SANT GADGE BABA AMRAVATI UNIVERSITY, AMRAVATI

Name of Class: B.Pharm. Eight Semester (New)

NAME OF THE SUBJECT: Biostatistics & Research Methodology (BP 801 T)
QUESTION BANK

Unit-I
1. MCQ
1. Which of the following is not a type of Central Tendency
a. Mean b. Mode c. Median d. None of these
2. Karl Pearson’s coefficient of correlation is also known as…….
a. Product moment correlation b. Result moment correlation
c. Both a and b d. None of these
3. Biostatistics is the application of statistics to a wide range of topic in….
a. Statistics b. Biology c. Both a & b d. None of these
4. The median of the data 1,4, 2,5,0
a. 1 b. 2 c. 4 d. 5
5. Frequency distribution is a ……that displays the frequency of various outcomes
in a sample
a. List b. Table c. Graph d. All of these
6. In multiple regression analysis ……..independent variables are used
a. 1 b. 2 c. 3 d. Both b and c
7. Karl Pearson’s coefficient of correlation is also called as…..
a. Simple b. Complex c. Both a & b d. None of these
8. In Biostatistics, “r” is term as ….
a. Probability b. Standard deviation c. Median d. Correlation coefficient
9. In biostatistics, Range of a set of data is the difference between……values
a. Smallest b. Largest c. Both a & b d. None of these
10. Dispersion is also called as……..
a. Variability b. Scatter c. Spread d. All of these

2. Long Answer questions

a. Find the population Mean and sample standard deviation for the following data set: 5,
10, 15, 20
b. Discuss and measure of central tendency in details with eg.
c. Discuss Statistics, Biostatistics and Frequency distribution and its application in
Pharmacy

3. Short Answer questions

a. Write about Karl Pearson’s coefficient of correlation
 b. Define Central tendency
c. Explain Multiple correlations
d. Determine Median from the given data 4, 1 and 7
e. What is Dispersion, Explain with one eg.
f. Determine the mode from the given data 2,4, 3, 2, 2
g. During a survey, 6 students were asked that how many hours per day they study on an
average. Their answer were as follows: 2, 6, 5, 3, 4, 1, Evaluate the standard
deviation.

Unit-II
1. MCQ
1. SEM is Standard Error of ……
a. Mean b. Mode c. Median d. None of these
2. Full form of LSD is…….
a. Low significant determination b. Least significant difference
c. Both a and b d. None of these
3. Correlation factor is….
a. T/2 b. T2N c. T2/N d. All of these
4. R Square also known as……..
a. Mean value b. Mode analysis coefficient
c. Coefficient of determination d. None of these
5. LSD is used when F ratio suggest rejection of the…..hypothesis
a. Null b. Alternative c. Both d. None of these
6. The basic relationship between X and Y in regression is given by……
a. X=b+ bX b. Y= b+ bX c. X=a +X d. Y= a +bX
7. Analysis of variance is also known as…..test
a. Student t b. ANOVA c. SEM d. None of these
8. Standard Error of mean is the ….of its sampling distribution
a. Probability b. Standard deviation c. Median
d. Correlation coefficient
9. Type I error occurs when the null hypothesis is …..
a. True b. False c. Both of these d. None of these
10. Poisson’s distribution is probability distribution of…….. trials
a. Pearson b. Skewness c. Kurtosis d. Bernoulli

2. Long Answer questions

a. Discuss in details about parametric test and its application in pharmacy
b. Define probability? Discuss about Binomial, Normal and Poisson distribution
c. What is hypothesis? Explain Null and Alternative hypothesis with ex.
 3. Short Answer questions
a. Write about One way ANOVA
b. Explain multiple regression analysis
c. Discuss about types of sampling
d. Explain about t-test and significance in pharmacy
e. What is probability? Explain with pharmaceutical ex.
f. What is Regression? Explain curve fitting by the method of least square
g. Write about types of Error and Standard error of Mean (SEM)

UNIT- III
I. Multiple Choice Questions
1. Test whether matched pair samples are drawn from populations with different mean rank
is known as ……… .
A. Sigma test
B. Wilcoxon signed-rank test
C. Friedman test
D. Median test
2. Empirical literature search is based on ……….
A. Concept
B. Theories
C. Earlier search
D. None of the above
3. A cohort study is a particular form of ……………. study that sample a cohort.
A. Vertical
B. Horizontal
C. Circular
D. Longitudinal
4. Clinical trials involving new drugs are commonly classified into …….. phases.
A. One
B. Two
C. Three
D. Four
5. Why is it important for a researcher to review the literature?
A. Because it will find if anyone has done the work before
B. Because it is traditional
C. Because it identifies like-minded researchers
D. Because it shows time has been spent on the
6. The advantages of random sampling are that….
A. It is free from personal biases
B. It produces reasonably accurate result
C. It is economical method of data collection
D. All of the above
7. What is a research design?
A. A way of conducting research that is not grounded in theory
B. The choice between using qualitative or quantitative methods
C. The style in which you present your research findings, e.g. a graph
D. A framework for every stage of the collection and analysis of data
8. Phase II clinical trial is called as ………
A. Post marketing surveillance
B. Therapeutic exploration and dosage ranging
C. Testing of drug in non-human subjects
D. Human Pharmacology and safety
9. Which of the following acts constitute plagiarism?
A. Presenting other’s work as own
B. Paraphrasing without citation
C. Quoting other’s work without quotation marks
D. All of these
10. A circle divided into sectors proportional to the frequency of item shown is called-
A. Bar chart
B. Pie chart
C. Histogram
D. Frequency polygon
 II. Short Answer Questions
1. What is plagiarism? Explain types of plagiarism and methods to avoid it.
2. What is importance of data presentation? Explain Graphs and Charts with
diagram.
3. What are non-parametric test? Explain Wilcoxon Rank Sum Test.
4. Explain the Cohorts Studies.
5. Write a note on protocol.
6. Explain report writing and presentation of data.
7. Discuss in detail about observational studies.

