Scribd
Upload
84 views

Precision: Repeatability, Intermediate Precision, Reproducibility

The document discusses different types of precision in analytical chemistry methods for measuring glyphosate in ground water samples. It defines repeatability as precision under the same operating conditions over a short period of time using one analyst and equipment. Intermediate precision involves multiple analysts, reagents, equipment over multiple days or weeks. Reproducibility refers to precision between different laboratories. Precision is expressed using calculations of standard deviation, variance, and relative standard deviation from multiple measurements.

Uploaded by

Gemblung01
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
84 views

Precision: Repeatability, Intermediate Precision, Reproducibility

The document discusses different types of precision in analytical chemistry methods for measuring glyphosate in ground water samples. It defines repeatability as precision under the same operating conditions over a short period of time using one analyst and equipment. Intermediate precision involves multiple analysts, reagents, equipment over multiple days or weeks. Reproducibility refers to precision between different laboratories. Precision is expressed using calculations of standard deviation, variance, and relative standard deviation from multiple measurements.

Uploaded by

Gemblung01
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
You are on page 1/ 3

11/22/16

Precision
Repeatability, intermediate precision,
reproducibility

Glyphosate in ground water:

1 sample

x2= 0.43 ng/L

x1= 0.51 ng/L Precision characterizes the


x4= 0.55 ng/L
x3= 0.53 ng/L
closeness of agreement between
the measured values.
x6= 0.49 ng/L
x5= 0.52 ng/L

x7= 0.44 ng/L x8= 0.47 ng/L


Precision relates to the random
error of a measurement system.

1
11/22/16

Glyphosate in ground water:

1 day x days

day2= 0.43 ng/L


x2= 0.43 ng/L
day1= 0.51 ng/L
x1= 0.51 ng/L day4= 0.55 ng/L
x4= 0.55 ng/L
day3= 0.53 ng/L
x3= 0.53 ng/L

Repeatability Intermediate
precision
one operator, different analysts, calibrants,
one experimental setup, batches of reagents, columns,
one set of reagents spray needles

Reproducibility
Precision between measurement
Lab 1= 0.51 ng/L results obtained at different
laboratories

Lab 2= 0.43 ng/L

Not always needed for single-lab validation but


important if the method is going to be used in
several laboratories

2
11/22/16

Glyphosate in ground water:


Expressed as absolute standard deviation:
How to express precision?
∑-./0 x% − x()*+ 2
s=
𝑛−1
Standard deviation
also as:
Relative standard deviation (RSD)
Variance (s2)
Coefficient of variance (CV)
s
RSD =
xmean

As a general rule…

srepeatability
≤ sintermediate precision

If not:
- Too few replicates
- Too short time interval

You might also like