Sardar Uddin

We are excited to announce that Behavioral Sciences MDPI (ISSN: 2076-328X, IF 2.5, CiteScore 2.6) has been selected for indexing in APA PsycInfo. This achievement reflects the dedication and contributions of our authors, reviewers, and editors, to whom we extend our sincere gratitude. As a peer-reviewed journal, Behavioral Sciences rapidly disseminates high-quality original articles, critical and systematic reviews, and short communications across diverse fields, including psychiatry, neuroscience, psychology, cognitive and behavioral sciences, and behavioral biology. Find out more about submitting to this journal: https://brnw.ch/21wPuHy #mdpi #openaccess #behavioralsciences #psychinfo

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Multicenter study of long-term outcome of resection of para-aortic lymph-node metastasis of CRC. Does this have a significant effect on survival? Read more in this month's #DCRJournal: https://bit.ly/4hcaCYu

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𝐂𝐚𝐫𝐝𝐢𝐚𝐜 𝐀𝐫𝐫𝐡𝐲𝐭𝐡𝐦𝐢𝐚𝐬: 𝐏𝐮𝐥𝐬𝐞𝐝-𝐅𝐢𝐞𝐥𝐝-𝐀𝐛𝐥𝐚𝐭𝐢𝐨𝐧 𝐌𝐚𝐫𝐤𝐞𝐭 🫀 The market for the use of #PFA (#PulsedFieldAblation) Technologies for the treatment of #CardiacArrhythmias is hotting up! With #HRS2024 kicking off in Boston, this is an area that has garnered a lot of attention in #cardiology, and #electrophysiology circles in particular, for the effective treatment of #Afib (#AtrialFibrillation). 𝐇𝐞𝐫𝐞 𝐚𝐫𝐞 𝐬𝐨𝐦𝐞 𝐨𝐟 𝐭𝐡𝐞 𝐤𝐞𝐲 𝐬𝐭𝐚𝐭𝐬 𝐲𝐨𝐮 𝐬𝐡𝐨𝐮𝐥𝐝 𝐤𝐧𝐨𝐰 𝐚𝐛𝐨𝐮𝐭 𝐭𝐡𝐢𝐬 𝐞𝐦𝐞𝐫𝐠𝐢𝐧𝐠 𝐭𝐞𝐜𝐡: • Clinical evidence supports excellent efficacy, with #pulmonaryvein isolation achieved in almost all patients. • Low rate of major complications (including #pericardialtamponade, #stroke and #coronary spasm) • Significantly faster procedure time than #cryoablation or #radiofrequency (#RF) ablation • Good overall freedom from #AFib after one year for #paroxysmal and persistent #AF 𝐑𝐞𝐜𝐞𝐧𝐭 𝐮𝐩𝐝𝐚𝐭𝐞𝐬 𝐟𝐫𝐨𝐦 𝐭𝐡𝐞 𝐩𝐥𝐚𝐲𝐞𝐫𝐬 𝐢𝐧 𝐭𝐡𝐢𝐬 𝐬𝐩𝐚𝐜𝐞 𝐢𝐧𝐜𝐥𝐮𝐝𝐞: Boston Scientific sparks 70% #electrophysiology growth after #Farapulse pulsed-field #ablation launch 🫀 https://shorturl.at/loAVZ Johnson & Johnson secures European #afib #CE approval for #Varipulse pulsed field ablation system 🫀 https://shorturl.at/gtyGY Abbott joins the #pulsedfieldablation party with first procedures using the #Volt #PFA system 🫀 https://shorturl.at/eJNUZ Medtronic nets approval in Japan for #pulsedfieldablation system 🫀 https://shorturl.at/hktER ...𝐚𝐧𝐝 𝐡𝐞𝐫𝐞'𝐬 𝐚𝐧 𝐞𝐱𝐜𝐢𝐭𝐢𝐧𝐠 𝐨𝐧𝐞: Field Medical Announces First-in-Human (#FIH) Trials for Groundbreaking #FieldForce™ #Ventricular Pulsed Field Ablation Technology. The first and only #PFA system designed for the treatment of #VentricularArrhythmias. 🫀 https://shorturl.at/swGP4 #medtech #medicaldevices #hrs #heartrhythmsociety #cardiology #electrophysiology #cardiacrhythmmanagement #cardiovascular #healthtech #heartfailure #healthcare #innovation #executivesearch #executiverecruitment #cardiacablation #cardiacarrhythmia

