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Sympathomimetic Drugs A. Direct-Acting

This document summarizes various sympathomimetic, sympathomimetic, parasympathomimetic, and parasympatholytic drugs. It categorizes them based on whether they are direct-acting, indirect-acting, selective vs non-selective, and examples are provided for each category and subcategory. A wide range of adrenergic agonists and antagonists are listed, as well as cholinergic agonists and antagonists.

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ZEBINA PIE GENORING
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397 views4 pages

Sympathomimetic Drugs A. Direct-Acting

This document summarizes various sympathomimetic, sympathomimetic, parasympathomimetic, and parasympatholytic drugs. It categorizes them based on whether they are direct-acting, indirect-acting, selective vs non-selective, and examples are provided for each category and subcategory. A wide range of adrenergic agonists and antagonists are listed, as well as cholinergic agonists and antagonists.

Uploaded by

ZEBINA PIE GENORING
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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1.

SYMPATHOMIMETIC DRUGS  Xylometazoline


 Adrenergic agonists  Tetrahydrozoline
A. DIRECT-ACTING  Midodrine- use for Orthostatic hypotension
 Non-selective (Catecholamines) Alpha 2-Selective Agonist
 Epinephrine- a1, a2, B1, B2  Clonidine
o DOC: Anaphylactic shock  Methyldopa
 Norepinephrine- a1, a2 ,B1  Guanfacine
o DOC: Septic shock (systemic infection)  Guanabenz
 Dopamine- D1, B1, a1  Apraclonidine
o D1- vasodilation  ↑ GFR  Brimonidine
 Selective D1-Selective Agonist
Beta Non-selective/B1B2 agonist  Fenoldopam
 Isoproterenol- used for heart failure o For Hypertensive Emergency
Beta 1-Selective Agonist
 Dopamine- DOC: shock associated with renal B. MIXED-ACTING
failure  Ephedrine
 Dobutamine- DOC: Cardiogenic shock  Pseudoephedrine
Beta 2-Selective Agonist  Phenylpropanolamine
 Short-acting Bronchodilators (relievers)
 Salbutamol/Albuterol C. INDIRECT-ACTING
 Metaproterenol  Amphetamine-like (Releasers)
 Pirbuterol Amphetamine- Mgt narcolepsy
 Long-acting Bronchodilators Methamphetamine
(controllers) Phenmetrazine- appetite suppressants
 Salmeterol Phentermine- ↑ risk for pulmonary HTN
 Formoterol Methylphenidate- Mgt ADHD
 Fenoterol Modafinil- Mgt narcolepsy
 Bambuterol Tyramine
 Tocolytics- delays premature labor  Catecholamine Reuptake Inhibitors
 Terbutaline Atomoxetine
 Ritodrine Reboxetine
 Isoxsuprine Sibutramine- anti-obesity
Alpha 1-Selective Agonist Duloxetine
 Phenylephrine Milnacipran
 Methoxamine Cocaine
 Oxymetazoline
 Naphazoline
2. SYMPATHOLYTIC DRUGS Based on Membrane Stabilizing Activity
 Adrenergic antagonists  Pindolol
A. ALPHA-BLOCKERS  Propranolol
 Non-selective Alpha-Blocker  Acebutolol
 Irreversible- Phenoxybenzamine  Labetalol
 Reversible- Phentolamine  Metoprolol
 Alpha1-Selective Blocker Based on Presence of Alpha-Blocking Activity (Mixed
 Prazosin Alpha & Beta Blocker)
 Terazosin  Labetalol
 Doxazosin  Carvedilol
 Alfuzosin
 Tamsulosin
 Silodosin
 Indoramin
 Urapidil
 Alpha2-Selective Blocker
 Yohimbine
 Rauwolscine

B. BETA-BLOCKERS
Based on Selectivity
o Beta-Nonselective (rest of –olols)
o Beta1-Selective
 Bisoprolol
 Betaxolol
 Esmolol
 Acebutolol
 Atenolol
 Metoprolol
 Celiprolol
 Nebivolol
Based on Intrinsic Sympathomimetic Activity
 Carteolol
 Labetalol
 Acebutolol
 Pindolol
3. PARASYMPATHOMIMETIC DRUGS  Sarin
 Cholinergic agonists  Soman
A. DIRECT-ACTING
 Choline Esters C. CENTRALLY-ACTING
 Acetylcholine  Tacrine
 Methacholine  Donepezil
 Carbachol  Galantamine
 Bethanechol  Rivastigmine
 Cholinergic Alkaloids
Muscarinic Agonist
 Muscarine
 Pilocarpine
 Cevimeline
Nicotinic Agonist
 Nicotine
 Lobeline
 Varenicline
 Arecoline

B. INDIRECT-ACTING
 Reversible Anticholinesterase
Short-acting
 Edrophonium
Intermediate Acting/Long Acting (Carbamates)
 Neostigmine
 Physostigmine
 Pyridostigmine
 Ambenonium
 Demecarium
 Irreversible Anticholinesterase (Very Long-acting)
Organophosphates
 Malathion
 Parathion
 Ecothiophate
 Isofluorophate
Nerve gases
 Tabun
4. PARASYMPATHOLYTIC DRUGS  Mecamylamine
 Cholinergic antagonists  Trimethaphan
A. ANTI-MUSCARINIC  Neuromuscular Blocker
 Centrally-Acting Depolarizing NMB
 Scopolamine  Succinylcholine
 Biperiden Non-depolarizing NMB
 Benztropine o Isoquinoline derivative
 Trihexyphenidyl  Tubocurarine
 Mydriatic-Cycloplegic  Atracurium
 Atropine  Cisatracurium
 Homatropine  Doxacurium
 Tropicamide  Mivacurium
 Cyclopentolate  Metocurine
 Bronchodilator o Steroidal derivative
 Ipratropium  Pancuronium
 Oxytropium  Vecuronium
 Tiotropium  Rocuronium
 Aclidinium  Pipecuronium
 GUT (Bladder Disorder/Hyperactivity)
 Oxybutynin C. REGENERATOR (Cholinesterase)
 Trospium  Pralidoxime
 Darifenacin
 Solifenacin
 Tolterodine
 Fesoterodine
 GIT (Spasm)
 HNBB
 Dicyclomine
 Glycopyrrolate
 M1-Selective Blocker
 Pirenzepine
 Telenzepine

B. ANTI-NICOTINIC
 Ganglionic Blocker
 Tetraethylammonium
 Hexamethonium

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