Bacteria

Bacteria (/bækˈtɪəriə/ ( listen); common noun bacteria, singular bacterium) are ubiquitous, mostly free-
living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic
microorganisms. Typically a few micrometres in length, bacteria were among the first life forms to appear
on Earth, and are present in most of its habitats. Bacteria inhabit soil, water, acidic hot springs,
radioactive waste, and the deep biosphere of the earth's crust. Bacteria are vital in many stages of the
nutrient cycle by recycling nutrients such as the fixation of nitrogen from the atmosphere. The nutrient
cycle includes the decomposition of dead bodies; bacteria are responsible for the putrefaction stage in this
process. In the biological communities surrounding hydrothermal vents and cold seeps, extremophile
bacteria provide the nutrients needed to sustain life by converting dissolved compounds, such as hydrogen
sulphide and methane, to energy. Bacteria also live in symbiotic and parasitic relationships with plants
and animals. Most bacteria have not been characterised and there are many species that cannot be
grown in the laboratory. The study of bacteria is known as bacteriology, a branch of microbiology.
 Bacteria

Scanning electron micrograph of Escherichia coli rods

Scientific classification

Domain: Bacteria

Phyla

Acidobacteria

Actinobacteria

Aquificae

Armatimonadetes

Bacteroidetes

Caldiserica

Chlamydiae

Chlorobi

Chloroflexi

Chrysiogenetes

Coprothermobacterota[1]

Cyanobacteria

Deferribacteres

Deinococcus-Thermus

Dictyoglomi
 Elusimicrobia

Fibrobacteres

Firmicutes

Fusobacteria

Gemmatimonadetes

Lentisphaerae

Nitrospirae

Planctomycetes

Proteobacteria

Spirochaetes

Synergistetes

Tenericutes

Thermodesulfobacteria

Thermotogae

Verrucomicrobia
Synonyms

Eubacteria

Humans and most animals carry millions of bacteria. Most are in the gut, and there are many on the
skin. Most of the bacteria in and on the body are harmless or rendered so by the protective effects of the
immune system, though many are beneficial, particularly the ones in the gut. However, several species of
bacteria are pathogenic and cause infectious diseases, including cholera, syphilis, anthrax, leprosy, and
bubonic plague. The most common fatal bacterial diseases are respiratory infections. Antibiotics are used
to treat bacterial infections and are also used in farming, making antibiotic resistance a growing
problem. In industry, bacteria are important in sewage treatment and the breakdown of oil spills, the
production of cheese and yogurt through fermentation, the recovery of gold, palladium, copper and other
metals in the mining sector, as well as in biotechnology, and the manufacture of antibiotics and other
chemicals.
Once regarded as plants constituting the class Schizomycetes ("fission fungi"), bacteria are now classified
as prokaryotes. Unlike cells of animals and other eukaryotes, bacterial cells do not contain a nucleus and
rarely harbour membrane-bound organelles. Although the term bacteria traditionally included all
prokaryotes, the scientific classification changed after the discovery in the 1990s that prokaryotes consist
of two very different groups of organisms that evolved from an ancient common ancestor. These
evolutionary domains are called Bacteria and Archaea.[2]

Etymology

Rod-shaped Bacillus subtilis

The word bacteria is the plural of the New Latin bacterium, which is the latinisation of the Greek
βακτήριον (bakterion),[3] the diminutive of βακτηρία (bakteria), meaning "staff, cane",[4] because the first
ones to be discovered were rod-shaped.[5] [6]

Origin and early evolution

Phylogenetic tree of Bacteria, Archaea and Eucarya. The vertical line at bottom represents the last universal common ancestor.[7]

The ancestors of bacteria were unicellular microorganisms that were the first forms of life to appear on
Earth, about 4 billion years ago.[8] For about 3 billion years, most organisms were microscopic, and
bacteria and archaea were the dominant forms of life.[9][10][11] Although bacterial fossils exist, such as
stromatolites, their lack of distinctive morphology prevents them from being used to examine the history
of bacterial evolution, or to date the time of origin of a particular bacterial species. However, gene
sequences can be used to reconstruct the bacterial phylogeny, and these studies indicate that bacteria
diverged first from the archaeal/eukaryotic lineage.[12] The most recent common ancestor of bacteria and
archaea was probably a hyperthermophile that lived about 2.5 billion–3.2 billion years ago.[13][14][15] The
earliest life on land may have been bacteria some 3.22 billion years ago.[16]

Bacteria were also involved in the second great evolutionary divergence, that of the archaea and
eukaryotes. Here, eukaryotes resulted from the entering of ancient bacteria into endosymbiotic
associations with the ancestors of eukaryotic cells, which were themselves possibly related to the
Archaea.[17][18] This involved the engulfment by proto-eukaryotic cells of alphaproteobacterial symbionts
to form either mitochondria or hydrogenosomes, which are still found in all known Eukarya (sometimes
in highly reduced form, e.g. in ancient "amitochondrial" protozoa). Later, some eukaryotes that already
contained mitochondria also engulfed cyanobacteria-like organisms, leading to the formation of
chloroplasts in algae and plants. This is known as primary endosymbiosis.[19]

Habitat

Bacteria are ubiquitous, living in every possible habitat on the planet including soil, underwater, deep in
the earth's crust and even such extreme environments as acidic hot springs and radioactive waste.[20][21]
There are approximately 2×1030 bacteria on Earth,[22] forming a biomass that is only exceeded by
plants.[23] They are abundant in lakes and oceans, in arctic ice, and geothermal springs[24] where they
provide the nutrients needed to sustain life by converting dissolved compounds, such as hydrogen sulphide
and methane, to energy.[25] They live on and in plants and animals but most do not cause diseases are
beneficial to their environments and are essential for life.[26] The soil is a rich source of bacteria and a few
grams contain around a thousand million of them. They are all essential to soil ecology, breaking down
toxic waste and recycling nutrients. They are even found in the atmosphere and one cubic metre of air
holds around one hundred million bacterial cells. The oceans and seas harbour around 3 x 1026 bacteria
which provide up to 50% of the oxygen we breathe.[27] Only around 2% of bacterial species have been
fully studied. [28]
Extremophile Bacteria
Habitat Species Reference
[29]
Cold (minus 15°C Antarctica) Cryptoendoliths

