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Phataphysiology: in Guillain - Barre Syndrome, The Myelin Qheath Surrounding The Axon Is Lost

Guillain-Barré syndrome is caused by demyelination of the nerves due to an immune response, commonly following an infection. There are different subtypes depending on whether the damage is to myelin sheaths or axons, and whether motor or sensory nerves are affected. The most common form is acute inflammatory demyelinating polyneuropathy where myelin sheaths are first damaged followed by axonal injury, typically affecting adults. Acute motor axonal neuropathy mainly impacts motor nerves through macrophage activation and is more common in children.

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59 views1 page

Phataphysiology: in Guillain - Barre Syndrome, The Myelin Qheath Surrounding The Axon Is Lost

Guillain-Barré syndrome is caused by demyelination of the nerves due to an immune response, commonly following an infection. There are different subtypes depending on whether the damage is to myelin sheaths or axons, and whether motor or sensory nerves are affected. The most common form is acute inflammatory demyelinating polyneuropathy where myelin sheaths are first damaged followed by axonal injury, typically affecting adults. Acute motor axonal neuropathy mainly impacts motor nerves through macrophage activation and is more common in children.

Uploaded by

sachin duduskar
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PHATAPHYSIOLOGY:

In Guillain Barre Syndrome, the myelin Qheath Surrounding the axon is lost.
Demyelination is common response of heural tissue to many agent &
conditions, including physical trauma, hupoxemia, toxic chemicals, vascular
insufficience & immunological reactions.
Loss of myelin sheath in Gaillian Barre Syndrome make never impulse
transmission aborted.
Probably a cell mediated immune response to preceding infection.

Subtypes of Guillian Barre Syndrome


Subtype

Feature

Electro
diagnosis

Acate
inflammatory
demuel in
polyncuropathy
(AIDP)
Acute motor
axonal
neuropathy
(AMAN)

Adult affected
more than
children

Demyelinating

Children & young


adult

Axonal

Acute motor
Sensory axonal
neuropathy
(AMSAN)

Adults & childrens


uncomonon

Axonal

M.Fisher
syndrome (MFS)

Adults & childrens


uncomonon

Demyelinating

Pathology
1st attack on
schwann all
myelin damage
2nd axonal
damage.
1st attack motor
nerve,
macrophage
activation.
Same as AMAN,
but also affect
sensory never &
roots, axonal
damage usually
severe.
Few case
examined,
resembles (AIDP)

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