DR.
JEANNE D'ARC MARIA TJIAM SIAN LIE,SPKK
Tanggal lahir : 13 Juni 1965
Riwayat Pendidikan :
Lulus Dokter Umum di Fakultas Kedokteran Universitas Kristen Maranatha th. 1994
Lulus Program Pendidikan Spsialis Kulit dan Kelamin di Fakultas Kedokteran Universitas
Padjajaran th. 2005
Jabatan
:
Ketua Kelompok Staf Medis Kulit dan Kelamin RS Santo Borromeus 2006 - sekarang
Ketua Komite Medik RS Santo Borromeus 2015 sekarang
Ketua Tim HIV/AIDS RS Santo Borromeus th 2010-2012
Anggota Komite Etik RS. Santo Borromeus th 2014-sekarang
Anggota forum komite medik Persi Jabar 2015-Sekarang
PREVENTION
OF
PREMATURE
AGING SKIN
Jeanne d'Arc Maria Tjiam Sian Lie
AGING SKIN PROCESS
IS AGING SKIN
PREVENTABLE?
No : natural process
Yes : slow the aging process
Problem : how much is your aging skin really under your control
Remember : it is never too late to start
AGING SKIN PROCESS
PREMATURE SKIN AGING
CONTRIBUTING FACTORS
Intense physical & psychological stress
Alcohol intake
Poor nutrition
Overeating
Environmental pollution
UV exposure
MAJOR THEORIES OF SKIN AGING
EXTRINSIC :
Sun exposure
Air pollution
Smoking
Poor nutrition
INTRINSIC
Genetic background
Hormonal status
Metabolic reactions
INTRINSIC FACTORS
GENETICS
Replicative senescence : cells becomes old, can no longer replicate
Result from DNA damage induced by : UV radiation, toxins,
age-related deterioration
Hallmark : shortening of telomeres
INTRINSIC FACTORS
HORMONES & METABOLIC REACTION
Decline in the level of sex hormones (estrogen, testosterone, dehydroepiandrosterone sulfate) &
growth hormone
Healthy collagen fibers loose their elasticity, becoming rigid, more brittle, and prone to breakage
Accelerated by hyperglycemia --> fibroblast apoptosis
Thinning, discoloration, loss of elasticity, tendency to rashes & infections
EXTRINSIC FACTORS
UV RADIATION
Chronic sun exposure damages the dermal connective tissue & alters normal
skin metabolism
Destruction of collagen induce loss of skin suppleness
UV irradiation target : surface epidermal layers
Depletion of antioxidants (alpha-tocopherol, ascorbic acid)
Fail of defense system (superoxide dismutase, catalase, glutathione-Stransferase)
EXTRINSIC FACTORS
ENVIRONMENTAL TOXINS
Smoking (tobacco) produce oxidative stress, impairs circulation, triggers DNA
damaging reactions
Skin more vulnerable to disease & aging skin
"Smokers skin" : increased lines & wrinkles, uneven tone, dehydration, dull &
frail skin.
Particle pollution as toxin exposure --> skin hyperpigmentation, sluggish skin
cell renewal
CLINICAL FEATURES
Dryness (flaking, scales)
Actinic keratosis
Irregular pigmentation : freckling, lentigenes
Guttate hypomelanosis
Diffuse irreversible hyperpigmentation (bronzing)
Rhytides-wrinkling (fine surface lines, deep furrows)
Stellate pseudoscars
Elastosis
CLINICAL FEATURES
Inelasticity
Telangictesia
Venous lakes
Purpura (easy brusing)
Comedones (maladie de Favre et Racouchot)
Sebaceous hyperplasia
Carcinomas (basal cell ca, squamous cell ca, melanomas)
Aging skin
Prevention and
Combating Skin Aging
Health Life Style
Be happy
Sleep
Don't smoke
Clean your body
Exercise : mental and physical
Hydrate
Wear sunscreen & sunglasses
DIETARY STRATEGIES
Fruits & vegetables (apples, berries, cherries, orange, soy)
Whole grains
Monounsaturated fats (eg. Olive oil)
Minerals (selenium, copper), Vitamin E, Vitamin D, Vitamin C
Green tea
Avoid sugar
Eat fish
Stay hydrated
DIETARY STRATEGIES
Antioxidants
TOPICAL INTERVENTIONS
Sunscreen
Moisturizer
Cleansing
MEDICAL PROCEDURES &
MODALITIES
Botox
Fillers
Chemical peeling
Radiofrequency
Dermabration
Laser
Surgery
THANK YOU
