Roseanne Wincek

Roseanne Wincek

San Francisco, California, United States
6K followers 500+ connections

About

Roseanne is a venture capitalist, early-stage startup founder and operator, scientist…

Activity

Experience

  • DubClub Graphic
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    San Francisco, California, United States

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    Shaker Heights, Ohio, United States

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    Denver, Colorado, United States

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Education

  • Stanford University Graphic

    Stanford University

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    Activities and Societies: Social Committee Chair, SA Senate Member, Venture Capital Club Co-President

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    Activities and Societies: Biophysics Graduate Group, Marqusee Lab, Haw Yang Lab

    ABD. Advanced to PhD Candidacy, May, 2007.

    Coursework: 2 semesters Quantum Mechanics (Department of Chemistry), 1 semester Statistical Mechanics (Department of Chemistry), 1 semester User Interfaces (Department of Computer Science).

    Teaching assistant for Introduction to Programming for Bioinformatics. 2 week intensive course for Biology Graduate Students. 3 sessions - Python & Perl.

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    Activities and Societies: Chi Omega - New Member Educator Klinman Lab

    Tutored Pre-Medical Students in Organic Chemistry.

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    Activities and Societies: AIESEC Residence Hall Association Tutor to Pre-Medical Students in General and Organic Chemistry

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Publications

  • Oxygen Isotope Effects on Electron Transfer to O2 Probed Using Chemically Modified Flavins Bound to Glucose Oxidase.

    Journal of the American Chemical Society

    Apo-glucose oxidase has been reconstituted with flavins modified in the 7 and 8 positions and characterized with regard to the catalytic rate of O2 reduction and oxygen-18 isotope effects on this process. Kinetic studies as a function of driving force indicate a reorganization energy for electron transfer to O2 of λ = 28 kcal mol-1 at optimal pH, which is similar to the value obtained earlier from temperature dependencies of rates (Roth, J. P.; Klinman, J. P. Proc. Natl. Acad. Sci. U.S.A. 2003,…

    Apo-glucose oxidase has been reconstituted with flavins modified in the 7 and 8 positions and characterized with regard to the catalytic rate of O2 reduction and oxygen-18 isotope effects on this process. Kinetic studies as a function of driving force indicate a reorganization energy for electron transfer to O2 of λ = 28 kcal mol-1 at optimal pH, which is similar to the value obtained earlier from temperature dependencies of rates (Roth, J. P.; Klinman, J. P. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 62−67). For the various enzyme-bound flavins, competitive oxygen-18 kinetic isotope effects fall within the narrow range of 1.0266(5) to 1.0279(6), apparently because of the dominant contribution of outer-sphere reorganization to the activation barrier; within the context of semiclassical and quantum mechanical electron transfer theories, the magnitude of the isotope effects reveals the importance of nuclear tunneling.

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