Understanding Pleomorphism and

Isopathic/Homeopathy
Portions of this booklet are reprinted from the Materia Medica with permission of the
publisher, Semmelweis-Verlag. Copyright by Semmelweis-Verlag. All rights reserved.
Pleomorphic Product Sales, Inc.
PO Box 82430, Phoenix, AZ 85071-2430
ph: 602-439-7977, toll free fax: 888-439-7980, fax: 602-439-7996
C. Jackson ph: 520-541-1920, fax: 520-541-1906
September 1998


. .  
 - 



   
Günther Enderlein (1872–1968) of Germany was and is the researcher who will for-
ever be inseparable from Pleomorphism and Isopathic/Homeopathy. Enderlein built
on the research of Antoine Béchamp and proved that blood is not sterile, and that a
microorganism can appear in various developmental stages and in diverse forms,
without the loss of its specific characteristics. Through intensive research, Enderlein
came to the conclusion that the monomorphistic perspective of disease conditions
favored by Pasteur and others could no longer be maintained and that a pleomorphic
perspective more accurately reflected the disease process. Enderlein devoted his
whole life and all of his scientific work to proving this thesis and to developing the
isopathic/homeopathic medicine that rose from it.

  
Pleomorphism rests on the idea that every warm-blooded organism houses a primal
plant germ, which can change in form through environmental influences. Allopathic
medicine rests on monomorphism which assigns only a single form and function to
microorganisms and does not recognize cyclic developmental changes. Thus
pleomorphists believe in the fundamental mutability of form in microorganisms and
that microorganisms can abruptly change from an avirulent benign form into a poten-
tially virulent, i.e. pathogenic, form.

   ⁄ 

Enderlein discovered in 1916 that primitive microorganic forms prepared in a rem-
edy, when combined with change in the biological terrain of the body, can cause the
virulent forms to return to their original avirulent condition bringing healing to the host
body. He found that when the tiniest, mobile living forms of bacteria, which he called
“Spermits,” exchanged genetic material with higher developmental organisms, the
highly developed organisms became suddenly invisible, having been broken down to
their primitive avirulent forms. Using this knowledge, he developed isopathic/homeo-
pathic remedies from fungal cultures. When these living remedies contact virulent
microbial masses, the masses are induced to return to their avirulent form, and then
leave the body through the natural organs of elimination.

  -
The founder of Sanum-Kehlbeck acquired the original Enderleinian cultures. Sanum-
Kehlbeck has the sole right to manufacture these original formulas by Prof. Dr. Günther
Enderlein. While other companies have attempted to copy these products, only those
produced by Sanum-Kehlbeck and available in North America through Pleomorphic
Product Sales, Inc. are manufactured from the specific disease-eradicating strains
that came from Enderlein’s original research which are maintained in the German
repository for biological cultures. Besides these original Enderlein isopathic/homeo-
pathic remedies, Sanum-Kehlbeck has developed a number of other remedies based
on Prof. Dr. Enderlein’s research which are also dealt with in this booklet.

    , .

Pleomorphic Product Sales, Inc. was founded by Chrystyne M. Jackson as part of her
ten-year battle to bring these indispensable isopathic/ homeopathic remedies to North
America. PPS is the only source of these FDA-sanctioned remedies in North America
today. Mrs. Jackson has had extensive experience in the field of complementary
medicine through her work and has had personal knowledge of their effects since
she was healed of cancer and multiple sclerosis through alternative medicine. Only
such a person, who has had the benefit of regaining health through biological medi-
cine, could have had the conviction to complete this decade-long task.


  
The concepts of pleomorphism and symbiosis are in the current perspective insepa-
rable from the name of the great researcher and microbiologist, Professor Dr. Günther
Enderlein (1872–1968).

The basis for his work was the book by the French researcher A. Béchamp, titled
“Microzymas”. It described that a microorganism can, under precisely determined
preconditions, occur in diverse developmental stages and, especially also in diversi-
fied forms, without the loss of its specific characteristics. The microorganism may
vary from the smallest rungs of electron microscopic magnitude up to the large,
multinucleic and highly developed stages, such as of bacteria and fungi.

Moreover, Béchamp was able to prove that all animal and plant cells contain tiny
particles which continue to live after the death of the organism and out of which
microorganisms can develop. In this book, Béchamp laid the foundation for the con-
cept of pleomorphism. The view that microorganisms can undergo a considerable
variation in form, without losing their specific functions, stood and continues to stand
diametrically opposed to the prevailing opinion of monomorphism, which admits only
a single form and function to an organism. Naturally, that opinion has also resulted in
a monomorphistic view of every disease process. Thus, in contrast to the opinion of
Pasteur, that microorganisms simply exist without any developmental changes,
Enderlein through intensive research came to the conclusion that the monomorphistic
perspective of disease processes can no longer be maintained and had to be given
up in favor of a pleomorphic perspective. He proved that every organism houses a
primal plant germ in erythrocytes, which can very well become subject of a variation
in form through exogenic influences.

  

The opinion represented by pleomorphic bacteriologists of the fundamental change-
ability of forms holds the possibility for microorganisms to abruptly change from origi-
nally avirulent into potentially virulent conditions.

