Read about the stellar science panel from #StateOfPossible24 and what was said about external innovation, finding success in down years, rebooting the immune system, advances in oncology & obesity, and what the panelists think is most exciting right now in the industry. https://lnkd.in/ep5ydWUM If you're a #MassBioMember, you can watch the panel in its entirety on MB Vision: https://lnkd.in/e5UeUPZ5. Abraham (Abe) Ceesay | Emma Lees | Stan Wang, MD, PhD | Jacob Petersen | Chris Garabedian
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🌟 Unveiling the #PEComaMarket Insights | A DelveInsight Report 🌟 Perivascular epithelioid cell tumors (#PEComa) may be rare, but their impact is significant. As the healthcare industry delves deeper into niche markets, the PEComa Market presents a unique opportunity for research, innovation, and growth. DelveInsight Business Research LLP's latest PEComa Market Report offers a comprehensive analysis of the market dynamics, shedding light on the current landscape, emerging trends, and future opportunities. The leading #PEComaCompanies are given below:- 1. Sarcoma Oncology Research Center 2. Aadi Bioscience, Inc Inc 3. Novartis Pharmaceuticals 4. CENTOGENE GmbH Rostock 5. Antia Therapeutics AG 6. Insmed Incorporated Heart Institute 7. Children's Health's Hospital Medical Center 📌 Don’t miss out on this opportunity to unlock the potential of the PEComa market. 👉 Read the full report here @ https://lnkd.in/dkn26Jpi 📈 Explore DelveInsight’s expertise in rare diseases and oncology. #PEComa #RareDiseases #MarketAnalysis #HealthcareInnovation #OncologyMarket #DelveInsightReports #HealthcareResearch #PharmaInsights
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CereMark applauds the recent FDA approvals of new therapeutics for Alzheimer's Disease, notably Eli Lilly's Kisunla, an antibody drug designed to target and remove amyloid beta plaques in the brain, and Eisai's Leqembi (created in partnership with Biogen), another therapy also focused upon removing amyloid plaques from the brain. These developments offer hope for the millions of Americans who suffer from AD, although the case is that millions of others are experiencing mild cognitive impairment without dementia and uncertainty regarding the course of their future neurodegeneration. At CereMark Pharma, our efforts continue to develop comprehensive PET imaging agents capable of assessing pathology associated with cognitive decline and monitoring therapy-driven changes in the brain burden of both amyloid and tau proteins in a single PET scan. Our commitment lies in developing PET biomarkers with the potential to predict neurodegeneration and greater precision in its pathological development. CereMark is dedicated to leading this charge and the potential of our investigational PET imaging agent, F-18 Flornaptitril, for the challenge of better care and management of neurodegenerative diseases. https://lnkd.in/epWjfi6n #BrainHealth #MedicalImaging #Neurodegeneration #CMS #PatientCare
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Telix Pharmaceuticals Limited has submitted an application to the U.S. Food and Drug Administration or FDA for its new prostate cancer imaging agent. The company said its innovative properties are designed to facilitate more flexible production and availability of the imaging. Telix said in the U.S. access to imaging is still severely limited for underserved patient demographics in many regions and Telix’s new investigational imaging product is intended to address the unmet needs of patients, referrers and health care professionals, and expand patient reach. If approved by the FDA, the new product will help accurately diagnose cancer early and increase the probability of a patient’s survival. #TelixPharma #FDAApplication #ProstateCancer #CancerImaging #MedicalInnovation #HealthcareAdvancement #PatientCare #EarlyDiagnosis #CancerResearch #MedicalBreakthrough #PatientAccess #UnderservedCommunities #HealthcareEquity #CancerSurvival #ImagingTechnology #ProstateHealth #MedicalApproval #HealthcareInnovation #LifeSciences #TelixInnovation
Telix has submitted an application to the FDA for its new prostate cancer imaging agent.
