Rajiv Ayyangar

Exciting news! We just sent out the inaugural newsletter for Future Frontier Capital, our pre-seed venture fund backing frontier tech startups. As I hit "send," I realized how launching FFC parallels the path of the founders we support. Starting FFC has required the same passion, perseverance, and self-belief that drive entrepreneurs. Just like a startup, getting a VC fund off the ground demands relentless hustle—building the brand, perfecting the pitch, and networking tirelessly. There are constant challenges that test your resolve and endless hours of unglamorous work behind the scenes. And perhaps most daunting - the self-doubt, wondering if you're crazy for attempting something so bold. Pushing through that negative self-talk requires unshakable faith in your mission. Raising this VC fund reminds me of starting our IP strategy and patent analytics firm two decades ago. It’s a powerful reminder of the perseverance, creativity, and resilience needed to turn an ambitious idea into reality. This experience makes us more empathetic partners, ready to support the founders we back. Our work is just beginning, and this inaugural newsletter underscores our commitment to supporting frontier tech startups every step of the way. #startups #VentureCapital #EmergingManagers #Entrepreneurship #InnovationMindSet

21

2 Comments

Why we invested: Gratsi Wine 🍷💸 We led the seed round of Gratsi back in November of '22. At the time, they had zero distribution and their ecommerce revenue was modest. But we were blown away and ultimately decided to partner with the team for a few key reasons: 1. Metrics and efficiency: the underlying metrics of the business were unlike anything we've seen in the space. Gratsi's ability to acquire and retain customers (online and in retail) is unrivaled. 2. Potential for premium boxed wine: we remain convinced that premium boxed wine will continue to become one of the most important categories in the wine space. The volume, margin, and customer experience implications are massive. 3. Founder vision and execution: Stephen Vlahos has been executing relentlessly against his vision since day 1. As we met and got to know Stephen in the early days, it quickly became obvious to us that he would stop at nothing in his mission to build one of the most important wine companies in the world. It's been an amazing two years for Gratsi since we invested and I'm incredibly proud of what the team has accomplished. But I'm perhaps even more excited for the years to come. This team is truly just getting started. Exciting times ahead for Gratsi and the team! cc: Top Shelf Ventures Noah Slakter Jason Sherman

142

33 Comments

I really like this PMF Framework from Sequoia. https://lnkd.in/gT2nWttx

25

2 Comments

An interesting article below, that demonstrates out how San Diego is punching above its weight.  And how Connect's strategy and execution over time, contintues to be central to that success. The article describes the current state of the market in Seattle.  (And i love Seattle.) It's a market that we tend to track with relative to venture fundings.  They used to kick our butts, we outraised them each of the last three years.  This despite the fact they have 3x as many funds there, and 9x the amount of resident capital there. (per pitchbook) Some key takeaways:  * They continue to compare themselves to SIlicon Valley. Instead, we leverage our proximity. *They whine there's not enough local investors (see note above - they have more than us). We bring over 200 VCs to SD annually! * They say founders are not connected with one another. We bring CEOs together regularly, in a variety of ways - private dinners and through our Springboard program. * They say they need to elevate their image on a national & international stage. Why we created and continue to build Five.Ten.Thirty (aka Inno Day).  * And the last paragraph - they need to concentrate on making their region a great place to live. Our mantra: "It's about Better, not Bigger." (See XEO, TL Fund). THANK YOU FOR ALL OF YOUR SUPPORT. WE ARE ON A MISSION TOGETHER!!!  (Comments, whining, suggestions on SD always welcome.) https://lnkd.in/g6Rq_f2Y

109

10 Comments

🎃 Ready to carve out your path to Product-Market Fit?🎃 Join Companyon Ventures’ Behind the Curtain roundtable tomorrow (Oct 30) with Michael Ho, Firas Raouf, Eric Morgan, and Hersh Tapadia as they 'exorcise' the mysteries of PMF. Don’t ghost us—RSVP in the comments 👻 https://lnkd.in/emCJcn4w #emergingmanager #venturecapital #productmarketfit