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Could Digestive Enzymes Contribute to Aging? UCSD researchers have hypothesized a mechanism of aging called “autodigestion”- where digestive enzymes like trypsin, normally confined to the small intestine, leak into peripheral organs as we age. This leakage causes significant tissue damage, resulting in higher levels of collagen damage within organs linking this autodigestion to aging. Using Collagen Hybridizing Peptides (CHPs) to detect damaged collagen, the study revealed how this enzyme leakage accelerates aging and harms vital tissues. Here are their key findings:  Older rats showed higher collagen damage across multiple organs, including the liver, lungs, heart, brain, skin, and kidneys. This damage was closely linked to the presence of leaked digestive enzymes. When older rats were treated with a serine protease inhibitor for just two weeks, enzyme leakage and collagen damage were significantly reduced, offering a potential therapeutic approach. Implications: These findings imply that dietary habits, such as meal frequency and caloric intake, could influence the rate of enzymatic leakage and associated tissue damage, shedding a light on new avenues for therapeutic and lifestyle interventions to preserve tissue integrity and metabolic health. Learn more by reading our full blog and the paper itself here: https://lnkd.in/eHKegbDU

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There has been a great deal of research published in the past 6 months on foundation models for histopathology. Most of these models focus on image tiles from whole slide images. Ramin Nakhli et al. instead focused on cells within these images. Their foundation model learns how to encode cells and their environment without any labels. Their model, VOLTA, was trained with a self-supervised contrastive learning framework. Each cell was cropped out and encoded using their "cell block" network. A separate self-supervised model was trained for the environment around the cell but with the cells themselves cropped out so a not to bias the model. They validated their model on ovarian and endometrial cancer datasets, demonstrating that VOLTA can be used to identify histotypes and molecular subtypes. paper: https://lnkd.in/eVnsbr6k code: https://lnkd.in/e_WZAejZ Want to learn more? Sign up for my Computer Vision Insights newsletter: https://lnkd.in/g9bSuQDP And if you need help training or fine-tuning your own domain-specific foundation model, please reach out. #Pathology #CancerResearch #PrecisionMedicine #MedicalImaging #MachineLearning #DeepLearning #ComputerVision

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New microlearning series! Review IgAN pathophysiology, current treatment approaches, and familiarize yourself with the several agents undergoing Phase III clinical trials for the treatment of IgAN.

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A recent study by Cansu Yanginlar et al. reveals how nuclear antigens in systemic lupus erythematosus (SLE) induce trained immunity, leading to hyper-inflammatory states in innate immune cells. Single Cell Discoveries contributed to this research by performing RNA sequencing on monocytes, which helped identify the transcriptomic changes associated with trained immunity in SLE patients. This insightful discovery paves the way for further biomarker identification to assess the risk of developing flares. Read the full paper here: https://lnkd.in/gtKUycP2

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🚀 Streamline Omics Data Analysis with Firehose 🚀 Analyzing large-scale cancer genomics and proteomics datasets is easy with Firehose, the Broad Institute's powerful suite of tools and pipelines. 🔹 What Sets Firehose Apart? End-to-End Workflows 🔄 From raw data processing to downstream analysis, Firehose has you covered. Multi-Omics Capabilities 🧬 Integrate data across genomics, transcriptomics, and proteomics. Reproducible Results ✅ Standardized pipelines ensure consistent analyses. Simplify your omics research with Firehose today! #BigData #CancerGenomics #DataAnalysis #TCGA

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The American Journal of Human Genetics (AJHG) paper examines accuracy rates and error modes for local ancestry inference (LAI) in admixed cohorts. This work informs best practices for high-quality LAI, which is vital for genomics applications in admixed populations. 🔗Read the full article here: https://lnkd.in/esWSgM8d #ASHG #HumanGenetics #GeneticsDiscoveries

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"Today, DELFI Diagnostics Inc., developer of accessible blood-based liquid biopsy tests that deliver a new way to enhance early cancer detection, is announcing the publication of a new paper, "Cancer treatment monitoring using cell-free DNA fragmentomes," in Nature Communications that demonstrates the effectiveness of cell-free DNA (cfDNA) fragmentomes as a means of assessing tumor burden for treatment response, monitoring, and clinical outcome prediction. cfDNA fragmentomes are tumor and mutation-independent, and the approach described in the paper (called DELFI-Tumor Fraction or "DELFI-TF") requires only 800ul of plasma." #diagnostics #liquidbiopsy #cancerscreening

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The simulation is based on established research regarding GLP-1 receptor agonist mechanisms: G-protein coupled receptor activation Incretin-based glucose regulation Beta-cell insulin secretion pathways Glucose homeostasis mechanisms Discussion Questions and Research Prompts Molecular Mechanisms How does the conformational change in the GLP-1 receptor upon Semaglutide binding compare to the natural GLP-1 hormone's effects? What role do specific amino acid sequences play in the binding affinity between Semaglutide and the GLP-1 receptor? How might modifications to the receptor structure impact binding efficiency and subsequent cellular responses?

