Notice for Displaying Purity Curve .......................................................................................... 26
3.7.2. Notice for Displaying Contour Plot .......................................................................................... 26
3.7.3. Notice for Spectrum Background Correction .......................................................................... 26
3.7.4. Notice for Peak Purity Calculation .......................................................................................... 26
3.7.5. Notice for Printing the Library Search Result .......................................................................... 27
3.7.6. Notice on the Similarity identification ...................................................................................... 27
3.7.7. Notice for Data Analysis of Fast Sampling Data ..................................................................... 27
3.7.8. Notice for Peak Separation and Impurity Analysis by Derivative Spectrophotometry ............. 27
3.7.9. Notice for PDA Zero Adjustment ............................................................................................. 27
3.7.10. Notice for Data Plot ................................................................................................................ 27
3.7.11. Notice on the Color settings of Reference data in Chromatogram view ................................. 27
3.8. Browser ....................................................................................................................................... 28
3.8.1. Notice for Data Processing on Browser .................................................................................. 28
3.8.2. Notice for Browser Operations................................................................................................ 28
3.8.3. Notice for Opening Many Data Files on Browser .................................................................... 28
3.8.4. Notice for Exporting Quantitative Results on Browser ............................................................ 28
3.8.5. Notice for Results displayed on Browser ................................................................................ 28
3.8.6. Notice for Printing Image of Data Browser.............................................................................. 29
3.8.7. Notice for Saving Layout Files ................................................................................................ 29
3.9. Report .......................................................................................................................................... 30
3.9.1. Notice for Round Method of Report Output ............................................................................ 30
3.9.2. Notice for Displaying Column Index Strings............................................................................ 30
3.9.3. Notice for the Specification of Enforce file name on each item[LC] .......................................... 31
3.9.4. Notice for Printing Report Image ............................................................................................ 31
3.9.5. Notice for Printing Chromatogram Report Item....................................................................... 31
3.9.6. Notice for Previewing Report Image ....................................................................................... 31

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 3.9.7. Notice for Using "Meiryo" Font................................................................................................ 31
3.9.8. Notice for Preview Window and Print Output .......................................................................... 31
3.9.9. Notice for Report Editor and Print Output ............................................................................... 32
3.9.10. Notice for Calibration Curve Item............................................................................................ 32
3.9.11. Notice for Editing Report Items ............................................................................................... 32
3.9.12. Notice for Inserting Object from Other Applications ................................................................ 32
3.9.13. Notice for Editing Print Image File .......................................................................................... 32
3.9.14. Notice for Summary Report Output ........................................................................................ 32
3.9.15. Notice for Block Setting in the Summary (Data) Item ............................................................. 33
3.9.16. Printing Graph Image ............................................................................................................. 33
3.9.17. Notice for Printing the UV Spectrum Item[LC]........................................................................... 33
3.9.18. Difference of the Number of Lines to Output Strings .............................................................. 33
3.9.19. Difference of the Output Order of the Method Item ................................................................. 33
3.9.20. Notice for the PDF Output of Contour and 3D Graph[LC] ......................................................... 33
3.9.21. Limitation of Printing the Overlapped Area of FRC Results and Simulation[LC] ....................... 33
3.9.22. Notice for Printing System Suitability Test Report................................................................... 34
3.9.23. Notice for "B Curve" command in the LC Time Program[LC] .................................................... 34
3.9.24. Notice for Contour and 3D Graph Report Item[LC] ................................................................... 34
3.9.25. Notice for Chromatogram Intensity Unit .................................................................................. 34
3.9.26. Notice for Intensity Unit when Overlaying Chromatogram ...................................................... 34
3.9.27. Notice for Transparent Setting of Report Items....................................................................... 34
3.9.28. Notice for Delete the Report Item ........................................................................................... 35
3.9.29. Fix Detector No. of PDA 2D mode and MWD[LC] ..................................................................... 35
3.9.30. Data Processing Parameters of PDA 2D mode[LC] .................................................................. 35
3.9.31. Notice for Property of Method Item[GC] .................................................................................... 35
3.10. PDF File Output .......................................................................................................................... 35
3.10.1. Notice for PDF Driver (SkyPDF) ............................................................................................. 35
3.10.2. Notice for Setting Default Printer ............................................................................................ 36
3.10.3. Notice for File Name and Folder Path of PDF Output............................................................. 36
3.10.4. Limitations for the System Suitability Function ....................................................................... 36
3.10.5. Not Supporting Security Password Function .......................................................................... 36
3.10.6. Notice for Registering PDF File to Agent Database ................................................................ 36
3.10.7. Notice for PDF Output from Batch .......................................................................................... 36
3.11. File Conversion........................................................................................................................... 37
3.11.1. Notice for Converting Method File .......................................................................................... 37
3.11.2. Notice for Converting CLASS-VP Method File[LC] ................................................................... 37
3.11.3. Not Supporting Grouping Settings of CLASS-VP Method File[LC] ........................................... 37
3.11.4. Limitation of Converting CLASS-VP Method Manually Configured[LC] .................................... 37
3.11.5. Notice for Converting Chromatogram to ASCII/AIA Format .................................................... 37
3.11.6. Notice for Converting ASCII Format to LabSolutions Data File............................................... 37
3.11.7. Notice for Generated Data such as Operations and Conversion from ASCII/AIA ................... 38
3.11.8. Notice for Converting AIA (Andi) File into LabSolutions Data File........................................... 38
3.11.9. Notice for System Configuration of AIA (Andi) File (.cdf) ........................................................ 38
3.11.10. Notice for the data processing parameters of AIA (Andi) File (.cdf) ...................................... 38
3.11.11. Notice for Status Curves[LC] .................................................................................................. 38
3.11.12. Using CLASS-LC10/GC10 and CLASS-VP Files ................................................................. 39
3.11.13. Notice for Converting LCsolution Data File and GCsolution Data File into LabSolutions Data
File 39
3.11.14. Notice for Converting ASCII Format of PDA/MWD 2D mode data[LC] ................................... 39
3.12. Notice for the QA/QC Calculation Results (Difference from GCsolution Ver. 1 and 2) [GC] ... 39
3.12.1. S/N Ratio of the QA/QC Calculation ....................................................................................... 39
3.12.2. Residual SD of Y Intercept ..................................................................................................... 40
4. LC Instrument Control Notes[LC] ................................................................................... 40

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 4.1. System ......................................................................................................................................... 40
4.1.1. Notice for using Prominence Web Control Function ............................................................... 40
4.1.2. Notice for automatic detection CBM-20A/20Alite from LabSolutions ...................................... 40
4.1.3. Restrictions in Fast LC Mode of Prominence UFLC/UFLCXR and Nexera system ................ 40
4.1.4. Notice for Key Lock of System Controller ............................................................................... 40
4.1.5. Notice for Using Optional Loop in LC-2010HT........................................................................ 41
4.1.6. Notice for Rinse Port Septum of LC-2010 series .................................................................... 41
4.1.7. Notice for Pump Time Program settings ................................................................................. 41
4.1.8. Notice for Shutdown ............................................................................................................... 41
4.1.9. Notice for the notation of solenoid valves with LC-2030/LC-2040 series ................................ 41
4.1.10. Notice for adding sample analysis on the instrument’s panel (LC-2030/LC-2040) ................. 41
4.2. Autosampler................................................................................................................................ 42
4.2.1. Sample Rack Name ................................................................................................................ 42
4.2.2. Not Supporting S.Pret Time Program Command .................................................................... 42
4.2.3. Using MTP/Deep Well Rack ................................................................................................... 42
4.2.4. Maximum Injection Volume and the step of the injection volume for SIL-20A series .............. 42
4.2.5. Pretreatment program of autosampler .................................................................................... 43
4.3. 2D Detector ................................................................................................................................. 43
4.3.1. Maximum Acquisition Time of 2D Detector ............................................................................. 43
4.3.2. Status Log of SPD-20A/V Cell Temperature ........................................................................... 43
4.3.3. Not Supporting Spectrum Scan .............................................................................................. 43
4.3.4. Spectrum Scan for LC-2030/LC-2040 series .......................................................................... 43
4.3.5. Supporting CDD-10Avp/sp Control via CBM-20A/lite ............................................................. 43
4.3.6. Fast Sampling......................................................................................................................... 44
4.4. Evaporative Light Scattering Detector ..................................................................................... 45
4.4.1. Notice for the ELSD operation ................................................................................................ 45
4.4.2. Displaying Nebulizer Gas Pressure ........................................................................................ 45
4.4.3. Offset Setting Range .............................................................................................................. 45
4.4.4. Zero Adjustment ..................................................................................................................... 45
4.4.5. Shutdown Function ................................................................................................................. 45
4.5. PDA Detector .............................................................................................................................. 46
4.5.1. Maximum Acquisition Time of SPD-M10Avp/SPD-M20A Detector ......................................... 46
4.5.2. Maximum Acquisition Time of SPD-M30A Detector ................................................................ 46
4.5.3. Maximum Acquisition Time of LC-2030/LC-2040 PDA Detector ............................................. 47
4.5.4. Maximum Acquisition Time of PDA 2D mode and MWD......................................................... 47
4.5.5. Notice for Data Acquisition...................................................................................................... 47
4.5.6. Notice for Setting Acquisition Time ......................................................................................... 47
4.5.7. Notice for SPD-M10Avp's Sampling Period ............................................................................ 47
4.5.8. Bandwidth for Multi-Chromatogram Settings .......................................................................... 47
4.5.9. Fast Sampling......................................................................................................................... 47
4.6. Fraction Collector ....................................................................................................................... 48
4.6.1. Notice for Displaying Fraction Mark ........................................................................................ 48
4.6.2. Display Period of Real Time Hatching of Fraction Collection .................................................. 48
4.6.3. Notice for Displaying Fraction Mark on PDA Multi-Chromatogram ......................................... 48
4.6.4. Notice for Stop Time of FRC Time Program ........................................................................... 48
4.6.5. Notice for I.VIAL and F.VIAL of FRC Time Program ............................................................... 48
4.6.6. Notice for Difference between FRC Simulation and Results................................................... 48
4.6.7. Notice for Time Setting of FRC Program ................................................................................ 48
5. Other Information........................................................................................................... 49
5.1. License Key................................................................................................................................. 49
5.1.1. Keeping License Key .............................................................................................................. 49
5.2. Other Notes ................................................................................................................................. 49
5.2.1. Notice for Virus Check Software ............................................................................................. 49

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 5.2.2. Notice for Windows Defender Exclusion Settings ................................................................... 49
5.2.3. Notice for the Instrument Administration Window ................................................................... 49
5.2.4. Notice for the PC Information in the Administration Tools ....................................................... 49
5.3. License use notation .................................................................................................................. 49
5.3.1. Notice for NLog....................................................................................................................... 49
5.3.2. Notice for TreeGridView.......................................................................................................... 49
5.3.3. Notice for LibJpeg................................................................................................................... 50
5.3.4. Notice for FreeType ................................................................................................................ 50
5.3.5. Notice for Eigen3 .................................................................................................................... 50
5.3.6. Notice for redsvd .................................................................................................................... 50
5.3.7. Notice for Spread Windows Forms 6.0 ................................................................................... 51
5.3.8. Notice for AutoMapper ............................................................................................................ 51
5.3.9. Notice for OxyPlot ................................................................................................................... 51

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1. Overview
This document provides additional information and notes regarding the specification issues of
LabSolutions. (The LC and GC specific issues are marked as [LC] and [GC], respectively.)
Please read the release notes before using LabSolutions Chromatography Data System.

2. Installation Notes
2.1. Operating Environment

2.1.1. Windows Version

This software operates on the following Windows version.
Software Name Windows Version
Windows 10 Pro English 64bit
LabSolutions Windows 7 Professional SP1 English 32bit
Windows 7 Professional SP1 English 64bit

2.1.2. Database Management System

This software operates with the MDB or the following Database Management System if you use
the CLASS-Agent user authentication tool.
Software Name Database Management System
Microsoft SQL Server 2005 (32bit)
LabSolutions
Microsoft SQL Server 2008 R2 (64it)

2.2. Computer System Issues

2.2.1. Memory Requirements

We recommend a minimum of 2 Gbytes of RAM to use LabSolutions on 32bit Windows, and
recommend a minimum of 4 Gbytes of RAM to use LabSolutions on 64bit Windows.

2.2.2. Windows Virtual Memory Settings

When too many applications or Postruns are launched, the following message may be
displayed and the operation may be terminated.
“Your system is running low on virtual memory. Please close some applications. “
This is because applications consume RAM and virtual memory allocated to the PC.
When the above message is displayed, it is necessary to limit number of applications
concurrently used or add more memory. If not often, this can be avoided by increasing the
paging file size of virtual memory on Windows. (To increase virtual memory size, select Control
Panel>System>Advanced tab, and press [Performance Options] and [Change] button. Then set
Initial Size and Maximum Size to increase the paging file size.)

2.2.3. Windows User Account

When using LabSolutions, set the access level to “Standard user” or higher.

2.2.4. Notice for Display Properties Settings

In the Control Panel under the Display Properties Settings, set Colors to "High Color (65536)"

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 or more.

2.2.5. Notice for Free Disk Space

It is recommended that 512 Mbytes free disk space or more be available at all times for the
LabSolutions software. Data files may consume more disk space during a batch run. When
LabSolutions data files are stored to the same drive as the Window system drive, available disk
space may drop below 512 Mbytes. In such a case, long batch runs may not be acquired
reliably. If you have multiple hard disk drive, it is recommended to store data files to another
drive which is not installed Windows system.
This software shows the following warning message if the available disk space is less than
1Gbyte when the Start button of Single Run or Batch is pressed.
“There is little free disk space. …”
When this message is displayed, please delete unnecessary files on the data drive to extend
available disk space.
When the available disk space is less than 512Mbytes on starting acquisition, the batch run is
stopped to wait restarting for safety. After extending available disk space, restart the batch.

