Research paper Variables for Matching

1. Mortality Risk Among Patients Used propensity score matching by:

With COVID-19 vs
2. Fluvoxamine Prescribed Selective
Placebo and 1.Age
1. Age
Clinical Deterioration in Outpatients 2. Sex
with Symptomatic COVID-19A 3. Race
Randomized Clinical Trial 4. Ethnicity or religion
5.Oxygen saturation, median (IQR) [range], %
6. Coexisting conditions
- Asthma
- Hypertension
- Diabetes
- High cholesterol
3. Safety and efficacy of 1.- Hyperthyroidism
Age
fluvoxamine in COVID‐19 ICU - Anxiety
2. Gender
4. Ongoing Use of SSRIs Does Not 1. Age
- Arthritis
Alter Outcome
5. Effect of earlyintreatment
Hospitalized
with 2.
1. Gender
- Depression
Age
fluvoxamine on risk of emergency - BMI
2.AgeSex
6. Identification of drugs associated 1. 7. Most severe COVID-19 symptom at baseline, No. (%)a
with reduced
7. Relation of severity of COVID-19
severe COVID-19 to – 1.2. sex of sense of smell
- Loss
Age
polypharmacy and prescribing of - Fatigue
2.Sex
8. Association between 1. Age aches
- Body
antidepressant use
9. Prospective Cohort ofand reduced risk 2. sex
1.- Cough
Age
Fluvoxamine
10. Observational Study of 2.
1. Race/ethnicity
- Subjective
Age fever
Hydroxychloroquine - Loss
2.AgeSex of appetite
11. Observational Study of 1.
- Chills
Hydroxychloroquine 2.- Shortness
Sex of breath
- Loss of taste
- Nausea
8. Duration of COVID-19 symptoms, median (IQR) [range],
 Source Link
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2786136
https://jamanetwork.com/journals/jama/fullarticle/2773108

