Siver Andreas Moestue
Om
I earned my PhD at the Norwegian University of Science and Technology (NTNU), and am now a research professor at the Dept. of Clinical and Molecular Medicine. Trained a MSc. Pharm at the University of Oslo, I started my career as a preclinical researcher in GE Healthcare. Here, I was involved in development of molecularly targeted contrast agents for SPECT/PET, and development of the Sonazoid® microbubble for diagnostic ultrasound imaging of liver cancer. In my current research, I study the role of metabolism in cancer, with focus on diagnostic and therapeutic applications in breast cancer. In an ongoing project funded by the Norwegian Research Council, I study the effect drugs inhibiting the metabolic enzyme cPLA2 in an aggressive subtype of breast cancer. Realizing the importance of the tumor microenvironment, I also have established activities in the interface between immunology, metabolism and metastasis.
Publikasjoner
2017
-
Euceda, Leslie R.;
Hill, Deborah Katherine;
Stokke, Endre Røsstad;
Hatem, Rana;
El Botty, Rania;
Bieche, Ivan.
(2017)
Metabolic Response to Everolimus in Patient-Derived Triple-Negative Breast Cancer Xenografts.
Journal of Proteome Research
Vitenskapelig artikkel
2016
-
Itkonen, Harri;
Gorad, Saurabh Sayajirao;
Duveau, Damien Y.;
Martin, Sara E.S.;
Barkovskaya, Anna;
Bathen, Tone Frost.
(2016)
Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism.
OncoTarget
Vitenskapelig artikkel
-
Jia, Min;
Andreassen, Trygve;
Jensen, Lasse;
Bathen, Tone Frost;
Sinha, Indranil;
Gao, Hui.
(2016)
Estrogen receptor α promotes breast cancer by reprogramming choline metabolism.
Cancer Research
Vitenskapelig artikkel
-
Kim, Eugene;
Tunset, Hanna Maja;
Cebulla, Jana;
Vettukattil, Muhammad Riyas;
Helgesen, Heidi;
Feuerherm, Astrid Jullumstrø.
(2016)
Anti-vascular effects of the cytosolic phospholipase A2 inhibitor AVX235 in a patient-derived basal-like breast cancer model.
BMC Cancer
Vitenskapelig artikkel
2015
-
Cebulla, Jana;
Huuse-Røneid, Else Marie;
Pettersen, Kristine;
van der Veen, Anna;
Kim, Eugene;
Andersen, Sonja.
(2015)
MRI Reveals the in Vivo Cellular and Vascular Response to BEZ235 in Ovarian Cancer Xenografts with Different PI3-Kinase Pathway Activity.
British Journal of Cancer
Vitenskapelig artikkel
-
Esmaeili, Morteza;
Moestue, Siver Andreas;
Hamans, Bob C.;
Veltien, Andor;
Kristian, Alexandr;
Engebråten, Olav.
(2015)
In vivo 31P MRSI for metabolic profiling of human breast cancer xenografts.
Journal of Magnetic Resonance Imaging
Vitenskapelig artikkel
-
Burggraf, Jacobus;
Kamerling, Ingrid;
Gordon, Paul B.;
Schrier, Lennecke;
de Kam, Marijke;
Kales, Andrea J.
(2015)
Detection of colorectal polyps in humans using an intravenously administered fluorescent peptide targeted against c-Met.
Nature Medicine
Vitenskapelig artikkel
-
Gorad, Saurabh Sayajirao;
Ellingsen, Christine;
Bathen, Tone Frost;
Mathiesen, Berit Synnøve;
Moestue, Siver Andreas;
Rofstad, Einar K.
(2015)
Identification of metastasis-associated metabolic profiles in tumors using 1H-HR-MAS-MRS.
Neoplasia
Vitenskapelig artikkel
2014
-
Esmaeili, Morteza;
Bathen, Tone Frost;
Engebråten, Olav;
Mælandsmo, Gunhild;
Gribbestad, Ingrid S;
Moestue, Siver Andreas.