2.2.6. Keeping Computer System Stable

It is highly recommended to reboot your PC periodically, for example once a week, in order to
avoid unexpected Windows incidents because resource leak and memory fragmentation may
occur depending on the PC environment.

2.2.7. Number of Systems being controlled with a PC

This software can control a maximum of 4 systems in a computer, where a maximum of 2 PDA
or MWD can be connected to HPLC systems. This restriction is applied also when using a PDA
detector in 2D mode.

2.2.8. Notice for Windows User Switching

Please be advised that LabSolutions does not work properly on the Windows user switching
(which allows several users to log on the Windows and run programs simultaneously).

2.2.9. Notice for Windows Aero in Windows 7

If you change angle or size of the 3D graph at its properties screen on the Windows Aero
environment, the graph is not drawn in the preview screen. Please disable the Windows Aero.

2.2.10. Notice for Taskbar

To always display the [LabSolutions Service] icon on the taskbar in Windows 10, click [Control
Panel]-[Taskbar and Navigation] to display the [Taskbar and Start Menu Properties] window. On
the [Taskbar] tab page, select [Customize] in the [Notification area] field. Click [Select which
icons appear on the taskbar], and for [LSSServiceMonitor.exe], select [On]. (For Windows 7,
click [Customize] on the taskbar. Change the selection for "LSSServiceMonitor.exe" from [Only
show notification] to [Show icon and notification].

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 2.2.11. Notice for Executing the Analysis Program
If the analysis program for instrument 2 or later is pinned on the taskbar by using [Pin to
taskbar] function (in Windows 7, [Pin this program to taskbar] function), the analysis program
for instrument 1 would be executed. The analysis program should be executed from the
LabSolutions launcher.

2.2.12. Precautions regarding hard disk defragmentation

Do not perform hard disk defragmentation during analysis.
If performed, it may cause unexpected problems such asdata buffer over flow and acquisition
will be terminated.
Because some PCs are configured to perform hard disk defragmentation automatically, make
sure that selecting [Start]Menu-[all programs]-[accessories]-[system tools]-[disk
defragmentater], scheduling function is disabled before Data Acquisition.

2.2.13. Restriction in using LabSolutions Direct

In using LabSolutions Direct, please set the decimal symbol of the PC to connect via
smartphone as “.” (period). If the decimal symbol of the PC is not “.” (period) such as “,”
(comma), the remaining time of analysis and decimal fraction such as pump flow are not
displayed correctly at smartphone.
To change the decimal symbol of the PC, select Control Panel> Region (in Windows 7, Region
and Language)>Formats tab - [Additional settings...]>Numbers tab.

2.3. PDA/MWD Installation Issues

2.3.1. Wavelength Calibration

When a PDA detector or a MWD (multi-wavelength detector) is installed, the Calibration
program must be run before LabSolutions can acquire data from the detector.
In many cases the actual calibration has already been done at the factory. If the detector is
recalibrated and the procedure is not followed accurately, the detector may not function
properly. We recommend that you check with your local service person prior to calibrating a
PDA/MWD.
To calibrate a PDA/MWD, select [Start]>[Programs]>[LabSolutions]>[Instrument Maintenance
Tools]. In the [Application] drop-down box select "PDA Utility(SPD-M10Avp/M20A)" or “SPD-
M30A Utility” or “SPD-30AM Utility” or “LC-2030/2040 PDA Utility”. The PDA/MWD must be
configured with LabSolutions prior to performing the wavelength calibration on the Utility. If it is
not configured, the Utility cannot recognize the PDA/MWD.

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3. LabSolutions Software Notes
3.1. General

3.1.1. LabSolutions File Compatibilities

LabSolutions methods, data, batch, and report format file is upper compatible. Files created in
the latest version may not be used in earlier versions.
Please use the same LabSolutions software version in your laboratory.

3.1.2. Area and Height Values Determined with LabSolutions

Area and Height values determined with LabSolutions, for data files acquired with CLASS-
LC10/GC10 software will typically differ from the precise values determined by CLASS-
LC10/GC10 software.
The Integration Algorithm is identical to CLASS-LC10/GC10. However, R.Time, Area and Height
are slightly different (R.Time: about 0.03% Area & Height: about 0.005%) because higher
precision arithmetic is used in the internal calculations. Below are examples of CLASS-
LC10/GC10 and LabSolutions data. In general, these differences have no effect on the
quantitation of results.
R.Time Area Height
CLASS- CLASS- CLASS-
LC10/CLASS- LabSolutions LC10/CLASS- LabSolutions LC10/CLASS- LabSolutions
GC10 GC10 GC10
1.439 1.439 700645 700645 119239 119239
1.863 1.863 7536053 7536053 882292 882292
3.018 685003
3.017 685004 85928 85928
(0.03%) (-0.0001%)
512517
5.183 5.183 512516 44088 44088
(0.0002%)
1114901
5.714 5.714 1114900 102930 102930
(0.0001%)

3.1.3. Compatibility with CLASS-LC10/GC10 and CLASS-VP Area and Height Values
To reduce the precision of LabSolutions calculations in order to make them more compatible
with CLASS-LC10/GC10, in Windows directory create a text file CRHAKEI.INI by using a text
editor like Notepad.exe, containing the following text:
[Mode]
PacCompatible=1
Although the above area and height become the same values between CLASS-LC10/GC10
and LabSolutions by this setting, it is not always matched for all data files. Please be advised
that the function check files included in the LabSolutions installation CD-ROM are not available
as the peak integration is performed by the CLASS-LC10/GC10 compatible mode.
The peak-integration algorithm of LabSolutions is identical to CLASS-VP CHROMATOPAC
Integration Package. However, concerning chromatograms which are acquired with sampling
period of other than 500msec (default setting), the peak integration results may slightly differ
between these software because LabSolutions takes into account the sampling period variable
with double precision while CLASS-VP does with single precision.

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 3.1.4. Compatibility of User Administrations Information
User Administration Information is not inherited from LCsolution and GCsolution, if their
versions are less than 5. Please register it on LabSolutions Ver. 5. If you use the CLASS-Agent
user authentication tool on the SQL Server or Oracle database, you can share a database to
inherit for user ID and user name. However, please set the user rights again.

3.1.5. Notice for System Log of LCsolution and GCsolution less than version 5
LabSolutions Ver. 5 cannot display System Log of LCsolution and GCsolution, if their versions
are less than 5. Please display it with Log Browser of LCsolution and GCsolution or check it as
an exported text file.

3.1.6. Notice for System Administration, Log and User Profile Database
LabSolutions manages system administration such as users and security policies, log and user
profile information by database.
By default, the following Microsoft database files are used.
C:\LabSolutions\System\ShimadzuAttest.mdb
C:\LabSolutions\Log\LSSLog.mdb
C:\LabSolutions\System\ LSSProfile.mdb
Please be advised that they cannot be shared on the network, though the above MDB files are
specified by the following MDB Setting Tool.
C:\Program Files\LabSolutions\LSSSetMdbForm.exe
To share system administration, log and user profile information on the network, please use the
SQLServer or Oracle database by referring "2.5 Link with CLASS-Agent in 223- 60092
LabSolutions System Users Guide".
When the MDB file is destroyed, it can be repaired by clicking the Optimize/Repair database
button in the MDB Setting Tool. However, please backup the above MDB files into another
folder or onto another media.

3.1.7. Notice when multiple programs are performed concurrently

When you perform many programs(Realtime Analysis, Analysis Editor, Postrun, Browser, etc)
the functions might be unstable due to lack of available memory. As the upper limit of total 8
programs, please close unnecessary programs if you have performed too many programs.

3.1.8. Notice for File Naming

File in Windows can be created with file name longer than 259 bytes, but LabSolutions cannot
handle the file with file name longer than 259 bytes.
In addition, this software limits the file name to 63 characters or less in the "Save As" dialog.
Please name it shorter than the above limitation.

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 3.1.9. Notice for Saving Method
When a method file is saved several times, the file size may increase due to compound file
fragmentation. In such a case, please save the method in a new file using the Save Method File
As command from the File menu. The file size will be optimized.

3.1.10. Restriction in multiple files selection

When you can select multiple files in the "File Open" dialog, there is a limit to the number of
files that can be selected.*
If you see the following message, it is exceeded the maximum number of files to open, please
reduce the number of selected files.
“(Filename) File not found. Please verify the correct name was given.”
* "Check Raw Data" > "Open Data Files" dialog, "Report" window > Summary Report Items >
"Open File(s)" dialog etc.

3.1.11. Restriction in handling multiple data files

In application windows like Quant Browser and Calibration Curve, you may not be able to read
more data files because of Insufficient memory error with large amount of data handling.

3.1.12. Assistant Bar Customization

In Assistant Bar Customization, LabSolutions gets the information from its corresponding child
window. When no detector is configured in System Configuration, the Calibration Curve child
window cannot be opened. Therefore the information of Calibration sub-bar is not displayed. If
you want to customize the Calibration sub-bar, please configure one or more detectors in
System Configuration.

3.1.13. Maximum Number of Detectors Supported by an HPLC System[LC]

Each system in LabSolutions is limited to a maximum of 5 LC detectors, including a PDA
detector, with the exception of CBM-20Alite in which a PC-55 Single Channel A/D board cannot
be used. Other detector types are supported in the following way: a maximum of 2 digital
detectors such as SPD-20AV, RF-20AXS and RID-10A, and a maximum of 2 PC-55 Single
Channel A/D boards.
LabSolutions is limited to an integrated UV detector and a PDA detector for LC-2010. A PDA
detector should be configured after the 2D normal detectors.
For LC-2030/LC-2040 with the internal UV detector model, LabSolutions is limited to a
maximum of 4 LC detectors, including the internal UV detector, 1 external detector supported
by the LC-2030/LC-2040, 1 A/D board and 1 PDA detector. For LC-2030/LC-2040 with the
internal PDA detector model, LabSolutions is limited to a maximum of 3 LC detectors, including
the internal PDA detector, 1 external detector supported by the LC-2030/LC-2040 and 1 A/D
board.
When using a PDA detector in 2D mode or a MWD(multi-wavelength detector), it becomes a
maximum of 4 detectors including a PDA/MWD (other 3 detectors consists of a maximum of 2
digital detectors such as SPD-20AV, RF-20AXS and RID-10A, and a maximum of 2 PC-55
Single Channel A/D boards). PDA and MWD cannot be configured in a same system.

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 3.1.14. Notice of Displaying Channel name
In the label of chromatogram shown in data acquisition and data analysis, or in the line name of
the chromatogram in report, if only one detector channel exists, channel name (Ch1) is not
displayed. For detectors which output multi-channel data such as SPD dual mode, channel
names (Ch1, Ch2 and so on) will be added.

3.1.15. Notice for System Check Result Output[LC]

When instrument type is not LC-2010, the output format of the system check results, though
LCsolution Ver. 1 had an output of instrument list on it, was changed to remove the list because
of duplicate contents.

3.1.16. Notice for absorbance range of PDA Contour plots[LC]

Absorbance range of the contour (the legend of colors) shows up to 4 digits.

3.1.17. Notice for the Graph Comment of the Magnification Intensity

When the factor is set to the chromatogram, it cannot be reflected in the intensity value of the
graph comment. Please select the check of the "Display Y axis value at intensity" in the "Graph
Property" and set the mouse position on the chromatogram if you display magnification
intensity.

3.1.18. Notice for opened child windows at starting the program

When the program starts, only the child window, which was active at the last ending of the
program, will be opened by default.
You can open multiple child windows by the settings shown below. However, more child
windows are opened, it takes longer time to start the program.
To change the mode of opening child windows, execute the following files that are included in
LabSolutionsLCGC\Supplement\x86 (32bit OS) or LabSolutionsLCGC\Supplement\x64 (64bit
OS) folder of the installation CD-ROM.
ChildDispModeAnalysis_AlwaysDefault.reg
The Realtime Analysis program will open the following child windows: "Data Acquisition",
"Realtime Batch", "Calibration Curve", "Report", "Method Editor" and "Batch Editor".
ChildDispModeAnalysis_LastActive.reg
The Realtime Analysis program will open only the child window, which was active at the last
ending. (Default)
ChildDispModeAnalysis_LastOpenAll.reg
The Realtime Analysis program will open all the child windows, which were opened at the last
ending.
ChildDispModePostrun_AlwaysDefault.reg
The Postrun Analysis program will open the following child windows: "Data Analysis", "PDA
Data Analysis", "Calibration Curve", "Postrun Batch", "Data Comparison", "Report" and "UV
Library Editor".
The Browser program will open the following child windows: "Quant Browser", "Data

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 Browser" and "Report".
ChildDispModePostrun_LastActive.reg
The Postrun Analysis or Browser program will open only the child window, which was active
at the last ending. (Default)
ChildDispModePostrun_LastOpenAll.reg
The Postrun Analysis or Browser program will open all the child windows, which were opened
at the last ending. (If both the Quant Browser and Calibration Curve child windows were
opened and the Quant Browser was active in Browser program at the last ending, the
Calibration Curve child will not be opened at the next start.)

3.1.19. Notice for the Complexity of User’s Password

When “Password must meet complexity requirements” is selected in Security Policy, it is
necessary for LabSolutions to use three kinds of characters (alphabet, number and mark) as
password for the secure user management.
(For CLASS-Agent, it is required to use two kinds of characters (alphabet and number) as
password.)
Therefore, when the LabSolutions user authentication database links up with the CLASS-Agent
user authentication database, it is required to use three kinds of characters (alphabet, number
and mark) as password on changing user passwords and adding users though the user created
in the CLASS-Agent can log in LabSolutions using the current password.

3.1.20. Notice for Screen Lock on the Multi-User Login Mode

Automatic screen lock time is applied to all users when multiple uses are logged in the
LabSolutions software. When the lock time is expired for a user because of no operation, all
user’s windows are locked.
For example, suppose the automatic screen lock time set to 3 minutes and 1 minute is expired
after User A logs in the LabSolutions software with no operation. When User B logs in the
LabSolutions software all windows are locked after 2 minutes if User A does not operate it.

