Frank Rimalovski

Wonderful article about Emily Knight and the whole The Engine Accelerator team on the amazing work their doing changing the world with #ToughTech!

28

Excited for DCVC portfolio co Alta Resource Technologies to emerge from stealth! The design space of biology is many orders of magnitude larger than inorganic chemistry, and Alta uses it to massively reduce the cost of extracting rare earth metals. https://lnkd.in/g_q5UwRF

70

1 Comment

Excited to announce Frist Cressey Ventures' investment in Qualified Health and privileged to partner w/ SignalFire, Healthier Capital, Town Hall Ventures and others!   Healthcare costs are increasing at a faster rate than ever before, with the US spending nearly twice as other wealthy countries and still ranking bottom in outcomes. It's a story you've all heard - - US healthcare is known for astronomical inefficiencies, waste, workforce supply constraints, fragmented access, appalling patient experiences, and driving patients and businesses into debt.   Yes these problems present opportunities. But opportunities are limited to the system's appetite for change, desire and incentive to try something new and the innovation available. At FCV we believe we've hit the trifecta with Generative AI. Generative AI has given us truly transformational tools in the toolkit and the healthcare ecosystem is demanding to absorb its benefits. This perfect collision of supply and demand means healthcare is poised for big change.   Generative AI is everywhere, it's buzzy, it dangles hope and opportunity. But many things need to be true for the Gen AI transformation in healthcare to take hold, such as but not limited to:   💡 Patient lives and data need to remain safe: We believe in a highly regulated and human life-touching sector such as healthcare we must ensure Gen AI can drive to unrivalled savings and improvements in the quality of care WHILE not putting patient lives or data at risk.   💡 Systems need to own their utilization of Gen AI: We believe systems will use some hybrid of external partners and homegrown solutions but importantly will want full control of data provisioning and utilization as well as the ability to solve an unlimited number of nuanced issues and not cookie cutter algorithms.   💡 Costs need to be looked at on an enterprise level: We believe the speed of innovation in Gen AI means costs will continue decreasing dramatically but at an enterprise level this will still not be a small detail. Systems will want the ability to understand costs and delegate as needed for the outcomes desired at the organizational level.   Enter Qualified.   We knew when we met Justin Norden, MD, MBA, MPhil and team we were standing in front of changemakers. These individuals have lived and breathed the true application and implementation of Generative AI far before we were asking ChatGPT to write our emails. In fact, if you’ve ever driven in a Waymo you’ve benefited from past products this team has built.   Qualified Health is on a mission to enforce governance in Gen AI, allow systems to rapidly build for their needs, monitor and make decisions for all GenAI (homegrown and external) and accelerate the value the sector can glean from these new technologies.   Huge shout out to William T., Tommaso Auerbach and Jamie Kuntz for their hard work!

240

14 Comments

I'm so excited to continue supporting Prolific Machines, Inc., and the incredible Deniz Kent, PhD ,Max Huisman, and Declan Jones. Today's cellular biology processes are incredibly expensive, inefficient, imprecise, and sometimes purely ineffective. These processes are used from everything from making antibodies to treat diseases, to fermentation used to make high-value nutritional proteins in baby formula, to whole cuts of cultured meat. Prolific has developed a biology platform that leverages light to guide cell behavior and optimize performance over time using AI. By combining light, bioengineering, hardware, and AI in fundamentally new ways, Prolific can help pharmaceutical, nutritional, and therapeutics companies get to market faster, less expensively, and more efficiently — ultimately in hopes of helping improve outcomes — a mission any of us can get behind. Mark Cuban Peter T. Frederick Blackford Cooper Rinzler David Adelman Darco Capital Breakthrough Energy Michael Schulson Kevin Love Tobias Harris Breyer Capital Charles Besser Brennan Besser Lettuce Entertain You Restaurants https://lnkd.in/ea2TqdQk

159

17 Comments

Interesting piece from Marc Andreessen on how startups are not getting the regulatory support they need to sustain America's technological leadership. "Regulatory agencies have been green lit to use brute force investigations, prosecutions, intimidation, and threats to hobble new industries, such as Blockchain. Regulatory agencies are being green lit in real time to do the same to Artificial Intelligence." While many investors themselves (both in the US and Europe) are worried how AI will change our lives, our jobs and social interactions, the top VC opinion leader thinks regulation is already too restrictive. #techstartups #techleadership #strategicgrowth

