Module 3 Revi
Module 3 Revi
1. Define common statistical terms used in the field, such as infant and
maternal mortality.
2. Identify 2020 National Goals related to genetic disorders that nurses
can help the nation achieve.
3. Formulate nursing diagnosis related to genetic disorder.
4. Established expected outcomes that meet the needs of the family
undergoing genetic assessment and counseling as well as manage
seamless transitions across differing healthcare settings.
5. Implement nursing care such as counseling a family with a genetic
disorder.
6. Evaluate expected outcomes for achievement and effectiveness of
care.
Introduction
Unlocking of Difficulties
1
Let’s define some terms that you will encounter in this lesson…
Lecture Notes
INFANT MORTALITY
The 2018 infant death rate increased by 5.9 percent from 11.9 infant
deaths per 1000 live births in 2017 to 12.6 infant deaths per 1000
live births in 2018.
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The 21,019 infant deaths comprised 3.6 percent of the total deaths
(590,709) reported during the year.
This represented a daily average of 57 infant deaths or two infant
deaths every hour. Statistics showed a decreasing IMR between ten-
year-period intervals, although there were minimal increases at
some point.
MATERNAL MORTALITY
In 2018, the number of registered maternal deaths reached a total of
1,616. There were more than 132 maternal deaths registered in 2018
than in 2017 (1,484). The 2018 Maternal Mortality Ratio (MMR) is
1.0 per one thousand live birth. This was an 11.1 percent increase in
MMR from 2017.
Eclampsia was the leading cause of maternal death in 2018 with 284
deaths and comprised 17.6 percent of maternal deaths. This was
followed by Gestational hypertension with significant proteinuria
with 198 deaths and was 12.3 percent of the total maternal deaths.
FETAL DEATHS
Two out of five of fetal deaths (3,603; 41.9%) died of unspecified
cause.
The next two leading causes of fetal death recorded were Fetus and
newborn affected by complication of placenta, cord and membrane
(1,736; 20.2%) and Birth asphyxia (1,301; 15.1%).
Most number of fetal deaths occurred to mothers in age-group 25-
29 years, with 1,884 reported deaths or 21.9 percent of total fetal
deaths.
High numbers of fetal deaths were also registered to mothers of
ages 20-24 years (1,750; 20.4%) and 30-34 years old (1,748; 20.31%).
However, statistics show that older mother (40-44, and 45-49 years
old) had the highest fetal death ratio as compared to other age-
groups of mother. Their corresponding FDR were 10.5 and 10.4 fetal
deaths per one thousand live births, respectively.
MORTALITY AMONG LOWER AGE GROUPS
The 2018 ten leading causes of mortality among lower age groups,
specifically to age groups 1-4; 5-9; 10-14 years were presented.
Pneumonia was the most common cause of death among children
age 1-4 years. In this age-group, Pneumonia recorded the highest
age-specific death rate (14.5 deaths per 100,000 of age-group
population).
Deaths from diseases of nervous system and diarrhea and
gastroenteritis of infectious origin were also high among this age
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group with seven and 6 deaths per 100,000 of age-group population,
respectively.
Statistics also showed that deaths due to accidental drowning and
submersion were still common cause of deaths of children of age-
group 5-9 and 10-14 years old. It was the second leading cause of
death in both age-groups.
MORTALITY AMONG IMMUNIZABLE DISEASES
The highest number of deaths was due to all forms of Tuberculosis,
which did not only include respiratory TB but also TB of other sites,
with 466 deaths.
It was then followed by Measles with 323 deaths. The number of
deaths from Measles among 0-14 years old, is 17 times higher as
compared to last year, with 18 deaths only.
Death from Acute poliomyelitis (1) was lower compared to last year,
with two deaths.
4
https://doh.gov.ph/sites/default/files/publications/2018%20Philippine%20Health
%20Statistics.pdf date retrieved: January 18, 2021
5
https://doh.gov.ph/sites/default/files/publications/2018%20Philippine%20Health
%20Statistics.pdf date retrieved: January 18, 2021
https://doh.gov.ph/sites/default/files/publications/2018%20Philippine%20Health
%20Statistics.pdf date retrieved: January 18, 2021
6
https://doh.gov.ph/sites/default/files/publications/2018%20Philippine%20Health
%20Statistics.pdf date retrieved: January 18, 2021
Genetic Disorders
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when the chromosome count is halved from 46 to 23.
