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Doze Antibiotice

This document provides dosing guidelines for various antibiotics in both adult and pediatric patients. It lists several classes of antibiotics including penicillins, cephalosporins, aminoglycosides, macrolides, fluoroquinolones, and others. For each antibiotic, it specifies the dosages for adults and children for different routes of administration including oral, intravenous, and intramuscular dosing. The document is organized by antibiotic class and provides the generic and trade names of common drugs along with their recommended dosages.

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Mocanu Cristina-Viorica
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1K views6 pages

Doze Antibiotice

This document provides dosing guidelines for various antibiotics in both adult and pediatric patients. It lists several classes of antibiotics including penicillins, cephalosporins, aminoglycosides, macrolides, fluoroquinolones, and others. For each antibiotic, it specifies the dosages for adults and children for different routes of administration including oral, intravenous, and intramuscular dosing. The document is organized by antibiotic class and provides the generic and trade names of common drugs along with their recommended dosages.

Uploaded by

Mocanu Cristina-Viorica
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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ANTIBIOTIC

PENICILINA G

DOZELE DE PENICILINE NATURALE


DOZE ADULI / ZI
DOZE COPIL / ZI
1-20 mil.UI, im/iv, 4/6/12 h
50.000-200.000 U/kg

PENICILINA V
EXTENCILINE
(BENZATHIN
PENICILINA G)

3-4 mil.U, po, la 6/8 h


1,2 mil. U/15 zile sau
2,4 mil.U/lun

50.000-100.000 U/kg
600.000 U/15 zile sau
1,2 mil U/lun

DOZELE DE PENICILINE REZISTENTE LA PENICILINAZE


ANTIBIOTIC
DOZE- ADULT
DOZE- COPIL
OXACILLINA/
2-4 g/zi (po:6/8 h; im,iv: 4-12 h)
50-100 mg/zi
NAFCILINA
CLOXACILINA
4-12 g/zi (im, iv: 5-6 h)
100-200 mg/kg/zi
DICLOXACILINA
1-4 g/zi (6-8 h)
50-100 mg/kg/zi

ANTIBIOTIC
AMPICILINA
AMOXICILINA
BACAMPICILINA
METAMPICILINA
PIVAMPICILINA
AMOXICILINA-AC.
CLAVULANIC
AMPICILINA-SULBACTAM

DOZE DE AMINOPENICILINE
DOZE - ADULT
Po:2-4 g/zi;
im,iv: 4-12 g/zi
Po, im, iv: 1-8 g/zi
0,8- 2,4 g/zi
2-12 g/zi
1-3 g/zi
2-3 g/zi
3- 4,5 g/zi

DOZE - COPIL
50-100 mg/zi
100-300 mg/zi
25- 200 mg/kg/zi
50-100 mg/kg/zi
50-200 mg/kg/zi
50-100 mg/kg/zi
30-40 mg/kg/zi
30-40 mg/kg/zi

DOZELE DE PENICILINE ANTIPSEUDOMONAS


ANTIBIOTIC
DOZE ADULT
DOZE COPIL
TICARCILINA
250 mg/kg/zi
75-100 mg/kg/zi
TICARCILINA + ACID CLAVULANIC
12,4- 18,6 g/zi
150-300 mg/kg/zi
MEZLOCILINA
6-15 g/zi
100-300 mg/kg/zi
PIPERACILINA
PIPERACILINA + TAZOBACTAM

6-15 g/zi
4,5- 13,5 g/zi

100-300 mg/kg/zi
100-300 mg/kg/zi

CARBAPENEME
ANTIBIOTIC
IMIPENEM

DOZE - ADULT
2 g/zi, iv

DOZE COPIL
30-60 mg/kg/zi

MEROPENEM
ERTAPENEM

3 g/zi, iv
1 g/zi, im,iv

40 mg/kg/zi

DOZELE DE CEFALOSPORINE DE PRIMA GENERAIE CIG


ANTIBIOTIC
DOZE ADULT
DOZE COPIL
CEFAZOLIN
1-6 g/zi, iv,im (la 6-8 h)
60 mg/kg/zi (la 8 h)
CEFADROXIL

1-2 g/zi, po

30 mg/kg/zi (la 12 h)

CEFALEXIN

1-2 g/zi, po (la 6h)

25-50 mg/kg/zi (la 6 h)