9

1 Comment

Last week, I had the pleasure of moderating a discussion on navigating FOAK in climate tech at the Greentown Labs Summit in Boston (which had >600 people!!). Here’s a quick rundown of what was shared by Katherine St. James of Spring Lane Capital, Paris Smalls, PhD of Eden GeoPower, and Hannah Friedman of Planeteer Capital: 🌱 What is the definition of FOAK? We discussed how the term can be controversial - it's almost too general because it doesn't identify what kind of "First" FOAK refers to - first team project? First geography? First of a technology in a sector? First time for the integration of a system? It's also too specific because it has the word "first" in it, which can be anathema to later stage / project finance investors. 💰 Partnerships for Funding FOAK Projects We discussed how important it is to build a blended capital stack & use off-balance sheet capital for a project so you're not using the most expensive equity dollars to fund an infrastructure project with low-ish IRR. We also talked through being creative about using corporate partners to provide in-kind services or ink some agreement (at least an LOI) to attract this funding. 🏛 Role of Government We talked about how government capital is seen by investors & how it can be catalytic for FOAK. Government capital can provide validation that a startup has passed a rigorous diligence process by a third party - and incentives like grants or credits can help improve returns for the first project- but it's important to be doing this in conjunction with getting customer validation and to be able to present line of sight to competitive economics without concessionary capital. 👥 Advice for FOAK startups The panelists offered some very specific pieces of advice for startups going through FOAK: how to get creative with things like revenue sharing agreements or convertible notes, getting smart with project development early on (like with DeveloperU), being careful about using FOAK too liberally with certain investor groups, getting the right commercialization / FOAK talent in and around you early Huge thanks to the panelists and the team at Greentown Labs (Jill Kirkpatrick, Julia Travaglini, Aisling Carlson, etc you rocked it!!) for hosting this discussion on bridging the FOAK gap. Also immensely enjoyed the rest of the agenda. Check out the full recap & videos here: https://lnkd.in/d9ApYe9Y #ClimateTech #FOAK #ClimateFinance #ProjectDevelopment #GreenTech #CleanEnergy

55

5 Comments

Check out my recent post on why President Trump is the forcing function for us to solve the “Missing Middle” and catch the industrial Tsunami of onshoring coming to the US!

84

9 Comments

Excited to announce our investment in Alta Resource Technologies alongside Leonardo Banchik (Voyager Ventures) with participation from Orion Resource Partners, Overture Ventures, and WovenEarth Ventures. Rare earths are critical in products from magnets to ceramics and it's important for the US to develop its own supply chain. While the US has some of the best rare earth resources, separating them has historically proven expensive and environmentally unfriendly. Alta through it's computationally designed and optimized proteins allows the US to bring back rare earth production with a cleaner, lower capex, and lower opex solution - and that's just the beginning. Congrats to Nathan Ratledge and the entire Alta team. Read more here: https://lnkd.in/gbGnAJn3

60

4 Comments

The (Healthcare) Ground Beneath Our Feet… This year it is likely that over $10 billion will be invested in the digital health sector – a robust amount, no doubt, but inconsequential when compared to the amount of capital tied up in healthcare real estate assets, which is estimated to be $1.2 trillion by Jones Lang Lasalle. Of that amount, approximately $790 billion is in the hospital sector while the remaining $490 billion is in medical office assets. It is estimated that there are 48.6k facilities with 3.4 billion square feet of healthcare real estate, 42% of which are owned by REITs and another 33% held by other private investment vehicles. Much of the digital health investment is meant to make the physical healthcare infrastructure more productive: greater operating efficiencies, greater patient throughput, more relevant personalized care models with better outcomes. As the healthcare system is being pushed to be more distributed to lower cost sites of care, accelerated now by the rapid proliferation of automation and AI capabilities, the potential impact on healthcare infrastructure assets will be profound. Thoughts on what that might look like... https://lnkd.in/eTfAdUbS #digitalhealth Flare Capital Partners

113

6 Comments

NY friends! Please come see me at Tech Day on my panel discussing the future of the NY tech ecosystem and what I hope to bring to it!