https://pubmed.ncbi.nlm.nih.gov/34719789/
https://pubmed.ncbi.nlm.nih.gov/35011811/
https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(21)00448-4/fulltext
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574266/
https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-021-01907-8
https://www.nature.com/articles/s41380-021-01021-4#:~:text=This%20analysis%20showed%20a%20significant,significant%2
https://academic.oup.com/ofid/article/8/2/ofab050/6124100
https://www.nejm.org/doi/pdf/10.1056/NEJMoa2012410?articleTools=true
https://www.nejm.org/doi/pdf/10.1056/NEJMoa2012410?articleTools=true
 Concept Set-Option 1
Description Conceptset Domains Excluded Status # of
Hypertension ID and Name Used
HYPERTENS Concepts(16) NA Concept Under research
0
Diabetes ION
[PASC](v1) Concepts NA Construction
Under 0
Chronic Diabetes (v1) (126)
[ITM] COPD Concepts NA Construction
Under 0
obstructive
Obesity Chronic
[CVDT] (103)
Concepts NA Construction
Under 0
Cerebrovascular Obesity
[ITM] (v1) (178)
Concepts NA Construction
Under 0
disease
Cancer Cerebrovasc Concepts
[VSAC] (1,001) NA Construction
Finished 0
Chronic kidney Cancer (v9) Concepts
[CVDT] (3,808) NA Under 0
disease
Mood disorder Chronic
mood- (240)
Concepts(36 NA Construction
Under 0
Anxiety disorder disorder-56
anxiety- 4)
Concepts NA Construction
Under 0
Other psychiatric disorder-125
[HCUP] (131)
Concepts NA Construction
Finished 0
disorder
Asthma Schizophreni
[CVDT] (224)
Concepts NA Under 0
High cholesterol Asthma (v1) (659)
ARIScience - Concepts(22) NA Construction
Under 0
Hyperthyroidism Elevated
ARIScience - Concepts NA Construction
Under 0
Anxiety Hyperthyroid (77)
ARIScience - Concepts NA Construction
Under 1
Arthritis Anxiety - JA (292)
Arthritis_Elixh Concepts NA Construction
Under 2
Depression auser_UC (1,715)
Depression Concepts NA Construction
Under 0
BMI (v1) (23)
ARIScience - Concepts(8) NA Construction
Under 1
Loss of sense of BMI -
HartwickPed - Concepts(13) NA Construction
Under 1
smell
Fatigue College -
ARIScience - Concepts(14 NA Construction
Under 1
Body aches Fatigue
[RP- - JA 0)
Concepts NA Construction
Under 0
Cough 6B45AE]Bod- Concepts
ARIScience (189) NA Construction
Under 1
Subjective fever Cough(v2)
Fever - JA Concepts(94)
(62) NA Construction
Under 1
Loss of appetite 480262980 - Concepts
ARIScience NA Construction
Under 0
Chills Anorexia - JA (15)
hpo_0025143 Concepts NA Construction
Under 0
Shortness of -chills (v1) (3)
ARIScience - Concepts NA Construction
Under 1
breath
Loss of taste Dyspnea
Hartwick - JA (69)
Concepts NA Construction
Under 1
Nausea College - (13)
hp_0002018- Concepts(21) NA Construction
Under 2
Chronic cardiac nausea
[VSAC] (v1) Concepts NA Construction
Finished 0
disease
Uncontrolled Cardiac
[DATOS] (87)
Concepts NA Under 1
hypertension
Chronic kidney Hypertension
[CVDT] (77)
Concepts(24 NA Construction
Under 0
disease
Rheumatological Chronic
RHEUMATO Concepts0) NA Construction
Under 0
disorder
Chronic LOGIC
Other (146)
Concepts NA Construction
Under 1
neurological
Autoimmune Neurological
[VSAC] (154)
Concepts NA Construction
Finished 0
disease
smoking status Autoimmune (223)
smoking (v1) Concepts NA Under 24
chronic kidney 708602015
chronic (96)
Concepts NA Construction
Under 2
disease (CKD)
congestive heart kidney
CONGESTIV (16)
Concepts(33) NA Construction
Under 0
failure [CHF]
malignancy E HEART-
[DATOS Concepts NA Construction
Under 1
ischemic heart Charlson] (4,501)
ischemic_hea Concepts(15 NA Construction
Under 0
disease
diseases of the rt_disease- 9) Construction
circulatory system
diseases of the ARIScience - Concepts NA Under 1
respiratory
neoplasms Respiratory
Malignant (3,822)
Concepts NA Construction
Under 0
diseases of the neoplasms of (18,821) Construction
blood
certainand blood-
disorders disorder of Concepts NA Under 0
involving the
hydroxychloroqui immune
hydroxychlor (1,786)
Concepts NA Construction
Under 0
ne
remdesivir oquine
[CVD]Remde (362)
(v1) Concepts NA Construction
Under 1
azithromycin sivir
N3C (v1) (57)
Concepts NA Construction
Finished 7
tocilizumab Azithromycin Concepts
[DATOS] (2,480) NA Under 1
sarilumab Tocilizumab
Sarilumab (248)
Concepts(20 NA Construction
Under 0
dexamethasone Immunomodu
JAA 1)
Concepts(48 NA Construction
Under 0
lung disease Dexamethaso
ARIScience - 1)Concepts(1,1 NA Construction
Under 1
Statin Lung
ARIScience - 82)
Concepts NA Construction
Under 0
ACE Statin
[DATOS] - JA (21,958)
Concepts NA Construction
Under 1
Steroids ACE (23,132) Construction
DOAC or
Coumadin
Other Antibiotics
bronchiectasis [VSAC] Concepts(19) NA Finished 0
Essential Bronchiectasi
Essential Concepts NA Under 1
hypertension
Transplant Hypertension
ARIScience - (14)
Concepts NA Construction
Under 0
HIV Transplant
[ITM] - (325)
Concepts(25 NA Construction
Under 0
Angina pectoris HIV/AIDs
angina- (v1) 8)
Concepts NA Construction
Under 0
Acute myocardial pectoris-94
[HCUP] (34)
Concepts(10 NA Construction
Finished 0
infarction
Subsequent Acute 6)
myocardial
Certain current [HCUP] Concepts NA Finished 0
complications
Other acute Complication (6,385)
ischemic
Chronic heart Chronic Concepts NA Under 2
ischaemic heart
Cardiomyopathy Ischemic
[CVDT] (181)
Concepts NA Construction
Under 0
Heart failure Cardiomyopa
[ITM] Heart (186)
Concepts NA Construction
Under 0
Acute myocardial Failure
[HCUP](v1) (140) NA Construction
Finished 0
infarction Acute
 Concept Set-Option 2 Concept Set-Opti
Conceptset Domains Excluded Status # of Conceptset Domains
ID and Name
ARIScience - Used
Concepts Concept
NA Under research
3 ID and Name
[RHDT] Used
Concepts(76
Hypertension
ARIScience - (508)
Concepts(1,0 NA Construction
Under 2 Hypertension
[N3C] [ISC] 5)
Concepts
Diabetes
Chronic - JA 99)
Concepts NA Construction
Under 0 Diabetes
chronic (v2) (2)
Concepts
obstructive
UVA Obesity (52)
Concepts NA Construction
Under 17 obstructive
[CV]obesity (19)
Concepts
(v2)
[VSAC] (333)
Concepts NA Construction
Finished 0 (v1)
[DATOS - (5)
Concepts
Cerebrovasc
Charlson - (64)
Concepts NA Under 36 Charlson] -
ARIScience (764)
Concepts
Cancer (v1)
Chronic (559)
Concepts NA Construction
Under 1 Cancer - JA
chronic (4,533)
Concepts
kidney
Mood (114)
Concepts NA Construction
Under 1 kidney (110)
Disorder
Anxiety (v1) (363)
Concepts NA Construction
Under 0 UIowa - Concepts
Disorder (v1) (278) Construction Anxiety (131)
asthma (v1) Concepts NA Finished 7 Asthma (v1) Concepts
413507552 (115) 818292046 (115)

Anxiety (v4) Concepts NA Under 1 Anxiety Concepts

682922728
Arthritis, (272)
Concepts NA Construction
Under 1 Disorder (v1) (278)
quasi-
DEPRESSIO (1,286)
Concepts NA Construction
Under 0 Depression, Concepts
N (v1)mass
body (157)
Concepts NA Construction
Finished 38 Elixhauser
ARIScience - (31)
Concepts
index
Smell (v2)
and (6)
Concepts NA Under 0 BMI
[RP- - JA (v1) (5)
Concepts
Taste
fatigueLoss
(v1) (19)
Concepts NA Construction
Under 0 6B45AE]Impa
Fatigue (v1) (20)
Concepts
960162921 (28) Construction 582941549 (31)
Hartwick Concepts NA Under 1 [RP- Concepts
College -
hp_0001945- (65)
Concepts NA Construction
Under 1 6B45AE]Cou- (54)
ARIScience
fever (v1)
hp_0002039- (102)
Concepts NA Construction
Under 1 Fever - JA
anorexia
hp_0025143-(v1) (11)
Concepts NA Construction
Under 1 [RP-6B45AE] Concepts
chills (v1)
hp_0002094- (1)
Concepts NA Construction
Under 2 Fever or (v1)
Dyspnea (54)
Concepts
dyspnea (v1) (68) Construction 380655488 (60)

