San Francisco Biotech Networks’ Post

The RAS-RAF-MEK-ERK signalling pathway is crucial yet challenging in drug discovery. Advanced assay technologies like live-cell NanoBRET® TE Intracellular Assays for RAS and RAF represent a significant advancement, enabling the creation of biologically relevant models. These tools are vital for understanding the complex biology of cancer progression and therapeutic resistance, paving the way for novel drugs targeting previously undruggable targets. Discover more at https://lnkd.in/eJzZK3Ve #RAS #assays #NanoBRET

A new study from NEOsphere Biotechnologies GmbH presents a high-throughput, proteome-wide molecular glue degrader (MGD) screening platform which uses label-free, data independent acquisition mass spectrometry (DIA-PASEF) for integrated #proteomics and #Ubiquitinomics analysis. By processing 100 CRBN-ligands across two cancer cell lines, NEOsphere identified a diverse set of neosubstrates, including 50 novel candidates using the #TPD workflow on the #timsTOF and global Ubiquitinomics on the timsTOF Ultra 2 for mechanistic validation. Read the study to discover how comprehensive, high-throughput proteomic screening can offer new opportunities in drug discovery: https://lnkd.in/eQzAsQJK #MS #Bruker #timsTOFUltra2 #proteomics #TPD #Ubiquitinomics

Jerome Boyd-Kirkup, Chief Scientific Officer at Hummingbird Bioscience, will be presenting our novel dual-payload technologies at Antibody Engineering & Therapeutics San Diego. Read more in the interview: https://bit.ly/4ioDXPY Our potentially first-in-class dual-payload ADC platform strategically combines two payloads in a manner that meaningfully potentiates cytotoxic activity in targeted cancer cells. Jerome will present the possibilities of this platform and share efficacy and safety data on HMBD-802, a HER2-targeted dual-payload ADC that could unlock new opportunities in areas of high unmet medical need.   If you will be at Antibody Engineering & Therapeutics San Diego, attend the talk to learn more. #adc #drugresistance #biotech 

We are helping to unleash innovation, as Siren Biotechnology wants to bring about a 'universal change' in how we treat cancer. Learn more from Lauren Kelly, Nicole K. Paulk, PhD and Nathalie Clement about how they are carving their own path to innovation. 🔬 🦠 💡 #pharma #innovation #cancertreatment #biotechnology

Methionine adenosyltransferase 2A (MAT2A) is involved in methionine metabolism and the production of S-adenosylmethionine (SAM), a major molecular methyl donor in cells. According to studies, MAT2A overexpression is connected with cancer cell proliferation and spreading, particularly in the liver. Discover a Biological Products Set from Chemspace: https://buff.ly/4405P68 Exploring MAT2A's role might lead to new opportunities in cancer therapy and detection, as well as tumor immunomodulation. Chemspace offers a wide selection of Biologics for a variety of applications, as well as specialized biological services. Have you become interested? Сontact us at info(AT)chem-space.com! #chemspace #openscience #research #science #drugdiscovery #chemicals #medicinalchemistry #drugdevelopment #chemistry #researchanddevelopment #search #chemicalindustry #science #structures

Learn how ME Therapeutics' G-CSF antibody candidate targets immune suppression in cancer. Discover more about our research progress. https://lnkd.in/effQ7kG4 #CancerResearch #BioTech #HealthcareInnovation #GCSFAntibody #ImmunoOncology #MedicalScience #DrugDevelopment #Research

"Valora Therapeutics has $30 million to jump-start research on immunotherapies based on sugars — the kind that dots cell surfaces and helps devastating cancers evade immune system attacks. The San Diego startup was built on research from The Nobel Prize laureate Carolyn Bertozzi of Stanford University and Massachusetts Institute of Technology glycoimmunology scientist Jessica Stark. The 11-person company is developing so-called antibody-lectin chimeras — or AbLecs for short. Lectins are proteins that bind to sugar chains, and researchers have found in some cases that binding helps cancer cells resist treatments by dodging the immune system." #sandiego #biotech #funding

Excited to share how a team of researchers have successfully combined AlphaFold's protein structure predictions with AI-powered drug discovery platforms to identify novel cancer treatment candidates in record time! Key achievements: • Discovered a potent CDK20 inhibitor for hepatocellular carcinoma (HCC) treatment • Completed initial hit identification in just 30 days • Achieved nanomolar potency with compound ISM042-2-048 (IC50 = 33.4 nM) • Demonstrated selective anti-proliferation activity in HCC cells This marks the first successful application of AlphaFold in hit identification for drug discovery, combining: AlphaFold's protein structure predictions PandaOmics biocomputational platform Chemistry42 generative chemistry platform The future of drug discovery is here – where AI-powered solutions dramatically reduce time and costs while increasing success rates in finding promising drug candidates. source:https://lnkd.in/gJGEnXFj #DrugDiscovery #ArtificialIntelligence #AlphaFold #Innovation #Biotechnology #Cancer #Research #AI #Science #PharmaTech

Target Validation using Inovotion's CAM model (#4/6)   Target validation is an essential and critical phase of the drug discovery process. It plays a role both before and after lead development.   INOVOTION’s technology allows the in vivo evaluation of the consequences of gene modification on cancer proliferation, the development of metastases, and resistance to Standard-of-Care treatments (chemo-, radio-, and/or immuno-therapies), by comparing wild-type cell strains with their mutated variants, and quantifying tumor size, and metastatic invasion.   INOVOTION has a high degree of expertise in this area, allowing us to work with top academic labs, biotechs, and pharma companies in this early phase of drug discovery.   Contact us so that we can give you further information and discuss your specific project. https://lnkd.in/gWQJncb     #oncology   #preclinical    #drugdiscovery   

🌟 Breakthrough Biological Therapies Enhance Precision in Cancer Treatment! 🌟 The landscape of cancer care is evolving with innovative biological therapies that offer targeted and less invasive options compared to traditional chemotherapy. 🔍 Key Highlights: - Enhanced precision targeting reduces side effects! - Integration of nanotechnology boosts drug delivery efficiency. - Ongoing research is crucial to overcome drug resistance. From DNA and RNA-based vaccines to CAR T cell therapy, these advancements are redefining treatment approaches, ensuring a more personalized experience for patients. However, challenges remain in maintaining effectiveness across diverse populations and addressing drug resistance. 💡 Staying informed about these developments is vital for patients and healthcare providers alike! 👉 Click the link to learn more about how these therapies are shaping the future of cancer treatment! #BiologicalTherapies #CancerResearch #CancerTreatment #InnovationInHealthcare #Pharma #PrecisionMedicine #Publications #MarketAccess #MarketAccessToday