New white paper on CAR T cells for blood cancers

July is Sarcoma Awareness Month, highlighting a rare group of cancers affecting bone and soft tissue. In Ireland, approximately 300 people are diagnosed with sarcoma annually and rare, sarcomas require specialised, multidisciplinary care and often present significant diagnostic challenges. 🔍 Key points for healthcare professionals: 🔵 Soft-tissue sarcomas are the most common, often appearing as deep, painless masses. 🔵 Early recognition and referral are critical to improving outcomes. 🔵 Sarcoma accounts for just 1% of all cancers diagnosed. We invite all healthcare professionals to engage and help drive awareness and early action. https://sarcoma.ie/

After being rigorously reviewed for almost a year, this article has finally been published in Veterinarski Arhiv 96(1):73–81. This research further elucidates the oncolytic mechanism of the Indonesian Newcastle Disease Virus (NDV) Tabanan-1/ARP/2017 in inhibiting mammary carcinoma in rat models. The study found that the virus reduces the expression of Ki67 and Vascular Endothelial Growth Factor (VEGF) immunohistochemically. Full article can be accessed at : https://lnkd.in/gwUeyQMS

Tumor markers are powerful tools in the management of malignant diseases, especially when interpreted accurately and in a personalized manner. In our recently published paper, we summarized the future perspectives of tumor markers. https://lnkd.in/dKXbg7aU

CAR T-cell therapy is a novel treatment that uses a patient’s own modified T cells to provide personalized treatment. It is already being used to treat certain blood cancers and multiple myeloma, and researchers are now exploring the potential for CAR T-cell therapy to treat other conditions, including autoimmune diseases. Link in bio. #AntigenStudios #medicalanimation

At Cedars-Sinai’s Kao Autoimmunity Institute, investigators are building new pathways to understand and screen for rheumatoid arthritis–associated lung disease. A cohort study is tracking patient data over time, while parallel research analyzes tissue from lung biopsies and transplants. “The amount we don’t understand is staggering,” said Jon Giles, MD, director of the Inflammatory Arthritis Clinical Center. “We don’t know what makes the disease go from relatively innocuous to a severe state requiring a lung transplant, so we are building the ideal pipeline to improve the evidence.” Read how Cedars-Sinai is advancing this work: https://ceda.rs/44FeEmR

In Professor Schumacher‘s latest article published in Nature Reviews Drug Discovery (“Targeting DNA damage in ageing: towards supercharging DNA repair”), he and colleagues review cutting-edge advances in addressing DNA damage at the root of ageing. They discuss pharmacological strategies to mitigate DNA damage’s harmful effects, aiming to delay ageing, prevent mutation-driven cancer, and alleviate age-related degenerative diseases. 👉 Read the full article for free here: https://lnkd.in/g6h35_eA

There are an estimated 18.5 million cancer survivors in the US. and studies show only 4% of such survivors are adherent to current American Cancer Society nutrition and physical activity guidelines (Baughman C). https://lnkd.in/gqD-dpEB

🔬 BREAKING: Science catches up with common sense. Researchers are now recognizing cancer as a redox deficiency disease. That’s right—at its core, it’s about cellular imbalance. 💡 So here’s a radical idea: What if we focused on empowering our cells instead of poisoning them? The body is brilliantly designed to heal when given the right tools. Redox signaling molecules are one of those tools—supporting cellular communication, repair, and resilience. Let’s shift the conversation from fear to function. From treatment to empowerment. From breakdown to balance. ⚖️ https://lnkd.in/g9k_ts2F

Aging-related diseases, including cancer, cardiovascular disorders and type 2 diabetes, are associated with defects in protein synthesis and folding. In a new study, U-M researchers found that mitochondria accumulate misfolded proteins, which kills β-cells. Reversing this process could help treat type 2 diabetes. Learn more at https://michmed.org/jV2yP.

🟣 June 29 is World Scleroderma Day—a day to raise awareness of a rare autoimmune disease that hardens the skin and organs, and often leads to life-threatening complications. GlycoNet Investigators Drs. Lisa Willis and Mo Osman have identified a potential biomarker for severe scleroderma: a sugar called polysialic acid, which has been linked to cancer. This breakthrough could help predict who is most at risk of disease progression, and one day lead to a simple blood test to guide earlier, more effective treatment. 📖 Read the story: https://lnkd.in/g_9GYvbZ #WorldSclerodermaDay #AutoimmuneDiseases #Glycomics #RareDiseaseResearch #SclerodermaAwareness