(2014)
Quantitative 31P HR-MAS MR spectroscopy for detection of response to PI3K/mTOR inhibition in breast cancer xenografts.
Magnetic Resonance in Medicine
Vitenskapelig artikkel
-
Grinde, Maria Tunset;
Skrbo, Nirma;
Moestue, Siver Andreas;
Rødland, Einar Andreas;
Borgan, Eldrid;
Kristian, Alexandr.
(2014)
Interplay of choline metabolites and genes in patient-derived breast cancer xenografts.
Breast Cancer Research
Vitenskapelig artikkel
2013
-
Moestue, Siver Andreas;
Huuse, Else Marie;
Lindholm, Evita Maria;
Bofin, Anna M.;
Engebråten, Olav;
Mælandsmo, Gunhild.
(2013)
Low-molecular contrast agent DCE-MRI and DW-MRI in early assessment of bevacizumab treatment in breast cancer xenografts.
Journal of Magnetic Resonance Imaging
Vitenskapelig artikkel
-
Moestue, Siver Andreas;
Dam, Cornelia Gerarda;
Gorad, Saurabh Sayajirao;
Kristian, Alexandr;
Bofin, Anna M.;
Mælandsmo, Gunhild.
(2013)
Metabolic biomarkers for response to PI3K inhibition in basal-like breast cancer.
Breast Cancer Research
Vitenskapelig artikkel
2012
-
Moestue, Siver Andreas;
Giskeødegård, Guro F.;
Cao, Maria Dung;
Bathen, Tone Frost;
Gribbestad, Ingrid S.
(2012)
Glycerophosphocholine (GPC) is a poorly understood biomarker in breast cancer.
Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Leserinnlegg
2011
-
Glunde, Kristine;
Jiang, Liu;
Moestue, Siver Andreas;
Gribbestad, Ingrid S.
(2011)
MRS and MRSI guidance in molecular medicine: targeting and monitoring of choline and glucose metabolism in cancer.
NMR in Biomedicine
Vitenskapelig oversiktsartikkel/review
2010
-
Moestue, Siver Andreas;
Borgan, Eldrid;
Huuse, Else Marie;
Lindholm, Evita Maria;
Sitter, Beathe;
Børresen-Dale, Anne-Lise .
(2010)
Distinct choline metabolic profiles are associated with differences in gene expression for basal-like and luminal-like breast cancer xenograft models.
BMC Cancer
Vitenskapelig artikkel
Tidsskriftspublikasjoner
-
Euceda, Leslie R.;
Hill, Deborah Katherine;
Stokke, Endre Røsstad;
Hatem, Rana;
El Botty, Rania;
Bieche, Ivan.
(2017)
Metabolic Response to Everolimus in Patient-Derived Triple-Negative Breast Cancer Xenografts.
Journal of Proteome Research
Vitenskapelig artikkel
-
Itkonen, Harri;
Gorad, Saurabh Sayajirao;
Duveau, Damien Y.;
Martin, Sara E.S.;
Barkovskaya, Anna;
Bathen, Tone Frost.
(2016)
Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism.
OncoTarget
Vitenskapelig artikkel
-
Jia, Min;
Andreassen, Trygve;
Jensen, Lasse;
Bathen, Tone Frost;
Sinha, Indranil;
Gao, Hui.
(2016)
Estrogen receptor α promotes breast cancer by reprogramming choline metabolism.
Cancer Research
Vitenskapelig artikkel
-
Kim, Eugene;
Tunset, Hanna Maja;
Cebulla, Jana;
Vettukattil, Muhammad Riyas;
Helgesen, Heidi;
Feuerherm, Astrid Jullumstrø.
(2016)
Anti-vascular effects of the cytosolic phospholipase A2 inhibitor AVX235 in a patient-derived basal-like breast cancer model.
BMC Cancer
Vitenskapelig artikkel
-
Cebulla, Jana;
Huuse-Røneid, Else Marie;
Pettersen, Kristine;
van der Veen, Anna;
Kim, Eugene;
Andersen, Sonja.
