Character Biosciences’ Post

Sounds like great progress by Aviv Regev, and Genentech Human Cell Atlas project aims to better understand human health, diagnose diseases, and develop innovative treatments. With 37 trillion cells in the human body—each with a unique function—scientists are working to complete the first draft of this atlas in the coming years. It might change the way we think about human biology—ushering in a new era of personalized medicine, diagnostics, and treatments. https://lnkd.in/dcdniJ9D #LLM #artificialintelligence #HumanCellAtlas #AIinHealthcare #MedicalInnovation #HealthTech #PrecisionMedicine

Thrilled to share the results of our latest study entitled "#Neurosteroid Levels in #GBA Mutated and Non-Mutated #Parkinson’s Disease: A Possible Factor Influencing Clinical Phenotype?" just published in Biomolecules MDPI. This pilot study provides the first observation of changes in #neurosteroid peripheral levels in #GBAPD representing a great collaboration between AUSL Reggio Emilia #IRCCS_RE and Università degli Studi di Modena e Reggio Emilia. Some key points: - we assessed neurosteroids’ serum levels in a cohort of GBA-PD compared with matched cohorts of consecutive non-mutated PD patients and healthy subjects with (GBA-HC) and without (NM-HC) GBA mutations. - 22 GBA-PD, 22 NM-PD, 14 GBA-HC and 15 HC were included. - most of the serum neurosteroids were reduced in both GBA-PD and NM-PD compared to the respective control cohorts, except for 5α-dihydroprogesterone. - Allopregnanolone was the only neurosteroid significantly lower in NM-PD compared to GBA-PD patients. - interestingly in GBA-PD, allopregnanolone, and pregnanolone levels correlated with a more severe MDS-UPDRS part-III, while Allopregnanolone levels also negatively correlated with MoCA scores, and pregnanolone levels correlated with more pronounced bradykinesia. Many thanks to all the co-authors in particular Giuseppe Biagini, Chiara Lucchi, franco valzania, Alessio di Fonzo, Edoardo Monfrini, Sara Grisanti, Valentina Fioravanti, Giulia Di Rauso and Jessica Rossi.

The Neutrophil World: A Comprehensive Review Worth Reading" In a recent article in Signal Transduction and Targeted Therapy (Dec 2024), Zhang et al. review the diversity of neutrophils in health and disease. These granulocytes are key contributors to the acute inflammatory response, traditionally considered as primarily involved in the immediate response to invading pathogens. However, recent studies highlight the versatility of neutrophils, demonstrating their ability to regulate various processes with significant implications for both human health and disease. The authors provide a historical perspective on the evolving understanding of neutrophils and discuss their diverse roles, including their importance in different cell death pathways. Additionally, the review explores the cellular and molecular aspects of signaling pathways in neutrophils and addresses current limitations in neutrophil research. This open-access, comprehensive perspective on neutrophils is highly recommended reading for anyone interested in the life and health sciences. https://lnkd.in/d4V3HiTv

Researchers identified a specific pattern of autoantibodies in the blood that precedes the clinical onset of multiple sclerosis (MS), potentially paving the way for early diagnosis and treatment. Their study found that 10% of MS patients displayed a unique set of autoantibodies against both human proteins and common pathogens like the Epstein-Barr Virus years before showing symptoms. These findings could lead to a simple blood test for early detection of MS, allowing for timely intervention with more effective therapies. This discovery holds promise for transforming the management of MS, moving towards earlier and more precise treatments. https://lnkd.in/grRdhV3u

🧬 Engineering the Future of Immune Protection 🛡️ In the quest for balance within our immune systems, an innovative breakthrough emerges! Scientists have successfully engineered synthetic suppressor T cells, designed to execute precisely targeted immunoprotective programs. This cutting-edge approach aims to maintain immune homeostasis by balancing inflammatory and suppressive activities. By adopting synthetic Notch receptors, these modified CD4+ T cells activate upon detecting specific antigens, producing potent anti-inflammatory factors and intercepting proinflammatory cytokines. This dual action not only shields tissues from harmful immune responses but does so without affecting the system as a whole. The implications are groundbreaking! These customizable synthetic suppressor T cells offer new potential treatments for autoimmune disorders, organ transplant rejections, and even mitigating CAR T cell therapy side effects. A promising step forward in precision medicine, harnessing the power of tailored immune responses for better health outcomes! 🌟🔬 Read Research 👉🏻 https://lnkd.in/dSbWGNkr #research #pubmed

