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Practice Question Paper BPPK

This document contains a practice question paper on biopharmaceutics and pharmacokinetics. It consists of 7 questions covering various topics related to pharmacokinetics parameters and concepts. Some of the questions ask to define or explain terms like protein binding sites, extraction ratio, intrinsic clearance, BCS classification, inclusion criteria for bioequivalence studies, trapezoidal rule of AUC estimation, effect of renal failure on pharmacokinetics, one compartment model parameters, criteria for valid urinary excretion data, factors affecting drug biotransformation and mechanisms of drug absorption. Other questions require calculation of pharmacokinetic parameters from given plasma concentration-time data or derivation of methods.

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Ayush Srinivasan
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432 views1 page

Practice Question Paper BPPK

This document contains a practice question paper on biopharmaceutics and pharmacokinetics. It consists of 7 questions covering various topics related to pharmacokinetics parameters and concepts. Some of the questions ask to define or explain terms like protein binding sites, extraction ratio, intrinsic clearance, BCS classification, inclusion criteria for bioequivalence studies, trapezoidal rule of AUC estimation, effect of renal failure on pharmacokinetics, one compartment model parameters, criteria for valid urinary excretion data, factors affecting drug biotransformation and mechanisms of drug absorption. Other questions require calculation of pharmacokinetic parameters from given plasma concentration-time data or derivation of methods.

Uploaded by

Ayush Srinivasan
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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Practice Question Paper (B. Pharm / B.

Pharm + MBA)
Biopharmaceutics and Pharmacokinetics 2016-17
Q. 1. Answer the Following… (14)
A) What are different sites of protein binding? Name them.
B) Define the terms – 1. Extraction ratio
2. Intrinsic clearance
C) A drug ‘X’ was administered by IV bolus route. If the dose administered produces
initial concentration of 100mcg/ml, what time will be required for the drug to fall
down to 25mcg/ml? Elimination rate constant is 0.198 mcg/hr.
D) Explain BCS classification of drugs.
E) Give any four inclusion criteria for BE studies.
F) Explain trapezoidal rule of estimation of AUC.
G) What is effect of renal failure on Pharmacokinetics of drugs? Explain how dose or
frequency is calculated in such patients.
Q. 2. A) An antibiotic was administered to a patient orally in a dose of 100mg. the equation
that fits its first order behaviour is, C = 45(e-0.17t – e-1.5t).
Calculate – tmax, Cmax, and t1/2. Concentrations are expressed in the terms of mcg/ml and
rate constant as hr-1. If the drug is 80% bioavailable, calculate its volume of distribution.
(07)
B) What is bioequivalence? What are various regulatory requirements for
bioequivalence studies? Add a note on “Biowaiver”. (07)
Q. 3. A) write a short note on … (14)
1. Enterohepatic recycling – (05)
2. Diffusion layer theory – (05)
3. Non-compartmental analysis – (04)
Q. 4. A) Explain physiochemical properties of drug affect absorption and bioavailability.
B) What are different parameters / models for IVIV correlation? Explain. (07)
Q. 5. A) Discuss various pharmacokinetic parameters for one compartment open model IV
bolus administration following first order kinetics. (07)
B) Give criteria for obtaining valid urinary excretion data. How will you calculate
elimination rate constant from urinary data? Explain any one method. (07)
Q. 6. A) Discuss Flip- Flop phenomenon with suitable derivation of method of residuals.
B) The loading dose is calculated on the basis of apparent volume of distribution of a
drug, while maintenance dose is determined by its half life – Explain. (07)
Q. 7. A) Explain different factors affecting biotransformation of drugs.
B) Enlist different mechanisms of drug absorption. Explain Any two. (07)

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