DEVELOPMENT OF BIO COMPATIBLE NANO PARTICLES OF VARIOUS DRUGS

AND THEIR POTENTIAL OUTCOMES IN FIELD OF PHARMACEUTICAL

NANOTECHNOLOGY

INTRODUCTION

Swift advancement in fabrication of nanoparticles having identical size, composition and shape

have started uprising in the field of pharmaceutical sciences. From the last decade, development

of nano size based drug delivery systems has attracted augmented attention of researchers. In fast-

developing field of nanotechnology nano size based drug delivery systems are leading due to

numerous potential uses in pharmaceutical drug delivery and other fields of sciences. Because of

unique size dependent properties, these drug delivery systems offers the opportunity to develop

novel ways for treating diseases. The assimilation of drugs into nano carrier systems gives a new

archetype in drugs delivery, used for drug targeting at secondary and tertiary levels. These drug

delivery systems as oral dosage form, potentially enhance the lymphatic transport, thus reducing

hepatic first pass metabolism and boosted oral bioavailability.

ABOUT PROJECT

In this project efforts will be made for Selection of excipients/carrier systems including lipids,

surfactants and co-surfactants, Adaptation of nanotechnology based approaches to enhance

solubility of different drugs, assessment of different approaches developed for the solubility

enhancement , dissolution followed by intestinal permeability for drugs and some other parameters

such as compatibility studies, spectral analysis and stability studies by using different techniques

like Zeta Sizer, Scanning Electron Microscopy(SEM), Transmission Electron Microscopy (TEM),

Differential Scanning Calorimetry (DSC), Fourier Transform Infra-Red (FTIR), X-Ray

Diffraction (XRD), Atomic Force Microscopy (AFM) etc followed by dosage form designing,
Evaluation of approaches for extent of upgrading of these parameters , assessment of suitable

approach for increase in oral bioavailability, in vivo evaluation such as pharmacokinetic,

pharmacodynamic and toxicological studies using different animal models.

COMPARISON WITH CONVENTIONAL TECHNOLOGY

Conventional formulation strategies may no longer be enough for poorly aqueous soluble drugs

emerged from drug discovery. In recent pharmaceutics, sophisticated drug delivery approaches

such as nano size based drug delivery systems become a vital technology in the development of

new drug entities. In addition to improving solubility and bioavailability, these drug delivery

systems also offer many other clinical advantages over conventional formulations for many poorly

soluble compounds, including:

a. Uniform dosing regimen

b. Reduce therapeutic dose as a result of better drug absorption

c. Decrease hepatic metabolism of drugs because of probable lymphatic transport of

compounds

d. Elimination or decrease of food effects on bioavailability of a compound hence improve

dose flexibility

e. Elimination or decrease of inter- and intra- subject variability because of reduced effects

of GIT variability on solubilization.

Nano drug delivery is also a smart option for controlled drug release and targeted drug delivery.

Using molecular assembly and coating technologies, formulations can be designed to tailor a

desired release profile and target it to a specific site.

Activity
Activities
Number 1st Quarter 2nd Quarter 3rd Quarter 4th Quarter

1. Literature study and Pre-

formulation study of raw

material

2.  Preparation of

Nanoparticles by using

different techniques

 Characterization of

Nanoparticles by

SEM/TEM/Zeta sizer

etc

 Characterization of
3.
nanoparticles by AFM,

DSC, FTIR, XRD etc

 Dosage form designing

 In- Vitro Study

 In- Vivo Study

 Documentation and

Publication
RESEARCH OUTCOMES

Proposed study is highly related with emerging area of nanotechnology which is a

multidisciplinary field with great scope and immense potential in numerous areas such as

pharmaceutical science, materials science, physics, chemistry, environmental sciences, materials

engineering, agriculture, food science, etc. Our research deals with the preparation of nano size

based drug delivery systems by cost effective methods for drugs having low bioavailability which

will be incorporated in these drug delivery systems.

Proposed work will show its impacts in the following ways:

TO ME AND MY UNIVERSITY

 Advance my education through various learning opportunities, both formally and through

projects and research activities, which will be determined in collaboration with Prof. Zihei

Dai (supervisor), University of Peking and China our friend country.

 Develop my skills by participating in other research projects of my supervisor

 Publish many original research results obtained during my tenure in appropriate journals

and other recognized media; and

 Attend scientific conferences agreed between me and my supervisor to present our results

(subject to the availability of travel funds).

NATIONAL & SCIENTIFIC OUTCOMES

Current proposal will also prove quite effective in strengthening our institutional facilities on

synthesis of nanostructured materials, characterization and their applications in the

pharmaceutical sciences. Moreover, our experimental data resulting from the proposed
 research will be of great worth which can be shared at national/international scientific forum

for reflection of our quality research. From this project, it is expected that at least two

presentations at national and international level would be generated. Dissemination of the

acquired data in internationally reputed journals of impact factor is an integral part of our

scientific data sharing plan. We expect that more than three research articles can be generated

from this proposed work.

Positive opinion will be established about pharmaceutical industries by giving them new

methods for the development of cost-effective drug delivery system. It will help in

improving patient compliance rate.

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