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Data Disolusi Higuchi

1. The document contains data from a dissolution test measuring the amount of drug dissolved over time (in minutes and hours) including concentration (Cp) and percentage dissolved. 2. A linear regression analysis was performed on the dissolution data based on the Higuchi model, showing a linear relationship between amount dissolved and the square root of time with an R2 value of 0.9628. 3. A calibration curve was constructed by measuring absorbance (Abs) values at different concentration levels of an active ingredient, showing a linear relationship between concentration and absorbance with an R2 value very close to 1.

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Khairunnisa Nisa
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48 views5 pages

Data Disolusi Higuchi

1. The document contains data from a dissolution test measuring the amount of drug dissolved over time (in minutes and hours) including concentration (Cp) and percentage dissolved. 2. A linear regression analysis was performed on the dissolution data based on the Higuchi model, showing a linear relationship between amount dissolved and the square root of time with an R2 value of 0.9628. 3. A calibration curve was constructed by measuring absorbance (Abs) values at different concentration levels of an active ingredient, showing a linear relationship between concentration and absorbance with an R2 value very close to 1.

Uploaded by

Khairunnisa Nisa
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as XLSX, PDF, TXT or read online on Scribd
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Data Disolusi

t (menit) t (jam) t1/2 (jam) fp Abs Cp (mg/mL) Jumlah terdisolusi (mg) f


0 0 0 0 0 0 0 0
5 0.083333 0.2886751 1 0.084 -0.0006896552 -0.0172413793 -8.2759E-05
10 0.166667 0.4082483 1 0.163 0.0047586207 0.1189655172 0.00048828
15 0.25 0.5 2.5 0.214 0.0206896552 0.5172413793 0.00297103
30 0.5 0.7071068 2.5 0.359 0.0456896552 1.1422413793 0.00845379
45 0.75 0.8660254 4 0.529 0.12 3 0.02285379
60 1 1 4 0.683 0.1624827586 4.0620689655 0.04235172
90 1.5 1.2247449 5 0.538 0.1531034483 3.8275862069 0.06072414
120 2 1.4142136 20 0.237 0.1972413793 4.9310344828 0.0843931
180 3 1.7320508 20 0.282 0.2593103448 6.4827586207 0.11551034
240 4 2 20 0.323 0.315862069 7.8965517241 0.15341379

Data Disolusi Higuch


18
16
14 f(x) = 9.7074026864x - 4.6631569146
12 R² = 0.9628074781
10
8
6
4
2
0
-2 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 1.8 2 2.2
Jumlah total obat terdisolusi %Pelepasan obat Kumulatif % pelepasan obat
0 0 0
-0.0173241379 -0.008662069 -0.008662069
0.1194537931 0.0597268966 0.0510648276
0.5202124138 0.2601062069 0.3111710345
1.1506951724 0.5753475862 0.8865186207
3.0228537931 1.5114268966 2.3979455172
4.1044206897 2.0522103448 4.4501558621
3.8883103448 1.9441551724 6.3943110345
5.0154275862 2.5077137931 8.9020248276
6.5982689655 3.2991344828 12.2011593103
8.0499655172 4.0249827586 16.226142069

Disolusi Higuchi

631569146
Data Disolusi Higuchi
Linear (Data Disolusi
Higuchi)

1.4 1.6 1.8 2 2.2


Kurva Baku
Kadar Cp
(mg%) (mg/mL) Abs
0.1 0.001 0.109
0.2 0.002 0.123
0.3 0.003 0.138
0.4 0.004 0.337
0.5 0.005 0.416 Kurva Baku
0.6 0.006 0.516 0.16
0.7 0.007 0.683
0.14
0.8 0.008 0.92 f(x) = 14.5x + 0.0943333333
0.9 0.009 0.706 0.12 R² = 0.9996038035
1 0.01 0.753 0.1
0.08
0.06
0.04
0.02
0
0.0005 0.001 0.0015 0.002 0.0025 0.003 0.0035
Kurva Baku

4.5x + 0.0943333333
996038035
Kurva Baku
Linear (Kurva Baku)

15 0.002 0.0025 0.003 0.0035


Data Disolusi

t (menit)

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