CEFALOSPORINE DE A DOUA GENERAIE


ANTIBIOTIC
DOZE ADULT
CEFAMANDOL
3-6 g/zi
CEFUROXIM
1,5- 4,5 g/zi, im,iv

DOZE COPIL
50-100 mg/kg/zi
50 mg/kg la 8 h, iv,
10-15 mg/kg x2/zi, po
10-15 mg/kg x 2 (max 1 g/zi)

CEFPROZIL

500 mg /zi, po

CEFOTETAN

CEFAMICINE:
2-6 g/zi, iv (la 12h)
30-60 mg/kg/zi

CEFOXITIN

3-6 g/zi , iv (la 4-8 h)

80-160 mg/kg/zi (la 6 h)

CEFALOSPORINE DE A TREIA GENERAIE


ANTIBIOTIC
DOZE ADULT
CEFOPERAZON
4 g/zi

DOZE COPIL
30-60 mg/kg/zi

CEFOTAXIMA

3-8 g/zi

50-100 mg/kg/zi

CEFTAZIDIMA
CEFTRIAXON

50-100 mg/kg/zi
50-75 mg/kg/zi

CEFTIZOXIMA
LATAMOXEF

3-6 g/zi
2 g/zi (<65 ani)
1 g/zi (>65 ani )
2-12 g/zi
2-6 g/zi

CEFIXIMA

ORALE
400 mg/zi, po

8 mg/kg/zi 2 prize

CEFPODOXIMA

200-400 mg/zi

10 mg/kg 2 prize

CEFTIBUTEN
CEFDINIR

400 mg/zi
600 mg/zi (1-2 prize)

4,5 mg/kg 2 prize


-

CEFALOSPORINE DE A PATRA GENERAIE


ANTIBIOTIC
DOZE ADULT
CEFEPIME
2-4 g/zi, iv
CEFPIROM

2-4 g/zi, iv

30-60 mg/kg/la 8h
-

DOZE COPIL
150 mg/kg/zi a 8 h

LINCOSAMIDE
ANTIBIOTIC
CLINDAMICINA

DOZE ADULT
0,6-2,4 g/zi, po, im, iv, (la 6-8 h)

LINCOMICINA

0,6-1,8 g/zi, im, iv, po (la 8 h)

DOZE COPIL
8-25 mg/kg, po
15-40 mg/kg, im,iv
30-60 mg/kg/zi, po
10-20 mg/kg/zi, im/iv

AMINOGLICOZIDE
ANTIBIOTIC
AMIKACINA

DOZE ADULT
15 mg/kg/zi (12-24 h)

DOZE COPIL
15 mg/kg/zi

DIBEKACINA

3 mg/kg/zi (12-24 h)

GENTAMICINA

3 mg/kg/zi (8,12,24 h)

2-4 mg/kg/zi

NETILMICINA

4-7 mg/kg/zi (8,12,24 h)

6-9 mg/kg/zi

SISOMICINA

3 mg/kg/zi (8,12,24 h)

3-5 mg/kg/zi

TOBRAMICINA

3-5 mg/kg/zi (8,12,24 h)

3 mg/kg/zi

KANAMICINA
STREPTOMICINA

15 mg/Kg/zi (12 h)
0,5-1 g/zi (24 h)

15 mg/kg/zi
30-50 mg/kg/zi

ISEPAMICINA

15 mg/kg/zi

CICLINELE
ANTIBIOTIC

DOZE ADULT

DOZE COPIL

PRIMA GENERAIE
TETRACICLIN

1-2 g (6 h), po

25-50 mg/kg/zi

OXITETRACICLIN
ROLITETRACICLIN

1-2 g (12 h), iv


300 mg, im

10-20 mg/kg/zi
-

LIMECICLIN

A 2-A GENERAIE
10-30 mg/kg (12 h)

10-15 mg/kg/zi

METACICLIN

10-30 mg/kg (12 h)