UVA Concepts NA Under 3

Hypertension
Chronic (61)
Concepts NA Construction
Under 1 chronic Concepts
kidney
[DATOS - (114)
Concepts NA Construction
Under 1 kidney (110)
Charlson]
ARIScience - (128)
Concepts(3,3 NA Construction
Under 1
Neuro - JA 58) Construction

congestive- Concepts NA Under 0 [DATOS - Concepts

heart-failure- (33) Construction Charlson] (113)
Hydroxychlor Concepts NA Finished 7 Hydroxychlor Concepts
oquine (v2) (356)
remdesivir Concepts NA Under 0 oquine [BA]
Remdesivir (308)
Concepts
(v1)
Azithromycin (1)
Concepts NA Construction
Under 1 (v2)
azithromycin- (46)
Concepts
[oneils] (v2) Concepts
tocilizumab (1,440) NA Construction
Finished 4 1-12 (v1)
Tocilizumab (2,595)
Concepts
(v1)
Sarilumab (248)
Concepts NA Under 4 (v2) (239)
(v1)
Dexamethaso (101)
Concepts NA Construction
Under 10 dexamethaso Concepts
ne (v2)
CHRONIC (441)
Concepts NA Construction
Under 0 ne (v1) (25)
LUNG
[DATOS] (437)
Concepts NA Construction
Under 1
Statins
[ICARIUS](v1) (21,900)
Concepts NA Construction
Under 2
ACE (22,423) Construction

hp_0002110- Concepts NA Under 1

bronchiectasi
Atlas 807 (23)
Concepts NA Construction
Under 10
N3C
organ (103)
Concepts NA Construction
Under 0
transplant
cci - (323)
Concepts NA Construction
Under 0 Charlson - Concepts
HIV/AIDS (158) Construction HIV (v1) (1)
[VSAC] Acute Concepts NA Finished 0
Myocardial (63)

[VSAC] Concepts NA Finished 0

Cardiomyopa
heart failure (149)
Concepts NA Finished 6 N3C Heart Concepts
(v1)
[VSAC] Acute (112)
Concepts NA Finished 0 Failure (v1) (118)
Myocardial (63)
Concept Set-Option 3 Concept Set-Option 4
Excluded Status # of Conceptset Domains Excluded Status
Concept
NA Under research
3 ID and Name
[AKI] Used
Concepts Concept
NA Under
NA Construction
Under 1 Hypertension
[VSAC] (44)
Concepts NA Construction
Finished
NA Construction
Under 0 Diabetes
[VSAC] (v1) (280)
Concepts NA Finished
NA Construction
Under 0 Chronic
ARIScience - (8)
Concepts(27 NA Under
NA Construction
Under 1 Obesity (v3)
[Cardioonc] 6)
Concepts NA Construction
Under
NA Construction
Under 1 Cerebrovasc
Cancer_Elixh (280)
Concepts NA Construction
Under
NA Construction
Finished 10 auser_UC
Chronic (3,765)
Concepts NA Construction
Under
Kidney (29) Construction
NA Under 1
Construction
NA Under 3 UIowa - Concepts NA Under
Construction Asthma (v1) (1) Construction

NA Under 0 hp_0000739- Concepts NA Under

Construction anxiety (v1) (355) Construction
NA Under 2 ARIScience - NA Under
NA Construction
Under 2 Depression
Ben BMI - Concepts NA Construction
Under
NA Construction
Under 1 Example (v1) (1) Construction
NA Construction
Under 1 hp_0012378- Concepts NA Under
Construction fatigue (v1) (49) Construction
NA Under 2 hp_0012735- Concepts(64) NA Under
NA Construction 0
Under cough (v1)
Hartwick Concepts NA Construction
Under
Construction College - (59) Construction
NA Under 0 [RP-6B45AE] Concepts NA Under
NA Construction
Under 0 Fever or (46) Construction
Construction

NA Finished 10 [VSAC] Concepts NA Finished

Chronic (61)

NA Under 2
Construction
NA Under 0 N3C Concepts NA N3C
NA Construction
N3C 18 Hydroxychlor (362) Validated
NA Validated
Under 0
NA Construction
Finished 6

NA Under 1 Dexamethaso Concepts NA Under

Construction ne [BA] (v1) (9,225) Construction

NA Finished 9

NA Under 0 [VSAC] Heart Concepts NA Finished

Construction Failure (v2) (72)
4 Concept Set-Option 5 Con
# of Conceptset Domains Excluded Status # of Conceptset
research
1 ID and Name
hypertension- Used
Concepts Concept
NA Under research
1 ID and Name
[VSAC]
0 bdc (v2) (v1)
Diabetes (141)
Concepts NA Construction
Finished 6 Hypertension
[Pitt N3C]
0 54654297 (547) Diabetes (v7)
1 OBESITY Concepts NA Under 0 obesity (v1)
1 (v1)
CEREBROV (77)
Concepts NA Construction
Under 0 229321427
2 ASCULAR
Cancer_wide (778)
Concepts NA Construction 0
Under
2 (v1)
[VSAC] (6,255) Construction
Chronic

1 [VSAC] Concepts NA Finished 0 [N3C] [ISC]

Asthma (v1) (144) Asthma (v1)

1 anxiety- Concepts NA Under 0 UIowa -

disorder-125 (131) Construction Anxiety
0 Depression_ Concepts NA Under 2
1 Elixhauser_U (165) Construction

