Generic Name Drug Dosage, Mechanism of Adverse Reaction Contraindication Nursing Responsibility

(Brand Name) Classification & Route, Action

Indication Frequency
Methergine PC: Ergot IV: Methergin Cardiovascular: > contraindicated in >Be alert for adverse
(methylergonovine Alkaloid and 0.2 mg after ↓ hypertension, patients reactions and drug
maleate) Derivative delivery of Stimulates uterine temporary chest hypersensitive to interactions.
anterior smooth muscles pain, palpitation methylergonovine or
TC: oxytocic, shoulder, ↓ any component of the >This drug should be
lactation after producing CNSHallucinations, formulation. used extremely
stimulant delivery of sustained dizziness, seizure, carefully because of it's
placenta, or contractions headache >ergot alkaloids are potent vasoconstrictor
Indication: during ↓ contraindicated with action. I.V. use may
Prevention and puerperium; thereby shortens Gastrointestinal: potent inhibitors of induce sudden
treatment of may be the third stage of Nausea, vomiting, CYP3A4 (includes hypertension and
postpartum and repeated as labor diarrhea, foul taste protease inhibitors, cerebrovascular
postabortion required at azole antifungals, and accidents. As a last
hemorrhage intervals of Local: some macrolide resort, give I.V. slowly
caused by uterine 2-4 hours Thrombophlebitis antibiotics); over several minutes
atony or hypertension; and monitor blood
subinvolution Otic: Tinnitus toxemia; pregnancy pressure closely.

Renal: Hematuria

Respiratory:
Dyspnea, nasal
congestion

Miscellaneous:
Diaphoresis

HERRERA, Perry Lee B.

BSN III – A3a
Generic Name Drug Dosage, Mechanism of Adverse Reaction Contraindication Nursing Responsibility
(Brand Name) Classification & Route, Action
Indication Frequency
Oxytocin PC: Exogenous I.V.: 10-40 Oxytocin Cardiovascular: > Contraindicated in > Monitor and record
Agent units by I.V. ↓ hypertension; patients hypersensitive uterine contractions,
infusion in Causes potent and increased heart rate, to the drug or any of heart rate, BP,
TC: oxytocic, 1000 mL of selective systemic venous its component. intrauterine pressure,
lactation intravenous stimulation of return, and cardiac fetal heart rate, and
stimulant fluid at a uterine and output, and > Also contraindicated blood loss q15.
rate mammary gland arrhytmias in cephalopelvic
Indication: sufficient to smooth muscles disproportion or >Be alert for adverse
Induction of labor control ↓ CNS: seizures, delivery that requires reaction
at term; control of uterine producing sustained coma from water conversion, as in
postpartum atony contractions intoxication tranverse lie; in fetal >Monitor I/O.
bleeding; ↓ distress when delivery Antidiuretic effect may
adjunctive Induces labor and Gastrointestinal: isn’t imminent; in lead to fluid overload,
therapy in milk ejection and Nausea, vomiting, prematurity and in seizures, and coma
management of reduces post partum severe toxemia,
abortion bleeding hypertonic uterine >never give oxytocin
GU: titanic uterine
patterns, total placenta simultaneously by more
contractions,
previa or vasa previa. than one route.
abruption
placentae, impaired >have 20% solution
uterine blood flow, magnesium sulfate
pelvic hematoma
> Also contraindicated available for relaxation
in fetal distress. of the myometrium.
Hematologic:
afibrinogenemia >If contractions are less
than 2 minutes apart, if
Respiratory: they’re above 50mm Hg
anoxia, asphyxia ,or if they last 90seconds
or longer, stop infusion,
and turn patient on her
side, and notify
prescriber

HERRERA, Perry Lee B.

BSN III – A3a
Generic Name Drug Dosage, Mechanism of Adverse Reaction Contraindication Nursing Responsibility
(Brand Name) Classification & Route, Action
Indication Frequency
Cefazolin PC: first- IV: Cefazolin CNS: dizziness, > contraindicated in >ask patient about
Sodium generation 250 mg to 2 ↓ headache, malaise patients hypersensitive previous reaction to
cephalosporin g every 6-12 Inhibits cell-wall to cephalosporins cephalosporin or
(usually 8) synthesis GI: nausea, penicillin before starting
TC: antibiotic hours, ↓ vomiting, diarrhea, >use cautiously in the therapy
depending Promoting osmotic glossitis, dyspepsia, patients with history
Indication: on severity instability of sensitivity to >If GI reaction occurs,
Perioperative of infection; ↓ Respi: Dyspnea penicillin because of monitor hydration
prophylaxis in maximum Hinders/kills cross-allergic reaction
contaminated dose: 12 susceptible bacteria Skin: Erythematous
surgery. g/day rashes >use cautiously in
pregnant and lactating
women

HERRERA, Perry Lee B.

