Character Biosciences’ Post

Today I posted the funniest video on my educational channel dedicated to genetics - you will find out what kind of video it is by following the link https://lnkd.in/dYdAdmgE #nikolaysgeneticslessons

Today I posted the funniest video on my educational channel dedicated to genetics - you will find out what kind of video it is by following the link https://lnkd.in/dYdAdmgE #nikolaysgeneticslessons

The Chemistry of Family Ties 🧬 How does genetics influence family dynamics? Explore the fascinating role of genes in shaping personalities and relationships within families. 🗣️🌌 #FamilyLove #FriendsForever #CherishRelationships #QualityTimeTogether #BondingMoments #CloseKnitFamily #FriendshipGoals #FamilyFirst #TrueConnections #LifeWithLovedOnes #RelationshipTips #Relationship

How to use a Punnett square in order to solve genetics problems Made with Explain Everything Youtube video: https://lnkd.in/den6UpqS #nikolaysgeneticslessons

Exploring the Art of Balance – Innate Skill, Learned Skill, or Genetic? Or a perfect balance of all? #ArtOfBalance #BalanceExploration #InnateVsLearned #GeneticBalance #PerfectBalance #SkillAndGenetics #BalancingAct #NatureVsNurture #BalanceInLife #LearningBalance #GeneticVsLearnedSkills #BalanceTheory #HolisticBalance #ExploringBalance

How to use a Punnett square in order to solve genetics problems Made with Explain Everything Youtube video: https://lnkd.in/d-6FYSX5 \#nikolays_genetics_lessons

Santiago Munne, thank you for publishing this enjoyable and thought-provoking paper with a strong argument to discuss! My concern with the paper is that it appears to compare all transferred, untested embryos versus all transferred, PGT-A tested embryos. If true, there may be important differences between groups complicating simple interpretation: 1. Embryos deemed suitable for biopsy, as a group, might be better in quality than all embryos deemed suitable for transfer.   2. Untested embryos likely include a significant number of day 3 transfers, while I would guess that very few day#3 biopsies are performed and even fewer cryopreserved on day#3.  3. There may be socioeconomic differences between groups, as PGT-A adds upfront costs. Application of PGT-A is a nuanced decision best made in consultation between the patient and physician. Some patients may prefer to avoid biopsy for many reasons and we need to use best evidence to help them make their best decision. P.S. I also agree with your paper, that we are unlikely to see large, non-intervention studies of PGT-A in the USA, partly due to the Dickey-Wicker and Hyde amendments preventing NIH support and partly because of market forces. P.P.S. Typo: The American Society for Reproductive Medicine - ASRM Practice Committee document reference has the wrong publication year. I will be interested to hear your thoughts about the substance, not the typo 😉.

An important contribution by Santiago Munne and Darren Griffin to what seems like an eternal discussion about PGT-A. As everyone knows, I can claim no scientific background, but I do have some experience about logical argument. I’ve noticed a familiar pattern in discussions about new reproductive technologies like PGT-A. Early on, there’s a lot of excitement and big promises—sometimes overselling what the technology can really achieve. In response, some critics push back, and occasionally their counterarguments overshoot, taking down claims that were never actually made. Before long, everyone’s caught in a loop—fighting about whose evidence is “right” and losing sight of the original breakthrough. What often gets lost are the practical benefits and nuanced trade-offs—like fewer miscarriages (as pointed by Tony Gordon) or fewer embryo transfers—that matter to patients. Meanwhile, the complexity of infertility itself—full of confounding factors and the difficulty of running perfect clinical trials—makes it even harder to have a balanced, honest conversation. It’s a reminder that we need more measured dialogue. Instead of focusing on extremes, we should acknowledge both the real improvements new technologies can bring, and their genuine limitations. That way, we can help prospective parents make informed decisions rather than just adding to the noise.

How to perform a testcross Under the law of dominance in genetics, an individual expressing a dominant phenotype could contain either two copies of the dominant allele or one copy of each dominant and recessive allele. By performing a test cross, one can determine whether the individual is heterozygous or homozygous dominant. Youtube video: https://lnkd.in/duuzWNjY #nikolaysgeneticslessons

Diabetes type 2 and the neurodegeneration I have been experiencing the last 6 yrs has lowered my quality of life more than the diagnosis of nephropathic cystinosis. Diabetes type 2 can be a side effect of solid organ transplant. Neurodegeneration, including things like epilepsy/seizures/migraines/early onset dementia are symptoms when a human being naturally ages with cystinosis. **** This article makes me more interested, as an adult with cystinosis, in the haematopoietic stem cells and gene therapy in research for the treatment of vascular disease and diabetes. An additional diagnosis of any kind of diabetes would make it harder for a human with cystinosis to qualify for a potential ex vivo gene therapy for the cystinosis. It was so interesting to learn about Friedreich's ataxia and Alzheimer's disease having the same potential as cystinosis with ex vivo....AND as cystinosis humans are living into our 30s and 40s and 50s we become less likely to be chosen for these first couple phases of clinical trial. It would be much more of a relief to see some of these more common illnesses like dementia and diabetes have cure options first, so that these kind of symptoms being cured could make a path to gene therapy more feasible to more people living with the rare disease. Otherwise, only a small percentage from an already marginalized patient population in predominantly western countries will be even having a cure potential possible in their future, if their health insurance determines their eligible. RARE Revolution Magazine Cystinosis Research Foundation Next Generation of Cystinosis Billion-Strong National Organization for Rare Disorders, Inc. (NORD) National Kidney Foundation #AdultsLivingRare #Alzheimers #Cystinosis #CystinosisResearchFoundation #Dementia #DisabledNOTDisposable #FreidrichsAtaxia #NotAnInspirationalStory #NGC #NextGenCystinosis #NextGenerationCystinosis #NextGenerationOfCystinosis #NextGenerationOfCystinosis #ReimagineRare #RightToBelong #WomenInRare #WeAreBillionStrong #WeAreStrongerTogether