1 ARIScience - Concepts NA Under 1 [RP-

Fatigue - JA (140) Construction 6B45AE]Fatig
2
1 [RP-6B45AE] Concepts NA Under 0 [RP-6B45AE]
Fever or (54) Construction Fever or
1

0 Chronic Concepts NA Under 2

Kidney (29) Construction
3 [OHDSI Concepts NA Under 0 [OHDSI
Cov19] (352) Construction Cov19]

0 [Pitt N3C] Concepts NA Under 0 ARIScience -

dexamethaso (1,475) Construction Drug

0 [AKI] Heart Concepts NA Under 1 All Heart

Failure (v1) (117) Construction Failure (v3)
 Concept Set-Option 6
Domains Excluded Status # of
Used
Concepts Concept
NA Finished research
0
(48)
Concepts NA Under 2
(90) Construction
Concepts NA Under 2
(375) Construction

Concepts NA Under 1
(51) Construction

Concepts NA Under 1
(131) Construction

Concepts NA Under 1
(25) Construction

Concepts NA Under 1
(46) Construction
Concepts NA Under 0
(352) Construction

Concepts NA Under 2
(6,242) Construction

Concepts NA Under 0
(141) Construction
 Concept Set-Option 1
Description Conceptset Domains Used Excluded Status # of
Anxiolytic ID and Name Concept research
Charlson index charlson Concepts(1) NA Under 0
OCD comorbidity
Obsessive Concepts(42) NA construction
Under 1
Psychiatric Compulsive construction
accident and
Psychiatric ED
non-
accident and ED
Psychotherapy
referrals
SSRI exposure
Sedative-
hypnotics
anxiety disorders Anxiety Concepts(278) NA Under 0
beta blockers Disorder
[DATOS] (v1) Drug (31,440) NA construction
Under 2
bipolar disorder Beta Blockers
[HCUP] Concepts(146) NA construction
Finished 0
chronic fatigue Bipolar and
syndrome
chronic pain ARIScience - Concepts(169) NA Under 1
eating disorders Chronic Pain- Concepts(38) NA
ARIScience construction
Under 0
weight fluctuation Eating construction
fatigue ARIScience - Fatigue
Concepts(140)
- JA (v3) NA Under Constru 1
lethargy 402442153
hospital
admission for
impulse control [HCUP] Concepts(47) NA Finished 0
disorders
irritability Disruptive,
anger
low income
melancholic
features
opioid and other [RHDT] Concepts(28) NA Under 2
substance use
phobic disorders Opioid Abuse construction
seasonal affective
disorder
tricyclic [DATOS] Concepts(4,290 NA Under 0
antidepressants
ADHD Tricyclic ) construction
BMI ARIScience - BMI
Concepts(8)
- Ped - JA (v2)
NA Under Constru 1
CAD 454694746
CAD ITM (v1) Concepts(312) NA Under 0
PTSD 719610090
PTSD - BCBI Concepts(11) NA construction
Under 1
T2Diabetes (v1)
Type 2 Concepts(17) NA construction
Finished 5
age diabetes
alcoholism alcoholism v2 Concepts(18) NA Under 5
benzodiazepines (v1)
[DATOS] Concepts(4,854 NA construction
Under 0
cancer Benzodiazepi
[VSAC] Cancer)Concepts(3,808)NA
(v9) construction
Finished 0
depression 122145229
Depression (v1)
Concepts(23) NA Under Constru 0
dyslipidemia 148488138 Concepts(17) NA
CardioOnc- Under 1
fibromyalgia Dyslipidemia construction
headache headache-23 Concepts(60) NA Under 0
hypertension (v1)
HYPERTENSION Concepts(16)
(v1) NA construction
Under Constru 0
insomnia 197465109
ARIScience - Concepts(36) NA Under 0
nausea Insomnia - JA Concepts(21)
hp_0002018-nausea (v1) NA construction
Under Constru 2
schizophrenia 1642067
schizophrenia Concepts(47) NA Under 0
sex -46 (v1) construction
smoking smoking (v1) Concepts(96) NA Under 24
stroke 708602015
Charlson - Concepts(107) NA construction
Under 30
venlafaxine Stroke (v1) -
ARIScience Concepts(4,212 NA construction
Under 0
tricyclic Drug
[DATOS] )Concepts(4,290 NA construction
Under 0
antidepressants
Psychotherapy Tricyclic ) construction
referrals
 Concept Set-Option 2 Con
Unique Conceptset Domains Excluded Status # of Conceptset
Counts in ID and Name Used Concept research ID and Name

12,029

773,346 anxiety- Concepts(13 NA Under 0 UIowa -

661,568 disorder-125 1) construction Anxiety
69,847

642,342
19,827

826,887 fatigue (v1) Concepts NA Under Constru 0 Fatigue (v1)

