Anastasiia Plashchova’s Post

💡💡💡 #NewPaper #Simulation #ClinicalTrials #PatientInvolvement Clinical trials entail complex processes that are more challenging when they are addressed to pediatric patients and include a decentralized design. High-realistic simulation allows for the testing and refining of procedures, organizational systems, and interactions between professionals and patients/families, narrowing the gap between work-as-imagined and work-as-done. 🔊 𝐔𝐬𝐢𝐧𝐠 𝐬𝐢𝐦𝐮𝐥𝐚𝐭𝐢𝐨𝐧 𝐰𝐞 𝐜𝐚𝐧 𝐩𝐞𝐫𝐟𝐨𝐫𝐦 𝐭𝐡𝐞 𝐭𝐫𝐢𝐚𝐥 𝐨𝐟 𝐭𝐡𝐞 𝐭𝐫𝐢𝐚𝐥. We can gather insights from patients, caregivers and professionals... and be sure that a clinical trial protocol is feasible to be replicated as designed in the paper copy format. This manuscript describes the experience and results of high-realistic simulations performed to evaluate and redefine three key activities of a pediatric clinical trial on an experimental therapy for a hematologic disease. Additionally, specific analysis about the return on the investment (ROI) and the return of the engagement (ROE) will be performed with the aim to potentially define a framework to assess future simulations on the basis of the definition of potential key performance indicators (KPIs). 𝐇𝐢𝐠𝐡-𝐅𝐢𝐝𝐞𝐥𝐢𝐭𝐲 𝐂𝐥𝐢𝐧𝐢𝐜𝐚𝐥 𝐒𝐢𝐦𝐮𝐥𝐚𝐭𝐢𝐨𝐧 𝐭𝐨 𝐈𝐦𝐩𝐫𝐨𝐯𝐞 𝐚 𝐏𝐞𝐝𝐢𝐚𝐭𝐫𝐢𝐜 𝐂𝐥𝐢𝐧𝐢𝐜𝐚𝐥 𝐓𝐫𝐢𝐚𝐥 𝐃𝐞𝐬𝐢𝐠𝐧: 𝐋𝐞𝐬𝐬𝐨𝐧𝐬 𝐋𝐞𝐚𝐫𝐧𝐞𝐝 𝐚𝐧𝐝 𝐂𝐨𝐧𝐜𝐞𝐩𝐭𝐮𝐚𝐥𝐢𝐳𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐭𝐡𝐞 𝐑𝐞𝐭𝐮𝐫𝐧 𝐨𝐧 𝐈𝐧𝐯𝐞𝐬𝐭𝐦𝐞𝐧𝐭 (𝐑𝐎𝐈) 𝐚𝐧𝐝 𝐑𝐞𝐭𝐮𝐫𝐧 𝐨𝐧 𝐄𝐧𝐠𝐚𝐠𝐞𝐦𝐞𝐧𝐭 (𝐑𝐎𝐄) 𝐀𝐧𝐚𝐥𝐲𝐬𝐢𝐬 📜 Access to the manuscript: https://lnkd.in/ekZN7hpZ It has been a real pleasure to work with this paper with our calleagues José M Quintillá Martínez Carmen De la Gala Rubén Berrueco Joana Claverol Bibiana Figueres i Ribés, M.D. Anna Bergós Civit Lourdes Karina Rodríguez Patiño Ana Mora Augusto Victoria DiBiaso Cristina Llanos Megan Heath

⭐ ⭐ ⭐ Honored to collaborate with the incredible team of Begoña Nafría Escalera, José M Quintilla Martínez, Carmen De la Gala, Rubén Berrueco, Joana Claverol Bibiana Figueres i Ribés, M.D. Anna Bergós Civit Lourdes Karina Rodríguez Patiño, Ana Mora Augusto and Cristina Llanos to publish a framework describing High Fidelity Clinical Trial Simulations. "High-realistic simulation allows for the testing and refining of clinical trial procedures, organizational systems, and interactions between professionals and patients/families, narrowing the gap between work-as-imagined and work-as-done." As every clinical trial developed at Sanofi is informed through integrating patient and caregiver input, high-fidelity simulations are one additional opportunity to assess ways to reduce participant and trial site burden. We look forward to publishing the impact in a future manuscript. 📜 Access to the manuscript: https://rdcu.be/d1uD9 #integratedpatientengagement #sanofistories #pediatrics #clinicaltrials #patientcentricity

How do you engage with your community? If clinical research doesn’t come to mind, it should. From the scientific community to everyday people living with common and rare conditions, research makes a real difference. Clinical trial awareness starts with education. Learn more at Clinical Trials For All: https://lnkd.in/gTbHuDvt

Diversity, equity, inclusion, and accessibility (DEIA) are foundational principles for clinical trials and medical research. In rare diseases clinical research, where numbers of participants are already challenged by rarity itself, maximizing inclusion is of particular importance to clinical trial success, as well as ensuring the generalizability and relevance of the trial results to the people affected by these diseases. In this article, the medical and gray literature and cite case examples to provide insights into how DEIA can be proactively integrated into rare diseases clinical research are reviewed. An interesting paper .

