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Explanation of Simplex Method

The document describes the processes involved in the production of aspirin and caffeine extraction, as well as packaging. Key steps in aspirin production include acetylation using a batch reactor at 88-92°C, filtration using a rotary vacuum drum filter at 90°C, crystallization using an agitated batch crystallizer cooled to 10-25°C, centrifugation at 25°C, drying using a rotary drum dryer at 60-70°C, and extractive distillation using a distillation column. Caffeine extraction steps are also outlined. Final packaging involves mixing, sieving, size reduction using a hammer mill, and compression into tablets using a rotary tablet machine, all at room temperature.

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Sam Denielle Tugaoen
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72 views

Explanation of Simplex Method

The document describes the processes involved in the production of aspirin and caffeine extraction, as well as packaging. Key steps in aspirin production include acetylation using a batch reactor at 88-92°C, filtration using a rotary vacuum drum filter at 90°C, crystallization using an agitated batch crystallizer cooled to 10-25°C, centrifugation at 25°C, drying using a rotary drum dryer at 60-70°C, and extractive distillation using a distillation column. Caffeine extraction steps are also outlined. Final packaging involves mixing, sieving, size reduction using a hammer mill, and compression into tablets using a rotary tablet machine, all at room temperature.

Uploaded by

Sam Denielle Tugaoen
Copyright
© © All Rights Reserved
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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I.

Aspirin Production

Process Equipment Operating Operating Other Details


Pressure Temperature
Acetylation Agitated 1 atm 88-92˚C Reaction Time: 2-3 hrs
Batch
Reactor Heating Rate Constant: 0.3 l/mol-hr
Medium:
(To be Superheated 95% Conversion of Salicylic acid
designed) steam or hot
water 20% stoichiometric excess of acetic anhydride and 10% by wt concentrated sulfuric acid
(based on the mass of salicylic acid)
Optimum
Reaction Sources:
Temperature:  https://www.chegg.com/homework-help/questions-and-answers/manufacture-
90˚C aspirin-acetylsalicylic-acid-synthesized-using-reaction-salicylic-acid-acetic--q5050378
 Chemical Reactions and Chemical Reactors by George W. Roberts
 Encyclopedia of Chemical Processing and Design- Volume 4 by John McKetta Jr.
 http://eleceng.dit.ie/gavin/DT275/Module%201/Assignment.htm?fbclid=IwAR371JVkl
Raifzm6CrBiQplSw6SNVqmL3pxewgYE41J59foI72GhYUnevOo
Filtration Rotary 1 atm 90˚C
Vacuum Sources:
Drum Filter  Chemical Reactions and Chemical Reactors by George W. Roberts
Crystallization Agitated 1 atm Cooling The cooling water from the cooling tower is used to precipitate aspirin at low temperature.
Batch water: 10-
Crystallizer 25˚C Aspirin Mixture Temperature: 10˚C
Sources:
(To be  Encyclopedia of Chemical Processing and Design- Volume 4 by John McKetta Jr.
designed)
Centrifugation Centrifugal 1 atm 25˚C The mother liquor contains 10-20% aspirin.
Bowl/
Continuous Sources:
Centrifuge  Encyclopedia of Chemical Processing and Design- Volume 4 by John McKetta Jr.
Drying Rotary 1 atm 60-70 ˚C Initial moisture content: 22% wet basis
Drum Final moisture content: 0.1% wet basis
Dryer
Source
(To be  Perry’s Chemical Engineering Handbook 8th Edition
designed)  Encyclopedia of Chemical Processing and Design- Volume 4 by John McKetta Jr.
Extractive Distillation 1 atm Feed: 29 wt% Acetic Acid (Subcooled Liquid)
Distillation Column Distillate: 99.5 wt% Water (Saturated Liquid)
Bottoms: 99% Acetic Acid (Saturated Liquid)
(To be Reflux Ratio: 4.76
designed)
Use Ponchon-Savarit Method (Acetic Acid-Water System) to determine the number of plates
and the duties of condenser and reboiler.

Sources:
 Enthalpy- Concentration Diagram: https://www.oreilly.com/library/view/basic-
principles-and/9780132885478/app10.html
 https://pdfs.semanticscholar.org/83c0/81efacca48e7807f0318f307a8de7eb3b78c.pdf

Cooling Cooling 1 atm Process water is cooled which will be used to precipitate aspirin in the crystallizer
Tower
Source: Perry’s Chemical Engineering Handbook 8th Edition

II. Caffeine Extraction

Process Equipment Operating Operating Other Details


Pressure Temperature
III. Packaging

Process Equipment Operating Operating Other Details


Pressure Temperature
Mixing Mixing Tank 1 atm 25˚C
Sieving Vibrating Screen 1 atm 25˚C
Size Reduction Hammer Mill 1 atm 25˚C
Compression Rotary Tablet 1 atm 25˚C
Machine

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