BSN III – A3a
Generic Name Drug Dosage, Mechanism of Adverse Reaction Contraindication Nursing Responsibility
(Brand Name) Classification & Route, Action
Indication Frequency
Hyoscine PC: IV: HBB CNS: dizziness, Contraindicated in >Be alert for adverse
Butylbromide anticholinergic 1 mg/ml ↓ headache, patients with angle- reactions and drug
Inhibits muscarinic restlessness, closure glaucoma, interactions.
TC: actions of disorientation, obstructive uropathy,
antimuscarinic, acetylcholine in the irritability, fever asthma, COPD, >Encourage pt. to void
antiemetic, ANS myasthenia gravis,
antivertigo drug, ↓ GI: constipation, paralytic ileus, >Monitor BP for
antiparkinsonism Affecting neural dry mouth, nausea, intestinal atony, & possible hypotension.
pathway vomiting unstable CV.
Indication: ↓ >Monitor cervical
To reduce Relieves spasticity, CV: palpitations, effacement and
secretions nausea and tachycardia, dilatation.
perioperatively. vomittin; reduces flushing
secretions; and
blocks cardiac EENT: dilated
vagal reflexes. pupils, blurred
vision,
↓ photophobia,
dysphagia
Promotes cervical
effacement GU: urinary
hesitancy, urinary
retention

Skin: rash, dryness

HERRERA, Perry Lee B.

BSN III – A3a
Generic Name Drug Dosage, Mechanism of Adverse Reaction Contraindication Nursing Responsibility
(Brand Name) Classification & Route, Action
Indication Frequency
Hydralazine PC: peripheral 5 mg/dose Hydralazine CNS: peripheral Contraindicated to pt.s Assess blood pressure
vasodilator then 5-10 ↓ neuritis, headache, hypersensitive to the before starting therapy
mg every Directly relaxes dizziness drug and any of its and regularly thereafter.
TC: anti- 20-30 arteriolar smooth component and in
hypertensive minutes as muscle CV: orthostatic those with coronary Instruct client to take
needed. ↓ hypotension, artery disease or mitral oral form with meals.
Indication: Vasodilaion tachycardia, valvular rheumatic
Pre-eclampsia / ↓ arrythmias, angina, heart disease. Inform client that
eclampsia Lowers Blood palpitations. orthostatic hypotension
Pressure Use cautiously in can be minimized by
GI: n/v, diarrhea, patients with rising slowly and not
anorexia suspected cardiac changing position
disease, CVA, or suddenly.
Hematologic: severe renal
neutropenia, impairment, and in Tell pt. not to abruptly
leukopenia, those taking other stop taking drug, but to
agranulocytopenia antihytensives. call prescriber if adverse
reaction occurs.
Metabolic: weight
gain, sodium Tell client to limit
retention sodium intake.

Skin: rash

HERRERA, Perry Lee B.

BSN III – A3a
Generic Name Drug Dosage, Mechanism of Adverse Reaction Contraindication Nursing Responsibility
(Brand Name) Classification & Route, Action
Indication Frequency
Magnesium PC: Magnesium I.M.: 1-4 g Magnesium Sulfate CNS: drowsiness, Parenteral > Assess pt.’s condition
Sulfate Salt every 4 ↓ depressed reflexes, administration before therapy and
hours may decrease flaccid paralysis contraindicated in regularly thereafter to
TC: Anti- I.V.: acetylcholine and hypothermia. patients with heart monitor the drug’s
convulsant, Initial: 4 g, released by nerve block or myocardial effectiveness.
Mineral then switch impulses CV: hypotension, damage.
to I.M. or 1- ↓ flushing, > BP monitoring, and
Indication: 4 g/hour by but anticonvulsant circulatory Use cautiously in hold if BP is <80/60
1. Control continuous mechanism is collapsed, patients with impaired
seizures in infusion unknown. decreased cardiac kidney function. >withhold if urine
preeclampsia and ↓ function and heat output is <30 cc/hour
eclampsia Control seizures block.
>withhold if respiration
2. To manage Metabolic: <12 cpm
preterm labor hypoglycemia
> Keep I.V. calcium
Respiratory: gluconate at all times to
Respiratory reverse magnesium
paralysis intoxication.
(↓ RR, ↓ BP, ↓ UO)
Skin: diaphoresis

HERRERA, Perry Lee B.

BSN III – A3a