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In the interview with Clinical Trial Vanguard, our CEO Ping Cao discusses targeting “hard to drug” proteins that evade traditional small-molecule therapies due to their complex structures and functions BridGene, leveraging its proprietary IMTAC™ technology, seeks to innovate drug discovery by focusing on proteins essential in disease pathways yet difficult to target. This approach aims to pioneer new classes of medicines that can directly interact with and modulate protein functions, addressing significant unmet medical needs in areas like oncology and neurodegenerative diseases. Read more here: https://lnkd.in/dSHR5UU3 #DrugDiscovery #Biotechnology #ClinicalTrials #BridGeneBiosciences #IMTACPlatform #Oncology #NeurodegenerativeDiseases #InnovativeTherapies #HardToDrugProteins #PharmaceuticalResearch #MolecularBiology #ProteinTargeting #PrecisionMedicine #BioTechInnovation #MedicalResearch #CancerResearch
BridGene Biosciences and How It Aims to Target Hard to Drug Proteins
https://www.clinicaltrialvanguard.com
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2024 was a groundbreaking year for precision medicine. With the FDA approving 48 new and expanded indications, we're witnessing the field transition from niche to mainstream. As our Chief Precision Medicine Officer, Susanne Munksted, shared in a recent GenomeWeb article, “It's been a year with a lot of novel drugs, biomarkers, and approaches coming to market. Precision medicine mainly started in oncology, but for the last couple of years, it's been expanding into other areas. We're almost at a tipping point where precision medicine is going from being niche to becoming more mainstream.” At Diaceutics, we are proud to play a key role in driving these advancements, ensuring that the promise of precision medicine translates into improved outcomes for all patients. Read the full article here: https://lnkd.in/eCAMERSZ #PrecisionMedicine #FDAApprovals #HealthcareInnovation
Precision Medicine in 2024: Field at a 'Tipping Point' From Niche to Mainstream
precisionmedicineonline.com
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In Episode 10 of our Pipeline Analysis series, we delve into the remarkable advancements at Roche. Here are the key takeaways: - Roche achieved substantial revenue of CHF 14.9 billion (approximately $16.2 billion) in Q1 2024, showcasing its financial strength and market position - With a robust pipeline of approximately 148 development programs, Roche focuses significantly on oncology, immunology, neurology and others - A considerable portion of their pipeline is in advanced stages,with 13% filed and 34% in Phase 3 - Roche leads with blockbuster drugs like Ocrevus, Tecentriq, and Perjeta, setting new standards in cancer and autoimmune disease treatment Stay tuned for more profound insights and updates from RAS LifeScience Solutions! #Roche #PipelineAnalysis #Innovation #Healthcare #Biopharmaceuticals #FutureOfMedicine
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These days new #insights into #disease #biology emerge at a rapid pace and the speed with which the #biotech industry responds is a key determinant of how quickly #patients #benefit from accelerating #innovation. Prof. Dr. Georg Schett in 2021 published a case study showing that depleting B-cells using CAR-T therapy had a transformational and lasting impact on a young woman suffering from systemic #lupus erythematosus (SLE), a severe #autoimmune disorder where B-cells, which normally help fight infections, switch to overdrive and form antibodies that attack the patient's own tissues. While interesting, the findings gained traction only slowly. Ultimately, however, Dr Schett's study received the attention it deserved and triggered a fundamental rethinking of how we treat immune-mediated conditions: While B-cell depletion is not a fundamentally new concept (I/I and blood cancer drug #Rituxan works this way) the realization that it is possible to achieve greater and durable B-cell depletion by aiming a patient's own immune system at disease-causing B-cells to kill them is what is now changing the field. UPMC Enterprises is proud to help advance this new approach into the clinic through our recent investment in Ouro Medicines. The talented team at Ouro, led by Jaideep Dudani, is finetuning this approach and making it more accessible to patients by using an antibody known as a bispecific T-cell engager (BiTE) to aim T-killer cells at disease-causing B-cells. This removes the underlying cause of autoimmune disease without the need for complex, high-cost CAR-T cell therapy. UPMC is proud to be working with the team at Ouro Medicines to advance this groundbreaking therapy, bringing to bear our investment prowess and deep scientific and clinical expertise in relevant disease such as #myositis and #Sjoegren's disease. We are excited to support Ouro and join a world-class syndicate venturing to create Life Changing Medicines. In collaboration with our partners at TPG, New Enterprise Associates (NEA), Norwest Venture Partners, Monograph Capital and GSK we look forward to bringing lasting cures to our patients here in #Pittsburgh and across the globe.
