Scribd
Upload
303 views1 page

Poster Presentation

Nanotechnology shows promise for treating melanoma skin cancer. Electrospun mats made of natural or synthetic polymers can be used as scaffolds for tissue engineering and drug delivery. The nanofibers produced through electrospinning allow drugs to bind to cancer cell membranes and receptors, reducing toxicity while increasing drug concentration in target cells. This takes advantage of the enhanced permeability and retention effect to selectively deliver drugs to tumor sites. As a case study, magnetic core-shell particles may be used to topically deliver drugs via electrospun nanofibers to treat skin cancer.

Uploaded by

Vency Katira
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
303 views1 page

Poster Presentation

Nanotechnology shows promise for treating melanoma skin cancer. Electrospun mats made of natural or synthetic polymers can be used as scaffolds for tissue engineering and drug delivery. The nanofibers produced through electrospinning allow drugs to bind to cancer cell membranes and receptors, reducing toxicity while increasing drug concentration in target cells. This takes advantage of the enhanced permeability and retention effect to selectively deliver drugs to tumor sites. As a case study, magnetic core-shell particles may be used to topically deliver drugs via electrospun nanofibers to treat skin cancer.

Uploaded by

Vency Katira
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
You are on page 1/ 1

Nanotechnology for Treatment of Melanoma Skin Cancer

(Vency katira,Nancy Choksi) RNGPIT(FETR Bardoli) E-mail: [email protected]


Guided By- Snehalsinh k. Thakor
Introduction to Skin Nanotechnology 2. Electrospun Mats
Nanostructures are significant due to their inherent
Cancer
Melanoma, originated from the malignant properties such as the large surface area to volume
transformation of melanocytes, is one of the most ratio and the engineered properties such as fibre
aggressive skin cancers , notorious for its high diameter, porosity, stability, hydrophilicity, and
multidrug resistance (MDR), easy to relapse and low permeability. Among the various nanomaterial
survival rate. Nearly 76,100 newly diagnosed cases synthesis procedures available, electrospinning
of melanoma were reported in the United States in serves to be a most promising technique for
2014 with an estimated 9710 expected deaths. designing natural and synthetic polymer-based
Skin, the largest organ in the body, has a surface nanofibrous scaffolds to engineer artificial organs
2
area of about 1.8 m and occupies 8% of the total for tissue engineering and drug delivery
body mass of an adult. The functions are foremost applications. These particles are possible to bind the
as a barrier, preventing pathogens from entering the polymer into malignancy cell membrane, to nuclear
body and also a sensory organ and a regulator for or cytoplasmic receptor sites, enabling to reduce
water retention and heat loss. Skin cancers are by toxicity to the normal tissue, once it is possible to
far the most common malignancy of humans, increase the drug concentration to the target cells.
particularly in the white population, with over a Enhanced permeability and retention (EPR) is the
million cases detected each year. Skin cancers are basis of nanotechnology for delivering drugs to the
named according to the cell from which they arise body sites. It allows molecules to enter the
Conclusion
and the clinical behaviour. The three commonest interstitial tumour space, by suppressing the
types are basal cell carcinomas (BCCs) and lymphatic filtration making it possible to keep the
squamous cell carcinomas (SCCs) (both referred as molecules in the malignant cells. The nanofibers
non-melanocytic skin cancer—NMSC) and obtained by the electrospinning process can be
cutaneous malignant melanomas (CMs) (also applied for wound healing and to topically drug
referred to malignant melanoma of the skin or delivery to the skin
melanoma).
Stage Depth
Case Study:
I Tumour with ≤1.0 mm
1. Magnetic based core-shell particles
IIA 1.01-2.0 mm

IIB 2.01-4.0 mm

III 4.0 mm ≤ Tumour depth

References:
• Hanson KM, Behne MJ, Barry NP, Mauro TM, Gratton
E, Clegg RM (2002) Two-photon fluorescence lifetime
imaging of the skin stratum corneum pH gradient.
• Green AC (1991) Premature ageing of the skin in a
Queensland population. Med J Aus 155(7):473–475
• Attwood D, Mallon C, Taylor CJ (1992) Phase studies
on oil-in-water phospholipid microemulsions. Int J
Pharma.

You might also like