Enderlein devoted the bulk of his scientific work which stretched for more than 40
years, to the complex question of pleomorphism, symbiosis and cyclogeny of micro-
organisms. He published over 500 scientific articles. His chief work was titled Bacte-
ria Cyclogeny, Berlin, 1925. (It is currently published by Semmelweis Verlag, Hoya, in
the German language, soon to be published in English.) In this book he described in
detail the changes and development of the parasite in its variable forms and its cycle.

This research was initiated by Enderlein in the year 1916, while he was working on
typhoid. In blood using a darkfield microscope he observed mobile, tiniest living forms,
named Spermits, which copulated with higher organized structures, whereafter the
product of the copulation became suddenly invisible. Enderlein interpreted this as
sexual processes, whereby tiniest, final products occurred, which are not visible to
the eye of the light microscope. He named the symbiotic, primal plant germ in the
erythrocyte Endobiont. This Endobiont lives in genuine symbiosis with the host or-
ganism, that is, with mutual benefits. Through outer factors, the Endobiont can multi-
ply and develop—a process which can considerably disturb the symbiotic equilib-
rium. A healthy organism is capable of restoring the equilibrium. In this process, the
more highly developed pathogenic germs are broken down into avirulent primitive
forms through the copulation described by Enderlein. They leave the body through
the natural organs of elimination.


       
However, the capacity for regenerating symbiosis is usually massively weakened
through unhealthy lifestyles that are not in harmony with nature! Symbiosis is com-
pleted when the symbiont makes itself independent and becomes a parasite. In this,
the Endobiont undergoes 3 basic phases: colloid-bacterium-fungus. This means, it de-
velops from the apathogenic, non-mobile, tiniest albuminoid particle (Protit)—which is
to be classified in size with the viruses (0. 01 µm)—via the nonvirulent chondrit stage
into the parasitic, pathogenic stages such as bacterium and fungus. According to
Enderlein, they are not representing unchanging organisms that are independent of
each other, but altogether they form a singular, common cycle, which has its origin in
the colloidal, albuminoid substances that are contained inside of each particular cell.

    

Assisted by darkfield microscopy and using living blood, Enderlein was able to de-
liver clear proof of this vital, microbiological process in both its origin and cycle. As soon
as this vital happening leaves a defined condition of equilibrium, all signs of parasitism
occur, whereby out of the apathogenic symbionts (Protits and Chondrits)—with their
enzymatic and metabolic active properties, they develop pathogenic microorganisms.

This explains, according to Enderlein, that all diseases of the Endobiosis complex
are based on the upward development of the Endobiont into higher valenced, para-
sitic growth forms with their own metabolism that is harmful for body fluids. These
disease processes are difficult to fathom, as they make themselves known in the
beginning by functional disturbances in most diversified organs, such as, by head-
aches, high or low blood pressure, feeling poorly, unmotivated attitude, lack of appe-
tite, drab complexion, coated tongue, wounds in the mouth, pimples, sores, hoarse-
ness, catarrhs, ear noises, diarrhea, lowered capacity for seeing and hearing, de-
pressions, weak concentration or poor memory.

Diseases, however, also indicate healing processes, which attempt to return a dis-
turbed symbiosis to the original healthy condition. Whether the biological self-healing
forces of the organism will win over the disease, or whether the symbiont is able to
develop unchecked into a parasite, depends on the condition of the milieu in which
the disturbance plays out. If the inner milieu is damaged through unhealthy nutrition
and lifestyles, with their resultant disturbance of the acid-base equilibrium, through
environmental toxins, through constant infections, or even through psychological de-
pressions, then our self-healing forces are incapable of restoring our symbiotic equi-
librium. Disease will manifest and damage the body. According to Enderlein, the mi-
lieu-conditioned cyclogenetic rise into higher stages of those microorganisms devel-
oped from the symbiont always determine the disease.

   

Enderlein developed Isopathic Therapy with its specific biological remedies for all
nonspecific, general symptoms that pertain to the Endobiosis Complex, based on the
knowledge of the mutability of forms and the fact of the biological, and essential for
life symbiosis between the mammal organism and the Endobiont. This unique per-
spective, at that time, distinguishes Enderlein as a pioneer of a modern, ecological
world-view and puts monomorphism, which is still being taught, in question.

In his Bacteria Cyclogeny, Enderlein describes the development of the two mold fungi
species Aspergillus niger van Tieghem (SA 4-20) and Mucor racemosus Fresen (SA
4-11), beginning from the primitive phases as tiniest colloidal albuminoid particles,
via the bacterial phase, up to the fungal stage.