Hot (70-100°C geysers) Thermus aquaticus [28]

Radiation, 5MRad Deinococcus radiodurans [29]

Saline, 47% salt (Dead Sea, Great Salt Lake) several species [28],[29]

Acid pH 3 several species [20]

Alkaline pH 12.8 Proteobacteria [29]

Space (6 years on a NASA satellite) Bacillus subtilis [29]

[29]
3.2 Km underground several species

High pressure (Mariana Trench – 1200 atm) Moritella, Shewanella and others [29]

Morphology

Bacteria display many cell morphologies and arrangements[6]

Bacteria display a wide diversity of shapes and sizes. Bacterial cells are about one-tenth the size of
eukaryotic cells and are typically 0.5–5.0 micrometres in length. However, a few species are visible to the
unaided eye—for example, Thiomargarita namibiensis is up to half a millimetre long[30] and
Epulopiscium fishelsoni reaches 0.7 mm.[31] Among the smallest bacteria are members of the genus
Mycoplasma, which measure only 0.3 micrometres, as small as the largest viruses.[32] Some bacteria may
be even smaller, but these ultramicrobacteria are not well-studied.[33]

Most bacterial species are either spherical, called cocci (singular coccus, from Greek kókkos, grain, seed),
or rod-shaped, called bacilli (sing. bacillus, from Latin baculus, stick).[34] Some bacteria, called vibrio, are
shaped like slightly curved rods or comma-shaped; others can be spiral-shaped, called spirilla, or tightly
coiled, called spirochaetes. A small number of other unusual shapes have been described, such as star-
shaped bacteria.[35] This wide variety of shapes is determined by the bacterial cell wall and cytoskeleton,
and is important because it can influence the ability of bacteria to acquire nutrients, attach to surfaces,
swim through liquids and escape predators.[36][37]

The range of sizes shown by prokaryotes (Bacteria), relative to those of other organisms and biomolecules.[38]

Many bacterial species exist simply as single cells, others associate in characteristic patterns: Neisseria
forms diploids (pairs), streptococci form chains, and stahphylococci group together in "bunch of grapes"
clusters. Bacteria can also group to form larger multicellular structures, such as the elongated filaments of
Actinobacteria species, the aggregates of Myxobacteria species, and the complex hyphae of Streptomyces
species.[39] These multicellular structures are often only seen in certain conditions. For example, when
starved of amino acids, myxobacteria detect surrounding cells in a process known as quorum sensing,
migrate towards each other, and aggregate to form fruiting bodies up to 500 micrometres long and
containing approximately 100,000 bacterial cells.[40] In these fruiting bodies, the bacteria perform
separate tasks; for example, about one in ten cells migrate to the top of a fruiting body and differentiate
into a specialised dormant state called a myxospore, which is more resistant to drying and other adverse
environmental conditions.[41]

Bacteria often attach to surfaces and form dense aggregations called biofilms,[42] and larger formations
known as microbial mats.[43] These biofilms and mats can range from a few micrometres in thickness to
up to half a metre in depth, and may contain multiple species of bacteria, protists and archaea. Bacteria
living in biofilms display a complex arrangement of cells and extracellular components, forming
secondary structures, such as microcolonies, through which there are networks of channels to enable
better diffusion of nutrients.[44][45] In natural environments, such as soil or the surfaces of plants, the
majority of bacteria are bound to surfaces in biofilms.[46] Biofilms are also important in medicine, as these
structures are often present during chronic bacterial infections or in infections of implanted medical
devices, and bacteria protected within biofilms are much harder to kill than individual isolated
bacteria.[47]

Cellular structure

Structure and contents of a typical Gram-positive bacterial cell (seen by the fact that only one cell membrane is present).

Intracellular structures

The bacterial cell is surrounded by a cell membrane, which is made primarily of phospholipids. This
membrane encloses the contents of the cell and acts as a barrier to hold nutrients, proteins and other
essential components of the cytoplasm within the cell.[48] Unlike eukaryotic cells, bacteria usually lack
large membrane-bound structures in their cytoplasm such as a nucleus, mitochondria, chloroplasts and
the other organelles present in eukaryotic cells.[49] However, some bacteria have protein-bound
organelles in the cytoplasm which compartmentalize aspects of bacterial metabolism,[50][51] such as the
carboxysome.[52] Additionally, bacteria have a multi-component cytoskeleton to control the localisation
of proteins and nucleic acids within the cell, and to manage the process of cell division.[53][54][55]

Many important biochemical reactions, such as energy generation, occur due to concentration gradients
across membranes, creating a potential difference analogous to a battery. The general lack of internal
membranes in bacteria means these reactions, such as electron transport, occur across the cell
membrane between the cytoplasm and the outside of the cell or periplasm.[56] However, in many
photosynthetic bacteria the plasma membrane is highly folded and fills most of the cell with layers of
light-gathering membrane.[57] These light-gathering complexes may even form lipid-enclosed structures
called chlorosomes in green sulfur bacteria.[58]

An electron micrograph of Halothiobacillus neapolitanus cells with carboxysomes inside, with arrows highlighting visible
carboxysomes. Scale bars indicate 100 nm.

