Name:_________________________________

The Circulatory System

1. Explain why large, multicellular organisms require circulatory systems. /1
2. No cell is further than ________ cells away from a blood vessel. This allows nutrients to pass to
cells via the process of _______________________. /2
3. Name six functions of the circulatory system. /6
4. Explain how Galens theory of circulation was incorrect. /1
5. Explain how Harvey improved on Galens theory of circulation. /1
6. The word capillary comes from the Latin for _______________________. These blood
vessels were discovered by ________________________. They connect arteries to
_______________________. /3
7. An artery always carries blood ___________________________ the heart. /1
8. A ___________________________ is when you can feel the blood pumping through
_________________________ which are close to the skin./2
9. An __________________________ is due to the weakening of the wall of an
_______________________. This leads to a bulge in the wall which easily ruptures. Why is this
bad? /3
10. _________________________ is caused by the nervous system and causes more blood to flow
to a certain tissue. /1
11. Explain how you blush or pale depending on your situation. /2
12. Hardening of the arteries is also known as ________________________. This is when
__________________ droplets mix with _______________________ and other minerals to form
_________________________ which is deposited on the artery wall.
_________________________ form around this, blocking off blood flow. /5
13. Capillaries are _________________________ cells thick and are the site of
______________________ and _______________________ exchange in tissue. (Because they are
so thin, ___________________ occurs easily.) /4
14. What are interstitial spaces? What happens when capillaries rupture and fill interstitial spaces
with blood? /2
15. Venules and veins carry blood ____________________________ the heart. /1
16. Blood pressure in the veins and venules is much ________________________ than arteries. /1
18. What two factors work together to push blood against gravity back up to the heart? /2

19. If blood pools for a long period of time in a vein, the ______________________ in the veins
can be damaged, leading to a condition known as _____________________
_____________________. Name two factors that can lead to this condition. /5
20. What is the pericardium? /1
21. The average heartbeat is __________ beats per minute (BPM). /1
22. The heart is actually two pumps, divided by a _______________________. The right side of
the heart pumps to the ________________________ circulatory system, and the left side of the
heart pumps to the ________________________ circulatory system. /3
24. Chordae Tendinae, also known as cuspids, support _______________________ valves. /1
25. Coronary arteries carry blood to the _________________. /1
26. What happens if too little oxygen reaches the heart? /2
27. ______________________ _________________ operations are used to reroute blocked
coronary arteries. A ______________ is removed from the leg and grafted into position on the
heart. In order to do this operation, the heart must be temporarily stopped. /3
28. Explain how cardiac catheterization works, and what three things can be diagnosed using the
process. /6
29. Myogenic muscle is muscle that: /1
30. The SA or _________________________ node sets: The AV or _________________________
node passes impulses through the ___________________ to the _________________________. /
5
31. Explain why surgeons must be very careful when doing open heart surgery. /1
32. Identify what each of the waves indicates on the following ECG. /5
33. Explain the difference between tachycardia and bradycardia. /2
34. What pushes blood into the ventricles? /1
35. Diastole is the stage of heart contraction when the ________________ relaxes/contracts. (pick
one) During this stage, the _________________ valves slam shut, producing the __________
sound of the heartbeat. /4
36. Systole is the stage of heart contraction when the ________________ relaxes/contracts. (pick
one) During this stage, the _________________ valves slam shut, producing the __________
sound of the heartbeat. /4
37. A heart murmur is when:
How can this condition be detected? Why is the condition harmful? (2 marks)
38. Differentiate between cardiac output, stroke volume and heart rate. /3
39. People who are more fit tend to have a ________________ stroke volume, and therefore
____________________ beats per minute. /2
40. A _________________________________ is used to measure blood pressure./1
41. Blood pressure readings include two numbers. Indicate what the average numbers are, and
what they represent. /4

42. Accumulation of cellular waste products in the blood leads to ________________ of the
arteries. /1
43. Why is low blood pressure a problem? High blood pressure? Briefly explain how the body
maintains normal blood pressure. /5
44. At the capillary level, water and nutrients are forced out of the capillaries due to
____________________ pressure. This is known as ______________________.
___________________, _____________________ and ____________________ remain in the
capillary. This leads to a high ______________________ pressure which brings
_______________ back into the capillaries, carrying wastes with it. /7
45. Hemorrhaging leads to a very low _________________ pressure, due to lack of
_________________. Starvation leads to a very low ____________________ pressure due to a
lack of __________________. This leads to swelling, otherwise known as _______________
Inflammation leads to a very low ____________________ pressure in the blood vessel due to: /7
46. Lymph is a fluid that is transported in vessels similar in structure to ___________. Lymph
contains _________________ from the blood that has leaked out, as well as high concentrations of
_________________ blood cells in the lymph nodes. /3
47. Describe the causes and symptoms of anemia. /4
48. Describe how blood clotting takes place. /5
49. What is a thrombus? Why can they be dangerous? /2
50. What is an embolus? Why can they be dangerous? /2
51. Antigens are ______________________ on the surface of __________________ cells.
Antibodies are ____________________ that attach to antigens and cause the blood to
____________________. /3
52. A person with type AB blood has ________________ antigens and ___________ antibodies.
They are referred to as the universal ____________________. /3
53. Erythroblastosis fetalis can occur when a mother is Rh ______ and the father is Rh _______.
The mothers immune system fights off any children after the __________ who are Rh ______. /4
54. Name three types of protection your body has against foreign invaders. /3
55. Match the following parts of the immune system with the description on the right:
a. Lymphocytes
b. Phagocytes
c. T-cells
d. B-cells
e. Macrophages
f. Helper T cells
g. Killer T cells
h. Suppressor T cells
i. Memory T cells
j. Antigens
k. Antibodies

_______ Identify

the antigens present on an invading cell

_______ Y-shaped proteins that attach to antigens and immobilize invaders
_______ Slows down immune reactions after the invader has been destroyed
_______ Proteins located on the surface of a cell membrane
_______ Retain information about the invader to speed up future reactions
_______ Puncture and rupture the cell membranes of intruders, and
digesting infected cells, also destroy mutated cells.
_______ White blood cells that produce antibodies.
_______ Produced in the bone marrow and stored in the thymus gland,
seek out intruders and signal the attack
_______ White blood cells that engulf and digest invaders
_______ White blood cells that produce antibodies.
_______ White blood cells that engulf and digest invaders /1

56. On average, an adult human contains about _______ litres of blood. Match the following contents
of blood with the description on the right: (more than one description can be used for each term)
_______ Produce

antibodies
Blood Cells
_______ Fight off infections through diapedesis
_______ Cells that do not contain a nucleus
_______ Cells that have no set shape, can change shapes
_______ Mostly water, but also contains proteins, glucose,
nutrients, and cellular waste products.
_______ Initiate blood clotting reactions
_______ Useful in blood clotting
_______ Biconcave discs (which gives a better
surface area for oxygen exchange)
_______ White Blood Cells
_______ Iron containing pigment that holds oxygen
_______ A combination of digested proteins
from white blood cells and invader cells
_______ Red

a. plasma
b. globulins
c. fibrinogens
d. erythrocytes
e. hemoglobin
f. leukocytes
g. platelets
h. pus

57. Fill in the following chart to compare arteries and veins:

Characteristic
Direction of blood flow
in relation to the heart

Usually carries what type

of Blood? (ie: oxygenated
or deoxygenated)

Pressure inside Vessel

Structural Differences
/10

Artery

Vein