 Both fungal species, which are likely obtained transplacentally, can occur as
Endobionts in all their developmental stages within mammal bodies. Although their
occurrence may be more or less frequent, they are to be seen as the cause of numer-
ous ailments. The tubercular and paratubercular diseases, caused by pathogenic
Aspergillus stages, do not occur quite as frequently as the disease processes more
frequently caused by pathogenic Mucor phases arising from the Mucor symbiosis.
The presence of the Endobiont in mammal organisms has been termed Endobiosis
by Enderlein since 1946. By this are meant the apathogenic, low valanced phases of
the Mucor racemosus Fresen (SA 4-11) (Protits, Symprotits, Chondrits, Fibrin). Fibrin
is the highest developmental form of the Chondrit, before the Endobiont changes
from the primitive phase into the bacterial phase (analogously to Siphonospora
polymorpha v. Brehmer). In these lower valences, the symbiont supports the metabo-
lism of the host organism, thus strengthening the defense. The higher the Endobiont
rises in its developmental series, the more it increases in toxicity. The upward devel-
opment of the Endobiont via the Chondrit form and higher is the cause for the
endobiontic diseases, up to the death of the host organism. In the course of this
process, the Endobiont is most likely partaking in the development of tumors. In the
stages of precancerosis, one finds higher valenced Endobionts in the blood. Accord-
ing to Devrient, the cancer problem cannot be solved without regard to blood parasit-
ism and polymorphism of the microorganisms. For Enderlein, “cancer is for the host
organism a fermentation and decomposition condition, forced upon it by a parasitic
fungus and its developmental forms.”

Because the Endobiont devours protein greedily, its upward development and the
Endobiosis or congestion resulting from it are especially co-created through improper
nutrition. Among these diseases belong vascular changes, pathological coagulatory
processes, geloses, rheumatism, arthritis, spondylosis, tonsillitis, lymphogranuloma-
tosis, diabetes, gout, tumors of every type (even those that are benign and their
prestages), anemia, leukemia, cerebral sclerosis and paralyses.

The restriction of protein intake causes the return to lower phases, which then leave
the body via the organs of excretion.

      

Another possibility for the breakdown of higher forms into lower stages is the exog-
enous supply of the so-called Chondritins in the quoted isopathic therapy. According
to Enderlein, Chondritins are apathogenic, low developmental stages of diverse fungi,
which can be either of a specific nature, as in the Mucor racemosus Fresen (SA 4-11)
and Aspergillus niger von Tieghem (SA 4-20), or of an unspecific nature such as in
Penicillium notatum (SA 4-30) and Penicillium frequentans (SA 4-31). The specific
Chondritins metabolize the virulent, parasitic microorganisms by copulation, thereby
initiating their breakdown. The nonspecific Chondritins act as stimulating irritants by
supporting the defensive capacity of the human organism through absorbing the fer-
ments of foreign microbes.

Chondritins from diverse mold fungi and yeasts are available for application, for ex-
ample, in the following preparations (see Table of Contents):

Pleo™Alb (Albicansan), Candida albicans

Pleo™Ex (Exmykehl), Candida albicans, Candida parapsilosis, Penicillium roquefortii

Pleo™Fort (Fortakehl), Penicillium roquefortii


 Pleo™Lari (Larifikehl), Laricifomes officinalis

Pleo™Mucedo (Mucedokehl), Mucor mucedo

Pleo™Muc (Mucokehl), Mucor racemosus

Pleo™Nig (Nigersan), Aspergillus niger

Pleo™Not (Notakehl), Penicillium chrysogenum

Pleo™Pef (Pefrakehl), Candida parapsilosis

Pleo™Pin (Pinikehl), Fomitopsis pinicola

Pleo™Quent (Quentakehl), Penicillium glabrum

Pleo™Rub (Ruberkehl), Aspergillus ruber

Pleo™Sancom (Sankombi), Mucor racemosus, Aspergillus niger

These remedies have been developed partly by Enderlein himself and partly on the
basis of his most valuable research. They act in the way of isopathy; that means, they
are not directed against the disease or its symptoms, but they support the body’s own
capabilities for regeneration, whereby genuine healing processes become possible.
Isopathic Therapy nonviolently normalizes the symbiontic equilibrium between the
Endobiont and its host organism on a basis of species-identical organisms.

In addition, through the administration of the so-called anti-Chondritins (Pleo™Muc

Ex) and Pleo™Nig Ex, antibodies for the fungal Chondritins, both their breakdown
and their elimination through the urinary paths, the bronchi, the skin, and especially
the intestine, can be accelerated.

The preparations Pleo™Lari, Pleo™Rub, and Pleo™Pin represent fungal prepara-

tions, which have had traditional healing reputations in folk medicine; these prepara-
tions are produced as isopathic substances based on the knowledge of Prof. Dr.
Enderlein.

      

Pleo™Alb holds a special position among the isopathic preparations. This prepara-
tion contains Chondritins of Candida albicans in diverse homeopathic dilutions as its
active substance. The therapeutic principle of the Candida preparations is based on
the dimorphism of the yeast organism, sometimes also referred to as “Soorpilz”. The
organism may exist in several growth forms or developmental phases, as yeast and
as fungus. Consequently, it is living proof for the accuracy of Enderlein’s Theory of
Pleomorphism. In its yeast form, the organism exists as a single cell. Candida yeasts
are saprophytic, which become pathogenic only under certain preconditions. A weak-
ened immune system, or antibiotic treatment, promotes the pathogenicity of Candida
yeast cells enormously. They are the cause for the far-spreading Candidiasis in the
form of a superficial colonization on mucous membranes.

If the infested host cell dies, the yeast cell comes into contact with dissolving cell
fragments and the cell fluid. This is the signal for the yeast cell to rise within the
cyclogenetic series into a parasitic, mycelia forming fungus, which then grows
invasively into the tissues and, thereby, initiates the widening of tissue lesions.