III. Long Answer Questions

1. What is importance of data presentation? Discuss different types of graphs and
charts used in data analysis.
2. What is research? Discuss experimental design technique in detail.
3. What is designing a clinical trial? Discuss various phases of clinical trials.

UNIT- IV

I. Multiple Choice Questions

1. MINITAB Software was developed at
A. Oklahoma State University, USA
B. Pennsylvania State University , USA
C. Stanford University, USA
D. Pacific University, USA
2. Full Form of SPSS is
A) Special Package for software services
B) Statistical Package for Social software
C) Statistical Product and service solutions
D) None of the above
3. Blocking is a design technique for arranging a complete factorial experiment.
A. Uncontrollable
B. Unbearable
C. Bearable
D. Controllable
4. Statistical software widely used in pharmacovigilance and BPO
A) SPSS
B) MINITAB
C) R-Online
D) Design Expert
5. Confounding is a design technique for arranging a complete factorial experiment.
A. Row
B. Blocks
C. Both (A) and (B)
D. None of these
6. Simple linear regression is a statistical method that allows us to summarize and study
relationship
A. One
B. Two
C. Three
D. Four
7. Which among the following is not a use of regression modeling?
A. Predictive Modeling
B. Segmentation
C. Testing
D. Analysis
8. The file associated with minitab graph is …….
A. *.mgf
B. *.mpj
C. *.mtmm
D. *.mt
9. Statistical software used to IVIV Correlation .?
A. R-Online
B. SPSS
C. EPI
D. MINITAB
10. In MS Excel – Spread sheet , Columns are labelled by
A) Numerical Numbers (1,2,3,4..)
B) Capital Alphabets (A,B,C,D…)
C) Small Alphabets (a,b,c,d…)
D) Both Numbers & Alphabets

II. Short Answer Questions

1. Define minitab and give its general layout.

2. Give the core function of SPSS.
3. Discuss in detail statistical analysis using Excel.
4. Discuss in detail statistical analysis using SPSS.
5. Write a note on hypothesis testing in Simple regression models.
6. Write a note on hypothesis testing in Multiple regression models.
7. Write a note on Regression modeling

III. Long Answer Questions

1. Define and discuss blocking and confounding system in detail.
2. Elaborate practical components of industrial and clinical trial problems.
3. Discuss in detail different statistical analysis softwares used in pharma industry.
 UNIT- V

I. Multiple Choice Questions

1. Design of experiments is the design of any …………
A. Force
B. Task
C. Moment
D. All of the above
2. A factor is a ………… used to classify experimental units.
A. Fixed variables
B. Discrete variable
C. Both (A) and (B)
D. None of the above
3. Central composite designs are ….. ….. level full factorial.
A. One
B. Two
C. Three
D. Four
4. Special geometrics is ………….
A. Cube
B. Sphere
C. Both (A) and (B)
D. None of the above
5. Which among the following is properties and features of response methodology.
A. Orthogonality
B. Rotatability
C. Uniformity
D. All of the above
6. This type of design is one where all participants participate in all experimental
treatment conditions.
A. Factorial design
B. Repeated measures design
C. Replicated design
D. Pretest-post test control-group design
7. Response Surface Plot (3D) were first introduced by
A) George E.P Box & K.B. Wilson
B) George E.P Box & Fisher
C) Yates & Fishers
D) None
8. Which is the MOST EFFICIENT design with LESS NUMBER of experiments
A) Full Factorial Design
B) Fractional Factorial Design
C) Central Composite Design
D) Box- Behnken Design
 9. What are factors in a factorial design?
A. The independent variable
B. The dependable variables
C. The experimental variables
D. None of the above
10. A 2 X 2 factorial design…..
A. is called a one-way ANOVA
B. result in a four-cell matrix
C. cannot yield interactions
D. must include an organismic independent variable.

II. Short Answer Questions

1. Explain in general central composite design.

2. Write a note on surface response methodology.
3. Discuss 22 factorial designs.
4. Discuss 23 factorial design
5. Define and discuss about factorial design.
6. What do you mean by historical design?
7. Explain in detail optimization techniques.

III. Long Answer Questions

1. What do you understand by 22and 23 factorial design? Write advantages of factorial

design.
2. Discuss about surface response methodology for design, development and optimization
of product designs and processes.
3. Elaborate basic ofresponse surface methodology.