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Epoetin Alfa

Eprex (epoetin alfa) is used to treat anemia caused by reduced endogenous erythropoietin production, primarily in end-stage renal disease and to correct hemostatic defects in uremia. It works by stimulating erythropoietin production. Close monitoring of renal function, bloodwork, iron levels, blood pressure, and symptoms is required due to potential side effects like hypertension, seizures, and bone pain. The dose is adjusted based on hemoglobin levels to maintain appropriate red blood cell counts.

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Izell Lee
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2K views2 pages

Epoetin Alfa

Eprex (epoetin alfa) is used to treat anemia caused by reduced endogenous erythropoietin production, primarily in end-stage renal disease and to correct hemostatic defects in uremia. It works by stimulating erythropoietin production. Close monitoring of renal function, bloodwork, iron levels, blood pressure, and symptoms is required due to potential side effects like hypertension, seizures, and bone pain. The dose is adjusted based on hemoglobin levels to maintain appropriate red blood cell counts.

Uploaded by

Izell Lee
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOC, PDF, TXT or read online on Scribd
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Brand Name Generic Indication and Nursing Consideration Action of the Dose and Side Effects

Name Contraindication Drug Administration


Eprex Epoetin alfa Anemia caused by -Monitor renal studies, urinalysis, Erythropoietin is SC/ IV 50- 100 CNS: Seizures,
reduction endogenous protein, blood,BUN, creatinine, one factor U/kg 3x/wk, coldness,
erythropoietin I&O; report drop in output < 50 controlling rate then adjust dose sweating
production primarily ml/hr of red cell by 25
end stage renal disease; production; drug U/kg/dose to CV:
to correct hemostatic -monitor blood studies; reticulocyte is developed by maintain Hypertension,
defect in uremia. count weekly; check for symptoms recombinant appropriate Hct. hypertensive
of anemia, fatigue, pallor, dyspnea DNA encephalopathy
Contraindications: technology. Available
hypersensitivity to -Assess CNS symptoms; coldness, forms: 2000, MS: bone pain
albumin, hypertension, sweating 3000, 4000,
erythropoietin levels of 10,000 U/ml
>200 mU/ml -Assess CV status: BP before and
during Tx; Htn may occur rapidly
Precautions: leading to Htn encephalopathy
pregnancy class C
-Assess patient during hemodialysis
for bruits, thrills of shunts; drug
prevents severe anemia in chronic
renal failure; clotting may need to be
treated with increased anticoagulant.

-Monitor serum iron levels, ferritin,


transferring levels; iron therapy may
be needed to prevent recurring
anemia.

-Monitor blood studies; BUN, WBC,


phosphorus, potassium, bleeding
time. Hct should be checked in
chronic renal failure.

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