 The preparation Pleo™Alb takes this dimorphism (the varying between yeast and
fungus) into account in the therapy.

Researchers have succeeded in cultivating the microorganism as yeast phase and also as
fungal phase, side by side, through appropriate conditions of cultivation. Therefore, the
superficial mucous membrane associated forms of Candidiasis, the deeper settled, tissue
infiltrating infections, and also massive intestinal mucosal forms can become therapeutic.

Moreover, the well-proven preparation Pleo™Pef is available for Candidiasis therapy.

It can also be applied, among other possibilities, as a cross antigen reaction that is
effective for superficial Candida albicans infections. Pleo™Pef is a preparation from
the yeast form of Candida parapsilosis, which is predominantly isolated from the
skin, from nail bed infections, Otitis externa and Endocarditis in human beings; a
most effective preparation. A must for every practice!

Pleo™Ex represents a combination of Candida albicans, Candida parapsilosis and

Penicillium roquefortii.

    

In the application of isopathic preparations, the guiding rule is that an increase in the
dosage may be undertaken only when the previous or identical dosages no longer
bring effective action. Every overdose has an excessive production of toxic decompo-
sition forms as its consequence. The task of the tissues in removing these decompo-
sition products out of the body, namely through the skin, the intestine, the urinary
passages and the bronchi—can, then, only be insufficiently or not at all fulfilled. In the
case of massive disease foci, such a condition can occur even with greatest precaution,
and it can bring the healing processes to a slower pace or even stop them. By repeated
injection of detoxified active fungal antibodies (Anti-Chondritins), the elimination of
each form of decomposition is accelerated and, thereby, the effectiveness of the
isopathic preparation becomes enhanced. The darkfield examination of the blood
reveals such “toxic” conditions, caused by the congestion of endobiontic decomposi-
tion products. At such times there is a fundamental need to look well to the effective
functioning of the organs of elimination (stool, urine, sweat, sputum). Under circum-
stances, a detoxification therapy (enemas, baths, teas, electrolytes) may be required.

The decomposition products of the Endobiont that are eliminated on an ongoing

basis without treatment under healthy conditions may, in patients, again adopt higher
valences or higher developmental stages during their outward passage through the
skin, intestine, urinary paths and bronchi. This way, especially in cancer cases, short
rods frequently form in the intestines. Because they are shaped like coli bacteria,
they are easily misinterpreted as degenerated coli bacteria. These forms are usually
easily decomposed within 12 hours after administration of the relevant capsule form,
which decompose them again into the Chondrit stage. These forms, which are also
referred to as Paracoli, cause intense constipation and must be closely watched in
cancer cases. For this reason, Isopathic Therapy plays an important role also in the
treatment of obstipation and dysbacteria.

Because Pleo™Muc (Mucor racemosus) also effects decongestion of agglutinated

erythrocytes, leucocytes, thrombocytes, etc., an appropriate massage of connective
tissues and muscles is of especially supportive significance. The myogeloses, painful
points, etc. affected thereby are nothing but the accumulation of low-valanced devel-
opmental stages.


 Every isopathic treatment can be performed with oral, inhalable, or percutaneously
rubbed-in preparations, suppositories, or through injection. These diverse forms of ap-
plication can be combined or alternatively administered, according to the situation of
the case. The intake, inhalation and rubbing are milder in effect and suitable for prophy-
lactic treatment during the intervals that are free from injections, and for follow-up
treatments. Drops are also very effective when dropping 1-2 drops into each nostril.

   (not available in the USA)

In general, one begins an injection series with the weakest strength (for example,
7X). In case of no reaction, one changes to 6X and finally to 5X.

    

Fungal antibodies (Antichondritins) serve for freeing the blood of stronger infestation
by decomposition products of the Endobiont after Chondritin injections. These do not
affect the higher cyclic forms, such as bacteria, but only the decomposition products
in the primitive phases. On the first or second day after administering injections, 1 ml
is injected s. c. or i. m.; this can be repeated in identical intervals.

 
Percutaneous application, according to the style of the Ponndorf Inoculation or the
Baunscheidt Method, raises the effectiveness of the isopathic remedy. In the area of
the diseased organ, or else in the elbow bends or groin, 5–10 drops daily, or at longer
intervals, externally rubbed in on injection-free days. Eye drops are dropped into the
palpebral tissue. The ointment is applied thinly on the affected skin portions 1–3
times daily, or spread knife-thick onto the bandage.

   
Using a sterile pocket inhalator, the drop form is externally inhaled; 10–20 drops
inhaled deeply, 2–3 times daily through the mouth and nose. The inhalator must not
contain even a trace of any cleaning agent!

 
The oral fungus preparations support the effect of the injected, rubbed in and inhaled
preparations; they have, moreover, a local impact on disease processes, especially
in the gastro-intestinal canal. Tablets or capsules can be taken with or without food.
One swallows the capsules with a little water. The tablets should be allowed to melt
under the tongue.
The appropriate combination of preparations from the endobiontic series is definitely
possible and useful. However, Pleo™Not (Penicillium chrysogenum) must not be taken
simultaneously with Pleo™Muc ( Mucor racemosus ), Pleo™Sancom ( Mucor
racemosus/Aspergillus niger) or Pleo™Nig (Aspergillus niger) because these prepa-
rations weaken or nullify their effects mutually (antagonism).

