DERMATOLOGY CHANTING BY DR.

PARAS
☆ LAYER 'S OF EPIDERMIS

☆ CELLS LAYER DERIVED FROM

1 KERATINOCYTES ALL LAYER 'S ECTODERM

2 MELANOCYTE St . BASALE NEURAL CREST CELL
3
MERKEL CELLS St BASALE
.
ECTODERM
YLANGERHANS CELLS St. SPINOSUM MESODERM

☆ CELLS
1. KERATINOCYTE =
90%
◦
HALLMARK -

PRESENCE OF KERATIN FILAMENT

2. MELANOCXTE
→ SYNTHESIZE -
MELANOSOME WHIM

CONTAIN -

MELANIN
↓ / MELANIN UNIT

36 KERATINOCYTES
3. MERKEL CELL
◦
THEY ARE SLOW ADAPTING TYPE I
Touch RECEPTOR

4. LANGERHANS CELL
◦ HALLMARK =
BIRBECK GRANULES
◦
APC → PHAGOCYTOSIS

☆ LAYER 'S

◦
St . BASALE =1St LAYER TO BE FORMED
◦ St. SPINOSUM THICKEST LAYER
=

◦
St .
GRAN ULOSUM CONTAIN FKAGGRIN
=

↓
DEFICIENCY

FISH LIKE SCALES ARE tht

 ◦ ST LUCIDUM
.
= ◦
CLEAR CELL LAYER
+ nt
PALM & SOLE
◦
IN

◦
ST . CORNEUM =
◦
LACK NUCLEUS
◦
CONTAIN DEAD KERATINOCYTES

CHAPTER -

I =
BLISTERING DISORDER

◦
BLISTER = FLUID FILLED LESION 'S
↳ 20.5cm → VESICLE
↳ > 0.5cm → BULLAE

☆ PEPPHIGUS
◦
AUTOIMMUNE DISORDER
IgG Ab
Against DESMOGLEIN → BLISTER 'S
◦

◦
E.
ROSIN WITH CRUSTING IS SEEN

PEMPHIGUS FOLIACEUS PEMPHIGUS VULGARIS

◦
DSG -1 ◦
DSG -3
°
ST . GRANULOSUM •
ST SPINOSUM
.

0 SUPERFICIAL BULLAE °
DEEP BULLAE
 >

CLINICAL SIGN → TANGENTIAL PRESSURE

1 PRESSURE → • SIZE

OF BULLA
BULLAE SPREAD SIGN

HISTOLOGY =

◦
ROW OF TOMB

APPERANCE

DIF = →
FISH NET LIKE PATTERN

Rx =
STEROID
CYCLOPHOSPHAMIDE
RITUXIMAB
☆ BULLOUS PEMPHIGOID
G
Ig against BPAGZ BULLAE
GENE ↑
◦ -

◦
CIF -

TENSE SUB
EPIDERMAL
◦
BLISTER
◦
NIKOLSKY SIGN -

NT
◦
ROW OF TOMBSTONE App
☆ LINEAR
IgA DISEASE
IgA BPAg2
Against PEARL
◦

◦
STRING OFOR BEADS
Appliances
0 DIF ◦ Doc = DAPSONE

☆ DERMATITIS HERPATIFORMIS
◦
GLUTEAN HYPERSENSITIVITY
◦
DOC =
DAPSONE B- BARLEY
◦
GLUTEN FREE DIET R RYE
Toc = -

1- AVOID → 0 -
OAT
W -
WHEAT
☆ DARTER 'S HAILEY -
HAILEY
◦ AD °
AD
◦
SEBORRHIC AREAS ◦ SKIN FOLDS
◦ SAND PAPER LIKE app .
◦
RECURRENT FLACCID
, ,

VESICULAR LESIONS
◦
BRICK WALL
App .

☆ ERYTHEMA MULTIFORME
CAUSE = VIRAL INFECTION 'S & DRUGS
LESION = TARGET SIGN
IIRIS LESION
BULLS EYE

☆ EPIDERMAL LESION me.c= DRUGS

/
◦
TEN -_ [ Toxic Epidermal Necrosis] ◦
STEVEN JOHNSON
Synch .