3.1.21. Notice when Analysis program is hung up by an unexpected error

When the analysis program is hung up by an unexpected error, there is a case the PC cannot
be shutdown. In such a case, terminate the analysis program by the following procedure.
[Procedure]
1) Run the following program from the Start menu.
C:\Program Files\LabSolutions\LSSEndProcess.exe
2) Select the instrument name from the list box.
When the Windows login user has Administrator right, the following message is displayed.
Then click [Yes] or [Continue].

Window 7
"Do you want to allow the following program to make changes to this computer?"
Windows10
"Do you want to allow this app to make changes to your PC?"

When the user does not have Administrator right, select “The following user” and set a user
name having Administrator right and password (required), and then click [OK].

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 Note. When a different user having Administrator right is specified, the user password except
for blank is required.
Note. Though the analysis window is closed, there is a case a background process is resident.
The process can be terminated by the above procedure, too.

3.1.22. Notice when printing a log from the Shimadzu User Authentication Tool
When in cooperation with the Shimadzu user authentication tool, the log about user
management can be displayed as a log of the Shimadzu user authentication tool, but a
character piece may be generated if it prints. In case printing the log about user management,
please print from the log browser of LabSolutions.

3.1.23. Notice for Screen Lock on the [Login by Windows account] mode
Be advised that you cannot use the LabSolutions Screen Lock function when [Login by
Windows account] is checked in the Security Policy Settings. Please use the Screen Lock
function supported by Windows.

3.1.24. Notice for peak integration by setting minimum area/height

When the minor peaks in the tailing/leading peak are deleted by setting the minimum area or
height in the integration parameters, the peak area of the deleted peaks is not added to the
area of the main peak.
Please note the boundary between the tailing/leading peak and the minor peaks is not shown in
the display and report.

3.1.25. Notice for compatibility with LCsolution GPC Software[LC]

There is a case factors of GPC calibration curve calculated by LabSolutions slightly differ from
those calculated by LCsolution because of the difference of compiler versions. Although the
difference is negligible for the Linear or the 3rd Order Curve, it may be found for the 5th Order
Curve or more.
When using LCsolution GPC method files, convert the method files to the LabSolutions format
and then re-calculate the GPC calibration curve.

3.1.26. Notice for Converting 3D Data to ASCII Format [LC]

When PDA data is output in ASCII format, the 3D data wavelength values are output with the
unit [nm] multiplied by 100. To output the wavelength values at the same magnification as the
units [nm], execute the file below, which is included in the installation media.
LabSolutionsLCGC\Supplement\x86\PDARawDataWavelengthExportMode_nm.reg (32-bit OS) or
LabSolutionsLCGC\Supplement\x64\PDARawDataWavelengthExportMode_nm.reg (64-bit OS)

3.1.27. Notice for the Floating-Point Arithmetical Results

In order to provide a better product, the compiler used to build LabSolutions was upgraded as
of version 5.95. General binary floating-point arithmetic is used for arithmetical processing in
LabSolutions. However, errors occur in the calculation results due to the representation of
significant digits by the calculator. This property of errors occurring in the floating-point

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 arithmetic, as well as differences in the optimization methods between the old and new
compiler, sometimes cause differences in various arithmetical results. However, agreement to 9
significant digits can be expected, based on the results of an examination of these differences.
It is rare for calculation results with the default in the system settings used for the digits
displayed to differ from those from versions prior to 5.95, so this is not likely to be an issue in
practice.

3.1.28. Notice for Changes to Numerical Exponential Notation

The compiler used to build LabSolutions has been upgraded as of version 5.95. The format of
numerical exponential notation has changed due to changes to the specifications for the standard
library provided with the compiler. In LabSolutions versions prior to 5.95, exponents were always
displayed with 3 digits. However, from version 5.95, they are in principle displayed with 2 digits (3
digits if necessary). For example, the notation "1.2e+003" in versions prior to 5.95 has been changed
to "1.2e+03."
With LabSolutions, exponential notation is used on the vertical axis in graphs and in the QA/QC
output results.
Note that this is only a change to the format of the notation, and has no impact on the numerical
values themselves.

3.2. Instrument Configuration

3.2.1. Notice for Changing Instrument Configuration

Once an instrument is configured with LabSolutions, the Instrument Configuration should
remain unchanged. On starting the Realtime Analysis window, if "Modules Used for Analysis"
set to LabSolutions is different from the actual system configuration, LabSolutions fails to
connect, the method cannot be downloaded, or you cannot start acquisition. In such cases,
please reconfigure the system.

3.2.2. Notice for Changing Configuration

When modules used for analysis, configuration parameters including system check criteria,
ROM version and serial number are changed, and the following message is displayed when the
method is opened.
[241a] The system configuration for this method is different from the current instrument configuration.
The configuration in the method is adapted to the current instrument configuration.
Save the method file to update the configuration information in the method.
The common instrument parameters in the method are taken over to the new configuration if
the range check is valid. For example, when a method created on the configuration with SIL-
30AC loop injection mode is opened on the configuration with SIL-30AC direct injection mode,
the Air Gap setting is taken over. Thus, air is inserted on sample injection, which may affect
acquisition data. Please confirm the method settings to avoid such an unexpected problem.

3.2.3. Notice for LC-2010 Unit ID[LC]

For LCsolution Ver. 1, Unit ID could be set to each unit of system controller, pump, autosampler,
oven and detector(s) in the LC-2010 configuration,. LabSolutions Ver. 5 has been modified to

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 deal it with only the system controller as it means the managed information for one device.
When the LC-2010 method file created in LCsolution Ver. 1 is opened in LabSolutions Ver. 5,
the Unit IDs except for the system controller potion are cleared.
When Unit ID is set to the other units of system controller for LCsolution Ver. 1, please use the
comment area of Communication Settings for LabSolutions Ver. 5.
In the system configuration report, Unit ID will be printed out for the LC-2010 system controller.
However, for data files created by LCsolution Ver. 1, Unit ID will be printed out in each unit.

3.2.4. Notice for the external detector for the LC-2030/LC-2040 (PDA detector model)
When using the LC-2030/LC-2040 (PDA detctor model) with an external detector, the external
detector is configured as a “Detector-B” (“Detector-A” doesn’t exist). When using the LC-
2030/LC-2040 (UV detctor model) with an external detector, the Internal UV detector is
“Detector-A” and the external detector is “Detector-B”.

3.2.5. Notice when configured instrument does not exist

When one instrument, for example, LC or PDA is failed to connect, the status of other
instruments becomes "Not Connected", too. The instrument failed to connect is displayed in the
message window under the analysis window.

3.2.6. Supporting Fast LC Control Mode[LC]

LabSolutions can set the Control Mode (Fast LC mode*) of system controller. The current
Control Mode is displayed on the Instrument Monitor.
* Control Mode is the feature added in CBM-20A/lite ROM version 1.11 or later. And Fast LC
mode is valid for Prominence UFLC/UFLCXR and Nexera series.

3.3. Instrument Operation

3.3.1. Notice for Turning Power Off the Instrument

If the instrument must be shut down due to a hardware error or other reasons, please be sure
to terminate LabSolutions first. If any modules like an HPLC detector unit were shut down and
restarted while LabSolutions was active, LabSolutions may become unable to control the
instrument correctly. In such a case, please close LabSolutions, restart the system controller,
and then start LabSolutions.

3.3.2. Notice for the ROM version up

When you update the unit ROM version, please press the Auto Configuration button on the
System Configuration window to update the current configuration information. Otherwise, you
may not be able to use the latest features as LabSolutions does not know the update.

3.3.3. Notice for LC-2010/LC-2030/LC-2040 On Time Injection[LC]

When the analysis is performed using the LC-2010/LC-2030/LC-2040 on time injection mode,
data acquisition starts after the mobile phase set in the delay volume starts flowing. In this
case, if the LC Stop Time (stop time of time program) and the End Time (stop time of data
acquisition) are set to the same value, the time program stops before data acquisition stops.

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 3.3.4. Notice for Performing Baseline Check after Auto Purge in LC instrument[LC]
As baseline is not always stable just after the Auto Purge, Baseline Check may fail in the first
test. In such a case, please specify long enough period between equilibration time and the Start
time, or longer Maximum Time in order to wait until baseline becomes stable.

3.3.5. Notice for System Check to LC instrument[LC]

Please fill the mobile phase (ex. H2O) in the detector cell before performing the LC system
check with the LC detector in a detailed mode.

3.3.6. Notice for the download of the Instruments Parameters[LC]

When the parameters are transmitted with the [Download] button to the LC units, which are
being stopped, the LC components such as the pump and oven do not start running. Please
activate those devices with the [activate] button in the toolbar.

3.3.7. Notice for Reading the Method File when the Auto Purge is running[LC]
When another method file is read while executing the auto purge, the Data Acquisition window
cannot be closed occasionally. Please open the file after it is stopped or ended.

3.3.8. 3.3.8 Notice for changing the Instrument Monitor in the "Fast LC" mode[LC]
When the [Fast LC] mode is selected in the Control Mode of the system controller, the [B.Conc]
value cannot be changed from the instrument monitor during analyzing.

3.3.9. Notice for System Check to GC instrument[GC]

While performing the GC-2010/2014 system check, if System Check is terminated by key
operation on the GC, incomplete check results will be displayed on the PC. Please operate on
the PC to stop System Check.

3.3.10. Notice for Baseline Check to CBM-201m

When performing Baseline Check, with setting End Time and Maximum Time to the same
amount, there is a case that the result of Baseline Check isn't calculated occasionally. In such
cases, Set Maximum Time longer than End Time.

3.3.11. Notice for Connecting GC and LabSolutions by CBM-201m [GC]

When connecting GC and LabSolutions by the ethernet / serial converter function of CBM-
201m, there is a case opening the Acquisition dialog and start of analysis data felt slow.
But, there are noproblems with data acquisition, controling instruments and other software
function.

3.3.12. Notice for the Pressure Limits for Pumps [LC]

For safety, pump unit"Pressure Limits" values can be suppressed automatically depending on
the pump unit operating conditions. As a result, the actual "Pressure Limits" values on the pump
units may be smaller than the values specified on LabSolutions. On the LC-20Ai/10Ai, the
pressure limits (the upper limit values) are suppressed depending on the flowrate and the
PMAX RANGE specified on the pump units.

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 3.3.13. Notice for the time of the operation logs for instrument's GXP mode [LC]
When GXP mode (to log the operations on the instrument panel into the LabSolutions log) is
enabled, the time recorded in the LabSolutions log is the time when the LabSolutions detected
and registered the instrument operation into the log. For this reason, the time recorded in the
LabSolutions log may be delayed by several seconds from the time that the operation was
performed.

3.3.14. Cautions for Executing [Carrier Gas Leak Check] or [Standard Diagnosis] from
the GC-2030 Instrument [GC]
When executing [Carrier Gas Leak Check] or [Standard Diagnosis] from the instrument, do not
connect to the GC from LabSolutions. This could cause a failure to communicate with the
instrument.

3.3.15. Notice for using GC-2010 Pro [GC]

GC-2010 Pro can be used in old versions earlier than LabSolutions 5.93 also. However, the
same problem is occard as the defect of GC-2010 Plus in old versions.

3.4. Data Acquisition

3.4.1. Notice for Multiple Channel Data Plot

When multiple channel data are plotted on the real time chromatogram window, the plot time is
slightly shifted between channels. This timing issue occurs because the data is acquired
asynchronously in the background thread for each detector channel.
As the detector data is temporarily buffered in the system controller with the retention time
information, the actual acquired data is never shifted for each detector channel.

3.4.2. Notice for the synchronization of the data acquisition between LC-2030/LC-2040
and PDA/MWD [LC]
With the configuration of LC-2030/LC-2040 (UV detctor model) with an external PDA/MWD, you
can synchronize the data acquisition of these detectors by the event input of the relay cables
connection. Synchronization via Ethernet/LAN connection is not supported.

3.4.3. Notice for changing parameters on Instrument Monitor

When you change the parameters on the Instrument Monitor, they may come back to the
original values for a while. However the change will come after a while. This is because it takes
time for a few seconds to send and change settings at the instrument side and to reflect the
new settings to the screen.

3.4.4. Acquisition Time for Status Log

The acquisition time for Status log is set to the maximum acquisition time of the detectors. If all
detector acquisition channels are disabled, the acquisition time for Status log is set to Stop
Time of the time program. In this case, Status Log is not displayed on the Data Analysis window
as no detector data exists. You can confirm it by report output with the Chromatogram report
item.

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 3.4.5. Retention Time Information of LC Instrument Operational Log[LC]
Retention time information added to operational logs during data acquisition and error logs is
created based on the detector's acquisition data. Therefore, when no LC detector is used,
retention time information of operational logs for the pump and autosampler and error logs
become 0.00 after LC detector data acquisition. Retention time information of operational logs
and error logs for the PDA/MWD also become 0.00 when the time exceeds the data acquisition
time of each detector.
Check the actual time added to the message.

3.4.6. Notice for Acquiring Data from Other Vendor Instrument

When acquiring data from other vendor instruments, start analysis after LabSolutions becomes
ready to acquire data. When acquiring multiple sample data continuously with a batch table, set
longer analysis time to the instrument than LabSolutions acquisition time so that LabSolutions
becomes ready before the next analysis starts.

3.4.7. Notice for Sharing Method File

A method file is shared as read only if it is used in the real time analysis, analysis editor or
postrun analysis at the same time. If calibration run is performed in real time analysis or the
postrun analysis while the method is shared, it can fail because the calibration information
cannot be updated.
It is recommended that a method currently being used for data acquisition should not be used
in the analysis editor or postrun analysis.

3.4.8. Notice for Performing Background Subtraction

When the Agent registration setting of "Delete after acquisition" is used in LabSolutions,
acquired data files are deleted after each single or batch run. When you perform background
subtraction in a batch run, background data files should be acquired in the same batch run as
the samples or the background data files should be restored in the folder specified in the batch
table.