A 3-A GENERAIE

DOXICICLIN

200 mg (1 zi), apoi 100 mg

2-4 mg/kg/zi

MINOCICLIN

200 mg (1 zi), apoi 100 mg

2-4 mg/kg/zi

MACROLIDE
ANTIBIOTIC
ERITROMICINA
CLARITROMICINA
DIRITROMICINA
ROXITROMICINA

DOZE- ADULT
14 ATOMI C
2-3 g/zi, po
0,5 -2 g/zi, po
0,5 mg/zi, po
300 mg/zi

AZITROMICINA

15 ATOMI C: AZALIDE
500 mg/zi, po

10 mg/kg/zi

SPIRAMICINA
JOSAMICINA

16 ATOMI C
2-3 g/zi;4,5-9 mil UI/zi
1-2 g/zi

50.000 UI/kg/zi
30-50 mg/kg/zi

PRISTINAMICINA
VIRGINIAMICINA

SINERGISTINE
3 g/zi, po
3g

50-100 mg/kg
50-100 mg/zi

GLICOPEPTIDE
ANTIBIOTIC
VANCOMICINA
TEICOPLANIN
ORITAVANCIN
DALBAVANCIN

DOZE ADULT
1,5-2 g, iv (12 h)
200-400 mg/zi
(ncrcare: 12 mg/kg la 12 h x 3)
200 mg/zi

DOZE- COPIL

25-50 mg/kg/zi
5-8 mg/kg/zi

DOZE COPIL
0-30 zile: 15 mg/kg/zi
> 30 zile: 10 mg/kg/zi
3 mg/kg/zi

CLORAMFENICOL
< 28 zile: 12,5- 25 mg/kg la 6 h.
Copii mari i aduli: 50 mg/kg/zi (la 6 ore interval)
Copii mari i aduli cu meningit: 100 mg/kg/zi (la 6 h interval)

CLASIFICAREA BIOLOGICA A
QUINOLONELOR
GRUPA I : SPECTRU LIMITAT

CLASIFICAREA
MICROBIOLOGIC

ACID NALIDIXIC
ACID OXOLINIQUE
ACID PIROMEDIQUE
ACID PIPEMEDIQUE
FLUMEQUINE
CINOXACINE
GRUPA II : SPECTRU LARG
FLUOROQUINOLONE
PEFLOXACIN : 400 mg la 12 -24 h, iv, po
NORFLOXACIN: 400 mg la 12 h, po
CIPROFLOXACIN: 500-750 mg la 12h, iv, po
LOMEFLOXACIN: 400 mg/zi
OFLOXACIN: 200-400 mg la 12h, po
ENOXACIN
GRUPA III: SPECTRU EXTINS
FLUOROQUINOLONE
MOXIFLOXACINA: 400 mg la 24 h, iv, po
LEVOFLOXACINA: 250-500 mg la 24h, po
GEMIFLOXACINA: 320 mg la 24 h po
GATIFLOXACINA: 400-600 mg la 24 h, iv, po

Enterobacteriaceae

Enterobacteriaceae i H.influenzae
Neisseria spp.
Staphylococus coagulazo negativ
Patogeni intracelulari (Mycoplasma spp.)
P.aeruginosa
Acinetobacter spp.
Vibrio holerae
M.tuberculosis, M.leprae

Spectrul grupei II + S.pneumoniae


Streptococcus spp. +/- anaerobi

KETOLIDE: TELITROMICINA
Doz: 800 mg/zi (doz unic/zi)

OXAZOLIDINONE : LINEZOLID
Doz: 600 mg x2/zi sau 25 mg/kg/zi

METRONIDAZOL
Doza depinde de infecie
Giardiaz: 250 mg x2/zi, 5-7 zile, sau 2 g/zi, 3 zile
Infecii anaerobi:
i.v. 15 mg/kg apoi 7,5 mg/kg (administrare la 6 h)
p.o. 1-2 g/zi n 2-4 doze
I ALI NITROIMIDAZOLI (ORNIDAZOLUL, CARNIDAZOLUL I SECNIDAZOLUL)

SULFONAMIDE: SULFADIAZINA, SULFISOXAZOL, SULFAMETOXAZOL,


SULFADOXINA I TIMETOPRIM (trimetoprim 80 mg; sulfametoxazol 400 mg)

LIPOPEPTIDE: DAPTOMICINA
Infecii complicate ale pielii i esuturilor moi : 4 mg/kg/zi, iv, doz unic
Endocardite: 6 mg/kg/zi, iv.

GLICILCICLINE: TIGECICLINA

RIFAMICINE

POLIMIXINE: POLIMIXINA E COLISTINUL


Doza p.o. n infecii digestive cu Salmonella, Shigella: 100.000 UI/kg/zi la 6 ore
Doza i.m. : 50.000 UI/kg/zi
Doza i.v.: 30.000 UI/kg/zi

MONOBACTAM: AZTREONAM

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