Bacteria do not have a membrane-bound nucleus, and their genetic material is typically a single circular
bacterial chromosome of DNA located in the cytoplasm in an irregularly shaped body called the
nucleoid.[59] The nucleoid contains the chromosome with its associated proteins and RNA. Like all other
organisms, bacteria contain ribosomes for the production of proteins, but the structure of the bacterial
ribosome is different from that of eukaryotes and archaea.[60]

Some bacteria produce intracellular nutrient storage granules, such as glycogen,[61] polyphosphate,[62]
sulfur[63] or polyhydroxyalkanoates.[64] Bacteria such as the photosynthetic cyanobacteria, produce
internal gas vacuoles, which they use to regulate their buoyancy, allowing them to move up or down into
water layers with different light intensities and nutrient levels.[65]
Extracellular structures

Around the outside of the cell membrane is the cell wall. Bacterial cell walls are made of peptidoglycan
(also called murein), which is made from polysaccharide chains cross-linked by peptides containing D-
amino acids.[66] Bacterial cell walls are different from the cell walls of plants and fungi, which are made
of cellulose and chitin, respectively.[67] The cell wall of bacteria is also distinct from that of achaea, which
do not contain peptidoglycan. The cell wall is essential to the survival of many bacteria, and the
antibiotic penicillin (produced by a fungus called Penicillium) is able to kill bacteria by inhibiting a step in
the synthesis of peptidoglycan.[67]

There are broadly speaking two different types of cell wall in bacteria, that classify bacteria into Gram-
positive bacteria and Gram-negative bacteria. The names originate from the reaction of cells to the
Gram stain, a long-standing test for the classification of bacterial species.[68]

Gram-positive bacteria possess a thick cell wall containing many layers of peptidoglycan and teichoic
acids. In contrast, Gram-negative bacteria have a relatively thin cell wall consisting of a few layers of
peptidoglycan surrounded by a second lipid membrane containing lipopolysaccharides and lipoproteins.
Most bacteria have the Gram-negative cell wall, and only members of the Firmicutes group and
actinobacteria (previously known as the low G+C and high G+C Gram-positive bacteria, respectively)
have the alternative Gram-positive arrangement.[69] These differences in structure can produce
differences in antibiotic susceptibility; for instance, vancomycin can kill only Gram-positive bacteria and
is ineffective against Gram-negative pathogens, such as Haemophilus influenzae or Pseudomonas
aeruginosa.[70] Some bacteria have cell wall structures that are neither classically Gram-positive or
Gram-negative. This includes clinically important bacteria such as mycobacteria which have a thick
peptidoglycan cell wall like a Gram-positive bacterium, but also a second outer layer of lipids.[71]

In many bacteria, an S-layer of rigidly arrayed protein molecules covers the outside of the cell.[72] This
layer provides chemical and physical protection for the cell surface and can act as a macromolecular
diffusion barrier. S-layers have diverse functions and are known to act as virulence factors in
Campylobacter species and contain surface enzymes in Bacillus stearothermophilus.[73][74]
Helicobacter pylori electron micrograph, showing multiple flagella on the cell surface

Flagella are rigid protein structures, about 20 nanometres in diameter and up to 20 micrometres in
length, that are used for motility. Flagella are driven by the energy released by the transfer of ions down
an electrochemical gradient across the cell membrane.[75]

Fimbriae (sometimes called "attachment pili") are fine filaments of protein, usually 2–10 nanometres in
diameter and up to several micrometres in length. They are distributed over the surface of the cell, and
resemble fine hairs when seen under the electron microscope.[76] Fimbriae are believed to be involved in
attachment to solid surfaces or to other cells, and are essential for the virulence of some bacterial
pathogens.[77] Pili (sing. pilus) are cellular appendages, slightly larger than fimbriae, that can transfer
genetic material between bacterial cells in a process called conjugation where they are called conjugation
pili or sex pili (see bacterial genetics, below).[78] They can also generate movement where they are called
type IV pili.[79]

Glycocalyx is produced by many bacteria to surround their cells,[80] and varies in structural complexity:
ranging from a disorganised slime layer of extracellular polymeric substances to a highly structured
capsule. These structures can protect cells from engulfment by eukaryotic cells such as macrophages (part
of the human immune system).[81] They can also act as antigens and be involved in cell recognition, as
well as aiding attachment to surfaces and the formation of biofilms.[82]

The assembly of these extracellular structures is dependent on bacterial secretion systems. These transfer
proteins from the cytoplasm into the periplasm or into the environment around the cell. Many types of
secretion systems are known and these structures are often essential for the virulence of pathogens, so are
intensively studied.[82]

Endospores
Bacillus anthracis (stained purple) growing in cerebrospinal fluid[83]

Some genera of Gram-positive bacteria, such as Bacillus, Clostridium, Sporohalobacter, Anaerobacter,

and Heliobacterium, can form highly resistant, dormant structures called endospores.[84] Endospores
develop within the cytoplasm of the cell; generally a single endospore develops in each cell.[85] Each
endospore contains a core of DNA and ribosomes surrounded by a cortex layer and protected by a
multilayer rigid coat composed of peptidoglycan and a variety of proteins.[85]

Endospores show no detectable metabolism and can survive extreme physical and chemical stresses, such
as high levels of UV light, gamma radiation, detergents, disinfectants, heat, freezing, pressure, and
desiccation.[86] In this dormant state, these organisms may remain viable for millions of years,[87][88][89]
and endospores even allow bacteria to survive exposure to the vacuum and radiation in space, possibly
bacteria could be distributed throughout the Universe by space dust, meteoroids, asteroids, comets,
planetoids or via directed panspermia.[90][91] Endospore-forming bacteria can also cause disease: for
example, anthrax can be contracted by the inhalation of Bacillus anthracis endospores, and
contamination of deep puncture wounds with Clostridium tetani endospores causes tetanus, which like
botulism is caused by a toxin released by the bacteria that grow from the spores.[92] Clostridioides difficile
infection, which is a problem in healthcare settings is also caused by spore-forming bacteria.[93]

Metabolism

Bacteria exhibit an extremely wide variety of metabolic types.[94] The distribution of metabolic traits
within a group of bacteria has traditionally been used to define their taxonomy, but these traits often do
not correspond with modern genetic classifications.[95] Bacterial metabolism is classified into nutritional
groups on the basis of three major criteria: the source of energy, the electron donors used, and the source
of carbon used for growth.[96]

