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Excited for DCVC portfolio co Alta Resource Technologies to emerge from stealth! The design space of biology is many orders of magnitude larger than inorganic chemistry, and Alta uses it to massively reduce the cost of extracting rare earth metals. https://lnkd.in/g_q5UwRF

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A SAFE and convertible note had a baby and Wilson Sonsini Goodrich & Rosati was the midwife- out popped the D-SAFE! 👶🏽🎉 A new #climatetech funding instrument was announced by Elemental Excelerator last week. One of the company’s main goals is to support smaller, up and coming companies during the awkward “Scale Gap” phase between #VC funding and natural growth. It’s called the #DSAFE (Development Simple Agreement for Future Equity) and it aims to aid the process by giving companies a small amount of cash to overcome initial risks and expenses during the developmental stages of a product launch or company. How does it work? D-SAFE has a redemption clause meaning companies can choose to have their payments offered as a loan or convert to equity at the investor’s discretion. Funders and companies will have clear communication and expectations about where the money is going and how it will be applied to either the company or the projects at hand. Financiers and companies will work together with more #transparency, and that’s a great boon for #startups and VC alike. As of this month, Elemental has already invested using D-SAFE in eight different companies, including Dimensional Energy and Origen — both companies investing in innovative and out-of-the-box solutions to environmental issues! Seems like a win-win on the surface. What do you all think about the D-SAFE? Alfredo Coppola Momoka Ueda Tim Wagner Stephen D. Torres Olya Irzak Natsuho Toyama Noriya Tarutani Shin Ogawa

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Is SF Climate Week banter a good barometer of the macro climate tech investment mood? Key nuggets to ponder: 💰💰💰 Climate solutions (like most science/engineering and hardware based deep tech) are capital intensive. They require an "all of the above", creative financing approach to obtain the capital needed to scale (from CVCs, government, public-private partnerships, green banks, debt financing...). 🤖 AI - Everything, Everywhere (all at once). As in most sectors, AI is white hot. It can be a key component of climate solutions, but also a demand accelerant ⏩ More AI = ↗ compute and power demand ⚡= ↗ need for energy storage and grid enhancing solutions 🔋. 🏛 🤵 Political Angst. Real worry that a new administration will cut or impede climate tech catalyzing funding (e.g., DOE funding from IRA). #climatetech #climateweek

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🧩 One thing we've noticed with #VentureIQ technology is how well it can distill and communicate complex technical material 🧩 Whether it's a #deeptech venture, a novel #AI application, or even a patent submission, we can quickly distill the business and strategic implications for investors...and sometimes even the founders/PIs themselves! 🤯 Based on our work so far, the tech can handle a wide array of research areas and technological sectors -- anything from blockchain algorithms to vaccine development. It handles the nuance of the field, the specific terminology, and extracts the key concepts which matter for venture-building. 🤓 To demonstrate, I took a patent I helped write with Eric Laber on reinforcement learning. I ran it through #Ventureiq to build a commercial assessment (key differentiators, target markets). Then for fun I had #NotebookLM make a podcast out of it. I've uploaded the result it here (DM me if you'd like the actual report): https://lnkd.in/eiTejsny This is more than just automation or streamlining operations - it's about unlocking clarity and insight when it was previously unattainable, and the ability to do it over and over again no matter the sector or vertical. Interested in more info? DM me so we can chat.

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This is just incredible. Neal Ghosh's demonstration of how #VentureIQ takes deeply technical and complicated content across a range of industrial use cases and ages/stages through an AI-generated conversational podcast (a la #notebookLM) is really mind-blowing. Check out his post, below, and if you haven't seen VentureIQ, yet, let's get you set up to learn more. You can visit VentureIQ.ai or DM any of us over here to book a demo!

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AI and Med Tech in Focus   AI System Developed to Identify Pathology in Tissues Engineers at Washington State University have developed an AI tool that uses images of human and animal tissue to detect abnormalities faster and more accurately than people. The AI algorithm was trained using images from past studies that involved kidney, testes, ovarian, prostate, breast and lymph node abnormalities. The new model detected disease in minutes—current processes take humans several hours and require specialized teams to check each other’s work. It was also found to be more accurate, sometimes detecting instances that humans had missed. The engineers designed the system to handle the processing load of the high-resolution gigapixel images by breaking them down into smaller tiles but still retaining the overall context of the tissue sample—akin to the zoom feature on a microscope or phone camera. Aside from getting diagnostic results more accurately and quickly, the new system also shows promise in epigenetics (the study of molecular processes that change gene behavior without changing underlying DNA). Epigenetic researchers can perform analyses and get results that used to take a year or more in just a couple of weeks. VC Investors are always adjusting their "Play Book" with a variety of options for investing. Mikal Ventures is one of those alternatives, offering curated solutions to real world problems. Reach out if you have questions on how we can be of assistance and bookmark https://mikalventures.com/ for additional insights and information.

