Pebc Compilation
Pebc Compilation
She just
delivered her baby 3 months ago and now she is currently breastfeeding her baby.
What is incorrect about the treatment and recommendation for Sarah?
Ans± D
(Shouldn’t we give sublingual nitrates just in acute cases not for managment?)
The pka of acetic acid, barbituric acid and ASA are 5.21, 4.371 and 3.31
respectively. Arrange these acids in their respective strengths (from lowest to
strongest)
A. Acetic acid, Barbituric acid and ASA
B. ASA, Barbituric acid and Acetic acid
C. Barbituric acid, Acetic acid and ASA
D. Acetic acid, ASA, and Barbituric acid
E. Barbituric acid, ASA, and Acetic acid
Ans± A lower the pKa stronger acid
CY is a 58 year old female who has heart failure (NYHA III). Her physician wants CY
to start therapy with spironolactone or eplerenone. Which of the following adverse
effects is found significantly more often with spironolactone than with eplerenone?
a. Bradycardia
b. Gynecomastia
c. Hyperkalemia
d. Prolonged QT interval
Ans± B
Reflex tachycardia, headache, postural hypertension are adverse effects that limit
the use of ?
1. Prazosin
2. Captopril
3.methyldopa
4. Guanabenz
5. Hydralazine
Ans± Hydralazine
A 10-year-old girl presents to the emergency department (ED) with a 2-day history
of frequent urination as well as burning, and she states that she just does not
feel right. The patient's vital signs in the ED include heart rate 110
beats/minute, respiratory rate 20 breaths/minute, and blood pressure 80/40 mm Hg.
Her capillary refill time is about 3 seconds. After access is obtained, the patient
is fluid resuscitated with isotonic fluids and initiated on dopamine that has been
titrated to 10 mcg/kg/minute. On examination, the patient is still hypotensive with
a blood pressure of 85/50 mm Hg, and her distal extremities are noted to be cold.
African american patient male 65y/o diagnosed with DM2 he is on metformin, he also
has dyslipidemia and is on Atorvastatin, last urianalysis detected some albuminuria
but appart of that he has no other complications, now he is also diagnosed with
Hypertension and his physician wants to start him on an Antihypertensive therapy,
which agent is more appropriate?
Amlodipine
Hydrochlorotiazid
Metoprolol
Ramipril
Ans± Ramipril (because it helps for both albuminuria as well as hypertension)
African american patient male 65y/o diagnosed with DM2 he is on metformin, no other
complications, now he is also diagnosed with Hypertension and his physician wants
to start him on an Antihypertensive therapy, which agent is more appropriate?
Amlodipine
Hydrochlorotiazid
Metoprolol
Ramipril
Ans± Amlodipine (American and african respond poorly to BB,ACE and ARBs)
Which of the following combinations of drugs, when used together, reduce both
preload and afterload?
(a) Nitroglycerin and isosorbide dinitrate
(b) Hydralazine and isosorbide dinitrate
(c) Captopril and methyldopa
(d) Prazosin and angiotension II
(e) Hydralazine and methyldopa
Ans± B
(Hydralazine=arterial vasodilation, Iso.dintrate= venodilation)
John is currently on captropil, carvediol and furosemide but his HF symptoms are
not improved. His LVEF = 32 % , HR = 75 bpm. The doctor is planning to titrate the
carvediol to the maximum dose. If his symptoms still persist, What should be
changed to John’s treatment?
A. Add eplerenone
B. Add Ivabradine
What is the most appropriate treatment option for patient with prosthetic heart
valves?
1. Warfarin 5 mg + Aspirin 81 mg
2. Clopidogrel 75 mg OD
4. Apixaban 5 mg BID
Ans± 1
A patient with stage I hypertension who has bronchospastic airway disease and who
is non compliant would be best treated with which of the following B/blocking
agent?
a) timolol
b) Penbutolol
c) esmolol
d) acebutalol
e) Propranolol
Ans± D
(Patient with airway disease. First go for cardioselective beta blockers.
BE A MAN
Bisoprolol, Esmolol, Acebutolol, Metoprolol, Atenolol, Nebivolol.
.
Esmolol here is short acting IV drug used to treat hypertensive crisis.
Acebutolol with t1/2 of 13 hrs (active metabolite) will help pt non
compliance ..fewer dose per day..and it is cardio selective.)
patient returns to her health care provider for routine monitoring 3 months after
her hypertension regimen was modified. Labs reveal elevated serum potassium. Which
is likely responsible for this hyperkalemia?
A. Chlorthalidone. B. Clonidine.
C. Furosemide.
D. Losartan.
E. Nifedipine
Ans± losartan..... All ARB, ACEi and potassium sparing diuretic cause hypokalemia
A 40-year-old male has recently been diagnosed with hypertension due to pressure
readings of 163/102 and 165/100 mm Hg. He also has diabetes that is well controlled
with oral hypoglycemic medications. Which is the best initial treatment regimen for
treatment of hypertension in this patient?
A. Felodipine.
B. Furosemide.
C. Lisinopril.
D. Lisinopril and hydrochlorothiazide.
E. Metoprolol.
Ans± C
55-year-old male with kidney stones has been placed on a diuretic to decrease
calcium excretion. However, after a few weeks, he develops an attack of gout. Which
diuretic was he taking?