Bacteria either derive energy from light using photosynthesis (called phototrophy), or by breaking down
chemical compounds using oxidation (called chemotrophy).[97] Chemotrophs use chemical compounds as
a source of energy by transferring electrons from a given electron donor to a terminal electron acceptor
in a redox reaction. This reaction releases energy that can be used to drive metabolism. Chemotrophs
are further divided by the types of compounds they use to transfer electrons. Bacteria that use inorganic
compounds such as hydrogen, carbon monoxide, or ammonia as sources of electrons are called
lithotrophs, while those that use organic compounds are called organotrophs.[97] The compounds used to
receive electrons are also used to classify bacteria: aerobic organisms use oxygen as the terminal electron
acceptor, while anaerobic organisms use other compounds such as nitrate, sulfate, or carbon dioxide.[97]

Many bacteria get their carbon from other organic carbon, called heterotrophy. Others such as
cyanobacteria and some purple bacteria are autotrophic, meaning that they obtain cellular carbon by
fixing carbon dioxide.[98] In unusual circumstances, the gas methane can be used by methanotrophic
bacteria as both a source of electrons and a substrate for carbon anabolism.[99]

Nutritional types in bacterial metabolism

Nutritional Source of
Source of carbon Examples
type energy

 Organic compounds  Cyanobacteria, Green sulfur

 Phototrophs  Sunlight (photoheterotrophs) or carbon fixation bacteria, Chloroflexi, or Purple
(photoautotrophs) bacteria 

 Organic compounds  Thermodesulfobacteria,

Inorganic
 Lithotrophs (lithoheterotrophs) or carbon fixation Hydrogenophilaceae, or
compounds
(lithoautotrophs) Nitrospirae 

 Organic compounds
Organic  Bacillus, Clostridium or
 Organotrophs (chemoheterotrophs) or carbon fixation
compounds Enterobacteriaceae 
(chemoautotrophs)  

In many ways, bacterial metabolism provides traits that are useful for ecological stability and for human
society. One example is that some bacteria called diazotrophs have the ability to fix nitrogen gas using
the enzyme nitrogenase.[100] This environmentally important trait can be found in bacteria of most
metabolic types listed above.[101] This leads to the ecologically important processes of denitrification,
sulfate reduction, and acetogenesis, respectively.[102] Bacterial metabolic processes are also important in
biological responses to pollution; for example, sulfate-reducing bacteria are largely responsible for the
production of the highly toxic forms of mercury (methyl- and dimethylmercury) in the environment.[103]
Non-respiratory anaerobes use fermentation to generate energy and reducing power, secreting metabolic
by-products (such as ethanol in brewing) as waste. Facultative anaerobes can switch between
fermentation and different terminal electron acceptors depending on the environmental conditions in
which they find themselves.[104]

Growth and reproduction

Many bacteria reproduce through binary fission, which is compared to mitosis and meiosis in this image.

Unlike in multicellular organisms, increases in cell size (cell growth) and reproduction by cell division are
tightly linked in unicellular organisms. Bacteria grow to a fixed size and then reproduce through binary
fission, a form of asexual reproduction.[105] Under optimal conditions, bacteria can grow and divide
extremely rapidly, and some bacterial populations can double as quickly as every 17 minutes.[106] In cell
division, two identical clone daughter cells are produced. Some bacteria, while still reproducing asexually,
form more complex reproductive structures that help disperse the newly formed daughter cells. Examples
include fruiting body formation by myxobacteria and aerial hyphae formation by Streptomyces species, or
budding. Budding involves a cell forming a protrusion that breaks away and produces a daughter cell.[107]
A colony of Escherichia coli[108]

In the laboratory, bacteria are usually grown using solid or liquid media.[109] Solid growth media, such as
agar plates, are used to isolate pure cultures of a bacterial strain. However, liquid growth media are used
when the measurement of growth or large volumes of cells are required. Growth in stirred liquid media
occurs as an even cell suspension, making the cultures easy to divide and transfer, although isolating
single bacteria from liquid media is difficult. The use of selective media (media with specific nutrients
added or deficient, or with antibiotics added) can help identify specific organisms.[110]

A culture of Salmonella

Most laboratory techniques for growing bacteria use high levels of nutrients to produce large amounts of
cells cheaply and quickly.[109] However, in natural environments, nutrients are limited, meaning that
bacteria cannot continue to reproduce indefinitely. This nutrient limitation has led the evolution of
different growth strategies (see r/K selection theory). Some organisms can grow extremely rapidly when
nutrients become available, such as the formation of algal (and cyanobacterial) blooms that often occur
in lakes during the summer.[111] Other organisms have adaptations to harsh environments, such as the
production of multiple antibiotics by streptomyces that inhibit the growth of competing
microorganisms.[112] In nature, many organisms live in communities (e.g., biofilms) that may allow for
increased supply of nutrients and protection from environmental stresses.[46] These relationships can be
essential for growth of a particular organism or group of organisms (syntrophy).[113]

Bacterial growth follows four phases. When a population of bacteria first enter a high-nutrient
environment that allows growth, the cells need to adapt to their new environment. The first phase of
growth is the lag phase, a period of slow growth when the cells are adapting to the high-nutrient
environment and preparing for fast growth. The lag phase has high biosynthesis rates, as proteins
necessary for rapid growth are produced.[114][115] The second phase of growth is the logarithmic phase,
also known as the exponential phase. The log phase is marked by rapid exponential growth. The rate at
which cells grow during this phase is known as the growth rate (k), and the time it takes the cells to
double is known as the generation time (g). During log phase, nutrients are metabolised at maximum
speed until one of the nutrients is depleted and starts limiting growth. The third phase of growth is the
stationary phase and is caused by depleted nutrients. The cells reduce their metabolic activity and
consume non-essential cellular proteins. The stationary phase is a transition from rapid growth to a stress
response state and there is increased expression of genes involved in DNA repair, antioxidant metabolism
and nutrient transport.[116] The final phase is the death phase where the bacteria run out of nutrients
and die.[117]

