Craig Lindsley, Ph.D., FRSC, FASPET, FAAS, FNAI’s Post

Did You Know? 🧪 The origins of modern analytical laboratories can be traced back to the 18th century, during the Chemical Revolution led by scientists like Antoine Lavoisier. Known as the "Father of Modern Chemistry," Lavoisier established principles like the conservation of mass and standardized methods for chemical analysis. Fast forward to today, analytical laboratories have evolved into high-tech hubs of innovation, using advanced techniques like chromatography, spectroscopy, and rapid testing to ensure product safety and quality across countless industries. At Prompt Praxis Labs, we’re proud to continue this legacy of scientific advancement by delivering precise and reliable results for our clients. #ScienceHistory #DidYouKnow #AnalyticalExcellence #service #womeninscience #promptpraxis #pharma #pharmaceuticals #laboratory #laboratorylife #laboratorywork #pharmaceuticalindustry #compounding #compoundinglab #womanowned #analyticaltestinglab #analyticaltesting #lifesciences

One of the key challenges of #pharmaceutical development and manufacturing is transferring lab processes to equipment suitable for large scale production. Upon transitioning in larger vessels, many parameters are impacted (scale-dependent variables) and the consequences of these changes are often difficult to predict. For these reasons, a thorough understanding of the synthetic process beyond the simple #chemical reactivity that will encompass #engineering aspects, is of paramount importance. #Olon has invested and implementing a large scale #development mindset that can contribute to design synthetic process that will consider these variable during early phase of development Proud to share our new White Paper in partnership with C&EN Chemical & Engineering News #chemistry Alessandro Agosti Margherita Pirola C&EN White Papers | FROM EXPERIMENTATION TO MODELLING: OLON STRATEGIES FOR "RIGHT FIRST TIME" SCALE-UP (discoveracs.org)

Dive into our latest drug chemistry product updates, webinars, and publications - synthesized and served fresh to your inbox. Subscribe now! #drugdiscovery

Dive into our latest drug chemistry product updates, webinars, and publications - synthesized and served fresh to your inbox. Subscribe now! #drugdiscovery

The more refined we can make the manufacturing process the more efficient and cost-effective it will be. Whether this is pure economics or a carbon-neutral effect, in most cases, the finished dosage products delivered to our customers allow them to serve the therapeutic needs more effectively. Notwithstanding this simple mantra and adhering to the qualities and compliance in all that we manufacture, we are always seeking the most efficient value solution. Our partners understand our philosophy and frequently help us achieve better operations by endorsing the concept of continual improvement. In R&D, we are currently focusing on research efforts in the field of biotechnology, through global collaborations. This is an extension of our ‘Keep it Simple’ philosophy but, in this case, trying to make a process easier or allowing value engineering to make something more accessible.   You might have the seed of an idea for cooperation or collaboration but are unsure of how to progress it and with what resources. No matter where you join us on our tree, from the roots to near the tips of the branches, you will receive a commitment to achieve value. See more on our website here: https://lnkd.in/diGxkqK #APIManufacturing #drugmanufacturing #pharma

I've just updated my role description here under my profile so I will also take a moment to post the new blurb under a post for a wider audience. I work as a Downstream Process Development Scientist within the Bioprocess Development Group located in Kalamazoo, Michigan, since January 2022. My responsibilities encompass both large and small molecule downstream processes aimed at isolating active pharmaceutical ingredients, eliminating impurities, and enhancing process robustness and economics. From initial laboratory experiments to later-scale production, I oversee the entire process, ensuring seamless tech transfer. For small molecule development, initial work involves whole cell extractions in various solvent systems, including solvent screening and volume optimization to maximize yields and minimize costs. Chemical derivatization of impurities and utilization of diverse processing techniques are integral to this phase, culminating in crystallization optimization for purity, yield, crystal forms, and cost reduction. Each developed processing step undergoes scaling to our pilot plant and production scale, with meticulous calculations to ensure integration with existing infrastructure, fostering strong collaboration with production professionals. In large molecule development, I focus on utilizing the AKTA Avant automated chromatography platform. Recently, I conducted performance tests on various alternate weak anion exchanging resins for a legacy process, involving resin selection and experimental design at lab scale. Parameters such as impurity removal, yield, cost, and efficiency are paramount. Collaboration with Pfizer experts globally is essential, with findings disseminated across the network for informed resin selections.

In this segment from Outsourced Pharma Live, Chief Editor Louis Garguilo asks our panel if CMC – chemistry, manufacturing, and controls – might be outdated, and whether biology should be added to the acronym. Watch it here: https://lnkd.in/e87xfN7Z

We're a biopharma engineering company, a small but essential piece of the massive life sciences ecosystem. By bringing together our customers, partners, industry thought leaders, regulators and governments, we affect a greater impact and bring our mission to life. #Biopharma #LifeSciences #HealthcareInnovation #Biotechnology #Engineering #Collaboration #FutureOfHealthcare #ImpactfulInnovation #GlobalHealth #IndustryLeaders #Regulators #GovernmentPartnerships #MissionDriven #ScienceForGood

Biosynth- What do we do? How are we different? What can we do for customers? ▶ We are rare in offering both a full catalog of Research Products and providing a full range of Manufacturing Services ▶ We are a team who excel in complex Chemistry but where it meets with and applies to Biology, including key biological products ▶ We are full of scientific experts, with a heart of Innovation, while we pride ourselves on our Reliability ▶ We work up to very large Scale but always maintain the highest Quality And this coming together - the point where these two things meet each time, that is where we are, Biosynth, at "The Edge" We are committed to reducing the number of suppliers needed for our customers in Pharma, Diagnostics and Vaccines. We provide a cohesive offering of both off the shelf/routine supply and custom production or process improvements to meet your needs. We partner for long term secure supply of quality products from our facilities across three continents. #biosynth #firstideatofinishedproduct #supplychain #lifesciences

Formulation scale-up is a significant challenge in drug development. Often, the initial research and development phases focus on optimizing the formulation at a milligram scale without fully addressing the complexities associated with scaling up for large-scale production. This oversight can lead to difficulty connected with transitioning from lab-scale to commercial manufacturing. By focusing on this problem, Enamine chemists can effectively address the challenges of scaling up synthetic processes in cost-effective manner, leading to more successful transitions from lab-scale to commercial production. Read the full blog post by Serhiy Ryabukhin and Dmytro Volochnyuk: https://lnkd.in/dMCv6zai