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After a multi-year period when it seems that venture capital funds would only get larger, CRV is moving in the opposite direction. Instead of raising a $500 million growth fund and then a $1 billion vehicle to follow it, the firm is returning just over half of its 2022-era growth fund. Why release $275 million worth of LP commits? "Market conditions have changed for the worse. And valuations for startups are too high relative to their potential payoff." Will other firms follow CRV? If exits do not recover in the next few quarters, the answer may be yes. The nuances of capital calls can play a larger role in eventual IRR than you might have thought.👇

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Three takeaways here: 1. #VentureIQ is insanely good at analyzing dense #RandD and #IP reports and detailing the potential applications of the underlying IP. That said, the reports still skew towards a technical audience... 2. #NotebookLM is insanely good at taking technical writing and producing "podcasts" that a 10 year-old can understand. If you don't believe me, just listen to the first 30 seconds: https://lnkd.in/ep-FNc_z Together #VentureIQ and #NotebookLM can take complex material seemingly written in a foreign language, distill what it does and why it matters, and then explain it to a 10 year-old. And it only takes 5 minutes. Pretty cool, right? This brings me to item #3.... Neal Ghosh, is crazy smart (he ran this on his own #ML patent) and has been working on #AI since before it was cool. Everyone should have a Neal on their team.

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I've seen countless startups stumble on regulatory strategy - it's painful, expensive, and often avoidable. The seminar shared by David Pudwill and Geetha Rao hosted by UCSF Innovation Ventures, absolutely nailed what matters most. Here are my key takeaways that every founder should know: 1. Understand your scope - this is where it all starts or stops You've got to nail this foundation: --Map out ALL potential clinical uses (yes, all of them) --Find your "regulatory siblings" (similar approved devices) --Get crystal clear on your impact level: 1)Wellness management (easiest route) 2)Screening/monitoring (middle ground) 3)Diagnostics/therapy (time to bring your A-game) 2. Pick your lane: regulatory pathways from "Easy" to "Buckle Up" Here's what you're looking at: --510(k) Exempt: The startup favorite (for good reason!) --510(k): Tried and true path --De Novo: The road less traveled (but sometimes necessary) --PMA: The regulatory marathon (pack your endurance) 3. Strategic roadmap: This part separates winners from the pack Smart execution is everything: --Start minimal, but make it smart --Grow strategically (think chess, not checkers) --Nail the execution sequence: Define → Design → Test → Produce → Sell Pro tips from the investor seat - know your audience and speak their language: --Investors need that solid IP story --Clinicians want real-world outcomes --Regulators love familiar territory (use it) --Claims strategy (this is crucial) Three rules to live by: --Start small (seriously, resist the temptation) --Expand methodically (no shortcuts) --Document everything (future you will thank you) Why this matters to investors - here's the bottom line: "Your regulatory strategy IS your market strategy. Plain and simple - you'll only get to sell what you get approved for. Plan accordingly." (Full credit goes to David and Geetha for sharing their invaluable insights)

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🚨 Breaking! 8090 Industries portfolio company Exowatt led by industrialist Hannan P. launches P3, fundamentally unleashing a new dawn for the energy industry! ☀️ Catch the story from Michelle Ma at Bloomberg below: https://lnkd.in/gkfHENST ⚡ Setting the stage: The power requirements to scale AI are astronomical. Within a decade AI will require 650TWh of new power generation – more than the electricity demand of South Korea. In the U.S. alone, data centers will require the equivalent amount of electricity to power 40 million households by 2030. Exowatt P3s can generate electricity at scale at just a $0.04 LCOE and with entirely baseload renewable tech. That’s lower than the cost of most fossil fuels and doesn’t account for subsidies. We have already amassed a 1.2 GW backlog, worth $Billions from the mega tech hyperscalers, energy and data center companies. 💡 How does it work? The system works by capturing the sun’s energy in the form of heat, storing it in a heat battery and converting it to electricity via a heat engine even when the sun is no longer out. This changes the economics of solar by solving a problem called the “Duck Curve” where all conventional solar producers are forced to sell their power at the same time while at maximum output, driving the electricity cost sometimes to zero or negative intraday and leaving no supply at night. Data centers need to operate 24/7 and typically have 60% of their OPEX from energy costs, so an inexpensive and ever available alternative is very important to them. Data centers are straining to bring capacity online and without solutions like Exowatt, are being forced to turn to fossil fuels like coal, oil and natural gas. Keep a close eye on this one, we have no doubt Hannan P. Jack Abraham and the Exowatt team will be pushing forward an exciting, abundant and carbon-free powered future!⚡️ cc Kerem Ozmen Wes Mendenhall Filip Vurdelja Haluk Sabanci Dincer Grant Brown Charles Oppenheimer Ishan Meswani Garuth A. Andrew Irwin

