DRUG MECHANIS INDICATION CONTRAINDICATIO PHARMACOKENITI ADVERSE NURSING

CLASSIFICATIO M OF N C EFFECT RESPONSIBILITIE

N ACTION S
Albendazole Albendazole is Albendazole is  Asses for
The principle For the treatment of contraindicated in any administered orally. In Severe possible
GENERIC mode of action hydatid cyst disease, person with known the treatment of hepatic failure / contraindicati
NAME: in neurocysticercosis, hypersensitivity to hydatid disease, tissue Delayed / 0-1.0 ons or
Albendazole is cysticercosis, albendazole, the concentrations of renal failure cautions:
by inhibitory ascariasis, enterobiasis benzimidazole class of albendazole sulfoxide (unspecified) / History of
BRAND NAME: effect on (pinworm infection), compounds, or any > 500 ng/mL are Delayed / allergy to any
Albenza tubulin hookworm infection, or product components, required for therapeutic Incidence not anthelmintic
polymerizatio trichuriasis. and in pregnancy. efficacy. Albendazole known to avoid
DOSAGE: n which sulfoxide is 70% rhabdomyolysi hypersensetiv
tablet results in the protein bound and has a s / Delayed / ity reaction;
 200mg loss of half life of Incidence not history of
Neurocysticercosi cytoplasmic approximately 8—12 known hepatic or
s (Taenia Solium microtubules hours. Concentrations Moderate renal
Tapeworm) in the intestine in plasma are elevated dysfunction
>60 kg: 400 mg of nemotides approximately 3-fold to hepatic that might
PO BID x 8-30 worms, 10-fold and 2-fold to 4- enzymes / interfere with
days ultimately fold higher than those Delayed / 0- drug
<60 kg: 15 causing energy seen in cyst fluid and 16.0 metabolism
mg/kg/day depletion and CSF, respectively. hepatitis / and excretion
divided BID PO x death of Albendazole is Delayed / 0-1.0 of the drug;
8-30 days; not to organism. extensively blurred vision / andcurrent
exceed 800 metabolized by the Early / status related
mg/day   liver to albendazole Incidence not to pregnancy
Hydatid sulfoxide, the primary known  Perform a
(Echinococcus active metabolite.The Mild physical
Tapeworm) primary elimination diarrhea / Early assessment to
>60 kg: 400 mg route is the bile. Renal / Incidence not establish
PO BID x 28 elimination is known baseline data
days, THEN 14 negligible (< 1%). drowsiness / for
drug-free days x 3   Early / determining
cycles Affected cytochrome Incidence not the
<60 kg: 15 P450 isoenzymes and known effectiveness
mg/kg/day drug transporters: asthenia / of the drug
divided BID PO, CYP1A Delayed / and the
no more than 800 Albendazole induces Incidence not occurrence of
mg/day x 28 days, cytochrome P450 1A known any adverse
THEN 14 drug- enzymes and may effect
free days x 3 induce its own  Obtain a
cycles   metabolism. After 4 culture stool
Ancylostoma, weeks of treatment for ova and
Ascariasis, with albendazole (200 parasites to
Hookworm, mg 3 times daily), determine the
Trichostrongylus plasma concentrations infecting
400 mg PO once were 20% lower than worm and
Capillariasis those observed in the establish
400 mg PO qDay first half of the appropriate
x10 days treatment period in 12 treatment
Larva Migrans, patients.  Evaluate liver
Cutaneous & function and
Trichuriasis renal function
400 mg PO qDay test
x 3 days  Examine
Larva Migrans, reflexes and
Visceral muscle
400 mg PO BID x strength
5 days
Enterobius
(Pinworm)
400 mg PO once,
repeat in 2 weeks
Fluke (Clonorchis
Sinensis)
10 mg/kg PO
qDay x7 days
Gnathostomiasis,
Microsporidiosis
400 mg BID x 21
days