South Africa has the highest number of people living with HIV in Africa South Africa has the highest number of people living with HIV in Africa, with approximately 7.7 million individuals affected by the virus in 2023. The country remains at the epicenter of the HIV epidemic in Sub-Saharan Africa, where the disease continues to be a major public health issue. Despite significant progress in treatment and awareness, South Africa faces ongoing challenges in curbing the spread of HIV, partly due to high levels of new infections each year. South Africa's large HIV-positive population highlights the need for sustained efforts in treatment, prevention, and education to address this ongoing health crisis.