A. Furosemide.
B. Hydrochlorothiazide.
C. Spironolactone.
D. Triamterene.
E. Urea.
Ans± furosemide.... bcoz it cause hupocalcemia and hyperurecemia
75-year-old woman with hypertension is being treated with a thiazide. Her blood
pressure responds well and reads at 120/76 mm Hg. After several months on the
medication, she complains of being tired and weak. An analysis of the blood
indicates low values for which of the following?
A. Calcium. B. Glucose. C. Potassium. D. Sodium.
E. Uric acid.
Ans± C
Which best describes the action of ACE inhibitors on the failing heart?
A. ACE inhibitors increase vascular resistance. B. ACE inhibitors decrease cardiac
output.
C. ACE inhibitors reduce preload.
D. ACE inhibitors increase aldosterone.
Ans± C
All of the following drugs can increase Digoxin serum concentration if used
concomitantly EXCEPT:
1. Clarithromycin
2. Posaconazole
3.Amiodarone.
4. Phenytoin
Ans± Phenytoin, as Phenytoin decreases Digoxin serum Concentration
Which of the following medicine shoud ideally be avoided in Heart Failure with
Preserved Ejection Fraction patients?
1.Verapamil
2. Diclofenac
3. Amlodipine
4. Metolozone
Ans± Diclofenac
NSAIDS should be avoided in Heart Failure
Verapamil can be used in HFpEF and should be avoided in HFrEF
which of the following medications used in patient with acute coronary syndrome
undergoing percutaneous coronary intervention
A bivaluridin
B ASA
C Asa+clopidogrel
D warfarin
E Alteplase
Ans± A
Bivaluridin used in patient undergoing PCI
Which of the following diuretics that change the color of urine to blue:
A triamterene
B eplerenone
C amiloride
D furosemide
E ethacrynic acid
Ans± A
Which of the following drugs can increase the risk of torsade de pointe
A sotalol
B amiodarone
C atenolol
D ciprofloxacin
E A&B
Ans± E
Amiodarone and sotalol cause QT prolongation
All of the following agents can be used to manage atrial fibrillation except
A verapamil
B lidocaine
C dronedarone
D propranolol
Ans± B
BH is 52 year old african american woman who has HFrEF. Shi is seen in clinic today
reporting stable HF symptoms, but is having ocassionally peripheral brightness.
Otherwise, vision is unchanged. Current medication regimen includes sacubitril-
valsarten, carvedilil, fixed dose hydralazine and isosorbide dinitrate, ivabradine
and bumetanide. Which is the best recommendation to minimize the adverse effect of
peripheral brightness±
a) Stopp all HF medications immediately
b) Discontinue sacubitril-valsarten only
c)Do nothing. This adverse effect will slowly improve over time
d) Reduce the dose of ivarbradine
Ans± d
A 70 year old woman has HFrEF and hypertension. She takes linsopril and metoprolol
tartrate. She feels well and has no cough, shortness of breath, or edema. Which of
the following changes is most appropriate for her drug therapy?
a) Initiate digoxin
b) Change linsopril to losartan
c) Initiate ivabradine
d) Change metoprolo tartarate to metoprolol succinate
Ans± D
Rhythm control with catheter ablation should be considered first line in atrial
flutter and should usually be considered second line in AF?? TorF
True
Avoid use of flecanide and propafenone in patient with structural heart disease
TorF
True
Normal breathing rate is 15 or 25??
12-16breath/min is correct
MP is 35 year old man diagnosed with type 2DM,hypertension and hyperlipidemia and
sexual dysfunction.what is the most appropriate treatment for him
A CCB+ACE
B BB+ACE
C ARBs+BB
D ACE+thiazidic
E B1 bloker+ACE
Ans± The correct answer is A
in higher risk patient use benazepril+CCB
HTN emergency
Saurav Ganguly HELP
Sodium NitroPrusside
GTN (nitroglycerin)
Hydralazine
Esmolol
Labetalol
Phentolamine
Post MI :
Lidocaine
Mexiletine
Tocainide
Contraindicated Post Mi:
Flecainide
Propafenone
Heart failure initially first line is ACEI and diuretics, then beta blockers,
positive inotropic agents like digoxin etc vasodilators combination
ISDN+hydralazine
All those medicines who work on dilation of blood vessels have 5 similar side
effects. These drug class includes Alpha Blockers (prazocin family), VasoDilators
(Sodium Nitroprusside, Minoxidil, Hydralazine, Diazoxide) and CCB (Nefidipine
Family):
1. Reflex Tachycardia
2. Orthostatic Hypotension (Dizziness)
3. Facial flushing
4. Headache
5. Nasal congestion
For White and Young patients, HTN recommended classes are A & B
Ace inhibitors and Beta Blockers
For Old and Black patients, HTN recommended classes are C & D
CCB and Diuretics
HYPERTENSION:
ACEI not for black patients, instead give: isosorbide dinitrate / hydralazine
BB not for over 60 years old
Diuretics preferred in elderly
Thiazides + loop diuretics - hypokalemia
Potassium sparring- hyperkalemia
Carbonic anhydrase I- for glaucoma + motion sickness ( climbing high mountains)
Diabetics -avoid BB + give ACE/ ARB + b.p:130/80 mm Hg
Avoid ACEI in isolated systolic hypertension
Sodium nitroprusside -for emergency hypertension
Drug Causes of HTN: oral contraceptives+ venlafaxine + MAO I