"Scientist Treats Own Cancer with Homegrown Viruses: A Pioneering Leap in Medicine!" 1⃣ Amidst a life-threatening health challenge, one determined scientist harnessed her innovative prowess to cultivate a bespoke viral therapy in her laboratory. This self-devised treatment not only showcases personal resilience but also represents the remarkable fusion of personal initiative and advanced scientific endeavors. Yet, it opens significant ethical debates about the boundaries and responsibilities of self-experimentation in modern medicine. #CancerResearch #MedicalInnovation #ViralTherapy #Ethics #SelfExperimentation #PersonalizedMedicine 2⃣ The extraordinary journey to self-administer a treatment highlights the evolving frontier of personalized cancer therapies, potentially revolutionizing how similar cases might be approached in the future. By tailoring a virus to suit her unique medical needs, she taps into a new horizon of potential cancer treatments, propelling the discussion around individual-centric medical solutions into the spotlight. However, inherent risks linger, underscoring the pressing balance between innovative therapies and tested medical protocols. #ScientificBreakthrough #Innovation #CancerTreatment #SelfCare #PersonalHealth #MedicalEthics 3⃣ This remarkable story compels the scientific community and the public alike to ponder the moral and ethical paradigms involved in crossing traditional boundaries of self-care and medicine. It raises pivotal questions about the extents to which individuals can or should engage in self-directed medical treatments and what implications this holds for the future of healthcare. How do we ensure safety while fostering innovative breakthroughs in personal treatment methodologies? #PublicHealth #MedicalResearch #EthicalDilemmas #HealthcareFuture #CancerWarrior #MedicalFrontiers Source: Nature https://lnkd.in/eWgNfZF3

June research highlights! Check out these three developments that caught our attention at Veritas Innovation:   1.       Advanced Cancer Treatment: Aarhus University researchers combine 4-OI with VSVD51 to enhance treatment for resistant cancers, potentially offering new hope where traditional therapies fall short. (https://lnkd.in/g-ARU6QP) 2.       Portable Diagnostics: University of Pittsburgh's new lab-on-a-chip device uses blood for quick metabolic disorder diagnostics, bridging gaps in healthcare accessibility, especially in remote areas. (https://lnkd.in/g6Grny3j) 3.       Early Parkinson's Detection: UCL and University Medical Center Goettingen use AI to predict Parkinson's up to seven years before symptoms, opening doors to early intervention and disease prevention strategies. (https://lnkd.in/gG_utgNF)   Which breakthrough excites you the most? Let us know if there are any other developments that you found interesting! Explore how Veritas Innovation supports groundbreaking research: https://lnkd.in/gWsJZHKB

The Institute for Biomedicine and Glycomics is a multidisciplinary biomedical research institute for the discovery, development and commercialisation of drugs, vaccines and diagnostics to fight diseases of global impact.   Our research targets the prevention and cure of infectious diseases, cancers and neurological disorders in a unique research environment.   Through world-class, innovative research; global collaboration; state-of-the-art facilities; world leading areas of expertise including glycomics and a focus on translating biomedical discoveries to the clinic, we strive to deliver real and immediate impact on human health globally and to create a brighter future for all. #BiomedicalResearch #Glycomics #DrugDiscovery #VaccineDevelopment #Diagnostics #InfectiousDiseases #CancerResearch #NeurologicalDisorders #GlobalHealth #InnovativeResearch #TranslationalResearch #ResearchCollaboration Research at Griffith The interim Australian Centre for Disease Control

As leaders in the senolytic therapeutic space, UNITY is at the forefront of developing novel therapies that could change the way we approach age-associated diseases.     In a recent interview, CEO Anirvan Ghosh, Ph.D. spoke with Carissa Wong at Nature to discuss our #senolytic approach of selectively targeting and eliminating senescent cells in diabetic retinas to treat and potentially restore vision in #DME.      Learn more about #senescence, current research in senolytics, and our senolytic candidate #UBX1325’s recent clinical data and upcoming milestones: https://bit.ly/3QPwlcZ   

Amazing research! As mentioned in the article this can be used in the future as personalized medicine by using these Mini-guts to testing with different therapies prior to the patient even starting treatment thus as guides for the best treatment option for the patient. I believe they can also be used to test the gut microbiome within these mini-guts to attempt to find any potential association with a microbe causing these epigenetic changes within patients with CD. Determining if CD pathogenesis may be due to changes in gut microbiome in genetically predisposed individuals that cause the DNA methylation or histone acetylation or miRNA disturbance to MHC-1 transcription. The use of AI can help accelerate this type of research. 🧐 #biotechnology #bioinformatics #AI