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Parameters of The Model: Name Deterministialpha Beta Description

The document describes the parameters used in a Markov model to analyze the costs and benefits of monotherapy versus combination therapy. It lists the transition probabilities (e.g. tpA2B) between health states, direct medical costs and community care costs for each state, drug costs, treatment effect and discount rates. It then shows sample Markov models for monotherapy and combination therapy with health states A through D over 20 years, calculating total life years and costs with and without discounting for each. The analysis section compares the deterministic results of life years, costs, life years gained and incremental cost-effectiveness ratio between the two therapies.

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Angga Prawira Kautsar
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50 views

Parameters of The Model: Name Deterministialpha Beta Description

The document describes the parameters used in a Markov model to analyze the costs and benefits of monotherapy versus combination therapy. It lists the transition probabilities (e.g. tpA2B) between health states, direct medical costs and community care costs for each state, drug costs, treatment effect and discount rates. It then shows sample Markov models for monotherapy and combination therapy with health states A through D over 20 years, calculating total life years and costs with and without discounting for each. The analysis section compares the deterministic results of life years, costs, life years gained and incremental cost-effectiveness ratio between the two therapies.

Uploaded by

Angga Prawira Kautsar
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as XLS, PDF, TXT or read online on Scribd
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Parameters of the model

Name deterministialpha beta description

Transition probabilities
events complement
tpA2A Transition probability from A to A
tpA2B Transition probability from A to B
tpA2C Transition probability from A to C
tpA2D Transition probability from A to D
tpB2B Transition probability from B to B
tpB2C Transition probability from B to C
tpB2D Transition probability from B to D
tpC2C Transition probability from C to C
tpC2D Transition probability from C to D

Costs

dmca Direct medical costs associated with state A


dmcb Direct medical costs associated with state B
dmcc Direct medical costs associated with state C
ccca Community care costs associated with state A
cccb Community care costs associated with state B
cccc Community care costs associated with state C

Drug costs

cAZT Zidovudine drug cost


cLam Lamivudine drug cost

Other parameters

RR Treatment effect (RR)


cDR Annual discount rate - costs (%)
oDR Annual discount rate - benefits (%)
Markov model

MONOTHERAPY Life Years


Year A B C D no disc disc
0 1 check
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20

sum
Costs COMBINATION THERAPY Life
no disc disc A B C D no disc
1 check

sum
Years Costs
disc no disc disc
Analysis

Mono Comb Difference Estimated


LYs Cost LYs Cost LYG incCost ICER
Deterministic

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