Scribd
Upload
229 views

Laksh Fine Chem. PVT LTD: Standard Operating Procedure Cleaning of Reactor Sop no:RC-01 Issue Number:01

Laksh Fine Chem. Pvt Ltd. has a standard operating procedure for cleaning reactors between batches of production. The procedure involves flushing the reactor with water and methanol, heating the methanol to reflux to clean the reactor, testing a methanol sample to ensure the previous product has been removed, and documenting the cleaning in an equipment log book. The reactor is then ready to be used for the next batch after being dried with steam and vacuum. A similar cleaning process is followed after any maintenance work on the reactor.

Uploaded by

ncubepharma
Copyright
© Attribution Non-Commercial (BY-NC)
Available Formats
Download as DOC, PDF, TXT or read online on Scribd
229 views

Laksh Fine Chem. PVT LTD: Standard Operating Procedure Cleaning of Reactor Sop no:RC-01 Issue Number:01

Laksh Fine Chem. Pvt Ltd. has a standard operating procedure for cleaning reactors between batches of production. The procedure involves flushing the reactor with water and methanol, heating the methanol to reflux to clean the reactor, testing a methanol sample to ensure the previous product has been removed, and documenting the cleaning in an equipment log book. The reactor is then ready to be used for the next batch after being dried with steam and vacuum. A similar cleaning process is followed after any maintenance work on the reactor.

Uploaded by

ncubepharma
Copyright
© Attribution Non-Commercial (BY-NC)
Available Formats
Download as DOC, PDF, TXT or read online on Scribd
You are on page 1/ 2

Laksh Fine Chem. Pvt Ltd.

(AN ISO??)

Standard operating procedure Sop no:RC-01 CLEANING OF REACTOR Issue number:01


Batch to batch cleaning of reactor: After using reactor update status board to be clean and date. Check that the Reactor is empty and bottom valve is closed. Flush the Reactor with plenty of water so as to remove any adhering material. A water fill in the reactor and clean it or to be clean with water reflux at 80 to 90C, and drain water. Close the bottom valve of the Reactor and charge Methanol, Make stirring ON and start heating, heat the content to reflux and reflux for 1hr. and distil out methanol about 40%. Apply Cooling and cool the content to About 30C to 35C. Unload the Solvent from the Reactor and Flush The Reactor with methanol, Collect 250ml flushed methanol from Reactor and send to QC with Test Request to check absence of previous product on TLC. Result: COMPLIES / DOES NOTCOMPLIES. If Result Complies, dry the Reactor by applying steam and vacuum in the Reactor for 30 min. Update Status Board of the Equipment as CLEANED and update Equipment usage Log Book. After maintenance work cleaning of reactor: Clean the reactor as per above method.

Managing director KantiBhai Madhani

Production Head

Equipment Cleaning Record


Sr. No. Date Batch No. Time From To

Equipment ID.
Product Activity Done by Checked by Remarks

You might also like