3.4.9. Notice for Starting LC Analysis with No Injection Mode[LC]

When starting LC analysis from LabSolutions with Oven Off in No Injection Mode (Vial# = -1)
the time program (gradient program) starts immediately without waiting for temperature
equilibration. To avoid this, set oven temperature control to on before starting analysis with No
Injection Mode.

3.4.10. Notice for Extending Data Acquisition

[Edit Method (Instrument Parameters)] right is necessary for extending the data acquisition.

3.4.11. Notice for the Method File when the Analysis is stopped.
When the analysis is started and then immediately stopped, the method file becomes "Untitled"
occasionally. For this case, please read the method file and download the instrument
parameters again.

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 3.4.12. Notice for Starting Analysis in Analysis Editor
In the Analysis Editor window, if the method file to open does not match the System
Configuration settings, you can choose whether to match the configuration settings in System
Configuration. If the configuration does not match between method and system, it will not be
able to register a single run or priority run.

3.4.13. Notice for using Dilution Factor

If the selection (Apply/Not Used) of Dilution Factor is changed in the System Settings/Data
Processing Settings window during operation, the initial value of Sample Amount in the Single
Run window will not be changed as the previous value is memorized.
To reset the initial value of Sample Amount, please press the Initialize button on the
Customizing Information window if the selection of Dilution Factor is changed.

3.4.14. Restriction after changing Sampling Rate

The chromatogram of 2D detector is always plotting, if it's during analysis or not. However if you
change and download the sampling rate, the chromatogram up to that point is cleared.

3.4.15. Display Settings after PDA data acquisition[LC]

When you change the display settings after PDA data acquisition, the chromatogram, contour,
UV spectrum, which are shown in the Data acquisition window, are cleared.

3.4.16. Detectors Intensity Unit Issues[LC]

When the intensity unit is set to [AU] in the instrument parameters (in case of UV detector) and
downloaded, the unit of intensity axis of graph will become Absorbance Unit series, too. But
after system configuration is done, the unit of intensity axis of graph will return to the Volt series
(The unit in the instrument parameters is left to [AU]). In such a case, please use the system
after downloading method.

3.4.17. Notice of data file in Snapshot

Snapshot shows the data during acquisition. The 'used files' item in the data file properties will
include only the method file information, the other files information will not be set.

3.4.18. Restriction in data recovering function[LC]

Even if the system configuration meets the requirement for the data recovery function, the data,
which has not been started from 0 min in SPD-M20A, cannot be recovered properly. The data
from other detectors, which acquired in the same time, will be recovered.

3.4.19. Notice of Contour plotting in PDA tab[LC]

The arrow cursor, which is used for spectrum extraction from contour graph, may disappear
with scrolling out the graph during plotting (for or not for data acquisition) from the passage of
time. In such case, please click the time axis of the Contour graph.

3.4.20. Restriction in data recovering function of PDA 2D mode and MWD[LC]

Data recovery is not made when a PDA detector is used in 2D mode or a MWD is used.

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 Data recovery of other LC detectors currently analyzed in the same system is not carried out.

3.5. Batch Analysis

3.5.1. Notice for Terminating LabSolutions after Stopping Batch

If Real Time Analysis is terminated while a batch is stopping, LabSolutions may not be finished
safely. LabSolutions can be finished safely after the batch start button becomes available.

3.5.2. The transition to another window during Realtime Batch analysis

When another window has been opened and it is in operation while running the Realtime Batch
analysis, the Realtime Batch windows will come up at its completion. To avoid coming up the
Realtime Batch window during operation, please reduce its window size or minimize the
Realtime Analysis program.

3.5.3. Time consumption to register batch tables

It takes from a few ten to a few hundred msec per line to check error on registering batch table.
Therefore, while a batch file with a large number of lines consumes time to check error on
registration, another application may not be operated. In such a case, please wait for a while
and operate it again.
(Typically, it takes about 30 sec to validate a batch file with 1000 lines on standard spec. PC.)

3.5.4. Estimated time for Realtime Batch analysis

The estimated time of the Realtime Batch analysis completion does not include the waiting time
for operations such as sample injection with the Autosampler, cooling for the oven, startup and
shutdown time set to the batch file. It is calculated based on the end time set to the method file.
However, if a method file is the same as the front line in batch table, the estimated time will be
compensated by actual time to perform each line in running batch analysis.

3.5.5. Notice to run Realtime Batch with using method file opened by others
When you perform a Realtime Batch analysis, and another application (e.g. Calibration Curve,
Quant. Browser, Analysis Editor etc.) is open the method file with the specified in the batch
table, the results of the batch processing (means Calibration information etc) does not reflect to
the method file. In this case, the Realtime Batch analysis will proceed to the end. After its
completion, please perform data processing with Postrun Batch or Quant. Browser.

3.5.6. Restrictions on the type of character for data filename

When the data filename may duplicate at the time of re-injection, '~(number)' will be added at
the end of the file name automatically. In this case, letter '~' is used as key. Therefore please
don't use the letter '~' for filename.

3.5.7. Notice for Sharing Batch Table

When executing a batch table in which file names of existing data files are specified, if the
batch table is opened in read-only mode, the batch table cannot be saved and the Auto-
Rename function is not available. In this case, execute the batch table after opening it in

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 writable mode.

3.5.8. Notice for Registering Batch Table to the Queue

If a batch analysis is added to the queue when batch analysis cannot be started immediately
(LabSolutions has already been analyzing.), the following message is displayed “Registered to
the Batch Queue...” LabSolutions cannot start next batch analysis while this message is
displayed. When a dialog box is open in the Real Time Analysis program, the same situation
occurs. Close the message box or dialog box by clicking the [OK] button to continue the next
analysis.

3.5.9. Notice for Restarting Batch Queue

If LabSolutions real time analysis is terminated when the batch queue is not empty, the queue is
memorized. When you start LabSolutions real time analysis next time, and then open batch
table and click [Start Realtime Batch], the batch is added to the queue. Please be advised that
the added batch is not started immediately as the queue is not empty. To restart the queue,
click [Start] button in the [Batch]-[Show Batch Queue] menu.

3.5.10. Limitation of Registering Batch Table to the Queue

A batch table in which data filenames are automatically created can be registered to the Batch
Queue as many times as needed. However, by way of exception, when the batch table is
executed with any rows selected for the execution range, the batch cannot be added to the
queue.

3.5.11. Notice for Printing from Realtime Batch analysis

When too many jobs are queued to printer spooler, unexpected error will occur. When printing a
report in an unattended operation, please prepare enough amount of paper to print.

3.5.12. Restriction on space in Report Format filename

On the batch table of Realtime Batch or Batch Editor, please keep out spaces at the top of the
filename to specify summary report format and report format. Such report format files will not be
opened from the batch table.

3.5.13. Restriction on re-registration of the batch file when it's running

The batch file, when it's running, can be opened only in read-only. Therefore, please save it by
the alias when you register the running batch file to the batch queue.

3.5.14. Notice for registration of batch, which includes the same data filenames
When the analysis of the same data filename by the Single Run or Realtime Batch registered in
the batch queue is going to start, only "Auto-increment" can be selected by "Overlapped Data
File Name" dialog.
Without any duplication of data filename at the time of registration, the same data filename
might be generated at runtime. At that time, the data file name newly created is automatically
changed.

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 3.5.15. Notice for Start/End Settings of Batch Table
When the batch analysis is stopped due to some errors while the Realtime Analysis program is
closed, the batch analysis is re-started from the first row even if [Star from Continuing Row] is
selected on the [Settings]/[General] tab/[Start/End Setting] in the batch table.

3.6. Data Analysis

3.6.1. Notice for Calculating Theoretical Plates and Resolution

When theoretical plates and resolution are calculated by the USP method, these values will be
0.00 if the inflection point cannot be calculated.

3.6.2. Notice for Registering Column Performance into Agent Database

At the Agent registration, only the result by the first calculating formula (*) is reflected though
two or more calculation methods for the column performance can be selected.
* The calculation formula is decided at the first selected row of the calculation method (USP
and JP...) on the Column Performance tab in Method view.

3.6.3. Notice for Manual Integration Command

When manual integration command "Move BL(Auto Correct)" is performed, the lower end point
of the baseline is corrected. In addition, when the PC has little graphics memory (video
memory), popup hint may affect the drawing. In this case, please hide the popup hint.

3.6.4. Notice for Manual Calibration

In the Calibration Curve Window, calibration points in the calibration curve can be removed and
recalculate the calibration curve by removing the check marks on the check boxes of
Area/Height. However, when any calculation is processed in this Window, all the check marks
are placed and recalculated. To remove calibration points, please remove the check marks after
necessary calculation is done.

3.6.5. Notice for QA/QC Calibration Results when Ref STD ID is specified
When "Ref STD ID" is set for compounds in the Compound Table, the results of QAQC
Calibration parameters for these compounds are output as the same results as those of the
referred compounds.

3.6.6. Notice for QA/QC terms

The term "Deviation%" is used in LabSolutions, even if the term "Accuracy%" has been used in
the previous version of LabSolutions Ver. 5 like LCsolution or GCsolution. (There is no change
in the calculating formula itself.)

3.6.7. Notice for Data Comparison (chromatogram division, multiplication)

The result of "Division and Multiplication" of the Chromatographic calculation is different from
LCsolution and GCsolution (the previous version of LabSolutions Ver. 5), though the result
chromatogram becomes similar graph plot.
Because the value of the result becomes too small in the division of the chromatograms if the
signal intensity is divided as it is, "Maximum value - Minimum value" of chromatogram 2 is

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 multiplied as a coefficient (The reciprocal of the coefficient is multiplied because the result
grows too much at multiplication).
Because of this processing, the result (signal intensity) by LabSolutions Ver. 5 might be different
from LCsolution Ver. 1.

3.6.8. ASCII output of the calculation results from the Data Comparison
When the chromatogram is operated with smoothing or addition in LabSolutions Ver. 5, its
ASCII output might be different from the older version.
In the previous version of LabSolutions Ver. 5, the result of chromatographic operation like
addition or smoothing, etc. is rounded to the decimal integers (long integer) and is saved to the
data file. The unit of this long integer is 0.1uVsec, and the value comes "Area" = "intensity" x
"Sampling rate".
In Ver. 5, the operation result is saved without rounding it off in double precision type.
In ASCII conversion, the result is output in intensity value by which both versions also rounded
to the decimal. But data files saved by the older versions might contain the deviation at the
rounding for file saving. It makes difference from ASCII output in LabSolutions Ver. 5.

3.6.9. Notice for checking raw data

When a lot of data files are processed at once by the Check Row Data function, it will cause
slow reaction of screen because of the load for processing. Please wait for a while until the
result comes up.

3.6.10. Notice for Method Created by LCsolution Version 1.2 or before[LC]

In LCsolution Ver. 1.21, the defect is fixed that when the quantitative parameter "# of Calib.
Levels" was changed in the Compound Table Wizard, if the parameter was applied to method
file, it caused a mismatch of "# of Calib. Levels" between configured detectors in the method,
and when editing the method in the Calibration Curve window, calibration points could not be
deleted or an application error occurred.
In LCsolution Ver. 1.21 or later, such method files are not created by the above procedure,
however the same problem occurs when such method files which had been already created are
used, or when method parameters are exported from data files which had been acquired by
such method files. In this case, please clear the mismatch in the method by following the next
procedure.
[Procedure]
1) Open the method file on the Analysis Editor window. When the next message appears,
select [No].
"The hardware configuration for this method is different from the current instrument
configuration. Do you want to modify the configuration in the method to the current
instrument configuration?"
2) From the [Method] menu, select [Data Analysis Parameters] of one of the configured
detectors.
3) In the [Quantitative] tab of the [Data Analysis Parameters] window, change the "# of Calib.
Levels" parameter to another value and close the window by clicking [OK] button.
4) Open the [Data Analysis Parameters] window again, and restore the "# of Calib. Levels"
value.
5) Save the method file.

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 3.6.11. Notice for Max. Slices
In the integration parameter settings, there is an advanced parameter of Max. Slices. When a
small value from 1 to 5000 is set as Max. Slices, it affects the integration results like the peak
area and height may change, so set Max. Slices to 0 (slice data is not exported) when slice
data is not required.

3.6.12. Notice for Custom Parameter

Custom parameters specified in the Batch Table are cleared when the postrun analysis is
executed on the Data Analysis window. In addition, on the Quant Browser, these cannot be
displayed. In the reporting the Quantitative Results View on the Quant Browser, values of
custom parameter 6 to 10 is displayed as a Zero if the summary report is edited to display
these custom parameters.

3.6.13. Notice of Statistic Calculation (Average, %RSD, Standard Deviation, etc.)

The results of the average, %RSD and standard deviation in the system suitability are
calculated by the value rounded by the digit number specified in the format settings.
They do not always match with the results in Quant Browser and QA/QC as the original value,
which is not rounded, is used for the calculation in Quant Browser and QA/QC.
In the summary report, either calculation method can be selected by checking on/off “Calculate
by specified digits” in the Summary tab of the properties.

3.7. PDA Data Analysis[LC]

3.7.1. Notice for Displaying Purity Curve

When the spectrum data used for peak purity calculation is of lower intensity than the noise
data, the purity curve is not drawn.

3.7.2. Notice for Displaying Contour Plot

If another window is opened over the contour plot, the time and wavelength cursor line may not
be updated. In such a case, perform [Initialize Zoom] of the contour view to refresh the screen.

3.7.3. Notice for Spectrum Background Correction

It is necessary to process PDA data before spectrum background correction, because spectrum
background correction is performed using the spectrum at the start and end time of the baseline
of the nearest peak of the specified chromatogram. (If the peak is not resolved, the start time of
the first peak and the end time of the last peak in these unresolved peaks are used.) The
chromatogram for the spectrum background correction is specified at the current channel
focused on the Chromatogram View. This is indicated in the text title of the spectrum display.

