Name of Drug Classification Indication Contra- Side-effects Nursing Monitoring

indication Responsibilities Parameters

Generic: Diuretic Promotion of Pulmonary Fluid and ✔ The * Monitor for

Mannitol diuresis in the congestion or electrolyte cardiovascular manifestation fo
prevention or oedema; imbalance; status of the
Action: Mannitol patient should be electrolyte
Brand: increases urinary treatment of the intracranial acidosis (with imbalance.
carefully
Osmitrol, output by oliguric phase of bleeding; CHF; high doses).
evaluated before
Resctisol inhibiting tubular acute renal metabolic Nausea, rapidly
reabsorption of failure before oedema with vomiting, thirst; administering
water and irreversible renal abnormal headache, mannitol since
Route: failure becomes capillary fragility; dizziness,
electrolytes. It sudden expansion
raises the established. anuria due to convulsions, of the
Reduction of severe renal chills, fever; extracellular fluid
osmotic pressure
Dose: of the plasma intracranial disease; severe tachycardia, may lead to
pressure and dehydration. chest pain; fulminating
allowing water to congestive heart
be drawn out of brain mass. blurred vision;
failure.
Frequency: body tissues. Reduction of high urticaria and ✔ Shift of sodium-
intraocular hypotension or free intracellular
pressure when hypertension; fluid into the
the pressure acute renal extracellular
cannot be failure; skin compartment
lowered by other necrosis; following
means. thrombophloebiti mannitol infusion
✔ Pro s. may lower serum
mo sodium
concentration and
tio
aggravate pre-
n existing
of hyponatremia.
uri ✔ By sustaining
nar diuresis, mannitol
y administration
exc may obscure and
reti intensify
on inadequate
hydration or
of
hypovolemia.
toxi
✔ Electrolyte-free
c mannitol
ma solutions should
teri not be given
als. conjointly with
✔ Ede blood. If it is
ma essential that
blood be given
simultaneously,
 at least 20 mEq
of sodium
chloride should
be added to each
liter of mannitol
solution to avoid
pseudoagglutinati
on.
✔ When exposed to
low
temperatures,
solutions of
mannitol may
crystalize. If
crystals are
observed, the
container should
be warmed to
redissolve, then
cooled to body
temperature
before
administering.
See NOTE under
how supplied.
When infusing
20% or 25%
mannitol
concentrations,
the
administration set
should include a
filter. Do not
infuse mannitol
solution if crystals
are present.
✔ Do not administer
unless solution is
clear and
container is
undamaged.
Discard unused
portion. Do not
administer
Mannitol 25% if
the Fliptop vial
seal is not intact.