“𝐅𝐨𝐫 𝐲𝐞𝐚𝐫𝐬, 𝐭𝐡𝐞𝐫𝐞 𝐡𝐚𝐬 𝐛𝐞𝐞𝐧 𝐚𝐧 𝐨𝐧𝐠𝐨𝐢𝐧𝐠 𝐝𝐞𝐛𝐚𝐭𝐞 𝐭𝐡𝐚𝐭 𝐫𝐞𝐚𝐥-𝐰𝐨𝐫𝐥𝐝 𝐩𝐨𝐩𝐮𝐥𝐚𝐭𝐢𝐨𝐧 𝐨𝐮𝐭𝐜𝐨𝐦𝐞𝐬 𝐚𝐫𝐞 𝐛𝐞𝐥𝐨𝐰 𝐭𝐡𝐨𝐬𝐞 𝐨𝐟 𝐭𝐡𝐞 𝐨𝐫𝐢𝐠𝐢𝐧𝐚𝐥 𝐜𝐥𝐢𝐧𝐢𝐜𝐚𝐥 𝐭𝐫𝐢𝐚𝐥 𝐩𝐨𝐩𝐮𝐥𝐚𝐭𝐢𝐨𝐧𝐬.” A new blog by Lindsey Gasparini, NeoGenomics’ VP of Informatics and Jeff Elton, PhD, CEO of ConcertAI, examines how outcomes reported from clinical trial data are not always reflected in real-world data (RWD). They discuss better collaboration, new clinical trial approaches to bridge the gap. Plus, hear their insights around the complexities of conducting hematological malignancy studies, where narrow sub-cohorts and evolving treatment options pose unique challenges. Read "Randomized Controlled Trials (RCTs) and Real-world Outcomes in Hematological Malignancies: Minding the Gap": https://lnkd.in/eDiBXFrV

How do you engage with your community? If clinical research doesn’t come to mind, it should. From the scientific community to everyday people living with common and rare conditions, research makes a real difference. Clinical trial awareness starts with education. Learn more at Clinical Trials For All: https://lnkd.in/gTbHuDvt  

Please share your insights with the Foundation as we outline the priority research areas that address the greatest unmet needs of the IBD community!! The Foundation has gathered nearly 80 experts in IBD, including researchers, clinicians, patients and caregivers, funders, industry representatives, and Foundation scientific staff, to create the Challenges in IBD Research 2024 document, which addresses five research focus areas. The topics include Preclinical Human IBD Mechanisms, Environmental Triggers, Precision Medicine, Novel Technologies, and Pragmatic Clinical Research. What: Read the draft documents in up to five research focus areas and provide feedback When: Feedback can be provided up until February 28th, 2024 Why: Your feedback can help shape the future research direction of the Foundation Help us shape the future research direction of the Foundation by reviewing any or all of the five draft manuscripts and providing your feedback.

"Clinical trial trends until the end of 2023 can be divided into two groups — those related to changes in the conduct of clinical trials and those related to the changes in the products of a given nosology." Here, Svyatoslav M. guides us through trends in clinical research, identifying which ones he believes will continue in 2024 and beyond. #clinicaltrials #clinicalresearch

May 20th is National Clinical Trials Day, commemorating the first randomized clinical trial in 1747. This milestone in medical history has evolved into a vital part of modern medicine, driving advancements and finding cures for diseases like sarcoidosis. Clinical trials test new treatments and diagnostics, with patient participation being crucial. For rare diseases like sarcoidosis, finding eligible participants is challenging due to strict criteria and a small patient population. The Foundation for Sarcoidosis Research works to inform patients about trial opportunities through our website, social media, Patient Registry, and Clinical Trial Interest Indicator. Interested in joining a clinical trial? Talk to your sarcoidosis specialist or contact FSR for more information. Together, we can advance research and find better treatments for sarcoidosis. Learn more about current recruiting trials here: https://loom.ly/rzqlBcU Happy National Clinical Trials Day! 🎉 #ClinicalTrialsDay #Sarcoidosis #MedicalResearch #FSR

🌟 I am thrilled to have participated in the Pre-Conference Workshop on "Effective Manuscript Preparation and SPSS Skills for Health Care Professionals" during the Real World Evidence in Oncology Conference at Vydehi Institute Of Medical Sciences and Research Centre! 🌟 This workshop was an amazing opportunity to deepen my understanding of manuscript preparation. The workshop had three modules: Module 1 (online): Included insights on manuscript writing and how effectively it can be written for publication in high-impact journals. Module 2 (online): This was a session on SPSS and Biostatistics specifically tailored for healthcare research. Module 3 (offline): This session highlighted effective techniques for reading and understanding the manuscript in epidemiological studies. This session was very interactive, and we were assigned to different groups to present a paper after a discussion within 15–30 minutes. The insights I gained will undoubtedly elevate the quality of my research and writing, ensuring that my work contributes effectively to the scientific community. I’m grateful for the opportunity to learn from distinguished experts in the field, and I'm eager to apply these new skills to my ongoing and future projects in oncology research. A big thank you to the RWE organizers for putting together such an insightful and practical workshop. Looking forward to implementing these skills and continuing to grow. #OncologyResearch #SPSSSkills #ManuscriptPreparation #HealthCareResearch #ProfessionalDevelopment #RealWorldEvidence