3.7.4. Notice for Peak Purity Calculation

If a target peak for peak purity calculation has been divided vertically, the peak should be
resolved by changing the peak integration parameter or analysis conditions. Peak purity
calculation result of unresolved peaks does not have any meaningful information.

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 3.7.5. Notice for Printing the Library Search Result
As a result of performing the re-retrieval on the Library Search Results, please print after
applying the method. The printing from Library Search Result, it is likely not to match as the
result on the screen if it prints without applying the method. Because the print is done according
to the method.

3.7.6. Notice on the Similarity identification

With the identification method of Similarity, when several peaks are in the same allowance time
range, the peak identification method differs according to the Window/Band method.
[Window (TIME WINDOW) method]
The peak with the retention time closest to the standard retention time specified on the
compound table is selected, and then the similarity is calculated between the peak spectrum
and the standard spectrum registered in the compound table. If the similarity satisfies the
threshold (minimum similarity) set in the compound table, the peak is identified as the
compound.
[Band (TIME BAND) method]
The peak with the largest similarity that satisfies the threshold (minimum similarity) is
identified.

3.7.7. Notice for Data Analysis of Fast Sampling Data

When fast sampling data of PDA detector is opened in the PDA Data Analysis window, the
Spectrum View may not be redrawn promptly when the extracted spectrum wavelength is
changed. This is because the purity calculation for the Purity View is processed. In this case,
the speed of response is improved by setting "Not Calculated" for the [Purity Index Mode] in the
Purity View Display Settings.

3.7.8. Notice for Peak Separation and Impurity Analysis by Derivative

Spectrophotometry
When performing peak separation and/or impurity analysis by selecting [Derivative] for the type
of chromatograms in [Multi Chromatogram] settings, please this function in analysis conditions
such that spectrum similarity of the peak is not influenced by noise, pH and so on.

3.7.9. Notice for PDA Zero Adjustment

Zero adjustment is performed to PDA Data at the start time of acquired data. As a result, the
shape of spectrum at each time is changed, when Start Time of Data Acquisition is changed. To
cancel the effect of zero adjustment to peak spectrum, please check [Background Correction] in
the UV Spectrum tab.

3.7.10. Notice for Data Plot

The maximum time of plotting is the maximum analysis time calculated by wavelength range or
sampling period if it is shorter than 60 min. Even when using a PDA detector in 2D mode, the
maximum time which can be plotted is the same.

3.7.11. Notice on the Color settings of Reference data in Chromatogram view

When adding the PDA deconvolution function, the "Deconvolution data 1 to 6" has been added
in front of the "Reference data" in the graph properties of the chromatogram view. Therefore,

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 there is the color settings of "Reference data" is changed in the software version-up.

3.8. Browser

3.8.1. Notice for Data Processing on Browser

In the Quant Browser, open data files are processed using the current method file whose name
is displayed on the title bar. Open data files, which use the same method for data processing.
These data files should have the same detector configuration (detector type and number) as
the method file. If the detector configurations do not match then, depending on the configuration, the
data may not be processed properly. And if the data file does not contain the chromatogram of
the detector channel in the method configuration information, the detector channel is not
processed. When data file detector channel is not included in the method configuration
information, then the detector channel is not processed.

3.8.2. Notice for Browser Operations

On the Quant Browser, even if you select row(s) on the Quantitative Result View and then press
the [Ctrl]+[C] on the keyboard, the Quantitative Result View cannot be copied to the clipboard.
In this case, the selected row(s) on the Compound Table View will be copied. To copy the
Quantitative Result View, please select [Copy] on the right-click menu.

3.8.3. Notice for Opening Many Data Files on Browser

When many data files are opened on the Quant Browser or Data Browser, the following
message may be displayed and the operation may be terminated.
"Insufficient memory."
In such a case, there is a possibility of having reached the maximum of the memory size which
can be used with application.
Please reduce the number of the data files opened simultaneously.

3.8.4. Notice for Exporting Quantitative Results on Browser

When the Quantitative results are exported to *.txt or *.csv file on the Quant Browser and then
you try to open the file on the Excel, the file may not be opened because it is recognized as a
SYLK (Symbolic Link File) format file.
This is because Excel recognizes it as a SYLK format file if the "ID" strings are found in the top
of file contents. In such a case, you should insert any characters or space in front of "ID" in the
top of contents using the Text Editor.

3.8.5. Notice for Results displayed on Browser

In the previous version of LabSolutions Ver. 5, %RSD and standard deviation in the Quant
Browser window are calculated by using the displayed values on the Quantitative Results view.
In LabSolutions Ver. 5, they are calculated by using the internal values without rounding.
In the previous version of LabSolutions Ver. 5, Deviation, %Dev and Accuracy[%] in the Quant
Browser window are calculated by using the displayed values of Conc. and Std. Conc. on the
Quantitative Results view.

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 In LabSolutions Ver. 5, they are calculated by using the internal values without rounding.

3.8.6. Notice for Printing Image of Data Browser

When Display Information Area in All Cells check box is selected, the information is displayed
on the right side of each cell. This layout does not affect the print image.
For other cases, not all information on the window is printed as the image though Print Image is
a function to print the window information as WYSWYG.

3.8.7. Notice for Saving Layout Files

The following information is not saved in the layout file.
• Channel setting on the LC peak table cell
• Display mode setting (overlay/stack/single) in the PDA chromatogram cell
The style of each peak table is saved as the data browser settings.

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 3.9. Report

3.9.1. Notice for Round Method of Report Output

In the report items such as peak table and quantitative results, round method for the values can
be selected in the property of the report items.
In LCsolution Ver. 1, the following four types of round methods are supported -
"Round(Standard)" method in which the values are processed by the Microsoft standard library
(original values of floating point are directly rounded) and "Round"/"Round Down"/"Round Up"
methods in which values are rounded after the original values are converted to decimal
numbers.
As the internal value is treated as floating point, there is a case round, round down and round
up at boundary values are affected by the quantitation error of floating point. As the result, in
rare case, the last digit of the value output by "Round(Standard)" differs from that of "Round"
method (becomes smaller than that of "Round" method).
(GCsolution Ver. 1 and 2 uses the "Round(Standard)" method.)
In LabSolutions Ver. 5, concerning the rounding methods, the algorithm is improved to round
boundary values more strictly by considering the quantitation error of floating point. By this
reason, the "Round(Standard)" and "Round" methods in the LCsolution Ver. 1 are unified as
"Round" method in the LabSolutions Ver. 5.
In addition, in the LabSolutions Ver. 5, rounding methods of values can be specified in the [Data
Proc. Settings] of the System Settings(Administration tool), which enables to unify all the
rounding methods for values in Postrun and Quant Browser windows, values of ASCII output,
values of report output(in the case when “Option Settings” are not specified for the values in the
report format).
By this reason, in rare case, the report output of LCsolution Ver. 1 is slightly different from that
of LabSolutions Ver. 5 for the same internal value.
To apply the previous version of LabSolutions Ver. 5 compatible rounding algorithm in which the
values are processed by the Microsoft standard library, run the following file included in the
installation CD.
LabSolutionsLCGC\Supplement\x86\RoundMode_LCsolution.reg (32bit OS) or
LabSolutionsLCGC\Supplement\x64\RoundMode_LCsolution.reg (64bit OS)
(Even after this setting is performed, the selection list in the report format does not show
"Round(Standard)", it shows "Round". To reset the restriction, execute
"RoundMode_LabSolutions.reg" which is included in the same folder.)

3.9.2. Notice for Displaying Column Index Strings

There are some report items whose Column Index string length is longer than the value of Ref.
String setting. For such items, please abbreviate notation or change the value of Ref. String
setting to display them in the table.

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 3.9.3. Notice for the Specification of Enforce file name on each item[LC]
For LCsolution Ver. 1, the file name is printed in all of the report item titles with @ mark at the
top of the file name if Enforce file name on each item is selected.
For LabSolutions Ver. 5, the file name without @ mark is printed in all of report item titles if it is
selected. If multiple report items have been added to a report, it compares the file names to
determine whether the report is for all of the items in a single file or from multiple files, and
prints * mark at the top of the file name if the file loaded on the item is different from that loaded
to the report format.

3.9.4. Notice for Printing Report Image

When a report image reaches slightly to the next page, there is a case that a blank page is
output to the next page depending on a printer driver. In this case, please adjust the size of the
report item to fit it in the same page.
And when large amount of data are printed out through the summary report item or the GPC
calculation report item, there is a case calculation error of printing region is accumulated and
the print image may be overlapped on the next report item. To avoid overlapping, please insert
the report item to the next page.

3.9.5. Notice for Printing Chromatogram Report Item

When printing out chromatogram report items, there is a case that the last number of time scale
(x-axis) is not output in the report despite it is output in the preview. This defect occurs when the
width (x-axis) of the chromatogram report item is short because of the calculation difference
between the graph area and font position for the zooming factor.
In such a case, please resize the width (x-axis) of the chromatogram report item.

3.9.6. Notice for Previewing Report Image

There is a case report image is not displayed properly when previewing report by using the
slide bar to jump page (this tend to occur as the number of pages increases).
In such a case, press the [Next] button from the first page to redisplay the report image
properly.

3.9.7. Notice for Using "Meiryo" Font

When you set "Meiryo" font in the report items, there is a case that the characters are not
output with the proper font size. Do not use Meiryo font in the report items.

3.9.8. Notice for Preview Window and Print Output

When the display size of the preview window is not almost the same as the print size, for
example when the [Zoom In] button is grayed out, the output image does not always match on
preview and on print. When proportional font is used, there is a case the output image is slightly
different on preview and on print.

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 3.9.9. Notice for Report Editor and Print Output
When Using Current Width is set as Display Settings in the Format Settings window for the
Display Items in the table such as Ret. Time in the Peak Table item, there is a case the
displayed digits are different between the report editor window and print output depending on
the cell width.
The image of the report editor is not always the same as that of the print output. Please confirm
the actual image by displaying by displaying the PDF output.

3.9.10. Notice for Calibration Curve Item

When the display width of the table is larger than the specified area, the calibration curve item
does not display the table by return. Please confirm if the table is fully displayed in the specified
area by preview.

3.9.11. Notice for Editing Report Items

When editing report items, for example when you input a larger value in the start time of
Chromatogram X/Y scale than the value of the end time, a warning message of "Minimum value
should be less than max value." appears. If this message is displayed, the input values are set
in the report item. In this case please revise the incorrect values.

3.9.12. Notice for Inserting Object from Other Applications

In the Report Editor windows, when objects of other applications are inserted, the close button,
menu and toolbars in the report window may not be displayed properly depending on the
inserted objects while editing them. In this case, cancel editing the report by entering [ESC] key,
and then edit it again. To close the Report Editor, after saving the report format by [File] menu,
click the close button or enter [Ctrl]+[F4] key while editing the object. Using the assistant bar,
tab control or [Window] menu also can change the active window to other windows.
Depending on the type of inserted objects, there is a case it takes a long time to output or the
object image is not printed out correctly. Please be advised that unexpected objects may be
inserted by [Paste] operation through clipboard.

3.9.13. Notice for Editing Print Image File

The intensity range of the current chromatogram view in Data Analysis, PDA Data Analysis or
Data Comparison window applies to the Y scale of chromatogram in the print image of Print
Graph/Print Graph image function. Please notice that Y scale setting in the report format file of
the print image does not function.

3.9.14. Notice for Summary Report Output

Summary report is printed out during a batch table run at those lines of the batch table where
"Summary End", "Summary Start&End", or "Summary End&Start" is set in the Summary Type
field. When the batch run (acquisition or reprocessing) is stopped at other lines, summary
report is not printed out.

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 3.9.15. Notice for Block Setting in the Summary (Data) Item
In the Summary (Data) item, setting Block in the Display tab to 2 or more is available only when
multiple chromatogram are included in a data file and Type in the Chromatogram tab is set to
separate.
For a single chromatogram data or setting to overlay as Type in the Chromatogram tab, blank
area is output if Block is set to 2 or more.

3.9.16. Printing Graph Image

The report format files of the Print Graph Image and Print Graph in the Data Analysis and
Browser window are memorized for each user. The report format files of the Print Method in the
Data Acquisition and Method Editor window, and the Print Batch Table in the Realtime/Postrun
Batch and Batch Editor window are memorized for each instrument and each user.

3.9.17. Notice for Printing the UV Spectrum Item[LC]

In the UV Spectrum report item, labels of lambda max and lambda min may be output on the
other labels when multiple spectra are overlaid on a graph, as the case of overlapping the
labels is not considered.

3.9.18. Difference of the Number of Lines to Output Strings

There is a case the number of lines to output strings in a window are different from the previous
version of LabSolutions Ver. 5 depending on display area, printer resolution and other
conditions.

3.9.19. Difference of the Output Order of the Method Item

As the data processing parameters in the method report item are output for each detector, the
output order of the method item is changed from the previous version of LabSolutions Ver. 5.

3.9.20. Notice for the PDF Output of Contour and 3D Graph[LC]

When contour or 3D graph is output to a PDF file, there is a case the output image or scale is
not displayed clearly. This is because of the compression settings of PDF output.
In the case of SkyPDF, it can be improved by changing the Down sampling setting as follows
though the PDF file size becomes larger.
Select "Sky PDF Pro Driver" in the Device and Printers in the Control Panel and open
Properties in the right click menu, and then press the Preferences button in the General tab to
open the SkyPDF Pro Driver Printing Preferences window. Set the value of down sampling to
600dpi or more in the Compression Options tab of the window. (Default setting is 300dpi.)

3.9.21. Limitation of Printing the Overlapped Area of FRC Results and Simulation[LC]
When printing the FRC Results and FRC Simulation on the Chromatogram report item, there is
a case either of the FRC Results or FRC Simulation in the overlapped area is printed with
hatching depending on a kind of printer drivers.