BSA -130% BSA=< 10%

←
→NIKOLAY
SIGN tht
CHAPTER =L →
INFECTION
1. BACTERIAL INFECTION

A. ERYTHRASMA
◦
CAUSED BY CORYNEBACTERIUM MINUTISSMUM
◦
RASH IS tnt ON AXILLA
0 DX -
WOOD 'S LAMP EXAMINATION -
CORAL RED
COLOUR

B. NON BULLOUS IMPETIGO

◦ CAUSED BY STREPTOCOCCUS PYOGENS
◦
me -
CHILDREN & + nt ON FACE

→ GOLDEN YELLOW /
HONEY COLOURED CRUSTING

C. CELLULITIS =

◦
CAUSED BY STREPTCOCCUSPYOGENS
& STAPH AUREUS
→ DIFFUSE BORDER as SEEN
2. FUNGAL INFECTION
A. PITYRIASIS VERSICOLOR
◦
CAUSED BY = MALASSEZIA FURFUR
◦
CIF =
RICE POWDER LIKE SCALING IS SEEN
◦ me -

SITE = UPPER TRUNK

◦
Ix =

10% KOH MOUNT WOODS LAMP

→SPAGHETTI & YELLOW / ←

MEATBALL APPLE GREEN Color

RX = TOPICAL → KETOCONAZOLE
SYSTEMIC → SELENIUM SULPHIDE

B. CANDIDIASIS →
VAGINAL> WHITE CURDY DISCHARGE
↳ ORAL → ORAL THRUSH
◦ CAUSED BY → CANDIDA ALBICANS

◦
Doc > FLUCONAZOLE
C. PIEDRA / TRICHO MYCOSIS NODULAR IS

→ BLACK PIEDRA → PIEDRAIAHORTAE

WHITE PIEDRA > BE / 944
→
Tsrichospooon

D. DERMATOPHYTOSIS
SKIN HAIR NAIL
+
TRICHOPHYTON + +

+ +
MKROSPORON
+ +
EPIDERMOPHYTON

E. TINEA INFECTIONS
↳ TINEA CAPITIS = HEAD IS INVOLVED
◦
KERION ◦
FAVUS

DOG GRISEOFLWIN

↳ TINEA MANUUM =
HANDS
↳ TINEA PEDIS =
FEET Doe
↳ TINEA UNGUIUM = NAIL TERBINAFINE>
↳ TINEA CRURIS = INGUINAL AREA ITRACONAZOLE
F. SPOROTRKHOSISCROSE GARDNER DISEASE)
→ CAUSED BY SPOROTHRIX SHANK /
→
Doc - '

ITRACONAZOLE
→ MC -

LINEAR NODULES ALONG THE DRAINING

LYMPHATICS

G. CHROMO BLASIO MYCOSIS

→ COPPER PENNY BODIES
DOC → ITRACONAZOLE

3- MYCOBACTERIAL INFECTIONS

A. LUPUS VULGARIS
→ PLAQUE C- CENTRAL SCALING
→ DIAS APPLE
copy = JELLY NODULE

B. SCROFULODERMA
→ me -

CHILDREN
→
commonly + nt C- SINUS
C. LEPROSY

CHAPTER 3 = STI sexually TRANSMITTED

INFECTION

A. SYPHILIS =

◦
CAUSED BY TREPONEMA PALLID / um
◦
4F= PAINLESS CHANCRE tht

◦ RX = BENZATHINE PENICILLIN
EXCEPT NEURO Syphilis →
Aqueous crystalline
PENICILLIN