46

2 Comments

Insightful look into bioplatform strategy, and what it takes to raise a Series A from my partner, Omri Amirav-Drory: https://lnkd.in/dFv7GbF6

20

Non-Engineering Roles at Early-Stage Startups Offering $120K+ Base Salary with Meaningful Bonus and Equity: Chief of Staff @ Milo (Consumer), Remote Biz Ops Lead @ Fractal Agriculture (FinTech), Remote; Backed by Virta Ventures Chief of Staff @ CakeAI (AI SaaS), NY; Backed by Primary Venture Partners Demand Generation Specialist @ Rootly (Consumer), Remote; Backed by YC, 8VC, Gradient Ventures Account Executive @ CommandBar (Enterprise SaaS), Remote; Backed by Soma Capital, YC, Insight Partners Product Marketing @ Slope (Enterprise), Remote; Backed by YC, Union Square Ventures, Liquid 2 Ventures Supply Planning Manager @ PROVEN Skincare (Consumer), Remote; Backed by YC, FJ Labs, Soma Capital, Social Capital Account Executive @ Accrue Savings (Consumer), NY; Backed by Ground Up Ventures, Tiger Global Chief of Staff @ UNIGRID Battery (Climate), CA; Backed by Union Square Ventures, LiquidMetal Ventures Job details and the full list (40+ opportunities) are in the comments below. If you're interested in non-tech jobs focused on specific industries like HardTech, HealthTech, Climate, etc., then DM me or let me know in the comments.

22

2 Comments

I like this idea of "technical taste". It gets into where software engineering is as much creative art as it is science. Four great takeaways (IMHO) for software devs in this era in particular: 1. Aspiring engineers should cultivate a sense of curiosity, experiment with different tools and technologies, and embrace a mindset of continuous learning. 2. AI has the potential to streamline processes and enhance productivity for engineers, but it may also lead to disruptions in traditional software development workflows. 3. Developing technical taste and judgment is essential for making informed decisions about which technologies and approaches to pursue. 4. Collaboration and open-mindedness are key to leveraging the full potential of AI and staying ahead of technological advancements. I also really liked these two quotes from Sam Schillace: 1. "The right time to do something is when you have that feeling in the pit of your stomach that's like, 'oh, this is a great idea and it's going to suck to build because nothing's ready yet.'" 2. "Technical taste is like, 'how well have you consolidated that set of experiences and heuristics into judgment that you can apply accurately when you see new things?'" 3. "It may be the case that very small teams can do very large projects, or like we were talking about before, it may be the case we're just going to get really ambitious about what we try to do with the same size of teams, which is kind of where I would put my money." Great job on continuing to put out great episodes, Brett Berson and team First Round Capital! #ai #engineering #softwaredevelopment

5

🚨🚨 🚨 Unlocking Innovation: The Power of the Adjacent Possible Innovation programs can stall when the team tries to ideate way beyond their collective perspective and frame of reference. Like a software engineer brainstorming genetic modification of mycelia, or a senior executive ideating process improvements which they haven't been participated in for decades. It's challenging, exhausting, and ultimately self-defeating. Enter the concept of the "Adjacent Possible" - a game-changer for innovation. What is it? The Adjacent Possible, coined by Stuart Kauffman, represents the realm of new ideas within reach based on our current knowledge, resources, and capabilities. Why it matters: ➡️ Realistic Innovation: it focuses on achievable advancements, not far-fetched concepts. ➡️ Incremental Progress: each innovation opens doors to new possibilities. How to leverage it: • Constantly explore the boundaries of your adjacent possible. What's in your line of sight is what you know best. • Combine existing ideas in novel ways. Even small perturbations from status quo can generate large innovation leaps. • Stay curious about developments in adjacent industries. Cross-domain patterns create fresh sources of ideas, while also expanding the adjacent possible. Most of all, it takes the 'genius' pressure off the team. No one knows everything, but each one of us knows a lot about something, and we can all drive plenty of innovation potential by focusing on the spaces we know best. Are you exploring your Adjacent Possible? Share your thoughts below! 👇 #Innovation #innovationsystems #AdjacentPossible

8

2 Comments

In this week's episode of the Mobile Dev Memo podcast, I speak with notable X personality Trung Phan about the evolving social media landscape, and how to tame the mayhem and pandemonium of X. https://lnkd.in/dVHMzbui

1

Worth reading: Generative AI is not going to build your engineering team for you. So, so good - peppered with gem quotes and observations- chuckle. https://lnkd.in/gZBKtU4X Thanks to Eric Brooke for sharing.