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Last week, I had the pleasure of moderating a discussion on navigating FOAK in climate tech at the Greentown Labs Summit in Boston (which had >600 people!!). Here’s a quick rundown of what was shared by Katherine St. James of Spring Lane Capital, Paris Smalls, PhD of Eden GeoPower, and Hannah Friedman of Planeteer Capital: 🌱 What is the definition of FOAK? We discussed how the term can be controversial - it's almost too general because it doesn't identify what kind of "First" FOAK refers to - first team project? First geography? First of a technology in a sector? First time for the integration of a system? It's also too specific because it has the word "first" in it, which can be anathema to later stage / project finance investors. 💰 Partnerships for Funding FOAK Projects We discussed how important it is to build a blended capital stack & use off-balance sheet capital for a project so you're not using the most expensive equity dollars to fund an infrastructure project with low-ish IRR. We also talked through being creative about using corporate partners to provide in-kind services or ink some agreement (at least an LOI) to attract this funding. 🏛 Role of Government We talked about how government capital is seen by investors & how it can be catalytic for FOAK. Government capital can provide validation that a startup has passed a rigorous diligence process by a third party - and incentives like grants or credits can help improve returns for the first project- but it's important to be doing this in conjunction with getting customer validation and to be able to present line of sight to competitive economics without concessionary capital. 👥 Advice for FOAK startups The panelists offered some very specific pieces of advice for startups going through FOAK: how to get creative with things like revenue sharing agreements or convertible notes, getting smart with project development early on (like with DeveloperU), being careful about using FOAK too liberally with certain investor groups, getting the right commercialization / FOAK talent in and around you early Huge thanks to the panelists and the team at Greentown Labs (Jill Kirkpatrick, Julia Travaglini, Aisling Carlson, etc you rocked it!!) for hosting this discussion on bridging the FOAK gap. Also immensely enjoyed the rest of the agenda. Check out the full recap & videos here: https://lnkd.in/d9ApYe9Y #ClimateTech #FOAK #ClimateFinance #ProjectDevelopment #GreenTech #CleanEnergy

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Exciting to see startups aiming to use AI to discover chemicals, materials, drugs, etc. Semi companies have taken notice: AMD is investing in and Cadence is acquiring them. Semi/EDA companies have broken out by becoming critical path, whether it’s through critical software, packaging, IP, design kits from foundries, or user communities. Aside from just making it easy to make new materials, these “AI for making X” companies also need to articulate a vision as to how they can establish monopolistic positions in their industries.

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Excited to announce Frist Cressey Ventures' investment in Qualified Health and privileged to partner w/ SignalFire, Healthier Capital, Town Hall Ventures and others!   Healthcare costs are increasing at a faster rate than ever before, with the US spending nearly twice as other wealthy countries and still ranking bottom in outcomes. It's a story you've all heard - - US healthcare is known for astronomical inefficiencies, waste, workforce supply constraints, fragmented access, appalling patient experiences, and driving patients and businesses into debt.   Yes these problems present opportunities. But opportunities are limited to the system's appetite for change, desire and incentive to try something new and the innovation available. At FCV we believe we've hit the trifecta with Generative AI. Generative AI has given us truly transformational tools in the toolkit and the healthcare ecosystem is demanding to absorb its benefits. This perfect collision of supply and demand means healthcare is poised for big change.   Generative AI is everywhere, it's buzzy, it dangles hope and opportunity. But many things need to be true for the Gen AI transformation in healthcare to take hold, such as but not limited to:   💡 Patient lives and data need to remain safe: We believe in a highly regulated and human life-touching sector such as healthcare we must ensure Gen AI can drive to unrivalled savings and improvements in the quality of care WHILE not putting patient lives or data at risk.   💡 Systems need to own their utilization of Gen AI: We believe systems will use some hybrid of external partners and homegrown solutions but importantly will want full control of data provisioning and utilization as well as the ability to solve an unlimited number of nuanced issues and not cookie cutter algorithms.   💡 Costs need to be looked at on an enterprise level: We believe the speed of innovation in Gen AI means costs will continue decreasing dramatically but at an enterprise level this will still not be a small detail. Systems will want the ability to understand costs and delegate as needed for the outcomes desired at the organizational level.   Enter Qualified.   We knew when we met Justin Norden, MD, MBA, MPhil and team we were standing in front of changemakers. These individuals have lived and breathed the true application and implementation of Generative AI far before we were asking ChatGPT to write our emails. In fact, if you’ve ever driven in a Waymo you’ve benefited from past products this team has built.   Qualified Health is on a mission to enforce governance in Gen AI, allow systems to rapidly build for their needs, monitor and make decisions for all GenAI (homegrown and external) and accelerate the value the sector can glean from these new technologies.   Huge shout out to William T., Tommaso Auerbach and Jamie Kuntz for their hard work!