90% of first trimester spontaneous miscarriages may occur as the
result of chromosomal disorders.
Other genetic disorders do not affect life in utero, so the result of the
disorder only becomes apparent at the time of fetal testing or after
birth.
Cytogenetics
Nature of Inheritance
Genes are the basic units of hereditary that determine both the
physical and cognitive characteristics of people. Composed of
segments of DNA, they are woven into strands in the nucleus of all
body cells to form chromosomes.
Humans (except sperm and ovum) - contains 46 chromosomes (44
autosomes and 2 sex chromosomes)
Spermatozoa and ova each carry only half of the chromosome
number (23chromosomes).
For each chromosomes in a sperm cell, there is a like chromosome of
similar size, shape, and function in the ovum (two like genes or
alleles)
A person’s phenotype refers to his or her outward appearance or the
expression of genes.
A person’s genotype refers to his or her actual gene composition.
A person’s genome is the complete set of genes present (about
50,000 - 100,000)
A normal genome is abbreviated as 46XX or 46XY.
If a chromosomal aberration exists, it is listed after the sex
chromosome pattern.
Ex. 46XX5p
In Down syndrome, the person has an extra chromosome 21, so this
is abbreviated as 47XX21+
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Genetic Counseling
History
Obtain information and document diseases in family members for a
minimum of three generations - physical examination of both the
parents, includes half brothers and half sisters or anyone related in
any way as family.
Include the mother’s age - some disorders increase in incidence with
age.
Laboratory assays of blood, amniocentesis
Family’s ethnic background - certain disorders occur more commonly
in some ethnic groups than others
Any spontaneous miscarriages or children in the family who died at
birth - many instances, these children died of unknown
chromosomal disorders.
Extensive prenatal history - to determine whether environmental
conditions could account for the condition.
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Physical Assessment
Pay particular attention to certain body areas:
Space between the eyes
Height
Contour and shape of ears
Number of fingers and toes
Presence of webbing
Dermatoglyphics - helpful because unusual fingerprints, abnormal
palmar creases, hair whorls, or coloring of hair are also present with
some disorder.
Infants born at less than 35 weeks gestation- infants with multiple
congenital anomaly.
Parents who have had other children with chromosomal disorders.
Reproductive Alternatives
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4. Adoption
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Edwards syndrome)
Children with trisomy 18 syndrome have three copies of
chromosome 18.
Incidence is approximately 0.23 per 1,000 live births
Severely cognitively challenged and tend to be small for gestational
age
Markedly low-set ears, a small jaw,congenital heart defects, and
usually misshapen fingers and toes (the index finger deviates or
crosses over other fingers)
Sole of their feet are often rounded instead of flat (rocker-bottom
feet)
Most of these children do not survive beyond infancy.
FRAGILE X SYNDROME
It is an an X-linked disorder in which one long arm of an X
chromosome is defective, which results in inadequate protein
synaptic responses.
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CHILDHOOD TUMORS
Retinoblastoma (chromosome 13)
Wilms tumor (chromosome 11)
Neuroblastoma (chromosome 1 or 11)
Focus Questions
Related Readings
https://doh.gov.ph/sites/default/files/publications/2018%20Philippin
e%20Health%20Statistics.pdf
https://www.nature.com/scitable/topicpage/gregor-mendel-and-the-
principles-of-inheritance-593/
https://www.cdc.gov/reproductivehealth/maternalinfanthealth/infant
mortality.htm#:~:text=Infant%20mortality%20is%20the%20death,for
%20every%201%2C000%20live%20births.
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3363315
Learning/Assessment Activities
Direction: Answer the multiple choice quiz in schoology. Choose the best
answer and tick your answer.
References
JoAnne Silbert-Flagg, DNP, CPNP, IBCLC, FAAN, and Adele Pillitteri, PhD,
RN, PNP (2018). Maternal and Child Health Nursing. Care of the
Childbearing and Childrearing Family. Eigth Edition.Wolters Kluwer
13
Dar, S., Lazer, T., Swanson, S., et al. (2015). Assisted reproduction
involving gestational surrogacy: An analysis of the medical, psychological
and legal issues: Experience from a large surrogacy program. Human
Reproduction. 30(2), 345-352
UNIT II: Care of At Risk/High Risk and Sick Mother and Child
Introduction
This unit addresses the nursing role and care provided to families
with pregnancy complications. It focuses on pregnant women with a
chronic condition, such as cardiovascular or kidney disease, and those
who experience unintentional injury or develop a chronic illness during
pregnancy.