16

Want a front-row seat to the frontier of tech? We’ve got the role (or two) for you! We’re expanding our frontier-tech team at Blackbird by hiring a Frontier Tech Investments Associate and Foundry Fellows! Got questions? We've got answers... 1️⃣ What are the roles? 🧪 Associate = a full-time VC investment gig in our Blackbird Investments team, working directly with me. We’re looking for someone with a science and/or engineering background and more curiosity than they can handle. You’ll grow your own investment brand and practice, support our portfolio founders, and will help build Foundry, our early-stage frontier-tech accelerator. ✨ Foundry Fellow = a casual/contract gig in our Blackbird Investments team, ~15h per week for 3 months. The Fellowship is ideal for PhD students and ECRs who want to learn more about startups and VC. You’ll go deep on emerging areas relevant to your expertise (or curiosity!), get a front-row seat to groundbreaking companies in those areas, build out your non-academic network, and develop a solid writing practice. 2️⃣ Why are you hiring? We love frontier tech, and we’re ready to grow our team. 3️⃣ Wow, it’s so great that you’re starting to look at deep tech! Look, we get it: we don’t make a lot of noise about our frontier tech investing. Buuuut we’ve been deep-tech investors since we backed Tim Kentley-Klay to found Zoox back in 2014—we’ve been on incredible journeys with PsiQuantum (building the world's first utility-scale quantum computer right here in Australia!), Inventia Life Science (transforming drug discovery with high-fidelity cell models), Remedy Robotics (surgical robots for remote endovascular procedures), Opto Biosystems (minimally-invasive neural implants to treat cancer), and more. We believe that frontier technologies, and great frontier-tech investing, will be part of the solutions to the greatest problems humanity faces today. 4️⃣ When do applications close? May 31st at 11:59pm AEST. 5️⃣ I have more questions! I’m sure you do! Clare Birch and I are hosting an AMA to answer any and all questions about these roles. Want to know what a week in the life of our team looks like? What’s keeping us up at night? What our ideal candidate looks like? Come along and find out - registration link in the comments 👇 Apply for these roles: Associate - https://lnkd.in/gCfj4EUJ Foundry Fellowships - https://lnkd.in/gj6ATZVZ If you know anyone that we should meet, send me their details! Cameron Elise Ben Andrew Robin Joseph Adelaide James Olivia Lucinda Raghav Jesse Christie Mohamed Tom Amee Pablo Haya Loong Hon Joshua Benjamin Megan Harry Denzil Matthew Diana Daniel Tom Deanna Justin Amar Lilly Stone Thomas

113

4 Comments

DayOne cohort #6 is shaping up. 5 teams already committed to participate 🚀 From agriculture to biotech to platform build outs. The founders look 👍🏼&💪🏽 We have interviews scheduled for this week, so if you are thinking of applying, act quickly! Anyone out there that knows of founders that are starting their journey, please also reach out to #genesisventures 👊🏼 It's never too late and the application is simple. 💡Revamping the structure to have even more hands-on and face to face. Applications Close-October 6th,2024. 6th Cohort Begins-November 4th,2024 #dayone #startup #greektech #founders

119

1 Comment

LLMs are trained on internet-scale data. But to make AI work for work, models need to be grounded in your enterprise data -- a much harder problem than meets the eye! How do you connect to all your data sources and ingest them frequently enough while managing compute/storage costs? How do you make sure that you only show users results from documents they have access to? How do you rank results without internet-scale click and link data? How do you process the content of documents that are often hidden in PDFs and presentations? These are tricky problems, and it's why enterprise search didn't work for nearly a decade, until Glean came along. Turns out it's the exact same set of challenges needed to give LLMs the right context to work their magic on your enterprise content. Glean spent 5 years building the ingestion, search, and ranking infra needed to solve this problem well. This has given them the right to run the "Work AI" race and delight users at work. CEO Arvind Jain shares more on the latest episode of Training Data. Listen here, or wherever you get your podcasts: YouTube: https://seq.vc/ytd Apple: https://seq.vc/pit Spotify: https://seq.vc/jnz 

