Siva Nadarajah

In this week’s The Yuan, I share my thoughts on advances in #QSM (Quantified Self Movement) and how newer technologies (like #wearables and #LLMs) can unlock the power held in #biomarkers to help us live healthier for longer. Medicine 3.0 is here! #mitoplus #mito #humanedge #docm #longevity #healthspan #healthcare #everdayhealth

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How will AI change the relationships between patients, caregivers, and doctors as each is empowered with more information and understanding? Patients, caregivers, and doctors will come into their visits a lot more prepared. For patients and caregivers: AI-enabled software agents will be used to support you in seeking better outcomes through personalized care. Healthcare often involves making complex medical decisions within a challenging environment: a balkanized medical system of many specialists, information overload and obsolescence, limited time with doctors, and siloed data. New AI tools can enable you to more actively participate in your treatment decisions. For example, consider receiving a complex scan report in a patient portal. Today you may be confused trying to interpret it, adding to your anxiety (“scanxiety”). However, a personalized generative AI agent can translate the scan report into language you can understand, and even contextualize it within your personal health history and clinical evidence/guidelines. By providing an understandable version of the report and the clinical context of your test results, you can engage more fully in decision-making with your medical team. For providers: - Visit preparation: The physician will be armed with the latest data and information, specific to that patient, e.g., test recommendations, treatment recommendations, referral recommendations, drug-drug interactions. - Notifications: Continuous notifications will come from patients and caregivers, e.g., from monitoring devices, and the medical team will have to respond to them. AI can triage the notifications and route them to different members of the medical team. - Treatment access: AI will help doctors in writing the letters that enable patients to access non-standard treatments. For more, please see our conversation with Ezra Cohen, MD, the Chief Medical Officer of Oncology at Tempus AI here: https://lnkd.in/erUhh4b7

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Healthcare innovation is roaring ahead, and it's changing the way healthcare is provided. Kudos to Nallan Sriraman and the team at Mass General Brigham, based in Somerville, Mass., which has been among the earliest and most aggressive adopters of artificial intelligence in healthcare. Their newly rolled-out ambient documentation capabilities "place the relationship between caregivers and patients at the center of healthcare delivery." The integration of AI, like the ambient documentation capabilities at Mass General Brigham, shows great promise in enhancing efficiency and allowing clinicians to focus more on patient care one-on-one rather than administrative tasks. So, what is healthcare's most significant challenge or obstacle in implementing AI? "The biggest challenge in implementing AI in healthcare has been ensuring patient privacy and security while maintaining compliance with stringent regulations like HIPAA. At the same time, making data available for clinical research is critical." One key strategy for overcoming these challenges is to build trust among healthcare professionals. Engaging them early in the process, addressing their concerns, and demonstrating the tangible benefits of AI can encourage innovations like these. Emphasizing the importance of patient-provider relationships is a great way to align these AI technologies with the core mission of healthcare. #nursesonlinkedin #healthcareinnovation #healthcareleaders #Healthcaretechnologies #nursing

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Here's what's happening in the Kidneyverse - your monthly dose of kidney innovation news, funding, policy, and reasons for optimism.💫👇🏼 Full update goes out next week: 📰 https://lnkd.in/egGsNwqs -- TOPICS: 🟪 Discovery & Innovation 🟦 Market Insight 🟨 Policy & Regulation 🟥 Community Voices -- STORIES: 🟪 The team at 34 Lives just rescued their first human kidney that had been deemed not usable for transplant! The company is on a mission to decrease the number of kidneys in the US that are recovered with the intent to transplant but subsequently not used. (h/t Kevin Longino) 🟪 Toku Eyes just received FDA Breakthrough Device designation for its MyKidneyAI product that uses #AI to analyze retinal images from routine eye exams to detect CKD risk in people with diabetes. (h/t Ehsan Vaghefi) 🟦 Outset Medical, Inc. announced it has received FDA 510(k) clearance of TabloCart™ with prefiltration! (h/t Fierce Healthcare) 🟨 CMS announced the proposed Increasing Organ Transplant Access Model earlier this week. The mandatory model is designed to support better outcomes for people living with kidney disease by incentivizing an increased number of kidney transplants. (h/t SMIT PATEL💊📲) 🟨 A newly introduced bill would provide funding for staff assistance and more training options for home dialysis. The legislation proposes covering the cost of in-home health care support staff for up to 90 days with an add-on payment to the dialysis payment bundle. (h/t Kerstin Leuther, PhD) 🟨 The Apple Watch AFib feature just became the first #digitalhealth product to receive FDA approval under the MDDT program. It will be used as a tool to assess atrial fibrillation burden estimates within clinical studies. (h/t Jaydeo Kinikar) 🟥 On May 6, 2024, the Kidney Health Initiative convened a 50+ person vascular access workshop to identify opportunities and challenges for much-needed innovations with POVs shared b/n care partners, patients, and clinical care teams with entrepreneurs, companies, investors, NIDDK, and FDA. (h/t Mark David Lim, Ph.D. PMP) 🟥 For those following the latest VBC and CKCC news, a comment thread on Nishant Jalandhara's latest post is an insightful collection of diverse POVs on what's happening in the space. It includes both high-level guiding wisdom and in-the-weeds candor on what it takes to participate in these models. (Much) more to come on this front via Signals From [Space]. 🟥 An article in MedCity News talks about the polarizing rhetoric around digital health these days. Authors Alyssa Jaffee and Mona Siddiqui, MD, MPH, MSE share thoughts on the early innings for #healthtech with examples like NOCD, Jasper Health, GroundGame.Health, Waymark, and Author Health. *** Each month I send out a recap of dozens of headlines like these, a few closer looks, and visuals of the month. Which resonated with you? Let us know in the comments below (and say hi next week at NKF👋🏼). 👉🏼 https://lnkd.in/egGsNwqs