Genetics

Helium ion microscopy image showing T4 phage infecting E. coli. Some of the attached phage have contracted tails indicating
that they have injected their DNA into the host. The bacterial cells are ~ 0.5 µm wide.[118]
Most bacteria have a single circular chromosome that can range in size from only 160,000 base pairs in
the endosymbiotic bacteria Carsonella ruddii,[119] to 12,200,000 base pairs (12.2 Mbp) in the soil-
dwelling bacteria Sorangium cellulosum.[120] There are many exceptions to this, for example some
Streptomyces and Borrelia species contain a single linear chromosome,[121][122] while some Vibrio species
contain more than one chromosome.[123] Bacteria can also contain plasmids, small extra-chromosomal
molecules of DNA that may contain genes for various useful functions such as antibiotic resistance,
metabolic capabilities, or various virulence factors.[124]

Bacteria genomes usually encode a few hundred to a few thousand genes. The genes in bacterial genomes
are usually a single continuous stretch of DNA and although several different types of introns do exist in
bacteria, these are much rarer than in eukaryotes.[125]

Bacteria, as asexual organisms, inherit an identical copy of the parent's genomes and are clonal.
However, all bacteria can evolve by selection on changes to their genetic material DNA caused by genetic
recombination or mutations. Mutations come from errors made during the replication of DNA or from
exposure to mutagens. Mutation rates vary widely among different species of bacteria and even among
different clones of a single species of bacteria.[126] Genetic changes in bacterial genomes come from
either random mutation during replication or "stress-directed mutation", where genes involved in a
particular growth-limiting process have an increased mutation rate.[127]

Some bacteria also transfer genetic material between cells. This can occur in three main ways. First,
bacteria can take up exogenous DNA from their environment, in a process called transformation.[128]
Many bacteria can naturally take up DNA from the environment, while others must be chemically
altered in order to induce them to take up DNA.[129] The development of competence in nature is usually
associated with stressful environmental conditions, and seems to be an adaptation for facilitating repair
of DNA damage in recipient cells.[130] The second way bacteria transfer genetic material is by
transduction, when the integration of a bacteriophage introduces foreign DNA into the chromosome.
Many types of bacteriophage exist, some simply infect and lyse their host bacteria, while others insert into
the bacterial chromosome.[131] Bacteria resist phage infection through restriction modification systems
that degrade foreign DNA,[132] and a system that uses CRISPR sequences to retain fragments of the
genomes of phage that the bacteria have come into contact with in the past, which allows them to block
virus replication through a form of RNA interference.[133][134] The third method of gene transfer is
conjugation, whereby DNA is transferred through direct cell contact. In ordinary circumstances,
transduction, conjugation, and transformation involve transfer of DNA between individual bacteria of
the same species, but occasionally transfer may occur between individuals of different bacterial species
and this may have significant consequences, such as the transfer of antibiotic resistance.[135][136] In such
cases, gene acquisition from other bacteria or the environment is called horizontal gene transfer and
may be common under natural conditions.[137]

Behaviour

Movement

Transmission electron micrograph of Desulfovibrio vulgaris showing a single flagellum at one end of the cell. Scale bar is 0.5
micrometers long.

Many bacteria are motile (able to move themselves) and do so using a variety of mechanisms. The best
studied of these are flagella, long filaments that are turned by a motor at the base to generate propeller-
like movement.[138] The bacterial flagellum is made of about 20 proteins, with approximately another 30
proteins required for its regulation and assembly.[138] The flagellum is a rotating structure driven by a
reversible motor at the base that uses the electrochemical gradient across the membrane for power.[139]
The different arrangements of bacterial flagella: A-Monotrichous; B-Lophotrichous; C-Amphitrichous; D-Peritrichous

Bacteria can use flagella in different ways to generate different kinds of movement. Many bacteria (such
as E. coli) have two distinct modes of movement: forward movement (swimming) and tumbling. The
tumbling allows them to reorient and makes their movement a three-dimensional random walk.[140]
Bacterial species differ in the number and arrangement of flagella on their surface; some have a single
flagellum (monotrichous), a flagellum at each end (amphitrichous), clusters of flagella at the poles of the
cell (lophotrichous), while others have flagella distributed over the entire surface of the cell (peritrichous).
The flagella of a unique group of bacteria, the spirochaetes, are found between two membranes in the
periplasmic space. They have a distinctive helical body that twists about as it moves.[138]

Two other types of bacterial motion are called twitching motility that relies on a structure called the type
IV pilus,[141] and gliding motility, that uses other mechanisms. In twitching motility, the rod-like pilus
extends out from the cell, binds some substrate, and then retracts, pulling the cell forward.[142]

Motile bacteria are attracted or repelled by certain stimuli in behaviours called taxes: these include
chemotaxis, phototaxis, energy taxis, and magnetotaxis.[143][144][145] In one peculiar group, the
myxobacteria, individual bacteria move together to form waves of cells that then differentiate to form
fruiting bodies containing spores.[41] The myxobacteria move only when on solid surfaces, unlike E. coli,
which is motile in liquid or solid media.[146]

Several Listeria and Shigella species move inside host cells by usurping the cytoskeleton, which is
normally used to move organelles inside the cell. By promoting actin polymerisation at one pole of their
cells, they can form a kind of tail that pushes them through the host cell's cytoplasm.[147]
Communication

A few bacteria have chemical systems that generate light. This bioluminescence often occurs in bacteria
that live in association with fish, and the light probably serves to attract fish or other large animals.[148]

Bacteria often function as multicellular aggregates known as biofilms, exchanging a variety of molecular
signals for inter-cell communication, and engaging in coordinated multicellular behaviour.[149][150]

The communal benefits of multicellular cooperation include a cellular division of labour, accessing
resources that cannot effectively be used by single cells, collectively defending against antagonists, and
optimising population survival by differentiating into distinct cell types.[149] For example, bacteria in
biofilms can have more than 500 times increased resistance to antibacterial agents than individual
"planktonic" bacteria of the same species.[150]

One type of inter-cellular communication by a molecular signal is called quorum sensing, which serves
the purpose of determining whether there is a local population density that is sufficiently high that it is
productive to invest in processes that are only successful if large numbers of similar organisms behave
similarly, as in excreting digestive enzymes or emitting light[151][152]

Quorum sensing allows bacteria to coordinate gene expression, and enables them to produce, release and
detect autoinducers or pheromones which accumulate with the growth in cell population.[153]

Classification and identification

Streptococcus mutans visualised with a Gram stain.