 
The normalization of the blood pH must be given very special significance in all dis-
eases of the Endobiosis complex. This is especially required if the patient’s blood
shows a Protit veil after a Chondritin injection, because it always points to a raised pH
or rH2 value of the blood. The stress that is thereby exerted on the circulation of the
blood aggravates or blocks the desired copulation of the Chondrits. An injection of
L(+) lactic acid (Pleo™San) several minutes before the Chondritin injection is recom-
mended for the necessary adjustment of the pH value.


 In regard to additional biological therapy in general, the therapist naturally remains in
control of all possibilities during the period of isopathic treatment.

Unfortunately, there continues to be insufficient awareness that the presence of a

focal disturbance field can limit or cancel the effectiveness of every holistic treatment.
It should be a precondition to examine the patient and to undertake sanitizations before
the administration of isopathic/homeopathic preparations. Not only should the usual
foci in teeth, tonsils, paranasal sinuses, intestine, etc. be considered, but also the amal-
gam fillings play an important part in the sense of focal toxicoses through years of
releasing mercury. The replacement of these fillings by neutral materials is desirable.

An article by Dr. med. A. Baum on “Paravertebral Whealing” (Sanum Remedy Pro-

duction Book {yellow}) points out the importance of a possible Neural or Segment
Therapy. This opens many possibilities, regardless of whether one wishes to apply
only the blocking infiltration methods, acupuncture, or manual forms of therapy.

In diseases from the Endobiosis complex, and especially in cases of overweight, a

diet rich in vitamins and vital substances, low in calories, giving concentrated nutri-
tion, is of fundamental importance. It is a precondition, not only for the healing proc-
ess, but also for the effectiveness of every isopathic and immunobiological treatment
of endobiontic conditions. Nutritional intake requires special attention in cases of
Endobiosis, including cancer. It should be lacto-vegetarian, rich in raw foods and
devoid of superfine flour and sugar, as well as all addictive substances. With a veg-
etarian diet, attention must be given to include sufficient lactic acid food for the body.

 
    
Beside the previously described isopathic preparations of the fungal phase, the
immunobiological preparations from the bacterial phase fill an important place in
biological therapy:

Pleo™Art “A” (Arthrokehlan “A”), Formol toxoid of the Propionibacterium acnes DSM 4217

Pleo™Art “U” (Arthrokehlan “U”), Formol toxoid of the Corynebacterium sp. DSM 4223

Bovisan, Mycobacterium bovis

Pleo™Lat (Latensin), Bacillus cereus M. U. 345 a* (DSM 5194)

Pleo™Lep (Leptucin), Propionibacterium avidum

Pleo™Rec (Recarcin), Bacillus firmus SA. C. 501* (= DSM 4816)

Pleo™San Series (Sanukehl), Hapten preparations from typical nosode germs

Pleo™Ut (Utilin), Bacillus subtilis M. U. 345* (= DSM 5330)

Pleo™Ut “S” (Utilin “S”), Mycobacterium phlei F. U. 36* (= DSM 4817)

The immunobiological preparations contain diverse fractions of various bacterial spe-

cies, such as intact cells, cellular extracts, cell wall fragments of polysaccharides.
Only especially suitable strains that were cultivated under specific conditions (note
strain numbers) are being applied; their effectiveness has been proven by decades of
application. They are capable of stepping into the course of a physical immune reac-
tion and to raise the immune system’s capacity for response through their nonspe-


 cific stimulation. This takes place through their influencing diverse sub-populations of
lymphoid and phagocytizing cells which take part in the immune functions. For in-
stance, they indirectly take part in the structuring of humoral antibodies.

  

   
. 
Mycobacteria and their fragments effect a strong stimulation of the T-cell system,
inducing cellular defense reactions. This is primarily utilized therapeutically in tumor
diseases, among others (J. Hartmann, Therapeutikon 9, 1990).

Therapy with the preparation Pleo™Ut “S” goes back historically to the application of
a pathogen of the sea-turtle tuberculosis for the treatment of pulmonary tuberculosis
by Professor Friedmann in the 1920s. Therefore, an outstanding immunotherapy be-
came possible, which worked similarly to the officially sanctioned BCG inoculation,
but without the occasional serious side effects. This preparation was further devel-
oped into an identically effective preparation of Mycobacterium phlei from the special
strain FU 36. In recent years, the immunostimulating properties of the cell-wall parts
of the Mycobacterium have been intensively researched, whereby the equivalence of
diverse mycobacterial species has been discovered. A focal point for therapy with
BCG (Mycobacterium bovis) in modern tumor treatment is presented in its instillation
for cancer of the bladder. Here, also, the effectiveness of the Mycobacterium phlei FU
36 has proven itself as comparable.

.  
In folk medicine, tea decoctions using hay, excrement from cows, or peat moss have long
been used, without any knowledge of their containing Bacillus subtilis as active agent.
Farmers in many countries utilized hay infusions for curing intestinal diseases in cattle.