With $120M, GSK-allied Ouro Medicines throws its hat into burgeoning TCE ring
endpts.com
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The life sciences sector continues to push boundaries, driving innovation and delivering transformative solutions to address critical healthcare challenges. This week’s highlights include: Bluejay Therapeutics, led by CEO Keting Chu, received U.S. FDA Breakthrough Therapy Designation for Brelovitug (BJT-778) for the treatment of chronic hepatitis delta. Inflammatix, Inc., under CEO Tim Sweeney, achieved FDA clearance for its first-in-class TriVerity Test. CellFE, guided by CEO Alla Zamarayeva, PhD, launched the first-in-class T-Rest (Resting T Cell Kit) to revolutionize CAR-T cell therapy manufacturing. ALX Oncology, with CEO Jason Lettmann, presented positive data from the ASPEN-06 Phase 2 Trial, showing that Evorpacept generates strong response and durable clinical benefit in HER2-positive gastric cancer patients. Attovia Therapeutics, led by CEO Tao Fu, dosed the first participant in its first-in-human Phase 1 study of ATTO-1310, a novel half-life extended anti-IL-31 ATTOBODY for chronic pruritus. Jaguar Health, under CEO Lisa Conte, dosed the first patient in an investigator-initiated trial (IIT) evaluating Crofelemer for the rare disease indication of microvillus inclusion disease (MVID), with proof-of-concept data anticipated in H1 2025. ExThera Medical, led by CEO Erin Borger, received an MTEC Award for a pivotal sepsis trial. These milestones highlight the relentless commitment of the life sciences community to improving global health. Each breakthrough is a step closer to a healthier, more sustainable future. #LifeScience #Biotech #HealthTech #Innovation #FDA #ClinicalTrials #CAR_T #GastricCancer #Pruritus #Sepsis #Hepatitis
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🌟 𝐑𝐢𝐬𝐢𝐧𝐠 𝐅𝐨𝐜𝐮𝐬 𝐨𝐧 𝐍𝐞𝐩𝐡𝐫𝐨𝐛𝐥𝐚𝐬𝐭𝐨𝐦𝐚 𝐓𝐫𝐞𝐚𝐭𝐦𝐞𝐧𝐭: 𝐀 𝐂𝐫𝐮𝐜𝐢𝐚𝐥 𝐒𝐭𝐞𝐩 𝐓𝐨𝐰𝐚𝐫𝐝 𝐁𝐞𝐭𝐭𝐞𝐫 𝐎𝐮𝐭𝐜𝐨𝐦𝐞𝐬 𝐟𝐨𝐫 𝐂𝐡𝐢𝐥𝐝𝐫𝐞𝐧 🌟 Nephroblastoma Treatment Market size was valued at USD 1,603.40 Million in 2022 and is projected to reach USD 2,164.98 Million by 2030, growing at a CAGR of 3.6% from 2023 to 2030. 𝐂𝐥𝐢𝐜𝐤 𝐇𝐞𝐫𝐞, 𝐓𝐨 𝐆𝐞𝐭 𝐅𝐫𝐞𝐞 𝐒𝐚𝐦𝐩𝐥𝐞 𝐑𝐞𝐩𝐨𝐫𝐭 https://lnkd.in/gAiJaB8Z The nephroblastoma treatment market is making strides, driven by advancements in pediatric oncology and personalized medicine. Nephroblastoma (Wilms' tumor), the most common kidney cancer in children, calls for innovative therapies and comprehensive care. 💡 Key trends in the market include: Personalized Medicine: Targeted therapies tailored to genetic profiles for higher efficacy. Immunotherapy Growth: Leveraging the immune system to fight tumors with promising outcomes. Improved Diagnostics: Early detection through advanced imaging and genetic testing leading to better treatment protocols. As research continues to evolve, we're seeing life-changing innovations that provide hope to families around the world. Collaboration between healthcare providers, pharmaceutical companies, and researchers is critical in bringing these advancements to the forefront. #Company Bayer HealthCare Roche Pfizer Sanofi Pasteur MSD Merck Group Bristol-Myers Squibb Pharma Company Apotex Inc. Segment by Drug • Dactinomycin • Doxorubicin • Vincristine • Cyclophosphamide • Etoposide • Irinotecan #Application • Hospitals • Specialty Clinic • Others #PediatricOncology #Nephroblastoma #CancerTreatment #HealthcareInnovation #Immunotherapy #PersonalizedMedicine #WilmsTumor #OncologyResearch
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More than 2 years ago, Healio reported on the groundbreaking cohort of #lupus patients undergoing #CART cell therapy and the explosive potential to treat the most severe and refractory forms of #AutoimmuneDisease 💥 2 years later, are we still waiting for the boom? 💥 “All five SLE patients are in remission and drug-free,” Dr. Georg Schett, whose lab produced the landmark 2022 study, said. “All of them are now 2 years disease-free, and the first of them is now 3 years disease free.” Since then, the potential for #CART cell therapy has proliferated across the rheumatology spectrum: 🔬 New data accrued for autoimmune myositis, #SystemicSclerosis and #MyastheniaGravis 💉 First treatments given in neuromyelitis optica and #MultipleSclerosis 👩⚕️ Potential indications for #RheumatoidArthritis, #Sjogrens syndrome, ANCA-associated #vasculitis and blistering skin diseases It is too soon to call CAR T cell therapy a “cure,” but this kind of excitement is rare in the #rheumatology space, and we are cautiously optimistic that – despite the checkered history of rheumatology therapies – this will lead to effective treatments in the most hard-to-treat populations 🤞 Join the conversation 💬
CAR T-cell therapy may be a ‘miracle,’ but it is too soon to say ‘cure’
healio.com
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