72

5 Comments

To my amazing network - I am thrilled to announce the launch of Pave Health Ventures, an early-stage venture fund dedicated to broadening access to healthcare and improving the overall well-being of our communities. I’ve been very fortunate in my healthcare career. As the Founder & CEO of MedPilot, we capped off a seven-year journey with a successful exit when we were acquired by Vytalize Health. For the last three years, serving as Chief Innovation Officer, I’ve had the honor to contribute to the remarkable growth at Vytalize, impacting the lives of hundreds of thousands of patients by enhancing the quality of care they receive. I am immensely grateful to Matt Buder Shapiro, not only for being the perfect partner and co-founder but also for being an incredible friend. Additionally, I extend my heartfelt appreciation to Faris Ghawi, Amer Alnajar, and Jordan Brown for their outstanding leadership and for broadening my perspective on the significance of value-based care. This journey has not only provided me with industry expertise but has allowed me to cultivate invaluable relationships and an incredible network. As I embark on this new chapter, I am profoundly grateful to be supported by top executives and thought leaders in the investment, wellness, and healthcare industries. Within the healthcare ecosystem, we are represented by key stakeholders from health systems, insurers, governmental organizations, retail health businesses, provider groups, and value-based care organizations. At Pave Health Ventures, we believe the timing couldn't be more opportune to help support health-focused startups. With the growing prevalence of illness and chronic health conditions impacting our communities, consumers and key Healthcare Stakeholders are increasingly prioritizing proactive and preventative care. This shift in focus is fueling demand for technology, products, and services aimed at improving health outcomes, unlocking trillions of dollars in growth potential within the healthcare landscape. Pave Health Ventures is all-in. We are actively seeking solutions that tackle the root causes of illness, manage chronic conditions, and optimize care and care teams. Please support us in our mission by opening your networks and introducing us to amazing founders and entrepreneurs. Together, let's help pave the way to a healthier tomorrow. Jacob Myers

140

34 Comments

I've seen countless startups stumble on regulatory strategy - it's painful, expensive, and often avoidable. The seminar shared by David Pudwill and Geetha Rao hosted by UCSF Innovation Ventures, absolutely nailed what matters most. Here are my key takeaways that every founder should know: 1. Understand your scope - this is where it all starts or stops You've got to nail this foundation: --Map out ALL potential clinical uses (yes, all of them) --Find your "regulatory siblings" (similar approved devices) --Get crystal clear on your impact level: 1)Wellness management (easiest route) 2)Screening/monitoring (middle ground) 3)Diagnostics/therapy (time to bring your A-game) 2. Pick your lane: regulatory pathways from "Easy" to "Buckle Up" Here's what you're looking at: --510(k) Exempt: The startup favorite (for good reason!) --510(k): Tried and true path --De Novo: The road less traveled (but sometimes necessary) --PMA: The regulatory marathon (pack your endurance) 3. Strategic roadmap: This part separates winners from the pack Smart execution is everything: --Start minimal, but make it smart --Grow strategically (think chess, not checkers) --Nail the execution sequence: Define → Design → Test → Produce → Sell Pro tips from the investor seat - know your audience and speak their language: --Investors need that solid IP story --Clinicians want real-world outcomes --Regulators love familiar territory (use it) --Claims strategy (this is crucial) Three rules to live by: --Start small (seriously, resist the temptation) --Expand methodically (no shortcuts) --Document everything (future you will thank you) Why this matters to investors - here's the bottom line: "Your regulatory strategy IS your market strategy. Plain and simple - you'll only get to sell what you get approved for. Plan accordingly." (Full credit goes to David and Geetha for sharing their invaluable insights)

16

HUGE thanks to everyone who came to Riffle Ventures and LabStart's #climateweekNYC event yesterday on how to close the "Zero to One" gap in #climatetech. We often say "Now all we have to do is deploy" or "We have all the solutions we need now we just need to scale them". But keep in mind that to roughly 40% of the technologies needed to hit 2050 net-zero goals are still not in the market, and these numbers don't reflect what's needed to enable climate adaptation and resilience either. Perhaps most importantly, of the solutions that are in the market, are they reaching those in most need, and are they being built and distributed equitably? Point being, the Zero to One phase matters. More early-stage entrepreneurship and co-creation is needed than we often think, and we can't solely focus on scale and deployment if we haven't even built much of what we need still. The unique mix of funding, technical inputs and infrastructure, talent, as well as longer timelines for testing and piloting make a lot of our highest impact climate solutions quite distinct from other technology verticals. On top of this, we face humungous equity and inclusion gaps throughout the tech and startup community writ large. Getting the Zero to One phase right gives us a chance to expedite the pathways into the market for climate technologies while also making sure these solutions are created and distributed equitably. We were extremely fortunate to be joined by leaders in this field - Halcyon, Autodesk Foundation, Hewlett Packard Enterprise, ClimateWorks Foundation, CATAL1.5°T LATAM, Stepchange, Salesforce, King Philanthropies, Enduring Planet, Fractal Climate and many others! Feeling very, very grateful to have such wonderful colleagues like Suma Reddy Ashdeep S. Cyntia Abarca Nigel Keen and Alhan Fakhr alongside amazing partners and leaders like Deepa Lounsbury Megan Holcomb Troy Daley John Meissner Felipe Gonzalez Rosas Cristian Dávila Rafael Lorenzo Piñón Andrew Don Mitch Gainer Saleem Chapman Fred Tan Daniel J. Barker Emmanuelle Palikuca Shereen D'Souza Anay Shah Sara Bender, Ph.D. Adria Wilson, Ph.D. Shaina Horowitz Esther Nai Midori Takasaki Dimitry Gershenson Jennifer Wagner John Alexander, CEPA®, CSRIC® and many more (apologies for the Linkedin mention limitation)!

