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Drug Study (Pyrazinamide)

Pyrazinamide is an oral antituberculotic drug used for initial treatment of active TB in conjunction with other antituberculotics. It is contraindicated in those with allergy to pyrazinamide or acute hepatic disease. Common side effects include hepatotoxicity, nausea, vomiting, diarrhea, anorexia, rashes, photosensitivity, and hyperuricemia leading to gout. Nursing considerations include assessing for allergies or conditions like hepatic disease or gout, administering the drug once daily in conjunction with other antituberculotics, monitoring for side effects, and discontinuing if liver damage occurs.

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Kristine Artes Aguilar
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4K views2 pages

Drug Study (Pyrazinamide)

Pyrazinamide is an oral antituberculotic drug used for initial treatment of active TB in conjunction with other antituberculotics. It is contraindicated in those with allergy to pyrazinamide or acute hepatic disease. Common side effects include hepatotoxicity, nausea, vomiting, diarrhea, anorexia, rashes, photosensitivity, and hyperuricemia leading to gout. Nursing considerations include assessing for allergies or conditions like hepatic disease or gout, administering the drug once daily in conjunction with other antituberculotics, monitoring for side effects, and discontinuing if liver damage occurs.

Uploaded by

Kristine Artes Aguilar
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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MECHANISISM SIDE EFFECTS/ NURSING

DRUG NAME OF ACTION INDICATION CONTRAINDICATION ADVERSE EFFECTS CONSIDERATIONS

Generic Name: Bacteriostatic or Initial treatment of Contraindicated with Dermatologic: Assessment:


Pyrazinamide bactericidal active TB in allergy to Rashes, History:
against adults and pyrazinamide, acute photosensitivity Allergy to
Brand Name: mycobacterium children with hepatic disease, Gastro Intestinal: pyrazinamide, acute
Tebrazid tuberculosis combined with lactation, acute gout. Hepatotoxicity, hepatic disease, gout,
other Use cautiously with nausea, vomiting, diabetes mellitus,
Classification: antituberculotic diabetes mellitus, diarrhea, anorexia acute intermittent
Antituberculotic Treatment of acute intermittent Hematologic: porphyria, pregnancy.
drug-resistant TB porphyria, pregnancy. Sideroblastic Physical:
Dosage: as part of an anemia, Skin color, lesions,
15 to 30 mg/kg once individualized thrombocytopenia, joint status, TB, liver
daily regimen. adverse effects on evaluation, LFTs,
clotting mechanism serum and urine uric
Route: or vascular integrity acid levels, blood and
Oral Other: urine glucose, CBC.
Active gout
Intervention:
Administer only in
conjunction with
other
antituberculotics.
Administer once a
day.
Discontinue drug if
liver damage or
hyperuricemia in
conjunction with
acute gouty
arthritis occurs.

Teaching pionts:
Take drugs once a
day, it will need to
be taken with other
tuberculosis drugs.
Take drugs
regularly, avoid
missing doses.
Do not discontinue
drug without first
consulting
healthcare
provider.
Have regular,
periodic medical
check-ups,
including blood test
to evaluate drug
effects.
Report fever,
malaise loss of
appetite, nausea,
vomiting, darkened
urine, yellowing of
skin and eyes,
severe pain in
great toe or wrist.

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