Nicolas Meier’s Post

New work from the lab: Cryo-EM structures of the cytotoxic food-borne pathogen Clostridium perfringens enterotoxin bound to its human receptor, claudin-4. https://lnkd.in/evU5uHpZ This is a structure we’ve been chasing since 2019 by crystallography that had stalled, but was resurrected by cryo-EM.

The Station One thaws frozen samples and reagents in a fraction of the time using only ambient air. Dual fans intake ambient air and channel it upward through a perforated thawing tray where it circulates over and around samples. This simple action decreases sample and reagent thawing times by up to 80% without any application of heat.  The unit includes accessory racks that will fit most industry standard tubes from 1 to 50ml. It’s large thawing surface accommodates two microplates or microtube racks at a time.  www.JDMLabSolutions.com More info: https://lnkd.in/d7bHFY7 Also available from Fisher Scientific: https://lnkd.in/ecCWUvX8 #labautomation #labequipment #Samplemanagement #SLAS2024 #PCR #Genomics #Proteomics #AACR2024 #Biobanking

Meet the experts. Join Britton Strickland, Ph.D., and Gustav Lindved in the webinar, Advanced, End-To-End Shotgun #Metagenomics Workflows, as they introduce the CosmosID-HUB and how it enables the understanding of the functional roles of microbes in various environments. Register for our webinar now! http://ms.spr.ly/6045mLPgR #Microbiome #Bioinformatics #microbialcommunities For research use only. Not for use in diagnostic procedures.

Template concentration can be crucial when it comes to Sanger sequencing sample read quality. Here are a few tips to ensure you hit the mark for the best results: - For plasmids, multiply 10 ng/µl by the length of the template in kilobases. Optimal plasmid concentration = 10 ng/µl x kb - For purified PCR products, multiply 2 ng/µl by the length of the template in kilobases. Optimal purified PCR product concentration = 2 ng/µl x kb Learn more about achieving optimal read quality in our new blog: https://hubs.ly/Q02BHQr00 #Sequencing #Genomics #BioTechnology

There are several papers about anti-virulence potential of metformin drug on Pseudomonas aeruginosa and other bacterial pathogens: ------ 1- Metformin reverse minocycline to inhibit minocycline-resistant Acinetobacter baumannii by destroy the outer membrane and enhance membrane potential in vitro ---------- 2- Effects of metformin on Streptococcus suis LuxS/AI-2 quorum sensing system and biofilm formation ---------- 3- Anti-virulence prospects of Metformin against Pseudomonas aeruginosa: A new dimension to a multifaceted drug ---------- 4- Synergistic Benefits: Exploring the Anti-Virulence Effects of Metformin/Vildagliptin Antidiabetic Combination against Pseudomonas aeruginosa via Controlling Quorum Sensing Systems

The Station One thaws frozen samples and reagents in a fraction of the time using only ambient air. Dual fans intake ambient air and channel it upward through a perforated thawing tray where it circulates over and around samples. This simple action decreases sample and reagent thawing times by up to 80% without any application of heat.  The unit includes accessory racks that will fit most industry standard tubes from 1 to 50ml. It’s large thawing surface accommodates two microplates or microtube racks at a time.  www.JDMLabSolutions.com More info: https://lnkd.in/dByKky2 Also available from Fisher Scientific: https://lnkd.in/eg8qDpcK #labautomation #labequipment #Samplemanagement #SLAS2024 #PCR #Genomics #Proteomics #AACR2024 #Biobanking

Enhance your dsDNA digestion with our recombinant #HeatLabile Double-Strand Specific #DNase (#NOVOPROTEIN Cat#M127) that has a strong preference for double-stranded DNA. This dsDNase can be rapidly, completely and irreversibly inactivated by incubation for 5 minutes at 55°C. Applications: 🌟Remove contaminating genomic DNA from #RNAPreparations, e.g., #IVT, #RTPCR. 🌟Remove unwanted external DNA from samples prior to analysis of nucleic acids protected by biological membranes, e.g., bacteria, viruses, and sperm. Learn more about HeatLabile Double-Strand Specific DNase: https://lnkd.in/gtcXR9-6 E-mail: [email protected] #DNase #RNAPreparations #InVitroTranscription #Sequencing #Enzymes #Biotech #LifeScience #NOVOPROTEIN

Use highly sensitive ELISA Kits from Cygnus Technologies, LLC to detect and measure host cell proteins and bioprocess impurities. Cygnus Technologies Kits feature: 🔹 96-well removable strip microplate format 🔹 All the ready-to-use materials you need 🔹 Excellent precision of <10% CVs 🔹 Minimal sample matrix interference from most bioprocess streams. Cygnus Technologies offers ELISA Kits for detecting and measuring various impurities, such as: 🔹 Protein A 🔹 Process-related impurities such as culture media components 🔹 Species-specific Immunoglobulins 🔹 Host cell proteins of mammalian, yeast, transgenic, bacterial and insect cell line expression systems Explore Cygnus Technologies ELISA Kits: https://lnkd.in/eyqBNfWy #BioprocessImpurity #HCP #HostCellProteins #ELISA #ELISAKit

🧬#PM Friday #PreventiveMaintenance #PreAnalytics #SamplePrep #TeamWork #LabAutomation #AutomatedWorkflow #IntegratedWorkflow #PolymeraseChainReaction #PCR #NucleicAcidTesting #NAT #MolecularMarkers #Detection #Quantification #DNAExtraction #Extraction #DNA #InVitroDiagnostics #IVD #RUO #ResearchUseOnly #FieldServiceEngineering #BMET #BiomedicalEngineering #Biotechnology #Assays #Covid #ViralLoad #Quantitative #Qualitative #DonorScreening #MPX #Histocompatibility #ClinicalLaboratory #MolecularLaboratory #PathologyLaboratory #HealthcareTechnology #MedicalLaboratoryScience

CICS-UBI PUBLICATIONS Upgrading Mitochondria-Targeting Peptide-Based Nanocomplexes for Zebrafish In Vivo Compatibility Assays https://lnkd.in/dzZWFDU5