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 3.9.22. Notice for Printing System Suitability Test Report
The system suitability test report is always printed out to the Windows default printer even when
another printer is selected in the Print Setup window of LabSolutions.

3.9.23. Notice for "B Curve" command in the LC Time Program[LC]

For method files, in which some LC Time Program commands are not supported with the
current system configuration, those commands are not run on the current system. For this
reason, when a method file, in which LC Time Program command of "B.Curve" is set, are used
in the CBM-20A "Fast LC" mode, the "B.Curve" command is not executed. However, the
"B.Curve" command affects on the gradient curve displayed in the Data Analysis windows and
the chromatogram report. To solve this mismatch, edit the method with the original system
configuration and delete the "B.Curve" commands.

3.9.24. Notice for Contour and 3D Graph Report Item[LC]

When many report items are inserted into the report format, it consumes memory proportional
to the number of items. As PDA report items such as Contour and 3D Graph take much
memory, your operation may be terminated when printing report or generating a PDF file.
In such a case, add more RAM or print report in the Postrun analysis after the data has been
acquired and unnecessary applications are closed.

3.9.25. Notice for Chromatogram Intensity Unit

In the chromatogram report item, the intensity unit can be selected from uV, mV and V. On the
other hand, in the instrument method, AU for UV detector, S/cm for CDD detector and RIU for
RID can be selected as intensity units. The chromatogram acquired with the instrument method
that these intensity units are specified is reported with the following intensity unit.
Instrument method setting
Report setting
AU S/cm RIU
uV uAU nS/cm nRIU
mV mAU uS/cm uRIU
V AU mS/cm mRIU

3.9.26. Notice for Intensity Unit when Overlaying Chromatogram

For LCsolution Ver. 1, the intensity unit is always uV when overlaying chromatogram.
For LabSolutions Ver. 5, the intensity unit is uV for multiple detector data, and the detector
specific unit for single detector data when overlaying chromatogram.
For example, when overlaying PDA detector data chromatogram, the intensity unit is uV for
LCsolution Ver. 1, and uAU for LabSolutions Ver. 5. To display the overlaid chromatogram in
units of uV, please replace the $Unit$ macro with “uV” strings in the Y Scale(Inten,) setting of
the Setting Scale tab in the Chromatogram properties.

3.9.27. Notice for Transparent Setting of Report Items

When the background of the report item is set to transparent, there is a case it may be filled
when the report is output into PDF file. (The transparent image is output on Preview and Print
to printer.)

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 3.9.28. Notice for Delete the Report Item
There is a case the report item cannot be deleted using the [Delete] key. In such a case, open
the right click menu and then select [Delete].

3.9.29. Fix Detector No. of PDA 2D mode and MWD[LC]

The data of a PDA detector (2D mode) and a MWD (multi-wavelength detector) are assigned to
either of the detector 1~4 in the report items such as the Chromatogram item where "Fix
Detector No." can be set.
"Fix Detector No." is Off
The data of a PDA/MWD is assigned to the last detector number.
"Fix Detector No." is On
It is assigned to the smallest detector number except for the fixed numbers which detectors
other than PDA/MWD(Detector A, Detector B, AD1, AD2) use.

Assignment of the detector number for typical configuration examples is shown below.
Configuration example and Report item (Detector 1~4)
Fix Detector A Detector A Detector B
Detector ＋AD1 ＋Detector B ＋AD1
No. ＋PDA(2D) or MWD ＋AD1 ＋PDA(2D) or MWD
＋PDA(2D) or MWD
Off Detector 1 : Detector A Detector 1 : Detector A Detector 1 : Detector B
Detector 2 : AD1 Detector 2 : Detector B Detector 2 : AD1
Detector 3 : PDA(2D) /MWD Detector 3 : AD1 Detector 3 : PDA(2D) /MWD
Detector 4 : Detector 4 : PDA(2D) /MWD Detector 4 :
On Detector 1 : Detector A Detector 1 : Detector A Detector 1 : PDA(2D) /MWD
Detector 2 : PDA(2D) /MWD Detector 2 : Detector B Detector 2 : Detector B
Detector 3 : AD1 Detector 3 : AD1 Detector 3 : AD1
Detector 4 : Detector 4 : PDA(2D) /MWD Detector 4 :

3.9.30. Data Processing Parameters of PDA 2D mode[LC]

The data processing parameters of the PDA 2D mode data are output to the "Data processing
parameters" instead of a "PDA data processing parameters" of the Method item.
Configuration is output to the "PDA configuration" of the Configuration item, and the instrument
parameters are output to the "PDA instrument parameters" of the Method item.

3.9.31. Notice for Property of Method Item[GC]

The settings for future enhancement is displayed in the report item properties.

3.10. PDF File Output

3.10.1. Notice for PDF Driver (SkyPDF)

LabSolutions uses the SkyPDF pro Driver (SKYCOM Corporation) for the PDF output function.
Although SkyPDF Pro Driver is displayed in the Printer Name list box in the Printer Setup
window, do not select SkyPDF Driver in the list box, as there is a case batch analysis stops
during run and you cannot continue analysis operations.
To output PDF file, perform PDF out directly from the menu (for example, the File/Data

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 Report/PDF Output menu in the Data Analysis window) or select the Redirect Report to PDF file
check box in the PDF Output tab of the Tools/Options menu.
When 'SkyPDF Pro Driver' is selected as Printer Name in Print Setup dialog, the output
redirection of PDF files is "C:\SkyPDF" by default after LabSolutions Ver.5.51.

3.10.2. Notice for Setting Default Printer

Other PDF drivers than SkyPDF Pro Driver may cause unexpected problems on printing
analysis reports and may affect the analysis. Please do not select Acrobat PDF and other PDF
drivers as the printer. For the same reason, please do not select Microsoft Office Document
Image Writer, Microsoft XPS Document Writer and other printers which open dialogs to specify
output image files.

3.10.3. Notice for File Name and Folder Path of PDF Output
If "," character is used for a file name or the folder path in which the file is stored, PDF files
cannot be exported. When exporting PDF files, "," character should not be used for the name of
data file and the folder path in which these files are stored.

3.10.4. Limitations for the System Suitability Function

The system suitability test report is always printed out to the Windows default printer even when
selecting the Redirect Report to PDF file check box in the PDF Output tab of the Tools/Options
menu.

3.10.5. Not Supporting Security Password Function

Although the previous versions of LabSolutions Ver. 5 supports the security password function
in the PDF Output tab of the Tools/Options menu, LabSolutions Ver. 5 no more supports this
function.

3.10.6. Notice for Registering PDF File to Agent Database

When a PDF document file is registered to the Agent database, please check the “Delete import
files after data registration (*.PDF)” check box. If a PDF file of the same name already exists,
there is a case the file may be registered to the database.

3.10.7. Notice for PDF Output from Batch

When processing batch analysis/reanalysis, if PDF files, whose name are the same as that of
PDF files to be output by the batch processing exist and are opened by other applications, PDF
files cannot be output. In this case, the previously existing PDF files are registered to Agent
database instead of the proper data reports. When processing batch analysis/reanalysis,
please don’t open the PDF files whose name is the same as that of PDF files to be output by
the batch processing.

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 3.11. File Conversion

3.11.1. Notice for Converting Method File

If method file is converted from CLASS-LC10/GC10 or CLASS-VP, the following message is
always displayed when you open it.
"The hardware configuration for this method is different from the current instrument
configuration. The configuration in the method is adapted to the current instrument
configuration. "
This is because LabSolutions has more configuration information than others and it detects
mismatches in the configuration settings of the method file. Please save the method file. After
that, it is not displayed.

3.11.2. Notice for Converting CLASS-VP Method File[LC]

When CLASS-VP method file is converted into the LabSolutions format, configuration file
InstrumentN.cfg (where N is instrument number) must be specified.
When the method and configuration file do not match, the instrument parameters are not
converted correctly.

3.11.3. Not Supporting Grouping Settings of CLASS-VP Method File[LC]

On the file conversion for CLASS-VP file, method file in which grouping is specified or data file
acquired using such a method file cannot be converted.

3.11.4. Limitation of Converting CLASS-VP Method Manually Configured[LC]

In CLASS-VP, when the system configuration is manually configured without executing "Auto
Configuration", the Analog detector which is normally configured as detector C (D) can be
configured as detector A or B. When converting the data files which were acquired in such a
configuration, LabSolutions cannot convert the data processing parameters in these data files,
and invalid values or values of other detectors may be set to the data processing parameters in
the converted data files. If the message of "Data processing parameters may not be converted
properly. Please check the parameters in converted file." is displayed, please confirm/reset the
data processing parameters in the converted data file.

3.11.5. Notice for Converting Chromatogram to ASCII/AIA Format

Chromatogram data is internally treated as double precision floating numbers. When the data is
converted to the ASCII format, the intensity data is rounded in units of UV equivalent integer.
When data is converted into AIA ANDI format, intensity data is converted to single precision
value. By this convention, processing imported data may result in slightly different values from
the original data.

3.11.6. Notice for Converting ASCII Format to LabSolutions Data File

The following items are converted to LabSolutions data when imported in ASCII format.
[Header] Header information
[File Information] File information
[Sample Information] Sample information
[Original Files] Original file information
[File Description] File description
[Configuration] Detector configuration
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 [LC Chromatogram (Detector Channel)] Chromatogram raw data
or [Chromatogram (Ch#)]
[PDA 3D] PDA 3D raw data
The following items from the list above are mandatory and cannot be omitted: [Header],
[Configuration] and corresponding raw data ([LC Chromatogram (Detector Channel)],
[Chromatogram(Ch#)] or [PDA 3D]).
For the system configuration of the imported data, CBM-20A is assigned as a system controller.
When status traces are included in the ASCII format data, LC-20AD, SIL-20A or SFE-30A,
CTO-20A, and SPD-20A and SFC-30A are assigned as pump, autosampler, oven, detector, and
supercritical controller respectively.

3.11.7. Notice for Generated Data such as Operations and Conversion from ASCII/AIA
Data files, which are made by calculation in the Data Comparison Window, don't have the
information of acquired date. In the sample information report of these data, the "Date Acquired"
is output as "1970/01/01 9:00:00". And these data cannot be registered to Oracle/SQL Agent
database. (There data can be registered to MDB Agent database, in this case the Acquisition
Date is registered as "1601/01/02 15:00:00" and the Instrument Name is registered as "Not
identified".)
This specification is the same for the data files, which are converted into LabSolutions data
from ASCII/AIA data in which information of acquired data does not exist.

3.11.8. Notice for Converting AIA (Andi) File into LabSolutions Data File
When converting the AIA (Andi) file into LabSolutions data file, there is a case that the date
acquired can not be read properly depending on a kind of the AIA files as date and time are not
stored properly following the Andi format. In this case, the analysis date is set as "1970/01/01
21:00:00".

3.11.9. Notice for System Configuration of AIA (Andi) File (.cdf)

When AIA file is opened in the LabSolutions software, the detector of the data is configured to
AD1, as AIA file does not include the system configuration information. By this reason, the
detector information in the Data Analysis window is displayed as AD1.

3.11.10. Notice for the data processing parameters of AIA (Andi) File (.cdf)
When AIA file is opened in the LabSolutions software, the data processing parameters such as
integration parameters are initialized.
Therefore, there is no relation between the values displayed in the peak table and the data
processing parameters. To make consistent between the values displayed in the peak table and
the data processing parameters, perform [Analyze] in the Method menu.

3.11.11. Notice for Status Curves[LC]

The status curves are not displayed when opening the following LCsolution Ver. 1 data file from
LabSolutions Ver. 5.
Data file imported from ASCII format file, was stored as LCsolution Ver. 1 data file.

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 3.11.12. Using CLASS-LC10/GC10 and CLASS-VP Files
When chromatogram channels and system configuration do not match in the CLASS-
LC10/GC10 and CLASS-VP data file, there is a case the detector information is removed from
the system configuration on converting files as the corresponding chromatogram does not exist.
By the same reason, there is a case the detector information is removed from the system
configuration for the LCsolution data file (.lcd) that was converted from CLASS-LC10 or
CLASS-VP data file on LCsolution Ver. 1.
(The same notice is necessary for the CLASS-GC10 data files.)
When the system configuration information is not included in the data file like CLASS-VP
sample data files s_multi_1(~6).DAT, it is not possible to convert to LabSolutions Ver. 5 data
file.

3.11.13. Notice for Converting LCsolution Data File and GCsolution Data File into
LabSolutions Data File
Please convert LCsolution data file and GCsolution data file whose instrument name has
prohibited characters in LabSolutions into data file by following the next procedure. (Refer to
Help for details about the prohibited characters.)
[Procedure]
1) Convert LCsolution data file or GCsolution data file into ASCII format file in LCsolution or
GCsolution.
2) Convert ASCII format file in 1) into LCsolution data file or GCsolution data file.
3) Convert the data file in 2) into LabSolutions data file in LabSolutions.

3.11.14. Notice for Converting ASCII Format of PDA/MWD 2D mode data[LC]

After exporting the data file of detector composition [Detector A, Detector B, AD1, PDA(2D
mode) or MWD] to ASCII format, this ASCII format file is imported to the data file of
LabSolutions format. Then, as for the chromatogram of a PDA detector (2D mode) or a MWD,
only Ch1 is restored. (It is because it is restored as data of AD2.)

3.12. Notice for the QA/QC Calculation Results (Difference from GCsolution
Ver. 1 and 2) [GC]

3.12.1. S/N Ratio of the QA/QC Calculation

GCsolution Ver. 1 and 2 calculates the interval noise divided for each 0.5 min so that the
intensity range between two parallel lines including all data points in the interval becomes
minimum by the successive approximation method.
LabSolutions Ver. 5 calculates the interval noise so that the intensity range between two parallel
lines of which line slope is obtained by applying the least square method to all data points in the
interval includes them. (The same calculation method is used in LCsolution Ver. 1. )
S/N Ratio of the QA/QC calculation is defined as the ratio of signal to noise.
AS the noise calculation algorithm is different, there is a case the value of S/N ratio calculated
by GCsolution Ver. 1 and 2 and by LabSolutions Ver. 5 does not match.

