Schrödinger’s Post

We're excited to share that our manuscript, "In Silico Enabled Discovery of KAI-11101," was featured on the front cover of today's issue of Journal of Medicinal Chemistry. This cover illustrates our preclinical candidate, KAI-11101, a potent, selective, brain-penetrant DLK inhibitor. Harnessing the power of computational chemistry to enable our discovery efforts, we tackled a number of common medicinal chemistry challenges by integrating innovative in silico workflows, efficiently identifying a promising ligand with neuroprotective properties. Read the paper: https://hubs.ly/Q036FWk50 Learn more about this work in our webinar: https://hubs.ly/Q036FXZ20