960162921 (28) 582941549

36,441

13,030 [NCATS Concepts(41) NA Under 1

Opioids] construction

98,051

body mass index

Concepts
(v2) NA Finished 38 ARIScience - BMI - JA (v1)
65622096 (6)
[N3C] [ISC] Concepts(18 NA Under 0 263016016
CAD_rama
69,047 CAD (v1) 9) construction (v2)
506,683 diabetes- Concepts(17) NA Under 0 [VSAC] Type
type-2-505 construction II Diabetes
alcoholism Concepts(10 NA Under 0
(v1) 6) construction
Charlson - Cancer
Concepts
(v1) NA Under Constru 36 ARIScience - Cancer - JA (v
166,855 535274723 (559)
DEPRESSIONConcepts
(v1) NA Under Constru 0 672055106
Depression, Elixhauser (v1)
70 147634576 (157) 809298289
hp_0002315- Concepts(12 NA Under 0 [VSAC]
headache 0)
ARIScience - Hypertension
Concepts - NA
JA (v2) construction
Under Constru 3 Headache
[RHDT] Hypertension (v2)
799270877 (508)
hp_0100785- Concepts(36) NA Under 1 119899917
insomnia (v1) construction
[HCUP] Concepts(22 NA Finished 0
Schizophreni 4)
CardioOnc- Concepts(3) NA Under 2 [Pitt N3C]
Smoking (v1) Concepts(65 NA
[neuro3x] construction
Under Smoking
1 UVA N3C(v1)
stroke (v1) 0) construction Stroke (v1)
 Concept Set-Option 3 Concept Set-Option 4
Domains Excluded Status # of Conceptset Domains Excluded
Used Concept research ID and Name Used Concept

Concepts(13 NA Under 1 Anxiety (v3) Concepts(27 NA

1) construction 163895217 5)

Concepts NA Under Constru 1 hp_0012378-fatigue

Concepts
(v1) NA
(31) 459484148 (49)

Concepts NA Under Constru 2 Ben BMI Example

Concepts
(v1) NA
(5)
Concepts(41 NA Under 27092666
1 Coronary (1)
Concepts(47) NA
4) construction Artery
Concepts(75) NA Finished 0 [DM]Type2 Concepts(64 NA
Diabetes 0)

Concepts NA Under Constru 1 Cancer_Elixhauser_UC

Concepts (v1) NA
(4,533)
Concepts NA Under Constru 721859940 (3,765)
2 ARIScience - Depression - JANA
(v2)
(31) 29772544
Concepts(45) NA Finished 0 [RP- Concepts(64) NA
Concepts(765)NA Under Constru 6B45AE]Hea
3 [AKI] Hypertension
Concepts
(v3) NA
382487596 (44)

Concepts(4) NA Under 3 [VSAC] Concepts(31) NA

Concepts(1,1 NA construction
Under Smoking
0 [N3C] or
[ISC] Concepts(10) NA
47) construction Stroke (v1)
pt Set-Option 4 Concept Set-Option 5
Status # of Conceptset Domains Excluded Status # of
research ID and Name Used Concept research

Under 1 hp_0000739- Concepts(35 NA Under 1

construction anxiety (v1) 5) construction

Under Constru 1 ARIScience - Fatigue

Concepts- JA (v3)
NA Under Constru 1
402442153 (140)

Under Constru 1
Under 1 coronary Concepts(15) NA Under 0
construction artery construction
Finished 7 [T2DM]Type Concepts(65 NA Under 0
2 Diabetes 0) construction

Under Constru 2 Cancer_wide (v1)

Concepts NA Under Constru 0
Under Constru 681718172 (6,255)
0 Depression_Elixhauser_UC
Concepts (v1)
NA Under Constru 2
743223706 (165)
Under 1 Hartwick Concepts(25) NA Under 1
construction
Under Constru College -
1 hypertension-bdc
Concepts
(v2) NA construction
Under Constru 1
179876469 (141)

Finished 0 [DATOS] Concepts(81) NA Under 4

Under 1 Tobacco construction
construction
 Concept Set-Option 6
Conceptset Domains Excluded Status # of
ID and Name Used Concept research

ARIScience - Concepts(29 NA Under 1

Anxiety - JA 2) construction

[RP-6B45AE]Fatigue
Concepts
(v2) NA Under Constru 1
351910165 (25)

CORONARY Concepts(22 NA Under 0

ARTERY 5) construction
[VSAC] Hypertension
Concepts
(v3) NA Finished 0
150036573 (48)
 Study 1 Study 2 Study 3 Study 4
Observational Retrospective Retrospective Retrospective
retrospective study study Case-Control
Outcomes
Death Y Y Y Y
Hospitalization Y
Admission to ICU
emergency
Need for mechanical ventilation/Intubation
Shortness of breath
Oxygen Saturation less than 92%
Transfer to /tertiary
Definition hospital
Timeframe considered for
Antidepressant or SSRI Usage
During hospital admission Y Y
Before Covid-19 Diagnosis Y
After Covid-19 diagnosis Y
Other
Variables Assessed
Age Y Y Y Y
Gender Y Y Y
Ethnicity Y
Race Y
Obesity Y
Smoking Status (Self-Reported) Y
Co-morbidities Y Y
Respiratory Rate Y
O2 Saturation Y Y
Blood Pressure Y Y
Temperature
lymphocyte to C-reactive protein ratio/ Y Y
plasma lactate levels) Y
Psychiatric Diagnosis/ ICD 10 Y
Medication History Y
Hospital Facility Y Y
Recieve SSRI Medication Y Y
Hospital Facility
Recieve Anti-Covid Drug Y
Consciousness Y
Need/No Need of O2 Y
Heart Rate Y
BMI
Respiratory Illness
Diabetes
Heart Disease
Medication Use
LDH Y
CRP Y
D-dimer Y
sNEWS and CX-score Y
Weighted Elixhauser comorbidity score
 Study 5 Study 6 Study 7 Study 8
Restrospective Retrospective Interventional Interventional overlap between various
Study Cohort Study Prospective Prospective hospitilizatoion and ICU end points..