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 3.12.2. Residual SD of Y Intercept
GCsolution Ver. 1 and 2 calculates the standard deviation of Y intercept of the calibration curve
for the residual SD of Y intercept in the QA/QC.
In LabSolutions Ver. 5, the formula of the residual SD of Y intercept is changed so that the
effect of the blank analysis is included. (The same formula as LCsolution Ver. 1.)

4. LC Instrument Control Notes[LC]

4.1. System

4.1.1. Notice for using Prominence Web Control Function

When using CBM-20A/lite system controller, leaving Internet Explorer open for extended
periods with the system controller connected may cause PC operation to become unstable. To
avoid this, shut down Internet Explorer once every day or so when running the system
controller continuously. Do not keep running any Internet Explorer programs to display CBM-
20A/lite and SPD-M20A/SPD-M30A status monitor.

4.1.2. Notice for automatic detection CBM-20A/20Alite from LabSolutions

Automatically detection works only the subnet mask is same between CBM-20A/lite and the
PC. If they are located the network which has other subnet mask, it is necessary to set CBM-
20A/lite IP address manually on the PC.

4.1.3. Restrictions in Fast LC Mode of Prominence UFLC/UFLCXR and Nexera system

LabSolutions supports Fast LC mode of Prominence UFLC/UFLCXR and Nexera system.
The following restrictions apply when the control mode is set to Fast LC mode instead of
Normal mode.
1) Number of Lines in Time Program
Please note that if more than 320 lines of pump-related commands are set in the time
program, those pump-related commands in excess of the 320 lines will not be executed. In
Normal mode, the time program can be comprised of up to 400 lines, however, in Fast LC
mode, the number of lines that can be used for pump-related commands is 320 lines
(although the total number of lines that can be used, including non-pump related commands,
remains at 400 lines).
2) Valid Pump Commands
Among the time program commands that can be used from LabSolutions, pump purge
command (Pump Purge/Ppurge) will not be executed in Fast LC mode.
In addition, B.CURV (B.Curve) is always 0 in Fast LC mode. Please note that even if
B.CURV (B.Curve) is set to a value other than 0 in Fast LC mode, only linear gradient
operation will be conducted.

4.1.4. Notice for Key Lock of System Controller

When LabSolutions real time analysis program is started, the system controller key operation is
locked. The key operation can be unlocked by the Instrument Control bar for initial settings. It
can be disabled by selecting "Prohibit editing parameters on instrument" in the Security Policy.
Even though, it can be unlocked by entering the password on the instrument control panel in
case of emergency.

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 4.1.5. Notice for Using Optional Loop in LC-2010HT
When the optional loop setting of the instrument LC-2010HT is changed, please press the [Auto
Configuration] button on the System Configuration window in LabSolutions, unless the change
is not updated in LabSolutions. In this case, the previous method files, which are to be used in
the updated system configuration, should be saved once in that configuration before analysis.

4.1.6. Notice for Rinse Port Septum of LC-2010 series

In the System Check for the LC-2010 series in which rinse port septum is not used (LC-
2010HT), "Number of Rinse" is excluded from the check item.

4.1.7. Notice for Pump Time Program settings

In the ternary gradient or low-pressure gradient mode, when the total value of B, C and D.Conc
exceeds 100%, the message "There is a section in which the total concentration of B, C and
D.Conc exceeds 100%." pops up on drawing the gradient curve. In this case, set these
concentrations as the total value not exceeding 100%.

4.1.8. Notice for Shutdown

The function of "Degasser(LC Pump, Subcontroller) OFF after cool down" in the Shutdown
works by turning off the power supply to the instruments connected to the
pumps/subcontrollers. When this function worked, the FCV solenoid valves connected to the
pumps/subcontrollers are also turned off, and the valve position or its state(Open/Close) returns
to the initial position(the position with the power off) of each FCV valve.

4.1.9. Notice for the notation of solenoid valves with LC-2030/LC-2040 series
When using the solenoid valve with the LC-2030/LC-2040 Pump, the notation for the selection
of IN-port are “1” or “2”, not “A” or “B”. As the LC-2030/LC-2040 series are equipped with LPGE
unit, in the configuration of FCV-11AL’s OUT-port ‘1’ ~ ‘3’ are connected with LPGE Port ‘A’ ~
‘C’, the notation for the solvent selection are “A-1”, “A-2”, “B-1”, “B-2”, “C-1”, “C-2” and “D”.
The notation in the status monitor (“solenoid valve”) is “1-1-1” ~ “2-2-2”, showing the valve
position of FCV-11AL.

4.1.10. Notice for adding sample analysis on the instrument’s panel (LC-2030/LC-2040)
In the state of LabSolutions connecting to the instruments, sample analysis can be added on
the instrument’s panel of LC-2030/LC-2040 directly sending it to LabSolutions. Please see
the detail below.
1) About user rights concerning “Upload instruments parameters”
By checking on the “Upload instruments parameter on the start of analysis” in the [Start
Acquisition] tab of [Tools] / [Options] menu, the parameters on the instruments are
uploaded to the LabSolutions method file at the time of adding sample analysis from
instrument’s panel. This behavior is related to the user right of the LabSolutions login user
as below.
・ For users of “Edit Method (Instrument Parameters)” right
Instrument parameters edited on the instrument itself are uploaded to the LabSolutions
method file at the time of adding sample analysis from instrument’s panel.
・ For users without “Edit Method (Instrument Parameters)” right
Instrument parameters are not uploaded, sample analysis starts with the LabSolutions
method parameters. Please be noted that the default right group of “Operator” does not

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 have this right.
・ For users of only “Edit Method (Pump Flow)” right
Pump parameters are not uploaded to LabSolutions method file.
2) About changing analysis time by uploading instrument parameters
When instrument parameters are uploaded from instruments on which “STOP” time has
been changed in the time program, the stop time is uploaded as “LC Stop Time” in the
LabSolutions method file. Please be noted that in this case, the data acquisition times of
detectors are not changed.
3) About changing instruments parameters during analysis
In the case when key lock is unlocked during analysis and instrument parameters are
changed on the instrument’s panel, the changes are valid only for the current analysis, not
being applied to the LabSolutions method file. The subsequent analysis is performed with
the LabSolutions method parameters without changes. The same goes for the case when
another sample analysis is added during analysis, on which instrument parameters are
changed on the instrument’s panel.
4) When analysis program is closed during analysis
When LabSolutions analysis window is closed during analysis, the analysis continues in
the background, however it cannot deal additional sample analysis from instrument’s panel.
To enable adding sample analysis from instrument’s panel, keep the LabSolutions analysis
window open.
5) Notice about method/batch files being edited
In the case when LabSolutions method/batch files are being edited, not saved and then
sample analysis is added from instrument’s panel, the edited changes in the method/batch
files are discarded without confirming messages.

4.2. Autosampler

4.2.1. Sample Rack Name

The notation of Autosampler sample rack has been changed as shown below since LCsolution
Ver. 1.22.
(Before) (After)
Rack 1.5mL Standard Rack 1.5mL 105vials
Rack 1.5mL Cool Rack 1.5mL 70vials

4.2.2. Not Supporting S.Pret Time Program Command

The S.Pret command for the Autosampler time program entry is not supported.

4.2.3. Using MTP/Deep Well Rack

When using MTP/Deep well rack, it is necessary to specify MTP Type in the Autosampler
parameters to 96 wells or 384 wells on CBM-20A/lite.
When using Rack Changer/C, please set MTP Type to 96 wells on CBM-20A/lite.

4.2.4. Maximum Injection Volume and the step of the injection volume for SIL-20A
series
Maximum injection volume of SIL-20A series (SIL-20A, SIL-20AC, SIL-20AXR, SIL-20ACXR)
can be specified on the Autosampler control panel. LabSolutions uses this value to validate the
upper limit of injection volume.
When the maximum injection volume of the Autosampler SIL-20A series is less than 100uL,
please set Sampling Speed to 5uL/sec for the best reproducibility of injection volume. When a
method file created on the maximum injection volume setting of the Autosampler different from
the current configuration is read, please confirm the value of Sampling Speed.
On the SIL-20A series of ROM version 2.1 or later (or 1.29 or later for version 1 series), by

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 changing the autosampler setting, it is enabled to specify the injection volume with 0.1 steps
between 0.1 - 10uL. (LabSolutions version corresponding to this document is necessary.)
Please contact your Shimadzu representative.

4.2.5. Pretreatment program of autosampler

In the case of using the autosampler pretreatment program, when the autosampler parameter
“Rinse Type” is changed or when the method files are transferred/shared between the systems
of different “Injection Type” (Direct Injection / Loop Injection), unintended pretreatment program
may be performed as it is not proper for the selected type. In this case, please confirm and
initialize the contents of the pretreatment program.

4.3. 2D Detector

4.3.1. Maximum Acquisition Time of 2D Detector

The maximum acquisition time using a conventional 2D detector is calculated as follows:
{7 [Mbytes] x 10242/4 [Byte]} x {Sampling period [msec]/60000}
For example, the maximum acquisition time is...
approx. 6116min when sampling period is 200msec
approx. 305min when sampling period is 10msec
9999.9min (Upper limit of acquisition time) when sampling period is 500msec
If the specified acquisition time exceeds the above limit, the method is not saved as the
acquisition time is validated and the warning message is displayed.
Please be advised that you should not extend the run time longer than the maximum time
calculated by the above formula.
To extend the maximum acquisition time, execute the file below, which is included in the
installation CD-ROM. The value rises threefold.
LabSolutionsLCGC\Supplement\x86\MaxMemorySizex3.reg (32bit OS) or
LabSolutionsLCGC\Supplement\x64\MaxMemorySizex3.reg (64bit OS)
(To reset the restriction, execute "DefaultMaxMemorySize.reg" which is included in the same
folder.)

4.3.2. Status Log of SPD-20A/V Cell Temperature

When SPD-20A/V temperature control cell is not installed, cell temperature is recorded as 0
degree Celsius.

4.3.3. Not Supporting Spectrum Scan

Although the SPD Scan (RF Scan) time program command performs spectrum scan at UV (RF)
detector, the scanned spectrum is not stored in the PC.

4.3.4. Spectrum Scan for LC-2030/LC-2040 series

The LC-2030/LC-2040 internal UV detector does not support the Spectrum Scan function. The
Spectrum Scan function with an RF detector connected as the LC-2030/LC-2040's optional
detector is supported if LC-2030/LC-2040 is Ver.2.20 or later.

4.3.5. Supporting CDD-10Avp/sp Control via CBM-20A/lite

For the CDD-10vp/sp control via CBM-20A/lite with LabSolutions, please notice the following

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 restrictions to use.
<Restrictions>
1. In the system configuration of LabSolutions, pump D cannot be set as the pump for
suppressors of CDD-10Avp/sp. Set pump A ~ C or pump A+B.
2. When you use CDD-10Avp/sp with CBM-20A/lite, operate the system via LabSolutions.
CDD-10Avp/sp cannot be controlled on the Internet Explorer via CBM-20A/lite.
(Operations of CDD-10Avp/sp system on the Internet Explorer are out of guarantee.)
3. When the analysis time is extended in a system where CBM-20A/lite controls CDD-
10Avp/sp with suppressors, the suppressor switch interval is automatically extended by
maximum 20 minutes. When the analysis is extended exceeding 20 minutes, the
regeneration of the suppressor starts, and the baseline change is recorded in the data.
Therefore, do not extend the analysis time exceeding 20 minutes.

4.3.6. Fast Sampling

Fast sampling of 100Hz is available for these detectors.
# Item CBM-20A/lite Other Units
1 Fast sampling of SPD-20A/20AV SPD-20A/20AV Ver. 1.10 or later
Ver. 2.02 or later
2 Fast sampling of RF-20A/20AXS RF-20A/20AXS Ver. 1.00 or later
1) When SPD-20A/20AV or RF-20A/20AXS is used with the fast sampling rate, connect the PC to the
system controller with the Ethernet connection. (Communication through RS-232C for the fast
sampling is not assured.)
2) For SPD-20A/20AV and RF-20A/20AXS, fast sampling can be set on the System Configuration
window. In the configuration where fast sampling rate (Base Period 10msec) is specified, the sampling
rate cannot be changed in the method editor.
3) When detector's ROM version are updated for the fast sampling, be sure to execute [Auto
Configuration] on the System Configuration window. The fast sampling rate cannot be set before
auto-configuring the updated detectors.

When acquiring data by SPD-20A/20AV or RF-20A/20AXS with fast sampling rate (100Hz),
specify the Response as "*No Filter”. With other settings, sharp peaks lose sharpness and are
not measured as they are.
* [Note] The description "0.02" for the Response is changed to "No Filter". The Response value
of "0.02" corresponds to "No Filter".
[Note] When the Response is small, the data becomes sensitive for sharp peaks, but the
baseline noise increases.

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 4.4. Evaporative Light Scattering Detector

4.4.1. Notice for the ELSD operation

While the ELSD is controlled by the LabSolutions software, the operation on the ELSD front
panel is locked. To operate the ELSD on the front panel, close the LabSolutions software and
stop controlling the ELSD from PC. When the communication between PC and ELSD is
disconnected by abnormal termination or other unexpected reasons, there is a case the
operation on the ELSD front panel is kept locked. In such a case, turn off the power supply of
the ELSD and turn it on again.

