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Silver Nitrate (Argenti Nitras) : The International Pharmacopoeia - Sixth Edition, 2016

Silver nitrate (AgNO3) is a colorless or white crystalline compound used as an anti-infective agent. It is soluble in water and ethanol. Silver nitrate should be stored in a tightly closed, non-metallic container protected from light to prevent degradation from humidity or discoloration from light and organic matter. The document outlines tests to verify the identity, purity, and concentration of silver nitrate samples, requiring them to contain 99.0-100.5% AgNO3 and specifying limits for contaminants.

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71 views1 page

Silver Nitrate (Argenti Nitras) : The International Pharmacopoeia - Sixth Edition, 2016

Silver nitrate (AgNO3) is a colorless or white crystalline compound used as an anti-infective agent. It is soluble in water and ethanol. Silver nitrate should be stored in a tightly closed, non-metallic container protected from light to prevent degradation from humidity or discoloration from light and organic matter. The document outlines tests to verify the identity, purity, and concentration of silver nitrate samples, requiring them to contain 99.0-100.5% AgNO3 and specifying limits for contaminants.

Uploaded by

Sozdar Argoshi
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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The International Pharmacopoeia - Sixth Edition, 2016 Silver nitrate (Argenti nitras)

Silver nitrate (Argenti nitras)


Molecular formula. AgNO3

Relative molecular mass. 169.9

Chemical name. Silver(1+) nitrate; CAS Reg. No. 7761-88-8.

Description. Colourless or white crystals or white cylindrical rods; odourless.

Solubility. Soluble in 0.5 parts of water; soluble in ethanol (~750 g/l) TS.

Category. Antiinfective agent.

Storage. Silver nitrate should be kept in a tightly closed, non-metallic container, protected from light.

Additional information. Even in the absence of light, Silver nitrate is gradually degraded on exposure to a humid atmosphere, the
decomposition being faster at higher temperatures. On exposure to light and in the presence of organic matter, it becomes grey
or greyish black.

Requirements

Definition. Silver nitrate contains not less than 99.0% and not more than 100.5% of AgNO3.

Identity tests

A. Dissolve 20 mg in 1.0 mL of water, add ammonia (~100 g/l) TS, drop by drop, until the precipitate first formed
just dissolves; add about 0.1 mL of formaldehyde TS and warm the mixture; glossy metallic silver forms on the
wall of the test-tube.

B. Dissolve 20 mg in 1.0 mL of water and add a few drops of potassium iodide (~80 g/l) TS; a cream-coloured
precipitate is produced which is insoluble in ammonia (~100 g/l) TS and nitric acid (~1000 g/l) TS.

C. To 2 mL of a 0.05 g/mL solution add 2 mL of ferrous sulfate (15 g/l) TS; it yields reaction A described under 2.1
General identification tests as characteristic of nitrates.

Clarity and colour. A solution of 0.4 g in 10 mL of water is clear and colourless.

Acidity or alkalinity. Dissolve 0.4 g in 10 mL of water; to a 2-mL portion add 0.1 mL of bromocresol green/ethanol TS; the colour
of the solution is blue. To another 2-mL portion of the test solution add 0.1 mL of phenol red/ethanol TS; the colour of the solution
is yellow.

Foreign salts. Dissolve 1.2 g in 30 mL of water, add 7.5 mL of hydrochloric acid (~70 g/l) TS, shake vigorously, heat on a water-
bath for 5 minutes and filter. Evaporate 20 mL of the filtrate to dryness on a water-bath and dry at 105 °C; the residue weighs not
more than 2.0 mg.

Bismuth, copper, and lead. Dissolve 1.0 g in 5 mL of water, add drop by drop ammonia (~100 g/l) TS until the precipitate first
formed just dissolves; the solution is clear and colourless.

Assay. Dissolve about 0.3 g, accurately weighed, in 50 mL of water, add 2 mL of nitric acid (~130 g/l) TS and 4 mL of ferric
ammonium sulfate (45 g/l) TS. Titrate with ammonium thiocyanate (0.1 mol/l) VS until a reddish yellow colour is produced. Each
mL of ammonium thiocyanate (0.1 mol/l) VS is equivalent to 16.99 mg of AgNO3.

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