204

10 Comments

Kettleborough VC has been active for ~6 years, invested in ~30 companies, gone through ~80 funding rounds, witnessed ~12 exits including ~4 instances of partial principal erosion, seen ~4 seed to $100M journeys, tracking ~29% XIRR across the portfolio. A couple of IPOs from the portfolio surely seem very much in line ahead.

257

17 Comments

Excited to announce Frist Cressey Ventures' investment in Qualified Health and privileged to partner w/ SignalFire, Healthier Capital, Town Hall Ventures and others!   Healthcare costs are increasing at a faster rate than ever before, with the US spending nearly twice as other wealthy countries and still ranking bottom in outcomes. It's a story you've all heard - - US healthcare is known for astronomical inefficiencies, waste, workforce supply constraints, fragmented access, appalling patient experiences, and driving patients and businesses into debt.   Yes these problems present opportunities. But opportunities are limited to the system's appetite for change, desire and incentive to try something new and the innovation available. At FCV we believe we've hit the trifecta with Generative AI. Generative AI has given us truly transformational tools in the toolkit and the healthcare ecosystem is demanding to absorb its benefits. This perfect collision of supply and demand means healthcare is poised for big change.   Generative AI is everywhere, it's buzzy, it dangles hope and opportunity. But many things need to be true for the Gen AI transformation in healthcare to take hold, such as but not limited to:   💡 Patient lives and data need to remain safe: We believe in a highly regulated and human life-touching sector such as healthcare we must ensure Gen AI can drive to unrivalled savings and improvements in the quality of care WHILE not putting patient lives or data at risk.   💡 Systems need to own their utilization of Gen AI: We believe systems will use some hybrid of external partners and homegrown solutions but importantly will want full control of data provisioning and utilization as well as the ability to solve an unlimited number of nuanced issues and not cookie cutter algorithms.   💡 Costs need to be looked at on an enterprise level: We believe the speed of innovation in Gen AI means costs will continue decreasing dramatically but at an enterprise level this will still not be a small detail. Systems will want the ability to understand costs and delegate as needed for the outcomes desired at the organizational level.   Enter Qualified.   We knew when we met Justin Norden, MD, MBA, MPhil and team we were standing in front of changemakers. These individuals have lived and breathed the true application and implementation of Generative AI far before we were asking ChatGPT to write our emails. In fact, if you’ve ever driven in a Waymo you’ve benefited from past products this team has built.   Qualified Health is on a mission to enforce governance in Gen AI, allow systems to rapidly build for their needs, monitor and make decisions for all GenAI (homegrown and external) and accelerate the value the sector can glean from these new technologies.   Huge shout out to William T., Tommaso Auerbach and Jamie Kuntz for their hard work!

240

14 Comments

Hot take on a lot of early-stage digital health companies out there: You're not a tech company. Most tech-enabled care companies I've seen over the past two years are only tech-enabled in the sense that they use telehealth as their delivery mechanism for care. There are exceptions to this, of course - companies who build computer vision and applied AI tools to better the doctor-patient experience, companies who build tooling around risk scoring and stratification to enable more personalized medicine, companies who build truly novel intakes to better route patients to the appropriate care, etc. These companies have real technology chops and, if they sell it right to the market, can get credit for this from investors. But if you're truly a telehealth provider, you need to realize now that the goal post has shifted dramatically from 2021 and you're going to be valued at maturity at something like 3x EBITDA. That's profit. Not revenue. Throw a revenue multiple out the window. That's not the world we live in if you're a virtual doctor's office. Think of how that impacts venture math. If you're raising a seed round at $15M post-money (or $12M pre-money), it means you'll have to generate something like $150-200M in annual EBITDA to be a fund returner for your seed investors. Maybe even more with dilution, since telehealth businesses are not traditionally capital efficient and will likely need to raise material additional capital to reach that scale. You need to be ridiculously profitable (probably on $800M-$1B in annual revenue since you're likely going to be a 40% gross margin business). Here's the good news: you can set yourself up well (and probably be a contrarian founder relative to your peers), by talking about EBITDA growth and how you can grow into a fund-returning outcome based on realistic mature market comps. This will stand out for the investors you're pitching, even at the early stage. This is how you can beat the malaise of the tech-enabled care market. Focus on the right metrics and the right type of growth. You don't have to have all the answers (no founder does), but you need to make sure the ship is headed in the right direction. A focus on profitability for "tech-enabled care" (*ahem* telehealth) businesses is a good first step.