62

8 Comments

If you are in the VC space, you should know one of the early drivers of "Moneyball for VC". That's Gopinath Sundaramurthy, Ph.D Gopi partnered with the Kauffman Fellows Fund on implementing these concepts in their investment process. The results were staggering. 50% of the investments the fund made became unicorns. In Gopi's words 👇🏻 "We knew something was working, so we thought: Let's build this a little bigger." What did that look like in practice? 1️⃣ Gopi's firm uses a single ‘source of truth’ platform to centralize information, improving decision-making and consistency. 2️⃣ They maintain an even 50/50 split between data engineers and investors to ensure they leverage data to gain insights into teams, markets, and products. Want to learn more about what Gopi and the team at Ensemble VC has implemented at their firm? Check out the case study that our sponsor Harmonic published about the firm -->

53

2 Comments

Two announcements re: our upcoming first-of-its-kind-event: a) 70+ Attendees are registered! b) The upcoming SiliconXL LaunchAthon is perfect for Job Seekers, Software Engineers and Boston-based Startups For more info or to register, visit ---> https://lnkd.in/efPxJ6Fk www - launchathons - com/boston The upcoming SiliconXL LaunchAthon is designed to provide job seekers with an immersive, hands-on experience that goes beyond traditional training. Through targeted AI coding workshops, attendees will dive deep into advanced AI tools and coding platforms, equipping them with practical skills that employers actively seek. These workshops allow job seekers to build real-world projects in collaboration with industry mentors, creating tangible portfolio pieces that showcase their abilities and problem-solving prowess. For those looking to enter the tech field, our LaunchAthon is an invaluable opportunity to gain relevant, hands-on experience that will make them stand out in a competitive job market. Furthermore, the collaborative environment encourages networking with potential employers and peers, giving job seekers a head start on forming connections that may lead to employment opportunities. For software engineers already in the workforce, our LaunchAthon’s workshops provide a vital opportunity to upskill and explore emerging technologies that might not be part of their current roles. The hands-on experience in AI-powered coding workshops offers a practical way to stay updated with industry trends, experiment with new tools, and learn innovative problem-solving techniques. These workshops encourage engineers to think outside their regular scope of work, sparking creativity and enhancing their adaptability to new challenges. Attending the SiliconXL LaunchAthon can add value not only to their current skill set but also to their role within their organization, as they bring back fresh insights and advanced knowledge that can be applied immediately to drive innovation in their day-to-day work. or startup entrepreneurs, the upcoming LaunchAthon offers an unparalleled opportunity to bring their ideas to life through hands-on experience with cutting-edge AI tools and collaborative workshops. Entrepreneurs will benefit from an environment where they can test, validate, and iterate on their concepts with the guidance of industry mentors and experienced tech professionals. These sessions are designed to accelerate the development process, providing valuable insights into product design, rapid prototyping, and market alignment. Beyond just building, entrepreneurs will also network with potential co-founders, partners, and investors, creating connections that can support their startup’s growth. LaunchAthon is more than an event; it’s a launchpad for entrepreneurial visionaries looking to create impactful, scalable tech solutions in a high-energy, supportive setting.

19

2 Comments

Adam Keating discussing how AI is going to change manufacturing and how CoLab Software is helping them make that transition with ReviewAI

15

This is just incredible. Neal Ghosh's demonstration of how #VentureIQ takes deeply technical and complicated content across a range of industrial use cases and ages/stages through an AI-generated conversational podcast (a la #notebookLM) is really mind-blowing. Check out his post, below, and if you haven't seen VentureIQ, yet, let's get you set up to learn more. You can visit VentureIQ.ai or DM any of us over here to book a demo!

2