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🧨 2025 FemTech Landscape I enjoyed my conversation with Jessica D'Amico of FirstWordPharma, where we chatted about how femtech is furthering women's health initiatives. Our conversation was influenced by a recent World Health Organization (WHO) report that highlighted how digital health technologies can improve women’s health and promote equity. 🧨 Questions we tackled for The FirstWordPharma article include: - How are digital technologies helping to reduce disparities in women’s health globally? - Where are you seeing the biggest demand for digital technologies in women’s healthcare? - How are pharmas using digital technologies to augment their women’s health therapeutic portfolios? And to what extent are they developing these in-house? - How do you see the role of AI and machine learning evolving in women’s healthcare?  - Addressing women’s health more comprehensively could unlock significant global economic and societal benefits. What are the most impactful ways digital health technologies could contribute to this? How is the industry addressing data privacy and security concerns in femtech? Please take a moment to read and share the article. #WomensHealth #Press #HealthcareInnovation #FemTech #HealthcareAI #FemTech #Innovation #Impact #HealthEquity Full Article:

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🎥 Our newest Beneath the Surface with Joel M Gelfand MD MSCE is now live! In this edition Dr. Gelfand gets in deep with Roxana Daneshjou about AI 🤖 and it's role in dermatology practice, as well as what's on the horizon. Key Takeaways 👉 AI is here to stay and needs to be harnessed safely and appropriately for the medical community. 👉 Physicians can be on the forefront of how to best integrate AI into practice. Hansa Bhargava MD Healio Penn Medicine, University of Pennsylvania Health System University of Pennsylvania Perelman School of Medicine Stanford University School of Medicine

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SEQSTER PDM Inc. and Boston University researchers, under the leadership of Dr. Rhoda Au, are working together to create an innovative early Alzheimer’s screening tool. Dr. Au, renowned for her expertise in digital health, will utilize SEQSTER’s 1-Click Records platform to gather longitudinal health data crucial for developing a risk-assessment AI tool. The collaboration aims to simplify data retrieval from electronic health records using SEQSTER’s platform, providing researchers with quick access to patients' medical histories. This comprehensive data will offer valuable insights into Alzheimer’s progression, aiding in the identification of individuals at high risk of developing the disease. Dr. Au's team plans to integrate health data with blood-based biomarkers and cognitive assessments to create a screening tool for early-stage Alzheimer’s detection. Supported by the Alzheimer’s Drug Discovery Foundation’s Melvin R. Goodes Prize, this project recognizes Dr. Au's groundbreaking work in digital health, promising early diagnosis and intervention capabilities crucial for Alzheimer’s management. Utilizing SEQSTER’s platform, patients can manage their medical data while supporting scientific advancements. By enabling participants to contribute their data, the collaboration promotes wider engagement in research efforts, ultimately advancing the understanding and treatment of Alzheimer’s. This initiative signifies a significant advancement in early Alzheimer’s detection, leveraging digital health technology and longitudinal data to develop tools that enhance patient outcomes and deepen knowledge of this challenging disease. Learn more about this revolutionary screening breakthrough at: https://lnkd.in/dKYn35QU 🇨🇦Dana Hosseini Matt Fisher Parsi Parsinejad