Y Y
Y Y Y
Y Y

Y Y
Y Y
Y
Y

Y
Y

Y
(28 days
Y Y Y Y
Y Y Y Y
Y Y Y
Y Y

Y
Y
Y
Y
Y

Y
Sr no Article Title Link Study type Specific Location Outcomes Measured
Dataset /
Institutio
n
1 Association https://www.nature.com/articles/s41380-021-01021-4
Multicenter AP-HP Paris Lower risk of death or
2 between
Mortality Risk observationa Health Data
Multicenter Cerner Real US intubation
Death in patients
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2786136
3 Among
OngoingPatients retrospective
Multicenter World Data (across
Use of https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745642/
Epic EHR US Mortality
4 SSRIs Does Not retrospective
Retrospectiv EHR of (Provide
Fluoxetine use is https://elitmed.hu/en/publications/clinical-neuroscience/fluoxetine-use-is-associated-with-
Hungary Mortality
5 associated with e Case- Uzsoki
DrugWAS: Drug- https://ascpt.onlinelibrary.wiley.com/doi/full/10.1002/cpt.2376
Restrospecti EHR of VUMC, Primary Outcomes:
6 wide Association
Analysis of the ve Study VUMC
Retrospectiv Online US
The ->Death
https://www.cambridge.org/core/journals/bjpsych-open/article/analysis-of-the-impact-of-a
COVID-19 infection (Odds
7 impact of e Cohort medical
Intervention NA Rocklan
Missouri Ratio)
Fluvoxamine vs https://jamanetwork.com/journals/jama/fullarticle/2773108
Primary Outcomes
8 Placebo and
Effect of early al and ->shortness of breath or
https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(21)00448-4/fulltext
Intervention NA Brazil ->Hospitalisation defined
treatment with al as either retention in a
Exposure/ Definition/ Criteria / Definition for Case Variables assessed &
SSRI Drugs Timeframe for use compared
of anti-
depressants or
SSRI
->Fluoxetine Receiving any Inclusion Criteria ->Sex
->Fluvoxamine antidepressant
->Escitalopram At least once ->Adults aged
Inclusion Criteria18 years or over ->Age
->Age
oxalate within a
SSRIs except Use of SSRI period of ->COVID-19 diagnosis
Inclusion criteria: adult ->Sex
-age category
Fluvoxamine
Exposure to during admission
Exposure to patients 18 and
Inclusion Criteria:over admitted -gender
-->anti-COVID-19 drug
fluoxetine adjuvant fluoxetine
58 drugs were Exposure to a -->Results of an
Inclusion Criteria: antigen or combinations
-->Gender (Favipiravir,
selected
Antidepressant drug between
In-patients 3- ->Tested
during Inclusion:covid positive
In-patient of the -->Ethinicity
-->Gender
s
"- including June 2 to 31 July psychiatric center
Inclusion Critera and had -->Ethinicity
->Age
>Fluvoxamine
->Fluvoxamine 28 days post- ->Men and woman
Inclusion Criteria: age 18 and ->Gender
->Age
->Placebo random ->Patients
> older than 18 years ->Gender
Definition of Control
Group

Patients not
receiving anti-
Patients with
COVID-19 and18
Adult patients no
and overwho
Patients admitted
fit the
inlcusion criteria
Not exposed to the and
mentioned
Those who class
were of
Covid-19 negative
Patients on Placebo
Outcomes CPT code Snomed Code ICD-10 Code
Death
Death 419620001
Accidental Death 7878000
Death due to asphyxiation 74332007
Death in home 4.40081E+14
Death in long term facility 4.40021E+14
Death occuring in less than 24 hrs from onset of symptoms 274639009
Sudden death/Unknown cause R99
Death in hospital in emergency department 4.40041E+14
Hospitalization
Hospitalization in community hospital 305337004
Hospitalization in private hospital 305339001
Hospitalization for day care procedures 305344008
Hospitalization for long duration 305340004
Hospital admission for short term 50699000
Emergency Hospitalization 183452005
Hospitalization for observation 76464004
Hospitalization 99221 32485007
(first encounter between patient and admitting physician)
99222
99223
Subsequent Hospitalizations 99231
99232
99233
Hospitalization and Discharge on same day 99234
Admission to ICU 99235

Admission to ICU 99291

(first 30-74 to
Admission mins)
ICU 99292
(each additional
Admission to ICU30 mins beyond the first 74 mins) 305351004
Admission to adult ICU 305352006
Admission to respiratory ICU 183447000
Unexpected admission to ICU 397945004
Ventilation/Intubation
Endotracheal Intubation 31500 112798008
16883004
182686001
Changing of endotracheal tube 225719006
Intubation -Awake State 304341005
Ventilation assistance & management 94002 40617009
94003 266700009
710976005
Ventilation in prone position 870391004

Inhalation treatment 94640

94644
94645
Shortness of breath
Shortness of breath(Dyspnea) 397889019 R06.02
Shortness of breath (others/NOS) 267036007 R06.00
R06.01
R06.03
R06.09
Dyspnea dur to SARS-Cov 2 1.19981E+14
Oxygen Saturation less than 92%
Abnormal Blood Gas level R79.81
Pulse Oxymetry 94760
94761
Transfer to Tertiary hospital
Transfer to tertiary hospital 305341000
Transfer from other hospital or health care facility 4563007
 LOINC Code
Death
Hospitilization
ICU visit
Ventilator

33443-3 (LOINC code for Intubation)

LA19779-0 (for Endotracheal Intubation)
20564-1
24336-0
59408-5
Endotracheal Intubation
 Concept Set-Option 1

Description Conceptset ID and Domains Used Excluded Status # of research Conceptset ID and
Name Concept papers used Name
Expressions