(2015)
MRI Reveals the in Vivo Cellular and Vascular Response to BEZ235 in Ovarian Cancer Xenografts with Different PI3-Kinase Pathway Activity.
British Journal of Cancer
Vitenskapelig artikkel
-
Esmaeili, Morteza;
Moestue, Siver Andreas;
Hamans, Bob C.;
Veltien, Andor;
Kristian, Alexandr;
Engebråten, Olav.
(2015)
In vivo 31P MRSI for metabolic profiling of human breast cancer xenografts.
Journal of Magnetic Resonance Imaging
Vitenskapelig artikkel
-
Burggraf, Jacobus;
Kamerling, Ingrid;
Gordon, Paul B.;
Schrier, Lennecke;
de Kam, Marijke;
Kales, Andrea J.
(2015)
Detection of colorectal polyps in humans using an intravenously administered fluorescent peptide targeted against c-Met.
Nature Medicine
Vitenskapelig artikkel
-
Gorad, Saurabh Sayajirao;
Ellingsen, Christine;
Bathen, Tone Frost;
Mathiesen, Berit Synnøve;
Moestue, Siver Andreas;
Rofstad, Einar K.
(2015)
Identification of metastasis-associated metabolic profiles in tumors using 1H-HR-MAS-MRS.
Neoplasia
Vitenskapelig artikkel
-
Esmaeili, Morteza;
Bathen, Tone Frost;
Engebråten, Olav;
Mælandsmo, Gunhild;
Gribbestad, Ingrid S;
Moestue, Siver Andreas.
(2014)
Quantitative 31P HR-MAS MR spectroscopy for detection of response to PI3K/mTOR inhibition in breast cancer xenografts.
Magnetic Resonance in Medicine
Vitenskapelig artikkel
-
Grinde, Maria Tunset;
Skrbo, Nirma;
Moestue, Siver Andreas;
Rødland, Einar Andreas;
Borgan, Eldrid;
Kristian, Alexandr.
(2014)
Interplay of choline metabolites and genes in patient-derived breast cancer xenografts.
Breast Cancer Research
Vitenskapelig artikkel
-
Moestue, Siver Andreas;
Huuse, Else Marie;
Lindholm, Evita Maria;
Bofin, Anna M.;
Engebråten, Olav;
Mælandsmo, Gunhild.
(2013)
Low-molecular contrast agent DCE-MRI and DW-MRI in early assessment of bevacizumab treatment in breast cancer xenografts.
Journal of Magnetic Resonance Imaging
Vitenskapelig artikkel
-
Moestue, Siver Andreas;
Dam, Cornelia Gerarda;
Gorad, Saurabh Sayajirao;
Kristian, Alexandr;
Bofin, Anna M.;
Mælandsmo, Gunhild.
(2013)
Metabolic biomarkers for response to PI3K inhibition in basal-like breast cancer.
Breast Cancer Research
Vitenskapelig artikkel
-
Moestue, Siver Andreas;
Giskeødegård, Guro F.;
Cao, Maria Dung;
Bathen, Tone Frost;
Gribbestad, Ingrid S.
(2012)
Glycerophosphocholine (GPC) is a poorly understood biomarker in breast cancer.
Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Leserinnlegg
-
Glunde, Kristine;
Jiang, Liu;
Moestue, Siver Andreas;
Gribbestad, Ingrid S.
(2011)
MRS and MRSI guidance in molecular medicine: targeting and monitoring of choline and glucose metabolism in cancer.
NMR in Biomedicine
Vitenskapelig oversiktsartikkel/review
-
Moestue, Siver Andreas;
Borgan, Eldrid;
Huuse, Else Marie;
Lindholm, Evita Maria;
Sitter, Beathe;
Børresen-Dale, Anne-Lise .
(2010)
Distinct choline metabolic profiles are associated with differences in gene expression for basal-like and luminal-like breast cancer xenograft models.
BMC Cancer
Vitenskapelig artikkel