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Unlocking of Difficulties
Lecture Notes
NURSING PROCESS
Assessment
Nursing Diagnosis
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Pain related to pyelonephritis secondary to uterine pressure on
ureters
Knowledge deficit related to normal changes of pregnancy versus
illness complications.
Fear regarding pregnancy outcome related to chronic illness.
Implementation
Outcome Evaluation
Examples
Patient states she rests for 2 hours morning and afternoon;
dependent edema remains at 1+ or less at next prenatal visit
Family members state they are all participating in an exercise
program since mother developed gestational diabetes.
If expected outcome is not being met, a new assessment, analysis, and
planning need to be done.
1. Obstetric history
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Last pregnancy less than 1 year previous
History of abnormal papsmear
Previous premature cervical dilatation, preterm labor, preterm birth,
low-birth weight infant, or ceasarean birth
Previous macrosomic infant or multiple gestation
Previous abnormal gestational trophoblastic disease
Previous ectopic pregnancy or stillborn/neonatal death
Previous infant with neurologic deficit, birth injury, or congenital
anomaly
2. Past illness
4. Psychosocial factor
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Lack of support people
Inadequate finances; inadequate nutrition or poor housing
Lack of acceptance of pregnancy
5. Demographic factors
6. Lifestyle
Vaginal bleeding
Persistent vomiting
Chills and fever
Sudden escape of clear fluid from the vagina
Abdominal or chest pain
Gestational hypertension
Increase or decrease in fetal movement
Uterine contractions before 37 weeks of pregnancy
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Varicosities
A woman with cardiovascular disease should visit care provider for
preconception care - so her state of health and baseline data when
she is not pregnant can be established
She should begin prenatal care as soon as she suspects she is
pregnant (1 week after the first missed menstrual period or as soon
as she has a positive pregnancy test) - so her general condition and
circulatory system can be monitored from the beginning of
pregnancy.
The danger of pregnancy in a woman with cardiac disease occurs
primarily because of increase circulatory volume.
The most dangerous time for the pregnant woman is in weeks 28 to
32 - just after the blood volume peaks.
If heart disease is severe, symptoms can occur at the very beginning
of pregnancy.
Toward the end of pregnancy, heart may become so overwhelmed
by the increase in blood volume that cardiac output falls to the point
vital organs (including the placenta) can no longer be perfused
adequately - oxygen and nutritional requirement of cells of both
mother and fetus are not met.
The estimation of whether a woman with cardiovascular disease can
complete a pregnancy successfully depends on the type and extent
of her disease
A woman with an artificial but well-functioning heart valves, those
with pacemaker implant, and heart transplant - can expect to have a
successful pregnancies as long as they have effective prenatal and
post natal care.
Left-sided heart failure happens when the left ventricle cannot shunt
the blood forward that it received by the left atrium from the
pulmonary circulation.
Right-sided heart failure happens when the output of the right
ventricle is less than the blood volume received by the right atrium
from the vena cava.
A WOMAN WITH PERIPARTUM HEART HEART DISEASE
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An extremely rare condition, peripartal cardiomyopathy, can
originate in pregnancy in women with no previous history of heart
disease. This occurs because of the stress of the pregnancy on the
circulatory system
Fatigue
Cough
Increased respiratory rate
Tachycardia
Decreased amniotic fluid from intrauterine growth restriction
Poor fetal heart tone variability from poor tissue perfusion
Edema from poor venous return
Fetal assessment
Infants tend to have low birth weights or small for gestational age -
because of acidosis, which develops due to poor oxygen/carbon
dioxide exchange or not being furnished with enough nutrients.
This can result to preterm labor, which exposes the newborn to the
hazards of immaturity
If the placenta is not filling well , a fetus may not respond well to
labor ( evidence by late deceleration patterns on a fetal heart
monitor) - a cesarean birth may be necessary (an increase risk for
both mother and child).
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Nursing Intervention During Labor and Birth
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Kegel exercise should not begin until approved by the primary care
provider.
schedule a post partum check up for both gynecologic health and
cardiac status.
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Advise the woman not to sit with her legs crossed at the knee and to
avoid standing in one position for a long time.