Conditions (157) 29772544

147634576
Depression Concepts NA Underconstruction 0 ARIScience -
Depression(v1)
(157) Depression - JA

405733646,
[HCUP] Bipolar
Bipolar Disorder Condition (146) NA Finished 0
and related
disorders (v1)

894827268
[HCUP] 81854676
Schizophrenia
Schizophrenia Condition (224) NA Finished 0
spectrum and schizophrenia-46 (v1)
other psychotic
disorders (v1)

727648761
439814592
[VSAC] Smoking
Smoking Observation (31) NA Finished 0 [Pitt N3C] Smoking
or Cigarette Use
(v1)
(v2)
 341951608 739240275
General Anxiety Condition (272)
Anxiety Disorder NA Underconstruction 0 anxiety-disorder-
Disorder Observation (6)
(v1) 125 (v1)

Psychotherapy

405121773
466714408
[N3C] [ISC] Obesity
[VSAC] Obesity (v2)
Obesity (v1) Condition (19) NA Underconstruction 1

92868150 Condition (431)

875380843
ARIScience - Observation(18)
Metabolic Syndrom NA Underconstruction 0 Metabolic
Metabolic Procedure(3)
Disorders (v1)
Disorder - JA (v4)
ADHD
 Concept Set-Option 2

Domains Used Excluded Concept Status # of research Domains Used

Expressions papers used Conceptset ID and
Name
Condition
(189)
148488138
NA Underconstruction 0 Condition (23)
Depression (v1)
Observation
(14)

Condition (47) NA Underconstruction 0

708602015
Observation (4) NA Underconstruction 3 Observation (96)
smoking (v1)
 682922728 Condition (268)
Condition(131) NA Underconstruction 0
Anxiety(v4) Observation 4

Conditions (65) NA Finished 0

Conditions (2912) NA Underconstruction 0

 Concept Set-Option 3

Excluded Concept Status # of research papers used

Expressions Conceptset ID and Name

809298289
NA Underconstruction 0
Depression, Elixhauser (v1)

724900300
NA Underconstruction 24
CardioOnc-Smoking (v1
-Anxiety due to dementia
--Parental anxiety Underconstruction 0 736743636
-Performance anxiety hp_0000739-anxiety (v1)
 Concept Set-Option 4

Domains Used Excluded Concept Status # of research papers used

Expressions

Condition (31) NA Underconstruction 1

Observation (3) NA Ubderconstruction 1

Condition (349)
NA Ubderconstruction 1
Observation (6)
 Concept Set-Option 5

Domains Used Excluded Concept Expressions Status # of research

Conceptset ID and Name papers used

479644615
Condition (22) NA Underconstruction 0
Single episode major depression (v1)

-Non Smoker for medical reason

-Tolerant non-smoker
-Tobacco smoking condition unknown
-Non Smoker
-Non smoker for religious reasons
-Never smoked tobacco
506560962 -42742406
Observation 78
-Agressive non smoker Underconstruction 4
Condition 3
[DATOS] Tobacco Smoking (v2) -Intolerant non-smoker
-Exposed to tobacco smoke at work
-Current non-smoker
-Non-smoker for personal reasons
-Current non smoker but past smoking history unknown
-Non-smoker annual review
-
 Condition (274)
605158011 NA Underconstruction 1
Observation (18)
ARIScience - Anxiety - JA (v1)
 Concept Set-Option 6

Domains Used Excluded Concept Status # of research papers used

Conceptset ID and Name Expressions

743223706
Condition (165) NA Underconstruction 2
Depression_Elixhauser_UC (v1)
 972296545
Condition (131) NA Underconstruction 0
UIowa - Anxiety Disorder (v1)
 Concept Set-Option 1
Excluded
Conceptset ID and Domains
ICD-10 Concept
Name Used
Labelled Indications Expressions
Major depressive F32.0, F32.1, 537591858 Conditions None
disorder F32.2, F32.3, (159)
F32.4, F32.5 [HCUP] Depressive
disorders (v1)

Generalized anxiety F41.1 UIowa - Anxiety Conditions None

disorder (includes
Bulimia nervosa F50.2 Disorder (v1) (131)
Obsessive- F42 Obsessive Conditions None
compulsive disorder
Panic disorder F41.0 Compulsive Disorder
UIowa - Anxiety (42)
Conditions None
Post-traumatic stress F43.10, F43.12, Disorder (v1) (v1)
PTSD - BCBI (131)
Conditions Stockholm
disorder
Social anxiety F43.13 F40.11
F40.10, UIowa - Anxiety (10)
Conditions Syndrome,
None
disorder
Treatment Resistant F33.9 Disorder (v1) (131)
Depression
Bipolar depression F31.30, F31.31, 405733646, Condition None
Premenstrual F31.32
F32. 81 [HCUP] Bipolar and (146)
dysphoric disorder
Schizophrenia 894827268 Condition None
Smoking [HCUP]
727648761 (224)
Observation None
Psychotherapy [VSAC] Smoking or (31)
Obesity 405121773 Condition (19) None
Metabolic Syndrome [N3C] [ISC]
92868150 Obesity Condition None
ADHD ARIScience - (431)

Off-Label Indications
Binge eating disorder
Body dysmorphic
disorder
Fibromyalgia
Premature ejaculation
Paraphilias
Autism
Raynaud
phenomenon
associated with
menopause
Concept Set-Option 1 # of
Concept set ID Domains
Status research Relevant Concept IDs
and Name Used
papers used
Finished 1 29772544 Condition
ARIScience - (189)
Depression - JA
Observation
(14)