4.4.2. Displaying Nebulizer Gas Pressure

There is a case the nebulizer gas pressure values displayed on the LabSolutions Instrument
Monitor window and the ELSD front panel are different. Although the nebulizer gas pressure is
displayed in units of 1kPa on the ELSD front panel when the pressure unit is kPa, it is displayed
in units of 10kPa on the LabSolutions Instrument Monitor window. This is the same for the other
pressure units such as bar.
Example)
(kPa)
On the ELSD front panel: 347 kPa
On the LabSolutions Instrument Monitor window: 340 kPa

(bar)
On the ELSD front panel: 3.47 bar
On the LabSolutions Instrument Monitor window: 3.4 bar

4.4.3. Offset Setting Range

Although the Offset setting range is -999mV through 1000mV on the ELSD front panel, it is
limited to -999mV through 999mV on the LabSolutions if the ROM version of ELSD-LTII is 1.5.
(When the ROM version of ELSD-LTII is 1.6 or later, the Offset can be set to -999mV through
1000mV.)

4.4.4. Zero Adjustment

When pressing the [Zeros ELS Detector] button on the Instrument Control tool bar, the offset
value is automatically changed by the ELSD to adjust the signal intensity at the time of [Zeros
ELS Detector] to zero. By this reason, [Zeros ELS Detector] is initialized when downloading the
instrument parameters as the offset value adjusted by [Zeros ELS Detector] is replaced with
that of the instrument method. Perform [Zeros ELS Detector] after downloading the instrument
parameters. When selecting the Auto-zero check box on the ELSD configuration window, the
signal intensity on start becomes zero regardless of the offset setting of the instrument
parameters as the zero adjustment is performed on starting acquisition.

4.4.5. Shutdown Function

While LabSolutions is controlling ELSD-LTII through RS-232C, the ELSD shutdown function by
the external event cable is not available.
In such a case, please shutdown the ELSD-LTII from the batch or instrument control bar in the
LabSolutions software.

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 4.5. PDA Detector

4.5.1. Maximum Acquisition Time of SPD-M10Avp/SPD-M20A Detector

The maximum acquisition time using a SPD-M10Avp/SPD-M20A detector is calculated as
follows:
{128 [Mbytes] x 10242/4 [Byte]} / {End Wavelength - Start Wavelength + 1 [nm]} x {Sampling
Period [msec]/60000} x 1.2
For example, the maximum acquisition time is...
approx. 2372min when Wavelength range: 190 - 370nm Sampling period: 640msec
approx. 702min when Wavelength range: 190 - 800nm Sampling period: 640msec
approx. 10min when Wavelength range: 190 - 800nm Sampling period: 10msec
If the specified acquisition time exceeds the above limit, the method is not saved as the
acquisition time is validated and the warning message is displayed.
Please be advised that you should not extend the run time longer than the maximum time
calculated by the above formula.
When the sampling period is high or the data acquisition time is long, the data file size becomes
large. In this case, please increase memory on the PC.
To extend the maximum acquisition time, execute the file below, which is included in the
installation CD-ROM. The value rises threefold.
LabSolutionsLCGC\Supplement\x86\MaxMemorySizex3.reg (32bit OS) or
LabSolutionsLCGC\Supplement\x64\MaxMemorySizex3.reg (64bit OS)
(To reset the restriction, execute "DefaultMaxMemorySize.reg" which is included in the same
folder.)

4.5.2. Maximum Acquisition Time of SPD-M30A Detector

The maximum acquisition time using a SPD-M30A detector is calculated as follows:
{Memory Size for PDA Data [Mbytes] x 10242/4 [Byte]} / {End Wavelength - Start Wavelength
+ 1 [nm]} x {Sampling Period [msec]/60000} x 0.5 x {1024 / Spectrum Resolution}
If the specified acquisition time exceeds the above limit, the method is not saved as the
acquisition time is validated and the warning message is displayed.
Please be advised that you should not extend the run time longer than the maximum time
calculated by the above formula.
When the sampling period is high or the data acquisition time is long, the data file size becomes
large. In this case, please increase memory on the PC.
Upper Limit
Wave Maximum
of Memory Sampling Spectrum
# Length Acquisition
Size for PDA Period [msec] Resolution
[nm] Time [min]
Data [MB]
1 128 640 512 190 - 370 1977
2 128 640 1024 190 - 370 988
3 128 640 1024 190 - 700 350
4 128 5 1024 190 - 370 7.7
5 128 5 1024 190 - 700 2.7
6 128 5 512 190 - 700 5.4
In addition, if the upper limit of memory size for PDA Data is set 0, restriction of the maximum
acquisition time is not checked.

LabSolutions Software Release Notes

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 4.5.3. Maximum Acquisition Time of LC-2030/LC-2040 PDA Detector
The maximum acquisition time using a LC-2030/LC-2040 PDA detector is calculated as follows:
{Memory Size for PDA Data [Mbytes] x 10242/4 [Byte]} / {End Wavelength - Start Wavelength
+ 1 [nm]} x {Sampling Period [msec]/60000} x 0.6 x {1024 / Spectrum Resolution}
Others are same to the SPD-M30A.

4.5.4. Maximum Acquisition Time of PDA 2D mode and MWD

When using a PDA detector in 2D mode or using a MWD (multi-wavelength detector), there are
no restrictions of the maximum acquisition time. It can set up by LabSolutions to "9999.9 min"
which can be set up as data acquisition time.

4.5.5. Notice for Data Acquisition

Care must be taken when performing other application such as MS-Word and MS-Excel while
acquiring PDA data. Memory and CPU intensive operations can consume large amounts of the
PC resources thereby causing PDA data acquisition to be interrupted. If problems like this
occur, please do not perform other applications during PDA data acquisition.

4.5.6. Notice for Setting Acquisition Time

The data acquisition time for PDA/MWD should be longer than 0.3min. If PDA/MWD data is
acquired with the acquisition time less than 0.3min, there is a case that the PDA/MWD data is
not normally saved and the data analysis fails, the quantitation calculation is not executed and
the data is not registered to the CLASS-Agent database.

4.5.7. Notice for SPD-M10Avp's Sampling Period

It is recommended that the sampling period for the SPD-M10Avp data acquisition is usually set
to 240 msec or longer, when acquiring data from multiple instruments.

4.5.8. Bandwidth for Multi-Chromatogram Settings

The chromatogram output from PDA detector is averaged using the Wavelength and Bandwidth
for multi-chromatograms in the Data Analysis Parameters.
For example, if the Wavelength is set to 250nm and the Band Width is n, the equation {250 +/-
n}} is used as follows:
n=1 : (250 +/- 1) nm
n=2 : (250 +/- 2) nm
n=3 : (250 +/- 3) nm
n=4 : (250 +/- 4) nm
n=5 : (250 +/- 5) nm
The chromatogram is averaged for larger n using the element data, which fall into the
wavelength range, specified by the Wavelength and Bandwidth.

4.5.9. Fast Sampling

Fast sampling (Sampling Period is upper than 100Hz, Sampling Time is lower than 10msec) is
available. When the new functions are required in use of SPD-M20A, please update the ROM
version of SPD-M20A to 1.10 or later.
[Note] When using SPD-M20A, SPD-M30A, SPD-30AM or LC-2030/LC-2040 (PDA detector
model) with the fast sampling rate, do not connect other PDA/MWD.

LabSolutions Software Release Notes

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 When acquiring data by SPD-M20A, SPD-M30A or LC-2030/LC-2040 (PDA detector model)
with fast sampling rate (upper than 100Hz), specify the Time Constant as "0" or "0.010", and the
Slit Width as "8". With other settings, sharp peaks lose sharpness and are not measured as
they are.
[Note] When the Time constant is small, the data becomes sensitive for sharp peaks, but the
baseline noise increases.

4.6. Fraction Collector

4.6.1. Notice for Displaying Fraction Mark

On the Real Time Analysis window, FRC Vial (number) is displayed only when the Fraction
Mark is displayed.

4.6.2. Display Period of Real Time Hatching of Fraction Collection

Real time hatching of fraction collection to the chromatogram plot is updated at the following
period in order to reduce communication stress.
Number of fractions Period
20 or less 10sec
21 through 40 20sec
41 through 80 30sec
81 or more 60sec

4.6.3. Notice for Displaying Fraction Mark on PDA Multi-Chromatogram

For PDA data, hatching of fraction collection is applied to all multi-chromatogram plots.

4.6.4. Notice for Stop Time of FRC Time Program

When using fraction collector, "LC Stop Time" should be longer than the end time set in FRC
time program. FRC time program commands set in the time later than the LC Stop Time do not
work. In FRC Simulation, all the FRC time program commands are considered regardless of the
LC Stop Time.

4.6.5. Notice for I.VIAL and F.VIAL of FRC Time Program

When using fraction collector, if "I.VIAL" and "F.VIAL" are set in the FRC time program, these
commands are not valid and not performed once after a fraction collection started. The FRC
simulation results change according to these commands, however it is not reflected on the
operation of the fraction collector.

4.6.6. Notice for Difference between FRC Simulation and Results

Simulation of Fraction collector reports is supported in the Fraction Collector setup tab. This will
result in the shading of chromatographic peaks based upon their inclusion in a given fraction.
This function is intended for convenient viewing of fractions not for fine time determination.
Shaded portions on the screen sometimes shift by 0.01min.

4.6.7. Notice for Time Setting of FRC Program

During FRC Simulation operations, if two events are separated by 0.01min or less in the time
program, the two shaded regions sometimes merge into one color. The FRC simulation does
not always match with the actual results as the analog signal from detector is converted to

LabSolutions Software Release Notes

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 digital data with the A/D converter, and conversion error and signal offset difference error are
included in this process.

5. Other Information
5.1. License Key

5.1.1. Keeping License Key

Please take the appropriate care of your license key as if you lose it, the new license may not
be issued.

5.2. Other Notes

5.2.1. Notice for Virus Check Software

If you are using real time virus scanning, exclude all LabSolutions-related folders and their sub-
directories. Some real time virus scanners mistake normal LabSolutions functionality for virus
activity and this can cause unexpected problem.

5.2.2. Notice for Windows Defender Exclusion Settings

There is an antivirus function "Windows Defender" in Windows functions.
Please exclude all folders, subdirectories and processes related to LabSolutions from Virus
Scan. Windows Defender always scans files and processes on the PC.
During scanning, Windows Defender may incorrectly determine LabSolutions behavior as virus
activity. It may cause troubles such as communication error during analysis.

5.2.3. Notice for the Instrument Administration Window

Once an instrument is registered in the Instrument Administration window, it cannot be deleted.
When the registered instrument is not used, select it in the Instrument List and select the
Disable instrument check box on the Edit Instrument window. They are not displayed on the
main window.

5.2.4. Notice for the PC Information in the Administration Tools

This menu is available only for users having the administration right.

5.3. License use notation

5.3.1. Notice for NLog

NLog 2.0 is used on this system.
NLog - Copyright (c) 2004-2011 Jaroslaw Kowalski <[email protected]> All rights reserved.
http://nlog-project.org/

5.3.2. Notice for TreeGridView

TreeGridView is used on this system.
TreeGridView - Copyright (c) Microsoft Corporation. All rights reserved.

LabSolutions Software Release Notes

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 THIS CODE AND INFORMATION ARE PROVIDED AS IS WITHOUT WARRANTY OF ANY
KIND, EITHER EXPRESSED OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE IMPLIED
WARRANTIES OF MERCHANTABILITY AND/OR FITNESS FOR A PARTICULAR PURPOSE.
http://blogs.msdn.com/b/markrideout/archive/2006/01/08/510700.aspx

5.3.3. Notice for LibJpeg

LibJpeg is used on this system.
LibJpeg - Copyright (C) 1991-1998, Thomas G. Lane.

5.3.4. Notice for FreeType

FreeType is used on this system.
FreeType - Copyright (C) 1996-2014 by David Turner, Robert Wilhelm, and Werner Lemberg.

5.3.5. Notice for Eigen3

Eigen3 is used on this system.
http://eigen.tuxfamily.org/index.php?title=Main_Page

5.3.6. Notice for redsvd

redsvd is used on this system.
https://code.google.com/p/redsvd/
Copyright (c) 2010 Daisuke Okanohara
All rights reserved.

Redistribution and use in source and binary forms, with or without modification, are permitted
provided that the following conditions are met:

1. Redistributions of source code must retain the above copyright notice, this list of conditions
and the following disclaimer.

2. Redistributions in binary form must reproduce the above copyright notice, this list of
conditions and the following disclaimer in the documentation and/or other materials provided
with the distribution.

3. Neither the name of the copyright holder nor the names of its contributors may be used to
endorse or promote products derived from this software without specific prior written
permission.

THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS

"AS IS" AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED
TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A
PARTICULAR PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT
HOLDER OR CONTRIBUTORS BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL,

LabSolutions Software Release Notes

Page 50 of 51
 SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED
TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR
PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF
LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING
NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS
SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE.

5.3.7. Notice for Spread Windows Forms 6.0

Spread Windows Forms 6.0 is used on this system.
Portions Copyright © GrapeCity, Inc. 1987-2011. All Rights Reserved.

5.3.8. Notice for AutoMapper

AutoMapper is used on this system.
Copyright (c) 2010 Jimmy Bogard

Permission is hereby granted, free of charge, to any person obtaining a copy of this software
and associated documentation files (the "Software"), to deal in the Software without restriction,
including without limitation the rights to use, copy, modify, merge, publish, distribute, sublicense,
and/or sell copies of the Software, and to permit persons to whom the Software is furnished to
do so, subject to the following conditions:

The above copyright notice and this permission notice shall be included in all copies or
substantial portions of the Software.

THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS
OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF
MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT.
IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY
CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT
OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE
OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.

5.3.9. Notice for OxyPlot

OxyPlot is used on this system.
Copyright (c) 2014 OxyPlot contributors

Permission is hereby granted, free of charge, to any person obtaining a

copy of this software and associated documentation files (the
"Software"), to deal in the Software without restriction, including
without limitation the rights to use, copy, modify, merge, publish,
distribute, sublicense, and/or sell copies of the Software, and to
permit persons to whom the Software is furnished to do so, subject to
the following conditions:

The above copyright notice and this permission notice shall be included
in all copies or substantial portions of the Software.

THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS
OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF
MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
NONINFRINGEMENT.
IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY
CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT,
TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE
SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.

LabSolutions Software Release Notes

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