A thrombus that occurred during pregnancy is diagnosed by Doppler
ultrasonography and a woman’s history.
The woman will be placed on bed rest and intravenous heparin
administration for 24 to 48 hours.
Women who are taking heparin during pregnancy are not candidates
for routine episiotomy or epidural anesthesia to prevent
hemorrhage.
PTT determination should be continued during labor.
A breastfeeding woman cannot take heparin or Coumadin, or
Coumadin should be used cautiously.
The main danger of thrombophlebitis is pulmonary embolism or a
clot that lodges in the pulmonary artery, blocking the circulation to
the lungs and heart.
IRON-DEFICIENCY ANEMIA
Prevention:
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Folic acid - necessary for the normal formation of red blood cells in
the woman as well as being associated with preventing neural tube
abdominal wall defects in the fetus.
SICKLE-CELL ANEMIA
Therapeutic Management:
Periodic exchange or blood transfusion
If crisis occurs - controlling pain, administering oxygen as needed, and
increasing the fluid volume of the circulatory system to lower
viscosity
Hospitalization if there is infection
Keep the woman well hydrated while in labor and help resist
strenous exertion
Epidural anesthesia is the method of choice if operation is needed.
Post-partal period - early ambulation and wearing of pressure
stockings or IPC boots can help reduce the risk of thromboembolism.
THALASSEMIA
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Are a group of autosomal recessively inherited blood disorders that
lead to poor hemoglobin formation and severe anemia
Treatment focuses on combating anemia through folic acid
supplementation and blood transfusion to infuse hemoglobin-rich
red blood cells.
MALARIA
Assessment
Frequency and pain in urination
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Pyelonephritis - pain in the lumbar region (usually in the right side
that radiates downward.
The area is tended to palpation
Accompanied by nausea, vomiting, and malaise
Elevated temperature (39° to 40°C)
Infection usually occurs in the right side
Urine culture - 100,000 organisms per milliliter of urine - a level
diagnostic of infection
Therapeutic Management:
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Women with severe renal disease may require dialysis to aid kidney
function during pregnancy
With dialysis, there is risk of preterm labor - because progesterone is
removed with the dialysis.
Progesterone may be administered intramuscularly before the
procedure.
For hemodialysis - scheduled for short duration to avoid fluid shifts
Heparin - does not crossed placenta
Diet must be on low-potassium - to avoid a buildup of potassium
Emotional support during pregnancy
Provide extra time with their infant at birth for bonding
V. RESPIRATORY DISORDERS AND PREGNANCY
Should not take high-dose aspirin - can interfere with blood clotting
in both the mother and fetus
Urge women to use simple measures to combat a cold such as:
Extra rest and sleep and eat a diet high in vitamin C to help boost
the immune system
Take acetaminophen )Tylenol) every 4 hours for aches and pains.
No Aspirin during pregnancy
Apply medicated vapor rub to the chest
Use cool or warm compresses to relieve sinus headaches
27
Pneumonia is the bacterial or viral invasion of lung tissue by
pathogens such as Streptococcus pneumoniae, Haemophilus
influenzae, and Mycoplasma pneumoniae.
Therapy involves the use of antibiotic and oxygen administration.
With severe disease- ventilation support may be necessary
Pneumonia during pregnancy is associated with fetal growth
restriction and preterm birth because of the oxygen deficit
If pneumonia is present during labor, oxygen should be administered
so the fetus has adequate oxygen resources during contractions.
Assessment
Chronic cough
Weight loss
Hemoptysis
Night sweats
In high risk area - women should undergo skin testing (PPD) at their
prenatal first visit - a positive result does not mean does not
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necessarily mean they have the disease, it can only mean they have
at some time been exposed to tuberculosis (and that they have
antibody in their system.
If (+) reaction - chest x-ray or a sputum culture for acid-fast bacillus
to confirm the diagnosis. (x-ray during pregnancy is safe as long as
her abdomen is lead shielded)
Therapeutic Management:
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Stop smoking - to provide smoke-free environment for her baby
Therapy:
30
Higher incidence of diabetes mellitus - needs close monitoring of
serum glucose levels at prenatal visits to detect development of
gestational diabetes
Chest physiotherapy - may need to plan more frequent and shorter
sessions in modified positions (other than prone) during pregnancy.