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70% of medical decisions are based on lab reports? Yet, for most patients, these reports are a maze of jargon and complex numbers—hard to decipher and even harder to act on. At NirogGyan, we’re changing that with Smart Reports. Our mission is simple: ~ Simplify diagnostic data so patients can easily understand their health. ~ Empower better decisions with clear, actionable insights. ~ Make healthcare transparent and patient-friendly. Because healthcare should be more than results—it should be clarity, confidence, and care. #PatientEmpowerment & #PatientEngagement oriented #SmartReports by #NirogGyan to #SimplifyHealthcare

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Dr. Ronald Klatz, MD, DO Worldhealth.net Should we be concerned about over-reliance on #AI in critical situations, where human judgement may be unduly influenced by #algorithms? This finding raises important questions about AI's role in decision-making process that have significant real-world consequences. #ai #artificialintelligence #tech #technology #innovation #machinelearning #humanoid #robotics #worldhealth #publichealth #antiaging #aging #clinicalresearch #research #health #wellness https://lnkd.in/gfM97p76

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Coming soon for preorder in February! 💎Please use code ADC24 for a discount💎 📚The full text, including the table of contents, is now available for viewing at https://lnkd.in/emvrHaUf #trauma #traumatherapy #childtrauma #dissociation #cptsd #ptsd #childdissociation #traumatreatment #traumaresearch #clinicalpsychology #socialwork #psychology

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Has the era of "Digital Health Integrators" begun? "Kaiser Permanente announced a significant AI partnership this week aimed at enhancing value-based care. The West Coast-based health system is deploying Innovaccer’s healthcare AI platform and population health management tools — starting with its Washington market and potentially expanding to new markets in the future. "San Francisco-based Innovaccer was founded in 2014. The healthcare technology company specializes in data-driven solutions that help providers enhance patient care and operation efficiency. "Its healthcare AI platform helps simplify patient care by bringing together data from various disparate sources. By combining all this information, the platform provides a complete and detailed view of each patient’s health, explained Innovaccer CEO Abhinav Shashank. “This helps doctors, nurses and other healthcare professionals get a clearer understanding of each patient’s situation and deliver better care. Therefore, it is not just a point AI application, but a holistic approach to healthcare AI that helps the healthcare ecosystem journey from data to data-driven decisions,” he remarked." #digitalhealth #dataintegration #digitalhealthintegrators #digitalhealthtwin #10phealth #digitaltransformation #ai #ai4h #artificialintelligence #artificialintelligenceinhealthcare #health #healthcare #healthsystem #biomedicine #medicine #telemedicine #telehealth #ehealth #medtech #medicalinnovation #healthtech #healthtechnology #healthtechinnovation #bioinformatics #genome, #phenome #10ph #systemsbiology #genomics #omics #precisionmedicine

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In her recent article for The New Orleans Advocate | The Times-Picayune | Nola.com, Dana Territo explains low-level laser (light) therapy as an innovative and noninvasive treatment for Alzheimer’s disease and other dementias. Also known as photobiomodulation, this therapy uses infrared light to stimulate brain tissue and potentially improve cognitive functions like memory and sleep. Clinical studies suggest that it can enhance blood flow in the brain and increase energy levels in nerve cells, which helps repair and support brain health. The therapy involves applying specific light wavelengths to the scalp, which can help reduce symptoms related to various neurological disorders, including stroke and traumatic brain injury. It’s a painless and relaxing procedure usually administered in a series of weekly sessions, followed by maintenance treatments. While side effects are rare, some patients might experience minor headaches or difficulty sleeping. This approach aims to improve overall well-being and cognitive function while supporting brain health through enhanced blood flow and reduced amyloid plaque. #LaserTherapy #Alzheimers #DementiaTreatment #BrainHealth #InnovationInMedicine #ENDALZ https://lnkd.in/ga-dTYi5