As early as 1887, Metchnikoff described the growth-inhibiting effect of aerobic soil

bacteria, particularly of Bacillus subtilis, in contrast to pathogens such as Strepto-
cocci, Staphylococci, Salmonella and Mycobacterium tuberculosis.

Works by Ramon and Richou, as well as Jansen and Hirschmann showed in 1943/44
the antitoxic and antibiotic properties of that pathogen, which was generally referred
to as “Hay bacillus”.

However, the first reports about the oral, subcutaneous and intravenous application
of Bacillus subtilis strains were published in the years 1938/39 with
outstanding therapeutic results. Particularly, its effectiveness with certain pseudo-
tubercular forms was discovered at that time. The general stimulation effect on the
nonspecific defensive capacity of the human organism already showed up in these
beginnings of Subtilis Therapy. The name UTILIN has been used under trade mark
protection for this new, special remedy since 1939. In later years, additional Bacillus
strains that are closely related to Bacillus subtilis found their entry into the therapy
under the terms of Pleo™Lat and Pleo™Rec.

Preparations with Bacillus species have manifold immunostimulating effects. Clinical

studies yielded good success in recurring diseases of the urinary passages and the
breathing organs in patients with defective immune situations in food allergies, as
well as other chronic diseases that were brought about by a reduced immune status
(J. Hartmann, Therapeutikon 4, 1990).


.   
The immunobiological preparations Pleo™Art “A” and Pleo™Art “U” were developed
from the Siphonospora polymorpha bacterial cultures of Dr. von Brehmer that were
made into the preparations Toxinal and Arthrisinal.

Von Brehmer (1883-1958), a contemporary of Enderlein (1872-1968), originally devoted

himself to virus research involving diseases of plants and animals. During the examina-
tion of an accidentally received human blood sample, he discovered also microorgan-
isms that were partly moving and partly of immobile nature. He gave them the name
of Siphonospora polymorpha. He was able to prove that even the smallest fluctua-
tions of the blood pH value within the alkaline area effected the cyclogenetic upward
development of the Siphonospora toward their pathological stages. However, in acidic
milieu, these higher stages fall apart again into their apathogenic, tiniest develop-
mental stages. These works brought additional proof for Enderlein’s publications on
pleomorphism and the cyclogeny of the Endobionts released at the identical time.

Beginning 1935, von Brehmer researched an avirulent Siphonospora vaccine for thera-
peutic purposes. The first material was obtained from a gangrenous tooth pulp and
root granuloma. From these sources, von Brehmer developed the preparation Toxinal,
which was applied for rheumatic arthritic diseases, neuralgia and Herpes zoster, and
Arthrisinal, a formol toxoid from highly active rod cultures, with its chief area of indica-
tion, the cancer diseases.

The original cultures of Dr. von Brehmer’s Research Institute were later purified and
identified, the Propionibacteria and Corynebacteria species were then isolated from
them. These improved cultures are now forming the basis of the preparations Pleo™Art
“A” and Pleo™Art “U”.

An additional therapeutic development with Corynebacteria followed in the applica-

tion of Corynebacterium parvum for infection prophylaxis. This strain was later re-
classified as Propionibacterium acnes. The activation of the monocyte-macrophage
System is a general characteristic of the species Propionibacterium. Its antibacterial,
antiviral, antiparasitic and antitumoral action are the result.

The latter, in particular, have been intensively examined in the strain Propionibacte-
rium avidum. Its stimulatory effects on the hematopoietic system qualify it in the im-
mune therapy especially in the treatment of myelosuppressive side effects of a cyto-
static or radiation therapy.

.  
The newly developed product series of Pleo™San preparations is based on a special
production process, in which the polysaccharides of bacteria are extracted. These prepa-
rations are to be considered haptens, made of typical pathogenic Nosode germs, and
defined as “antigen absorbers” (Cornelius). Their active principle is based on the bind-
ing of the pathogen antigens or pathogen toxins. The latter are commonly mobilized out
of their body depots within a therapy with corresponding nosodes. In this way they
effect a first reaction. However, persistent antigens can be a considerable obstruction
for a nosode therapy. In such cases, the matching SANUKEHL preparation for each
nosode is to be applied as middle agent, in order to restore the full nosode efficacy.

Pleo™San ACNE, Hapten from Propionibacterium acnes

Pleo™San BRUCEL, Hapten from Brucella melitensis


 Pleo™San CAND (Sanukehl Cand), Hapten from Candida albicans of Serotypes A and B

Pleo™San COLI (Sanukehl Coli), Hapten from Escherichia coli

Pleo™San KLEBS (Sanukehl Klebs), Hapten from Klebsiella pneumoniae

Pleo™San MYC (Sanukehl Myc), Hapten from Mycobacterium bovis

Pleo™San PROT (Sanukehl Prot), Hapten from Proteus vulgaris

Pleo™San PSEU (Sanukehl Pseu), Hapten from Pseudomonas aeruginosa

Pleo™San SALM (Sanukehl Salm), Hapten from Salmonella enteriditis

Pleo™San SERRA (Sanukehl Serra), Hapten from Serratia marcescens

Pleo™San STAPH (Sanukehl Staph), Hapten from Staphylococcus aureus

Pleo™San STREP (Sanukehl Strep), Hapten from Streptococcus pyogenens

Pleo™San TRICH (Sanukehl Trich), Hapten from Trichophyton verrucosum

 
  
The purpose of applying bacterial suspensions consists in the generation of an ac-
tive immunity in the living organism by artificial means. This is achieved by exerting
specific and nonspecific stimulation through application of substances into the or-
ganism, which cause tissue cells to become stimulated, and the body to form defen-
sive substances. From the type and amount of these formed substances one can
then estimate the degree of currently existing immunity. To be sure, it is possible for
active immunity to exist under certain circumstances, without proof that humoral bod-
ies are circulating in the blood. However, these substances can immediately reoccur
when a new impulse is given to the reactive tissue through a renewed administration
of preparations or through specific or nonspecific stimulants.