Under 1 Generalized anxiety disorder Anxiety Disorder Conditions

Construction 434613 (v1) (272)
Under 1
Construction
Under 1 Panic disorder with agoraphobia, Anxiety Disorder Conditions
Construction
Under 1 severe agoraphobic avoidance (v1) (272)
construction
Under 1 Social phobia Anxiety Disorder Conditions
Construction Concept ID (440690) (v1) (272)
Finished 0 405733646,
[HCUP]
Finished 0 81854676 Condition
Finished 0 439814592 (47)
Observation
[Pitt N3C] Smoking (4)
Underconstructio 1 466714408 Conditions
n
Underconstructio 0 [VSAC] Obesity
875380843 (65)
Conditions
n Metabolic (2912)
 Excluded Concept Set-Option
# of 2
Concept Status research Relevant Concept IDs
Expressions papers used
NA Underconstructio 0
n

None Underconstructio 0 Generalized anxiety disorder:

n

None Underconstructio 0 41 concept IDs for 'Panic Disorder'

n
None Underconstructio 0 Social phobia
n Concept ID (440690)
Condition (146) None Finished 0

None Underconstructio 0
None n
Underconstructio 3
n
None Finished 0
None Underconstructio 0
n
 Concept Set-Option 3
Excluded # of
Conceptset ID Domains Relevant
Concept Status research
and Name Used Concept IDs
Expressions papers used
148488138 Condition NA Underconstructio 0
Depression (v1) (23) n

739240275 Condition(13 NA Underconstructio 0

anxiety-disorder- 1) n

708602015 Observation None Underconstructio 24

(96) n
 Concept Set-Option 4 # of
Concept set Domains Excluded Concept Relevant
Status research
ID and Name Used Expressions Concept IDs
papers used
809298289 Condition None Underconstructi 1
(31) on
Depression,
Elixhauser
(v1)

682922728 Condition -Anxiety due to Underconstructi 0

Anxiety(v4) (268) dementia on

724900300 Observation None Ubderconstructi 1

CardioOnc- (3) on
 Concept Set-Option 5
Conceptset ID and Domains
Excluded Concept Expressions Status
Name Used

479644615 Condition None Underconstructio

Single episode major (22) n
depression (v1)

736743636 Condition None Ubderconstructio

hp_0000739-anxiety (349) n

506560962 Observation -Non Smoker for medical reason Underconstructio

78 -Tolerant non-smoker n
# of Concept Set-Option 6
Excluded # of
Relevant Concept set Domains
research Concept Status research
Concept IDs ID and Name Used
papers used Expressions papers used
0 743223706 Condition None Underconstru 2
Depression_ (165) ction
Elixhauser_U
C (v1)

1 605158011 Condition None Underconstru 1

ARIScience - (274) ction

4
 Relevant
Concept IDs
 Concept Set-Option 1

Description Conceptset Domains Used Excluded Concept Status # of

ID and Name Expressions research
papers used
Death Death-test Observation (141) None Under 0
Hospitilization version
Inpatient(v1)
or Visit (6) None Construction
Under 0
ICU admission critical
ICU_covidcare Observation (11) None Construction
Under 0
Ventilator (v1) construction
-Invasive Invasive Procedure (5) None Under 0
ventilation
-Non-Invasive ventilation
Noninvasive Procedure (7) None construction
Under 1
ventilation
-Mechanical Ventilation
N3C Procedure (135) Expired air construction
Under 8
Ventilation
Shortness of Mechanical
Dyspnea (v1) Observation (13)
Condition (60) ventilation
Able to complete Construction
Under 0
breath ID: sentence in one Construction
 Concept Set-Option 2 Concep

Conceptset ID Domains Used Excluded Concept Status # of

and Name Expressions research Conceptset
papers used ID and Name
Death (v1) Observation None Under 0
[RP-B9DD40] (136)
Visit (4) None Construction
Finished 1 Inpatient or
Inpatient
Intensive and
Care Observation Trauma intensive In progress 1 ER Visit
Unit [oneils] (12) care unit
Acute Procedure (5) None Under 1
Respiratory
NIPPV - Procedure (7) None construction
Under 1
Noninvasive
Mechanical Device (5)
Procedure Not available construction
Under 1 Kostka -
ventilation
ARIScience(v1)
- (103)
Condition (63) Borg Breathlessness Construction
Under 1 Mechanical
hp_0002094-
Dyspnea - JA Score: 0.5 very, very construction dyspnea (v1)
 Concept Set-Option 3 Concept Set-Option 4

Domains Excluded Status # of Domains Excluded

Used Concept research Conceptset Used Concept
Expressions papers used ID and Name Expressions

Visit (8) None Under 2

construction

Procedure Not available Under 1 Kostka - Procedure None

(39)
Condition None Construction
Under 2 Mechanical (30)
(68) Construction
pt Set-Option 4 Concept Set-Option 5

Status # of Domains Excluded Concept Status

research Conceptset Used Expressions
papers used ID and Name

Under 1 Kostka - Procedure Artificial ventilation Under

Construction Mechanical (135) finding Construction
 Concept Set-Option 6

# of Domains Excluded Status # of

research Conceptset Used Concept research
papers used ID and Name Expressions papers used

1
Pointers
-SSRIs are used as adjuvant drugs for a few treatments (fibromyalgia and bulimia ner
-The effect of SSRIs may take up to 6 weeks before the patients feel the effects of tr
Source
https://www.sciencedirect.com/science/article/pii/S0048969722017491
https://www.ncbi.nlm.nih.gov/books/NBK554406/