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Researchers from The Hebrew University of Jerusalem have found an exciting way to help fight diseases like Alzheimer's. They discovered a special complex in cells that helps keep proteins in balance and healthy. Proteins in our cells need to be folded and managed properly to work well. When this system breaks down, it can cause problems like Alzheimer's. By reducing the activity of a complex called FIB-1-NOL-56, they found that toxic proteins connected to Alzheimer's were much less harmful. This discovery shows that cells can be protected, helping to prevent the damage that leads to diseases. This breakthrough could lead to new treatments for Alzheimer's and other brain diseases that come with aging. The research team, including Prof. Ehud Cohen, Huadong Zhu, and Dr. Yonatan B. Tzur, showed that the complex controls how proteins are managed in cells, and changing its activity can help reduce harmful protein buildup. Their work offers hope for preventing these diseases in the future, allowing people to age more healthily and live longer without the effects of neurodegenerative diseases. This is a major step toward improving the lives of millions of people who suffer from these conditions. #AlzheimersResearch #NeurodegenerativeDiseases #HealthyAging #ProteinHealth #MedicalBreakthrough #HebrewUniversity #trustscience #ENDALZ

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In order to encourage more patients to complete early cancer screenings, Montefiore Einstein Comprehensive Cancer Center partnered with MyndYou to create an #AI tool to reach out to patients who missed or canceled their colonoscopy screenings. In a recent report, the researchers found that this doubled the colonoscopy completion rate among these patients. Called MyEleanor, this new tool not only ensured more people completed their exams, it also saved an average of 52 hours per month for each employee on the navigator team who helps with this outreach. Given the success of this tool in the Bronx, one of the most disadvantaged communities in New York City, the researchers believe that this tool could help to close healthcare divides in other communities with limited healthcare resources. As a next step, Montefiore Einstein and MyndYou hope to roll out this tool for lung and breast cancer screenings. Technological advancements will help us deliver the care that all patients need and deserve. https://lnkd.in/gfjwr5ga 

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Does anyone want to put together a symposium for ABCT? Something on scaling evidence-based treatments, or using digital tools to disseminate EBTs in the real world? Or even using AI to scale EBTs? Let me know!

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In this insightful discussion, we interview Anthony Caggiano, MD, PhD, Chief Medical Officer and Lisa Ricciardi, CEO, of Cognition Therapeutics, Inc. about their innovative work in Alzheimer’s disease and dementia with Lewy bodies. They delve into the outcomes of the SHINE Phase II study, the significance of biomarkers in Alzheimer’s pathology, and the unique approach of CT1812. They also explore the challenges and future directions in treating neurodegenerative diseases. 𝐑𝐞𝐚𝐝 𝐌𝐨𝐫𝐞: https://lnkd.in/dtt3ikQV

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Honored to Join the Conversation on #PatientsUseAI Thank you, Dave, for your kind words and for sharing your incredible journey—one that underscores the transformative power of 𝐢𝐧𝐟𝐨𝐫𝐦𝐞𝐝 𝐚𝐧𝐝 𝐞𝐦𝐩𝐨𝐰𝐞𝐫𝐞𝐝 𝐩𝐚𝐭𝐢𝐞𝐧𝐭𝐬. As Dave mentioned, this is about more than just technology. It’s part of a long trajectory: our ongoing climb out of 𝐩𝐚𝐭𝐞𝐫𝐧𝐚𝐥𝐢𝐬𝐭𝐢𝐜 𝐜𝐚𝐫𝐞 toward a future where patients have true 𝐚𝐮𝐭𝐨𝐧𝐨𝐦𝐲 and 𝐚𝐠𝐞𝐧𝐜𝐲. Generative AI represents a critical step forward, giving patients the tools to access knowledge, advocate for themselves, and actively shape their healthcare. In the latest post on #PatientsUseAI Substack, I explore how AI can amplify the legacy of patient-driven initiatives like ACOR, which proved that patients are more than just participants in healthcare—they are 𝐥𝐞𝐚𝐝𝐞𝐫𝐬 𝐚𝐧𝐝 𝐢𝐧𝐧𝐨𝐯𝐚𝐭𝐨𝐫𝐬 when given the right tools and support. If you’re curious about how patients are already using AI to transform their care—or if you want to be part of shaping what comes next—I invite you to read the post and join the conversation. 𝐓𝐨𝐠𝐞𝐭𝐡𝐞𝐫, 𝐰𝐞 𝐜𝐚𝐧 𝐫𝐞𝐢𝐦𝐚𝐠𝐢𝐧𝐞 𝐰𝐡𝐚𝐭 𝐢𝐭 𝐦𝐞𝐚𝐧𝐬 𝐭𝐨 𝐛𝐞 𝐚 𝐩𝐚𝐭𝐢𝐞𝐧𝐭 𝐢𝐧 𝐭𝐡𝐞 𝐚𝐠𝐞 𝐨𝐟 𝐀𝐈.

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New #podcast episode on #thyroid health - a quick but deep dive. Do check out the show notes as well. Like, share and subscribe!

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