B. LGV
◦
CAUSED BY -
CHLAMYDIA
TRACHOMA-11s
◦
Rx → D. OXYCLINE
C. CHANCROID = PAINFUL ULCER
◦
CAUSED BY Ho DUCREYI

RX AZITHROMYCIN
 D. DONOVAN 051s

◦ CAUSED BY -

KLEBSIELLA GRANULOMA-11s

◦ CIF →
BEEFY RED ULCERS & BLEED ON
Touch
◦
Rx→ AZITHROMYCIN

E. CONGENITAL SYPHILIS -
s

◦
INTESTINAL KERATITIS
◦
DEAFNESS
◦
HUTCHINSON 'S TEETH

F. GONORRHEA
◦
Mcc -
N .
GONORRHEA
◦
Doc = CEFTRIAXONE

CIF → PURULENT WHITE

DISCHARGE
 CHAPTER =Y PAPULO SQUAMOUS
DISORDER

A. PSORIASIS =

me -
PSORIASIS VULGARIS
◦
GF ◦
SILVER-
WHITE SCALING
•
AUZPITZ SIGN +VE

◦
TYPE =

→
PLAQUE PSORIASIS → GUTTATE PSORIASIS

→ PUSTULAR PSORIASIS → INVERSE PSORIASIS

Rx → TOPICAL →
CORTICOSTEROID
SYSTEMIC → METHOTREXATE

KERATOLYTIC AGENT → SALCYLK ACID

PHOTOTHERAPY
B. LICHEN PLANUS
•
AUTOIMMUNE CONDITION

CIF KOEBNER as PHENOMENON / ISOMORPHIC PHENOMENON

◦
-

C. PITYRIASIS ROSEA
CHRISTMAS TREE PATTERN

→
Associated c- HMV 647

D. ISOMORPHIC / KOEBNAR PHENOMENON

→ tnt in VITILIGO
PSORIASIS
LICHEN PLANUS
Rx →
PHOTOTHERAPY
☆ CHAPTER -5
-

PIGMENTARY DISORDER

A. MELASMA = ↑ MELANIN
◦
BROWN PIGMENTATION SEEN

AFTER PREGNANCY

B. MONGOLIAN SPOT
◦
BLUISH SPOTS OVER LOWER
BACK

C. NEVUS OF OTA D. NEVUS ITO

'

OF

E. BECKER 'S NEVUS F. CONTACT DERMATITIS

◦
HYPER PIGMENTATION
Localized
depigmentation
◦

◦ HYPETKTRICHOSIS
G. ACANTHOSIS NIGRICANS
◦
VELVETY SKIN
◦
Mcc -
OBESITY
H . PEUTZ -

SEGHERS SYNDROME

→
PERIORALLENTIGENS SEEN

I. FIXED DRUG ERUPTIONS

◦
HYPER PIGMENTED PATCH OVER LIPS/

GENITALS DUE TO DRUG INTAKE

3. PIEBALD ISM K VITILIGO

L : FRECKLES M .
ALBINISM
 0 HAIR
0 NAIL
☆
CHAPTER -6 SKIN APPENDAGES ◦
GLANDS

☆ HAIR CYCLE
I ANAGEN → GROWTH = 3 YEARS

I CATAGEN → INVOLUTION =3 WEEKS

II TELOGEN → RESTING =3 MONTH

☆
ANDROGENIC ALOPECIA
Mcc → DHT DIHYDROTESTOSTERONE
-

MALE FEMALE
HAMILTON OLSEN LUDWIG

RX =
TOPICAL →MINOXIDIL S✗= HAIR TRANSPLANT
SYSTEMIC → FINASTERIDE
☆ ALOPECIA AREA-1A
→ AUTO -
IMMUNE CONDITION

→ PATCHY HAIR LOSS

→ EXCLAMATION MARK SIGN
 ☆ NAIL
A- ◦ NAIL PSORIASIS
"
MC -

CHRACTERISTIC FINDING .
] "

ÑÉ
•

PATCH !
-

oil PITTING
drop sign / SALMON -

B. TERRY NAILS C. HALF & HALF NAILS

◦
HEPATIC FAILURE 1- °
CHRONIC RENAL FAILURE
CHF
D. PARONYCHIA E. SUB UNGAL HYPERKERATOSIS
◦
THICKENING

OF NAIL PLATE

◦ INFECTION OF NAIL BED

* SWEAT GLANDS
ECCRINE APOCRINE
◦
DUCT -

DIRECTLY OPEN ◦ DUCT -

OPEN ALONG Hair Follicle
◦ ANHIDROSIS °
BROMHYDROSIS
◦
HYPERHIDROSIS •
CHROMHYDROSIS
◦ MILIARIA 0
FOX FORDYCE DISEASE
→ITCHY PAPULES

ARE SEEN

☆ ACNE VULGARIS
◦
MOST CHARACTERISTIC FEATURE
&
→ OPEN = BLACK < COME DONES
] Magoo
→ CLOSE = WHITE <

DOC → ORAL ISOTRETINOIN

☆ ROSACEA
→ FLUSHING SEEN AFTER
DRINKING HOT LIQUIDS OR

AFTER WORKING IN HOT

AREAS .