Phylogenetic tree showing the diversity of bacteria, compared to other organisms. Here bacteria are represented by three main
supergroups: the CPR ultramicrobacterias, Terrabacteria and Gracilicutes according to recent genomic analyzes (2019).[154]

Classification seeks to describe the diversity of bacterial species by naming and grouping organisms based
on similarities. Bacteria can be classified on the basis of cell structure, cellular metabolism or on
differences in cell components, such as DNA, fatty acids, pigments, antigens and quinones.[110] While
these schemes allowed the identification and classification of bacterial strains, it was unclear whether
these differences represented variation between distinct species or between strains of the same species.
This uncertainty was due to the lack of distinctive structures in most bacteria, as well as lateral gene
transfer between unrelated species.[155] Due to lateral gene transfer, some closely related bacteria can
have very different morphologies and metabolisms. To overcome this uncertainty, modern bacterial
classification emphasises molecular systematics, using genetic techniques such as guanine cytosine ratio
determination, genome-genome hybridisation, as well as sequencing genes that have not undergone
extensive lateral gene transfer, such as the rRNA gene.[156] Classification of bacteria is determined by
publication in the International Journal of Systematic Bacteriology,[157] and Bergey's Manual of
Systematic Bacteriology.[158] The International Committee on Systematic Bacteriology (ICSB)
maintains international rules for the naming of bacteria and taxonomic categories and for the ranking of
them in the International Code of Nomenclature of Bacteria.[159]

Historically, bacteria were considered a part of the Plantae, the Plant kingdom, and were called
"Schizomycetes" (fission-fungi).[160] For the reason, collective bacteria and other microorganisms in a host
are often called "flora".[161] The term "bacteria" was traditionally applied to all microscopic, single-cell
prokaryotes. However, molecular systematics showed prokaryotic life to consist of two separate domains,
originally called Eubacteria and Archaebacteria, but now called Bacteria and Archaea that evolved
independently from an ancient common ancestor.[2] The archaea and eukaryotes are more closely
related to each other than either is to the bacteria. These two domains, along with Eukarya, are the
basis of the three-domain system, which is currently the most widely used classification system in
microbiology.[162] However, due to the relatively recent introduction of molecular systematics and a rapid
increase in the number of genome sequences that are available, bacterial classification remains a
changing and expanding field.[163][164] For example, Cavalier-Smith argued that the Archaea and
Eukaryotes evolved from Gram-positive bacteria.[165]

The identification of bacteria in the laboratory is particularly relevant in medicine, where the correct
treatment is determined by the bacterial species causing an infection. Consequently, the need to identify
human pathogens was a major impetus for the development of techniques to identify bacteria.[166]

The Gram stain, developed in 1884 by Hans Christian Gram, characterises bacteria based on the
structural characteristics of their cell walls.[167][68] The thick layers of peptidoglycan in the "Gram-
positive" cell wall stain purple, while the thin "Gram-negative" cell wall appears pink.[167] By combining
morphology and Gram-staining, most bacteria can be classified as belonging to one of four groups
(Gram-positive cocci, Gram-positive bacilli, Gram-negative cocci and Gram-negative bacilli). Some
organisms are best identified by stains other than the Gram stain, particularly mycobacteria or Nocardia,
which show acid-fastness on Ziehl–Neelsen or similar stains.[168] Other organisms may need to be
identified by their growth in special media, or by other techniques, such as serology.[169]

Culture techniques are designed to promote the growth and identify particular bacteria, while restricting
the growth of the other bacteria in the sample.[170] Often these techniques are designed for specific
specimens; for example, a sputum sample will be treated to identify organisms that cause pneumonia,
while stool specimens are cultured on selective media to identify organisms that cause diarrhea, while
preventing growth of non-pathogenic bacteria. Specimens that are normally sterile, such as blood, urine
or spinal fluid, are cultured under conditions designed to grow all possible organisms.[110][171] Once a
pathogenic organism has been isolated, it can be further characterised by its morphology, growth
patterns (such as aerobic or anaerobic growth), patterns of hemolysis, and staining.[172]

As with bacterial classification, identification of bacteria is increasingly using molecular methods,[173]

and mass spectroscopy.[174] Most bacteria have not been characterised and there are may species that
cannot be grown in the laboratory.[175] Diagnostics using DNA-based tools, such as polymerase chain
reaction, are increasingly popular due to their specificity and speed, compared to culture-based
methods.[176] These methods also allow the detection and identification of "viable but nonculturable" cells
that are metabolically active but non-dividing.[177] However, even using these improved methods, the
total number of bacterial species is not known and cannot even be estimated with any certainty.
Following present classification, there are a little less than 9,300 known species of prokaryotes, which
includes bacteria and archaea;[178] but attempts to estimate the true number of bacterial diversity have
ranged from 107 to 109 total species—and even these diverse estimates may be off by many orders of
magnitude.[179][180]

Interactions with other organisms

Overview of bacterial infections and main species involved.[181]

Despite their apparent simplicity, bacteria can form complex associations with other organisms. These
symbiotic associations can be divided into parasitism, mutualism and commensalism.[182]

Commensals

The word "commensalism" is derived from the word "commensal", meaning "eating at the same
table"[183] and all plants and animals are colonised by commensal bacteria. In humans and other
animals millions of them live on the skin, the airways, the gut and other orifices.[184][185] Referred to as
"normal flora"[186] or "commensals",[187] these bacteria usually cause no harm but can invade other sites
of the body and give rise infections. Escherichia coli is a commensal in the human gut but can cause
urinary tract infections.[188] Similarly, streptoccoci, which are part of the normal flora of the human
mouth, can cause heart disease.[189]
Predators