Fetal health - may be monitored by ultrasound and nonstress tests to
identify intrauterine growth restriction.
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disease symptoms -can continue taking this medication during
pregnancy but with caution. - may reduce of salicylates 2 weeks prior
to labor to prevent bleeding in the newborn and premature closure
of the ductus arteriosus.
Increase in the blood pressure due to nephritis (chief complication of
the disorder) -will develop hematuria, proteinuria, with decreased
urine output, and edema.
Frequent monitoring of serum creatinine levels
if value is over 1.5 mg/dl , and proteinuria, and a decreased
creatinine clearance value are present - fetus is seriously threatened
with growth restriction, may have preterm pregnancy.
Dialysis may be necessary
During labor - intravenous hydrocortisone may be administered
Infants of women with SLE may be born with a lupus-like rash,
anemia, thrombocytopenia, and neonatal heart block - symptoms
last for 6 months and then fade.
Assessment:
Appendicitis usually begins with a few hours of nausea and then an
hour or two of generalized abdominal discomfort, then a typical
sharp peristaltic, lower right quadrant pain of acute appendicitis.
Pain from an overstretched round ligament or rupture ectopic
pregnancy may both cause sharp lower quadrant pain - needs to be
differentiated from that of appendicitis
Major difference - pain of an overstretched round ligament fades
almost instantly while pain form appendicitis is continuous and
grows more intense.
Temperature is usually elevated
urine sample reveals ketones
CBC - leukocytosis
MRI - confirmed the inflamed appendix
Advise woman while at the emergency room not to eat, drink liquid,
or consume any laxatives because increasing peristalsis could cause
an inflamed appendix to rupture.
Therapeutic Management:
Cesarean birth - if near term (past 37 weeks)
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If early in pregnancy - laparoscopy
Focus Questions
33
B. Cautioning her that her hemoglobin level will be closely
monitored during therapy.
C. Allowing her to choose a subcutaneous site for the injection.
D. Monitoring her white blood cell count daily for decrease
coagulation.
2. Christina is friends with a woman in the clinic who has sickle- cell
anemia, and they often talk together about their care. Which
statement would alert the nurse that her friend may need further
instruction on prenatal care?
A. “I understand why folic acid is important for red cell formation.”
B. “I’m careful to drink at least eight glasses of fluid everyday.”
C. “I take an iron pill every day to help grow new red blood cell.”
D. “I’ve temporarily stopped jogging so I don’t risk becoming
dehydrated.”
3. While reviewing antenatal electronic records, the charge nurse of a
prenatal clinic notes that a high number of pregnant women seen in
the clinic, including Christina, have developed UTIs during their
pregnancies. The nurse should emphasize the need for staff nurses
to do which of the following?
A. Ensure that the housekeeping department is adequately cleaning
the toilet.
B. Suggest all women be prescribed a prophylactic antibiotic during
their first trimester.
C. Educate women on the need for sound perinatal care during
pregnancy.
D. Urge women to restrict fluid to keep their urine acidic and
concentrated.
Related Readings
https://www.mayoclinic.org/diseases-conditions/gestational-
diabetes/symptoms-causes/syc-20355339#:~:text=Gestational
%20diabetes%20is%20diabetes%20diagnosed,pregnancy%20and
%20your%20baby's%20health.
https://www.escardio.org/Journals/E-Journal-of-Cardiology-
Practice/Volume-17/hypertension-in-pregnancy#:~:text=The%20target
%20BP%20should%20be,their%20antihypertensive%20medication
%20%5B2%5D.
34
Learning/Assessment Activities
Direction: Answer the multiple choice quiz in schoology. Choose the best
answer and tick your answer.
References
Basta, P., Bak, A., & Roszkowski, K. (2015). cancer treatment in pregnant
women. Contemporary Oncology, 19(5), 354-360.
JoAnne Silbert-Flagg, DNP, CPNP, IBCLC, FAAN, and Adele Pillitteri, PhD,
RN, PNP (2018). Maternal and Child Health Nursing. Care of the
Childbearing and Childrearing Family. Eigth Edition.Wolters Kluwer
https://www.mayoclinic.org/diseases-conditions/gestational-
diabetes/symptoms-causes/syc-20355339#:~:text=Gestational
%20diabetes%20is%20diabetes%20diagnosed,pregnancy%20and
%20your%20baby's%20health.
35