26

3 Comments

A SAFE and convertible note had a baby and Wilson Sonsini Goodrich & Rosati was the midwife- out popped the D-SAFE! 👶🏽🎉 A new #climatetech funding instrument was announced by Elemental Excelerator last week. One of the company’s main goals is to support smaller, up and coming companies during the awkward “Scale Gap” phase between #VC funding and natural growth. It’s called the #DSAFE (Development Simple Agreement for Future Equity) and it aims to aid the process by giving companies a small amount of cash to overcome initial risks and expenses during the developmental stages of a product launch or company. How does it work? D-SAFE has a redemption clause meaning companies can choose to have their payments offered as a loan or convert to equity at the investor’s discretion. Funders and companies will have clear communication and expectations about where the money is going and how it will be applied to either the company or the projects at hand. Financiers and companies will work together with more #transparency, and that’s a great boon for #startups and VC alike. As of this month, Elemental has already invested using D-SAFE in eight different companies, including Dimensional Energy and Origen — both companies investing in innovative and out-of-the-box solutions to environmental issues! Seems like a win-win on the surface. What do you all think about the D-SAFE? Alfredo Coppola Momoka Ueda Tim Wagner Stephen D. Torres Olya Irzak Natsuho Toyama Noriya Tarutani Shin Ogawa

15

6 Comments

Unique role in a unique company! *Board Chair position* for one of the leading teams in generative machine learning committed to designing proteins - https://www.dreamfold.ai/ If that's you or someone you know - please reach out! About the Company: * DreamFold’s mission is to find treatments for severe, life-threatening diseases.  * DreamFold originated from the labs of renowned AI experts Yoshua Bengio (Turing Award winner) and Michael Bronstein (co-founder & DeepMind professor at Oxford).  * DreamFold has established a strong publication record: FoldFlow and  FoldFlow-2 are state-of-the-art models for protein structure design.  * With initial funding from top-tier deep tech investors, DreamFold is now preparing for a funding round it aims to close in Q3 2025. Objective: Work closely with the founding team and investors to help position DreamFold as a leading company in generative protein design. Bring expertise, insight, and capabilities to build a biotech company with an innovative modality and platform. Year 1: Prepare DreamFold for fundraising by supporting the CEO and team in fine-tuning the value proposition.  Year 2: Complete the Series A funding round to help scale DreamFold and establish two or more significant partnerships. In addition to the usual responsibilities of a Chair of the Board, the candidate will:  * Work with the founding team and investors to establish and articulate a clear, investable vision, strategic roadmap, and plan for sustainable growth.  * Take a leading role in promoting DreamFold’s assets, people, and technologies to the stakeholder community (e.g., biopharma, investors).  * Help develop the skills and competency base by mentoring and recruiting the initial advisory board. Attributes: The founding DreamFold team and investors are ambitious and strongly believe they can contribute to developing new treatments. Chair candidates should possess the following attributes:  * Ideally, the candidate has been a founder of a biotech company that scaled through multiple rounds of funding and deployed innovative technologies in biologics or novel advanced modalities to the clinic.  * Has personally led a company through value-enhancing milestones and returned value to shareholders through a meaningful liquidity event.  * Enthusiastic about the potential of generative algorithms in protein/drug design and willing to collaborate closely with the technical team.  * Able to commit to one day a week initially. #ai #genai #board #recruiting #biotech #pharma

13

1 Comment