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Breaking down the Seattle Venture Ecosystem! Kudos to Jacob Laes and Nick Khormaei for shedding light on the often complex and opaque Seattle funding ecosystem with their comprehensive investor map. For founders, navigating the venture capital world can feel like a maze, but this map offers a much-needed clearer view of where Seattle’s investors are truly placing their bets. And you know me—data is everything! Data drives decisions and, in this case, holds the key to unlocking new opportunities for startups. This project covers 58 firms with insights on: Industry sector focus Investment stages Portfolio track records It’s a game-changer for founders looking to connect with the right investors more efficiently. Check out their breakdown for a detailed view, and feel free to reach out for the full data set! Evan Poncelet Jesse Posey #Startups #Entrepreneurship #VentureCapital #SeattleTech #Funding #TechInnovation #Investing #StartupCommunity #VentureEcosystem #FounderJourney #BusinessGrowth #SeattleStartups

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Friends, Q2 was a quarter of progress and learning for us at HawkTower, where we invest in early-stage startups applying breakthrough computing technologies to maximize California's natural resource markets. Our focus is on technology-enabled interventions (e.g., AI-enabled geospatial radars for lithium-ion batteries in the waste stream) for critical, market-level imperatives (e.g., disaster prevention) that can drive rapid commercial adoption (e.g., placed on every recycling truck in the world). Our current investment priorities are: - Agricultural productivity and efficiency - Biomanufacturing - Labor and mobility automation - Waste stream optimization and decarbonization - Disaster prevention and management Here’s a snapshot of what we’ve been up to: Milestones and Investments: - In late April, we officially launched our fund, filing with the SEC. Yay. - By June, we completed our first fund close ahead of schedule, with backing from family offices, foundations, high-net-worth individuals, and organizations aligned with California's future. - Our portfolio now includes three early-stage investments (Farm-ng, Agriful Software, and Nexstera Tech). Strategic Partnerships: - We believe that startups operating closer to their customers and resources, especially in agriculture and biomanufacturing, have a strategic advantage. For instance, the Salinas Valley, a major agricultural hub, is less than an hour from Silicon Valley and serves as a center of thought leadership in the convergence of agriculture and AI (from Western Growers, Taylor Farms, and others). - Similarly, the North San Joaquin Valley is emerging as a biotech and agtech innovation hub, and we are proud to support BEAM Circular, a startup hub for the circular bioeconomy. Key Relationships: - Karen Warner, CEO of BEAM Circular, joined HawkTower as a strategic advisor. - Jackie Cruz, Ed. D. Cruz, Hartnell College’s VP of Advancement, advises on Salinas Valley and workforce development. - Ben Palone from Western Growers, with his technical background in agriculture, became a trusted advisor. - Matthew Hoffman from Driscoll's Global R&D team provides insights on global agriculture, product positioning, and investment strategy. - We collaborated with Monterey Bay DART for workforce development and automation in agtech. - Dominic Milano and the Milano Technical Group from Merced collaborated on key initiatives and advised us on investments. - HawkTower is participating in Santa Cruz Works's accelerator cohort as a mentor and advisor. Thank you Doug Erickson. - We published an overview of entrepreneurship across the UC system with input from across the University of California system. Moving into the fall, we remain deeply committed to supporting founders shaping California's future natural resource markets. Stay tuned and be in touch! : ) Db

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That feeling when you watch the macro forces that undergird your Industrial Transformation & Supply Chain Technology investment thesis at ⁦‪REFASHIOND Ventures: The Industrial Transformation Fund unfolding every single day: Escalating Geopolitical Tensions; The Climate Crisis & Severe Weather; Consumer Behavior & Demographics. At most venture capital firms, Industrial Transformation & Supply Chain Technology is a tiny, emerging “area of interest” . . . At REFASHIOND Ventures, it’s our entire world. Join us. #IndustrialTransformation #SupplyChain #Innovation #Technology #Startups #VentureCapital

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Sanctuary AI ranks 4th globally for patent holdings on general-purpose #robotics technology and dexterous manipulation technology, only behind NVIDIA, Alphabet and Hyundai. In this Bloomberg Tech Disruptors podcast, co-founder and CTPO, Olivia Norton, discusses how her company is leading the charge, despite being an emerging #startup in a field of tech giants. A great listen for anyone interested in learning how the future of #humanoid robotics is taking shape today! #ThriveVentureFund #FutureIsNow BDC BDC Capital (Canada)

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A new era of deep tech has emerged. First time funds will raise “unheard of” amounts of capital to fuel next gen deep tech startups - producing outsized, superior returns for LP’s compared to the rest. Prudent investors will act on this data and shift investment strategy as LP’s or risk being left behind savvy wealth managers and CIO’s / FO’s who saw this trend begin 4 years ago.

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