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Pathophysiology of Tia

Transient ischemic attacks are caused by a temporary obstruction in a blood vessel leading to the brain, disrupting cerebral blood flow below critical levels and preventing neurons from maintaining aerobic respiration. Without sufficient oxygen and glucose, neurons switch to anaerobic respiration causing energy failure, acidosis, ion imbalance and increased glutamate and calcium, breaking down cell membranes, proteins and forming free radicals that can cause irreversible cell injury and death if blood flow is not restored quickly. Symptoms include numbness or weakness on one side of the body and impaired sensory perception.

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5K views1 page

Pathophysiology of Tia

Transient ischemic attacks are caused by a temporary obstruction in a blood vessel leading to the brain, disrupting cerebral blood flow below critical levels and preventing neurons from maintaining aerobic respiration. Without sufficient oxygen and glucose, neurons switch to anaerobic respiration causing energy failure, acidosis, ion imbalance and increased glutamate and calcium, breaking down cell membranes, proteins and forming free radicals that can cause irreversible cell injury and death if blood flow is not restored quickly. Symptoms include numbness or weakness on one side of the body and impaired sensory perception.

Uploaded by

abbeeyy
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOC, PDF, TXT or read online on Scribd
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PATHOPHYSIOLOGY OF TIA (Transient Ischemic Attack)

Obstruction of a blood vessel


Disruption of Cerebral blood flow
Cerebral blood flow <25mL/100g/min
Ineffective
cerebral tissue
perfusion

Neurons unable to maintain aerobic respiration


Mitochondria switches to Anaerobic respiration
low ATP (energy failure)
acidosis ion imbalance
inc glutamate depolarization
intracellular calcium increased
cell membranes and proteins break down
formation of free radicals
cell injury and death
*the death of a neuron is irreversible and nonregenerative
Manifestations:
Numbness and weakness of face, arm, leg (left side numbness)
Sudden severe headache
Impaired sensory perception (tactile)

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