  

Occasionally, a first immune response occurs because the immunologic prepara-
tions contain biological substances. Therefore hypersensitivity is possible, in which
case the remedy should be discontinued.

  
  
The preparations can either be given parenterally, that is, bypassing the gastro-intes-
tinal tract, or (orally) through the intestinal tract.
The parenteral intake guarantees a good and generous immunity. One can inject
subcutaneously, intramuscularly and intracutaneously. Finally, also the percutaneous
and nasal administration can be used by rubbing the suspension into the skin or
dropping into each nostril.

 
The oral application of the immunobiological preparations in capsulated form, espe-
cially for certain reasons of suitability, for prophylaxis of diseases of the digestive tract,
is preferred. Orally taken preparations are intended for reaching immunity and reducing
sensitivity toward the relevant infectious pathogen. If a quick and lasting immunization

 is the target, one can first bring about a basic immunity through a subcutaneous
injection. Then, this effect can be maintained and increased through oral intake.

 (not available in the USA)

The injecting process of the injection solution must occur slowly and under sterile
conditions. Only disposable syringes are to be used.

Important Comment: The ampules must be shaken before use in order to assure
even distribution of the bacterial suspension.

  (not available in the USA)

Subcutaneous injection is recommended when one targets a lasting effect through
slow absorption. Therefore, this type of injection is recommended especially for pro-
phylactic purposes, when one wishes for a maximally long lasting immunity. For the
injection, one must naturally avoid locations near the periosteum or nerves and, in-
stead, inject where the correspondingly developed subcutaneous tissue and the
musculature beneath it allow for better tolerance. At the beginning of the injection
treatment, 0.5 to 1.0 ml 6X are, as a rule, injected into the axillary fold.

  (not available in the USA)

The intramuscular injection is preferred when the goal is to obtain a maximally fast ab-
sorption without obtaining a larger general reaction. Therefore, it is highly recommended
for therapeutic purposes, especially for suspensions that would cause subcutaneous
local reactions because of the stronger active substances contained in them. For the
intramuscular injection those locations are to be chosen where the strength of the
musculature guarantees a fast absorption. One chooses for this the upper external
quadrant of the glutea, and injects deeply intramuscular with 50 or 60 mm needles.

  (not available in the USA)

The intracutaneous application is less used for stimulation therapy because it is too
painful. However, because the skin is generally considered to be an important carrier
of immunity, an intracutaneous administration of the suspension can in many cases
be of excellent usefulness, particularly when the skin itself is the seat of disease (furun-
culosis, acne, etc. ). Naturally, one can use only smaller dosages of 0.2 - 0.5 ml (6X)
maximally for the intracutaneous injection, due to the size of the wheal formation and
the accompanying parallel painfulness. The stretching side of the left upper or lower
arm is suitable for this type of application.

 
Percutaneous rubbing has proven itself well in every case that involves organ stress
or nervous irritation and where segmental therapy is appropriate.

 - 

As already mentioned, fluctuations of the blood pH value in the alkaline area—which
is generally preceded by a massive acidification of the tissue—give support for the
upward development of the symbionts toward parasitic germination, the cause or
support for diseases.

It is nowadays beyond argumentation that most of civilization’s diseases are condi-

tioned by our poor nutritional habits. The unhealthy lifestyle of human beings through
inappropriate nutrition with excessive ingestion of proteins makes one acidified in the
actual sense of the word. The accompanying manifestations today’s civilization dis-
eases are always a mesenchymal acidosis with a simultaneously excessively raised


 alkaline blood pH value, a pathological acidity quotient, according to Sander, along
with an extremely low defensive factor. These are sure criteria for a metabolic derail-
ment, with the danger of an acute or chronic disease.

Merely by changing one’s nutrition, healthy human beings can expect a balanced
acid-base maintenance by choosing a lacto-vegetarian diet. As a supportive meas-
ure for the restoration of the acid-base equilibrium, Pleo™Alkala is the perfect treat-
ment. For excessive acidification of the gastro-intestinal tract with its consequences,
such as heartburn and gas. It is important to note that all products are calibrated to
be in balance with one another.

Pleo™Citro brings regulatory action into cell respiration and acid-base management,
by acting against the alkalosis of the blood.

Pleo™San is an additional preparation for regulating the pH value of the blood and
tissue, with L (+) lactic acid as its active constituent. The specialty of Pleo™San lies
in the various potencies which are brought together within the preparation. The lower
potencies serve the raising of cellular breathing, while the higher potencies serve the
elimination of excessive lactic acid concentrations, especially of the nonphysiological
D-(-) lactic acid.