Some species of bacteria kill and then consume other microorganisms, these species are called predatory
bacteria.[190] These include organisms such as Myxococcus xanthus, which forms swarms of cells that kill
and digest any bacteria they encounter.[191] Other bacterial predators either attach to their prey in order
to digest them and absorb nutrients or invade another cell and multiply inside the cytosol. [192] These
predatory bacteria are thought to have evolved from saprophages that consumed dead microorganisms,
through adaptations that allowed them to entrap and kill other organisms.[193]

Mutualists

Certain bacteria form close spatial associations that are essential for their survival. One such mutualistic
association, called interspecies hydrogen transfer, occurs between clusters of anaerobic bacteria that
consume organic acids, such as butyric acid or propionic acid, and produce hydrogen, and methanogenic
archaea that consume hydrogen.[194] The bacteria in this association are unable to consume the organic
acids as this reaction produces hydrogen that accumulates in their surroundings. Only the intimate
association with the hydrogen-consuming archaea keeps the hydrogen concentration low enough to
allow the bacteria to grow.[195]

In soil, microorganisms that reside in the rhizosphere (a zone that includes the root surface and the soil
that adheres to the root after gentle shaking) carry out nitrogen fixation, converting nitrogen gas to
nitrogenous compounds.[196] This serves to provide an easily absorbable form of nitrogen for many plants,
which cannot fix nitrogen themselves. Many other bacteria are found as symbionts in humans and other
organisms. For example, the presence of over 1,000 bacterial species in the normal human gut flora of
the intestines can contribute to gut immunity, synthesise vitamins, such as folic acid, vitamin K and
biotin, convert sugars to lactic acid (see Lactobacillus), as well as fermenting complex undigestible
carbohydrates.[197][198][199] The presence of this gut flora also inhibits the growth of potentially
pathogenic bacteria (usually through competitive exclusion) and these beneficial bacteria are
consequently sold as probiotic dietary supplements.[200]

Nearly all animal life is dependent on bacteria for survival as only bacteria and some archaea possess the
genes and enzymes necessary to synthesize vitamin B12, also known as cobalamin, and provide it through
the food chain. Vitamin B12 is a water-soluble vitamin that is involved in the metabolism of every cell of
the human body. It is a cofactor in DNA synthesis, and in both fatty acid and amino acid metabolism. It
is particularly important in the normal functioning of the nervous system via its role in the synthesis of
myelin.[201]
Pathogens

Colour-enhanced scanning electron micrograph showing Salmonella typhimurium (red) invading cultured human cells

The body is continually exposed to many species of bacteria, including beneficial commensals, which
grow on the skin and mucous membranes, and saprophytes, which grow mainly in the soil and in
decaying matter. The blood and tissue fluids contain nutrients sufficient to sustain the growth of many
bacteria. The body has defence mechanisms that enable it to resist microbial invasion of its tissues and
give it a natural immunity or innate resistance against many microorganisms.[202] Unlike some viruses,
bacteria evolve relatively slowly so many bacterial diseases also occur in other animals.[203]

If bacteria form a parasitic association with other organisms, they are classed as pathogens.[204]
Pathogenic bacteria are a major cause of human death and disease and cause infections such as tetanus
(caused by Clostridium tetani), typhoid fever, diphtheria, syphilis, cholera, foodborne illness, leprosy
(caused by Micobacterium leprae) and tuberculosis (caused by Mycobacterium tuberculosis).[205] A
pathogenic cause for a known medical disease may only be discovered many years later, as was the case
with Helicobacter pylori and peptic ulcer disease.[206] Bacterial diseases are also important in agriculture,
with bacteria causing leaf spot, fire blight and wilts in plants, as well as Johne's disease, mastitis,
salmonella and anthrax in farm animals.[207]
In bacterial vaginosis beneficial bacteria in the vagina (top) are displaced by pathogens (bottom). Gram stain.

Each species of pathogen has a characteristic spectrum of interactions with its human hosts. Some
organisms, such as Staphylococcus or Streptococcus, can cause skin infections, pneumonia, meningitis
and sepsis, a systemic inflammatory response producing shock, massive vasodilation and death.[208] Yet
these organisms are also part of the normal human flora and usually exist on the skin or in the nose
without causing any disease at all. Other organisms invariably cause disease in humans, such as the
Rickettsia, which are obligate intracellular parasites able to grow and reproduce only within the cells of
other organisms. One species of Rickettsia causes typhus, while another causes Rocky Mountain spotted
fever. Chlamydia, another phylum of obligate intracellular parasites, contains species that can cause
pneumonia or urinary tract infection and may be involved in coronary heart disease.[209] Some species,
such as Pseudomonas aeruginosa, Burkholderia cenocepacia, and Mycobacterium avium, are
opportunistic pathogens and cause disease mainly in people suffering from immunosuppression or cystic
fibrosis.[210][211] Some bacteria produce toxins, which cause diseases.[212] These are endotoxins, which
come from broken bacterial cells, and exotoxins, which are produced by bacteria and released into the
environment.[213] The bacterium Clostridium botulinum for example, produces a powerful extoxin that
cause respiratory paralysis and Salmonellae produce an endotoxin that causes gastroenteritis.[213] Some
exotoxins can be converted to toxoids, which are used as vaccines to prevent the disease.[214]

Bacterial infections may be treated with antibiotics, which are classified as bacteriocidal if they kill
bacteria or bacteriostatic if they just prevent bacterial growth. There are many types of antibiotics, and
each class inhibits a process that is different in the pathogen from that found in the host. An example of
how antibiotics produce selective toxicity are chloramphenicol and puromycin, which inhibit the
bacterial ribosome, but not the structurally different eukaryotic ribosome.[215] Antibiotics are used both
in treating human disease and in intensive farming to promote animal growth, where they may be
contributing to the rapid development of antibiotic resistance in bacterial populations.[216] Infections can
be prevented by antiseptic measures such as sterilising the skin prior to piercing it with the needle of a
syringe, and by proper care of indwelling catheters. Surgical and dental instruments are also sterilised to
prevent contamination by bacteria. Disinfectants such as bleach are used to kill bacteria or other
pathogens on surfaces to prevent contamination and further reduce the risk of infection.[217]

