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Shift Reagents PDF

Lanthanide shift reagents containing Eu3+ or Pr3+ ions are used in NMR spectroscopy to induce chemical shift changes in diamagnetic samples through space interactions. Europium complexes cause downfield shifts while praseodymium complexes cause upfield shifts. These reagents are coordinated by ligands like β-diketonates that impart solubility and short relaxation times to reduce peak broadening. Praseodymium(III) tris(heptafluorodiacetylacetonate) is a chiral lanthanide shift reagent that allows determination of enantiomeric excess through signal integration.

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772 views

Shift Reagents PDF

Lanthanide shift reagents containing Eu3+ or Pr3+ ions are used in NMR spectroscopy to induce chemical shift changes in diamagnetic samples through space interactions. Europium complexes cause downfield shifts while praseodymium complexes cause upfield shifts. These reagents are coordinated by ligands like β-diketonates that impart solubility and short relaxation times to reduce peak broadening. Praseodymium(III) tris(heptafluorodiacetylacetonate) is a chiral lanthanide shift reagent that allows determination of enantiomeric excess through signal integration.

Uploaded by

evsgoud_goud
Copyright
© Attribution Non-Commercial (BY-NC)
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Lanthanide shift reagents Most Ln3+ complexes are strongly paramagnetic do not give useful NMR spectroscopic data

- unusual shifts and broadened lanthanide shift reagents can be added to diamagnetic samples and induce chemical shift changes via through space interactions most common reagents are based upon Eu3+ and Pr3+ ions short relaxation times reducing broadening in 1H NMR spectra Eu3+ down field shifts and Pr3+up field coordinated by e.g -diketonate (acac) ligands Ligands impart solubility
O
R
-

O
R

O O O Eu O O O

CF3 O O Pr 3 Pr(facam)3

transient coordination to the lanthanide centre. simplify the spectrum Pr(facam)3 a chiral reagent allows the determination of ee by integration

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