 
Pleo™Thym activates the metabolism, stimulates the prestages of the
T- lymphocytes to maturation and strengthens the immune system.

Pleo™Chrys, a human placenta hydrolysate, contains biogenic stimulators that enter

actively into the metabolism by raising the cellular respiration.

Pleo™Reb, an organ extract of Peyer’s Patches (taken from US calves under control-
led conditions and veterinar y supervision) that stimulates the B- and
T-lymphocytes, thus strengthening the humoral defenses, and supporting the body in
the maintenance or establishment of an intact immune system.

 
Plant extracts are an ideal and necessary support therapy, especially since this entire
homeopathic/isopathic product line (fungal, mineral & trace elements, bacterial, herbal,
organ, etc.) is calibrated to be in perfect balance with one another to achieve best results.

Pleo™Cerivi promotes blood flow through the mucous membranes; it has, addition-
ally, a regulatory influence on pathogens in the gastro-intestinal area.

Pleo™Ginkgo is based on the active constituent complex of the leaves of the Ginkgo
tree, this is well known from Asian folk medicine.

In Pleo™Relivora Complex, the active substance concentrations of Drosera, Echina-

cea angustifolia and Juglans are ideally combined for best efficacy. Diseases of the
respiratory tract, frequent general infections and diseases of the skin are a broad
field for application for the Pleo™Relivora Complex.

Pleo™Oku and Pleo™Usnea are herbal homeopathic remedies. Pleo™Usnea, made

from the lichen Usnea barbata, is predominantly used for illnesses in the head area
(headaches), while Pleo™Oku, from the tree bark of Okoubaka aubrevillei, finds its
application in detoxifying the gastro-intestinal tract, in cases of food intolerance or,
prophylactically, for changes in climate and nutrition. Besides, there are many areas of


 application for patients who are stressed through pesticides, insecticides, environmental
disturbances. These are excellent preparations for detoxification of the entire sys-
tem—especially effective in the early stages of colds & flu.

    

An important factor for the maintenance of our health lies in providing the body with neces-
sary mineral and trace elements. Regulatory processes in the organism, which are the
precondition for a regulated metabolic process, cannot take their course without a stable
electrolyte equilibrium of ions, such as Sodium, Potassium, Calcium and Magnesium.

The trace elements, which according to their name are needed by the body in only
very small amounts, enter catalytically into the metabolic processes. Without the pres-
ence of these “Bio- catalysts”—including Iron, Zinc, Maganese, Copper, Cobalt, Io-
dine and Fluor—many processes that are essential for life cannot take their course,
such as the action of the heart.

These mineral and trace element preparations are offered for a broad application
spectrum: Pleo™Alkala (Na, K), Mapurit (Mg), Pleo™Zinc (Zn), and Pleo™Cup (Cu),
and, of course, they are calibrated to a perfectly balanced total therapy with all the
aforementioned products.
    
SIPS ORAL PERCUTANEOUS

day 1: 1 ml Pleo™Ut “S”

1 ml Pleo™Muc
2 ml Pleo™Sanuvis

day 2: 2 tablets Pleo™Muc 5X

day 3: 5-10 drops Pleo™Sancom 5X

WEEK 1

(rub into bend of elbow)

day 4: eliminate, detoxify

day 5: 5-10 drops Pleo™Sancom 5X

(rub into bend of elbow)

day 6: 2 tablets Pleo™Muc 5X

day 7: 5-10 drops Pleo™Sancom 5X

(rub into bend of elbow)

day 1: 1 ml Pleo™Muc

day 2: 2 tablets Pleo™Muc 5X

day 3: 5-10 drops Pleo™Sancom 5X

(rub into bend of elbow)
WEEK 2

day 4: eliminate, detoxify

day 5: 5-10 drops Pleo™Sancom 5X

(rub into bend of elbow)

day 6: 2 tablets Pleo™Muc 5X

day 7: 5-10 drops Pleo™Sancom 5X

(rub into bend of elbow)


 SIPS ORAL PERCUTANEOUS

day 1: 1 ml Pleo™Nig

day 2: 2 tablets Pleo™Muc 5X

day 3: 5-10 drops Pleo™Sancom 5X

(rub into bend of elbow)
WEEK 3

day 4: eliminate, detoxify

day 5: 5-10 drops Pleo™Sancom 5X

(rub into bend of elbow)

day 6: 1 capsule Pleo™Ut “S”

day 7: 5-10 drops Pleo™Sancom 5X

(rub into bend of elbow)

day 1: break

day 2: 2 tablets Pleo™Not 5X

WEEK 4

day 3: 5-10 drops Pleo™Sancom 5X

(rub into bend of elbow)

day 4: break

day 5: 1 ml Pleo™Not

       

       

THERAPY CYCLE ORAL

day 1: 1 capsule Pleo™Ut “S” 4X

day 3: 2 tablets Pleo™Muc 5X

day 5: 1 capsule Pleo™Lat 4X

day 7: 2 tablets Pleo™Not 5X

day 9: 1 capsule Pleo™Rec

day 11: 2 tablets Pleo™Nig 5X

Daily: 1 tablespoon Pleo™San

Repeat the therapy cycle according to need.