Significance in technology and industry

Bacteria, often lactic acid bacteria, such as Lactobacillus species and Lactococcus species, in combination
with yeasts and moulds, have been used for thousands of years in the preparation of fermented foods, such
as cheese, pickles, soy sauce, sauerkraut, vinegar, wine and yogurt.[218][219]

The ability of bacteria to degrade a variety of organic compounds is remarkable and has been used in
waste processing and bioremediation. Bacteria capable of digesting the hydrocarbons in petroleum are
often used to clean up oil spills.[220] Fertiliser was added to some of the beaches in Prince William Sound
in an attempt to promote the growth of these naturally occurring bacteria after the 1989 Exxon Valdez
oil spill. These efforts were effective on beaches that were not too thickly covered in oil. Bacteria are also
used for the bioremediation of industrial toxic wastes.[221] In the chemical industry, bacteria are most
important in the production of enantiomerically pure chemicals for use as pharmaceuticals or
agrichemicals.[222]

Bacteria can also be used in the place of pesticides in the biological pest control. This commonly involves
Bacillus thuringiensis (also called BT), a Gram-positive, soil dwelling bacterium. Subspecies of this
bacteria are used as a Lepidopteran-specific insecticides under trade names such as Dipel and
Thuricide.[223] Because of their specificity, these pesticides are regarded as environmentally friendly, with
little or no effect on humans, wildlife, pollinators and most other beneficial insects.[224][225]

Because of their ability to quickly grow and the relative ease with which they can be manipulated,
bacteria are the workhorses for the fields of molecular biology, genetics and biochemistry. By making
mutations in bacterial DNA and examining the resulting phenotypes, scientists can determine the
function of genes, enzymes and metabolic pathways in bacteria, then apply this knowledge to more
complex organisms.[226] This aim of understanding the biochemistry of a cell reaches its most complex
expression in the synthesis of huge amounts of enzyme kinetic and gene expression data into
mathematical models of entire organisms. This is achievable in some well-studied bacteria, with models
of Escherichia coli metabolism now being produced and tested.[227][228] This understanding of bacterial
metabolism and genetics allows the use of biotechnology to bioengineer bacteria for the production of
therapeutic proteins, such as insulin, growth factors, or antibodies.[229][230]

Because of their importance for research in general, samples of bacterial strains are isolated and
preserved in Biological Resource Centers. This ensures the availability of the strain to scientists
worldwide.[231]

History of bacteriology

Antonie van Leeuwenhoek, the first microbiologist and the first person to observe bacteria using a microscope.

Bacteria were first observed by the Dutch microscopist Antonie van Leeuwenhoek in 1676, using a single-
lens microscope of his own design. He then published his observations in a series of letters to the Royal
Society of London.[232] Bacteria were Leeuwenhoek's most remarkable microscopic discovery. They were
just at the limit of what his simple lenses could make out and, in one of the most striking hiatuses in the
history of science, no one else would see them again for over a century.[233] His observations had also
included protozoans which he called animalcules, and his findings were looked at again in the light of the
more recent findings of cell theory.[234]

Christian Gottfried Ehrenberg introduced the word "bacterium" in 1828.[235] In fact, his Bacterium was
a genus that contained non-spore-forming rod-shaped bacteria,[236] as opposed to Bacillus, a genus of
spore-forming rod-shaped bacteria defined by Ehrenberg in 1835.[237]
Louis Pasteur demonstrated in 1859 that the growth of microorganisms causes the fermentation process,
and that this growth is not due to spontaneous generation (yeasts and molds, commonly associated with
fermentation, are not bacteria, but rather fungi). Along with his contemporary Robert Koch, Pasteur
was an early advocate of the germ theory of disease.[238] Before them, Ignaz Semmelweis and Joseph
Lister had realised the importance of sanitized hands in medical work. Semmelweis ideas was rejected
and his book on the topic condemned by the medical community, but after Lister doctors started
sanitizing their hands in the 1870s. While Semmelweis who started with rules about handwashing in his
hospital in the 1840s predated the spread of the ideas about germs themselves and attributed diseases to
"decomposing animal organic matter", Lister was active later.[239]

Robert Koch, a pioneer in medical microbiology, worked on cholera, anthrax and tuberculosis. In his
research into tuberculosis Koch finally proved the germ theory, for which he received a Nobel Prize in
1905.[240] In Koch's postulates, he set out criteria to test if an organism is the cause of a disease, and these
postulates are still used today.[241]

Ferdinand Cohn is said to be a founder of bacteriology, studying bacteria from 1870. Cohn was the first
to classify bacteria based on their morphology.[242][243]

Though it was known in the nineteenth century that bacteria are the cause of many diseases, no effective
antibacterial treatments were available.[244] In 1910, Paul Ehrlich developed the first antibiotic, by
changing dyes that selectively stained Treponema pallidum—the spirochaete that causes syphilis—into
compounds that selectively killed the pathogen.[245] Ehrlich had been awarded a 1908 Nobel Prize for his
work on immunology, and pioneered the use of stains to detect and identify bacteria, with his work being
the basis of the Gram stain and the Ziehl–Neelsen stain.[246]

A major step forward in the study of bacteria came in 1977 when Carl Woese recognised that archaea
have a separate line of evolutionary descent from bacteria.[247] This new phylogenetic taxonomy
depended on the sequencing of 16S ribosomal RNA, and divided prokaryotes into two evolutionary
domains, as part of the three-domain system.[2]

See also

Genetically modified bacteria

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External links

On-line text book on bacteriology (2015) (http://www.textbookofbacteriology.net/)

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