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A team at Los Alamos National Laboratory has leveraged machine learning to identify molecular properties that could lead to new antibiotics. This innovative approach, focuses on overcoming the defenses of gram-negative bacteria, particularly 'Pseudomonas aeruginosa'. The study highlights how data-driven models can predict compounds' success in breaching bacterial membranes, opening up new avenues for fighting antibiotic-resistant pathogens. #MachineLearning #DrugDiscovery #Antibiotics #Biotechnology #Innovation #Pharmaceuticals #AIinHealthcare #DataScience #MedicalResearch

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My 2024 review for Prospology (Part 1–the technical stuff) 👇🏼 We started out the year with 16 students, 7 Masterminders, and 2 Grads Group members, from all parts of the world—Montreal, Chicago, Costa Rica, Spain, Alberta, San Francisco… you name it; we catered to every time-zone! 🌎 We brought everyone together with a common goal: to build independently thriving freelance writing businesses as a community. And that we did. 26 professionals went through our program this year, with outstanding results. I had to reimagine our entire website to try and catch up with how quickly we were evolving (which is still being developed, even now). We delivered the pilot of our elective course at University of Missouri-Kansas City, which was met with positive feedback by all 7 faculty members who participated. We’ve already got another cohort lined up for next month, as well as several other schools interested in partnering with us in 2025 and beyond 🙌🏼. We had some great media exposure, which is documented on our new website. We expanded and refined our entire course library (now 30 courses with 350 expert trainings) and migrated everything/everyone over to a new platform that we LOVE. We grew our YouTube channel to 415 subscribers, which now houses 288 videos that are continuing to get better month after month. I published 22 articles in my Freedom-Focused Entrepreneurs newsletter, generating 23,000 impressions, 16,000 article views, and 1,200 new subscribers. I published 13 editions of my Freelance Medical Writing newsletter, resulting in 42,000 impressions, 12,000 article views, and 1,600 new subscribers. We made our own custom quiz to help new and aspiring freelance medical writers see exactly where their biggest strengths and weaknesses are in their business. We sponsored and/or presented at in-person conferences in Virginia, New Orleans, and New York, presented in several online webinars and events, and I caught up with Prospology Team members in England, San Diego (x2), and Portugal (x2). We hosted 81 live, Pop-Up Events in our community as well as 14 additional lectures in our first ever virtual conference. 80% of conference attendees rated our speakers as “excellent,” and 95% felt inspired in their career afterwards. We introduced a free, lifetime membership to graduates of our coaching program, allowing them to continue attending and/or hosting Pop-Up Events indefinitely. We launched a ‘Do It Yourself’ version of our program for those whose budget can’t stretch to accommodate a 1:1, hands-on approach. And we created a cool visual to demonstrate our bespoke coaching framework (more on that in 2025!). So, all in all, it’s been a pretty productive year 🤩. What were your biggest accomplishments and milestones in 2024? #businesscoach #prospology #entrepreneur --------- I help ambitious professionals transform burnout 🥱 into financial freedom 💸 by healing their relationship with work ❤️‍🩹 and aligning with their true purpose 🎯.

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https://lnkd.in/e3JfCVXc An inexpensive aminoguanidine efficiently catalyzes a reductive cyclization of o-phenylenediamines with CO2 in the presence of triethoxysilane.

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#HighlyCitedPapers   📝 Role of CCR2-Positive Macrophages in Pathological Ventricular Remodelling — Veera Ganesh Yerra and Andrew Advani.   In this paper, the authors present a well-structured and comprehensive review on chemokine receptor C-C type 2 that has an implicated role in adverse remodeling as a specific subset of #macrophages.   Full text is available 👇 https://lnkd.in/dwhuAGTe   #medicine #health #research #science

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Beyond Standard Liquid Biopsy: MSK ACCESS®'s Dual Analysis for Unmatched Precision. Liquid Biopsy is a non-invasive laboratory test that analyzes a patient's body fluids to detect cancer cells or tumor DNA. Typically liquid biopsy assessment of tumor DNA is performed from a blood sample. Liquid Biopsy can complement tissue-based methods or supplement them in cases where the tissue is not readily accessible for the detection of clinically relevant, and clinically actionable genomic alterations, many of which are recommended by professional guidelines. Additionally, Liquid biopsy could be used to monitor the treatment of cancer - by detecting minimal residual disease (MRD). Therefore the technique is widely used to guide initiation of targeted therapies and to identify resistance mechanisms through non-invasive testing of tumor DNA. What is MSK ACCESS® Liquid Biopsy? MSK ACCESS® (Analysis of Circulating cfDNA to Evaluate Somatic Status) is a comprehensive cfDNA-based liquid biopsy test designed & developed by Memorial Sloan Kettering Cancer Center and has been extensively validated and widely used for clinical decision-making. The genes have been meticulously curated by MSK experts, featuring up-to-date content and the most recurrent oncogenic mutations. How is MSK ACCESS® Different? Typical liquid biopsy methods sequence and analyze cell free tumor DNA alone and this could have issues as age-related genetic mutations could be a common cause of false positives. Clinical guidelines like ESMO & AMP (Association for Molecular Pathology) highlight the value of matched sequencing of white blood cells (WBCs), to avoid false positives in ctDNA testing. MSK ACCESS® offers a Dual approach - paired tumor cfDNA and matched normal WBC sequencing making the liquid biopsy testing more robust and accurate. Now available in India! Karkinos Healthcare brings this leading liquid biopsy test accessible in India in partnership with SOPHiA GENETICS. For more information, email at [email protected].

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